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The peritoneum from Cav1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice showed increased EMT, thickness, and fibrosis. Exposure of Cav1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice to PD fluids further increased peritoneal membrane thickness, altered permeability, and increased the number of FSP\u20101\/cytokeratin\u2010positive cells invading the sub\u2010mesothelial stroma. High\u2010throughput quantitative proteomics revealed increased abundance of collagens, FN, and laminin, as well as proteins related to TGF\u2010\u03b2 activity in matrices derived from Cav1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    cells. Lack of Cav1 was associated with hyperactivation of a MEK\u2010ERK1\/2\u2010Snail\u20101 pathway that regulated the Smad2\u20103\/Smad1\u20105\u20108 balance. Pharmacological blockade of MEK rescued E\u2010cadherin and ZO\u20101 inter\u2010cellular junction localization, reduced fibrosis, and restored peritoneal function in Cav1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Moreover, treatment of human PD\u2010patient\u2010derived MCs with drugs increasing Cav1 levels, as well as ectopic Cav1 expression, induced re\u2010acquisition of epithelial features. This study demonstrates a pivotal role of Cav1 in the balance of epithelial versus mesenchymal state and suggests targets for the prevention of fibrosis during PD.\n                  <\/jats:p>","DOI":"10.15252\/emmm.201404127","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T23:33:11Z","timestamp":1419982391000},"page":"102-123","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Caveolin\u20101 deficiency induces a MEK\u2010ERK1\/2\u2010Snail\u20101\u2010dependent epithelial\u2013mesenchymal transition and fibrosis during peritoneal dialysis"],"prefix":"10.1038","volume":"7","author":[{"given":"Raffaele","family":"Strippoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Loureiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Benedicto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"P\u00e9rez Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Barreiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teijo","family":"Pellinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Minguet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Foronda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Osteso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"L\u00f3pez Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"del Pozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,12,30]]},"reference":[{"key":"BFEMMM201404127_CR1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1083\/jcb.201307055","volume":"204","author":"N Ariotti","year":"2014","unstructured":"Ariotti N, Fernandez\u2010Rojo MA, Zhou Y, Hill MM, Rodkey TL, Inder KL, Tanner LB, Wenk MR, Hancock JF, Parton RG (2014) Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling. 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