{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:19:56Z","timestamp":1784290796650,"version":"3.55.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T00:00:00Z","timestamp":1482451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"NSC","doi-asserted-by":"publisher","award":["100\u20102319\u2010B\u2010001\u2010002"],"award-info":[{"award-number":["100\u20102319\u2010B\u2010001\u2010002"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006245","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["102\u20102321\u2010B\u2010001\u2010069\u2010MY3"],"award-info":[{"award-number":["102\u20102321\u2010B\u2010001\u2010069\u2010MY3"]}],"id":[{"id":"10.13039\/501100006245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006245","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["104\u20102325\u2010B\u2010001\u2010010"],"award-info":[{"award-number":["104\u20102325\u2010B\u2010001\u2010010"]}],"id":[{"id":"10.13039\/501100006245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Although remnant cardiomyocytes (CMs) possess a certain degree of proliferative ability, efficiency is too low for cardiac regeneration after injury. In this study, we identified a distinct stage within the initiation phase of CM reprogramming before the MET process, and microarray analysis revealed the strong up\u2010regulation of several mitosis\u2010related genes at this stage of reprogramming. Several candidate genes were selected and tested for their ability to induce CM proliferation. Delivering a cocktail of three genes, FoxM1, Id1, and Jnk3\u2010shRNA (FIJs), induced CMs to re\u2010enter the cell cycle and complete mitosis and cytokinesis\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    . More importantly, this gene cocktail increased CM proliferation\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    and significantly improved cardiac function and reduced fibrosis after myocardial infarction. Collectively, our findings present a cocktail FIJs that may be useful in cardiac regeneration and also provide a practical strategy for probing reprogramming assays for regeneration of other tissues.\n                  <\/jats:p>","DOI":"10.15252\/emmm.201606558","type":"journal-article","created":{"date-parts":[[2016,12,23]],"date-time":"2016-12-23T21:42:21Z","timestamp":1482529341000},"page":"251-264","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Reprogramming\u2010derived gene cocktail increases cardiomyocyte proliferation for heart regeneration"],"prefix":"10.1038","volume":"9","author":[{"given":"Yuan\u2010Yuan","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ting","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Lundy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie HA","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Chian","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Ju","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8910-3596","authenticated-orcid":false,"given":"Patrick CH","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"key":"BFEMMM201606558_CR1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1474-9728.2004.00137.x","volume":"4","author":"AJ Ball","year":"2005","unstructured":"Ball AJ, Levine F (2005) Telomere\u2010independent cellular senescence in human fetal cardiomyocytes. Aging Cell 4: 21\u201330","journal-title":"Aging Cell"},{"key":"BFEMMM201606558_CR2","doi-asserted-by":"crossref","first-page":"e48713","DOI":"10.1371\/journal.pone.0048713","volume":"7","author":"C Bolte","year":"2012","unstructured":"Bolte C, Zhang Y, York A, Kalin TV, Schultz Jel J, Molkentin JD, Kalinichenko VV (2012) Postnatal ablation of Foxm1 from cardiomyocytes causes late onset cardiac hypertrophy and fibrosis without exacerbating pressure overload\u2010induced cardiac remodeling. PLoS ONE 7: e48713","journal-title":"PLoS ONE"},{"key":"BFEMMM201606558_CR3","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.aaf1502","volume":"352","author":"N Cao","year":"2016","unstructured":"Cao N, Huang Y, Zheng J, Spencer CI, Zhang Y, Fu JD, Nie B, Xie M, Zhang M, Wang H et\u00a0al (2016) Conversion of human fibroblasts into\u00a0functional cardiomyocytes by small molecules. Science 352: 1216\u20131220","journal-title":"Science"},{"key":"BFEMMM201606558_CR4","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.stem.2011.11.003","volume":"9","author":"BW Carey","year":"2011","unstructured":"Carey BW, Markoulaki S, Hanna JH, Faddah DA, Buganim Y, Kim J, Ganz K, Steine EJ, Cassady JP, Creyghton MP et\u00a0al (2011) Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. Cell Stem Cell 9: 588\u2013598","journal-title":"Cell Stem Cell"},{"key":"BFEMMM201606558_CR5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nature13233","volume":"510","author":"JJ Chong","year":"2014","unstructured":"Chong JJ, Yang X, Don CW, Minami E, Liu YW, Weyers JJ, Mahoney WM, Van Biber B, Cook SM, Palpant NJ et\u00a0al (2014) Human embryonic\u2010stem\u2010cell\u2010derived cardiomyocytes regenerate non\u2010human primate hearts. Nature 510: 273\u2013277","journal-title":"Nature"},{"key":"BFEMMM201606558_CR6","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/01.CIR.101.2.178","volume":"101","author":"G Christensen","year":"2000","unstructured":"Christensen G, Minamisawa S, Gruber PJ, Wang YB, Chien KR (2000) High\u2010efficiency, long\u2010term cardiac expression of foreign genes in living mouse embryos and neonates. Circulation 101: 178\u2013184","journal-title":"Circulation"},{"key":"BFEMMM201606558_CR7","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1096\/fj.02-0419com","volume":"16","author":"G Condorelli","year":"2002","unstructured":"Condorelli G, Morisco C, Latronico MV, Claudio PP, Dent P, Tsichlis P, Condorelli G, Frati G, Drusco A, Croce CM et\u00a0al (2002) TNF\u2010alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF\u2010alpha receptor. FASEB J 16: 1732\u20131737","journal-title":"FASEB J"},{"key":"BFEMMM201606558_CR8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/cvr\/cvn194","volume":"80","author":"H Ebelt","year":"2008","unstructured":"Ebelt H, Zhang Y, Kampke A, Xu J, Schlitt A, Buerke M, Muller\u2010Werdan U, Werdan K, Braun T (2008) E2F2 expression induces proliferation of terminally differentiated cardiomyocytes in\u00a0vivo. Cardiovasc Res 80: 219\u2013226","journal-title":"Cardiovasc Res"},{"key":"BFEMMM201606558_CR9","doi-asserted-by":"crossref","first-page":"15546","DOI":"10.1073\/pnas.0607382103","volume":"103","author":"FB Engel","year":"2006","unstructured":"Engel FB, Hsieh PC, Lee RT, Keating MT (2006) FGF1\/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc Nat Acad Sci USA 103: 15546\u201315551","journal-title":"Proc Nat Acad Sci USA"},{"key":"BFEMMM201606558_CR10","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature11739","volume":"492","author":"A Eulalio","year":"2012","unstructured":"Eulalio A, Mano M, Dal Ferro M, Zentilin L, Sinagra G, Zacchigna S, Giacca M (2012) Functional screening identifies miRNAs inducing cardiac regeneration. Nature 492: 376\u2013381","journal-title":"Nature"},{"key":"BFEMMM201606558_CR11","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature11045","volume":"484","author":"V Gupta","year":"2012","unstructured":"Gupta V, Poss KD (2012) Clonally dominant cardiomyocytes direct heart morphogenesis. Nature 484: 479\u2013484","journal-title":"Nature"},{"key":"BFEMMM201606558_CR12","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.celrep.2012.10.014","volume":"2","author":"J Hansson","year":"2012","unstructured":"Hansson J, Rafiee MR, Reiland S, Polo JM, Gehring J, Okawa S, Huber W, Hochedlinger K, Krijgsveld J (2012) Highly coordinated proteome dynamics during reprogramming of somatic cells to pluripotency. Cell Rep 2: 1579\u20131592","journal-title":"Cell Rep"},{"key":"BFEMMM201606558_CR13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1161\/01.RES.85.2.128","volume":"85","author":"R von Harsdorf","year":"1999","unstructured":"von Harsdorf R, Hauck L, Mehrhof F, Wegenka U, Cardoso MC, Dietz R (1999) E2F\u20101 overexpression in cardiomyocytes induces downregulation\u00a0of p21CIP1 and p27KIP1 and release of active cyclin\u2010dependent kinases in the presence of insulin\u2010like growth factor I. Circ Res 85: 128\u2013136","journal-title":"Circ Res"},{"key":"BFEMMM201606558_CR14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nmeth.1403","volume":"7","author":"F Hattori","year":"2010","unstructured":"Hattori F, Chen H, Yamashita H, Tohyama S, Satoh YS, Yuasa S, Li W, Yamakawa H, Tanaka T, Onitsuka T et\u00a0al (2010) Nongenetic method for purifying stem cell\u2010derived cardiomyocytes. Nat Methods 7: 61\u201366","journal-title":"Nat Methods"},{"key":"BFEMMM201606558_CR15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"DW Huang","year":"2009","unstructured":"Huang DW, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44\u201357","journal-title":"Nat Protoc"},{"key":"BFEMMM201606558_CR16","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nature08899","volume":"464","author":"C Jopling","year":"2010","unstructured":"Jopling C, Sleep E, Raya M, Marti M, Raya A, Izpisua Belmonte JC (2010) Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature 464: 606\u2013609","journal-title":"Nature"},{"key":"BFEMMM201606558_CR17","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1161\/CIRCULATIONAHA.105.535294","volume":"112","author":"R Khurana","year":"2005","unstructured":"Khurana R, Simons M, Martin JF, Zachary IC (2005) Role of angiogenesis in cardiovascular disease: a critical appraisal. Circulation 112: 1813\u20131824","journal-title":"Circulation"},{"key":"BFEMMM201606558_CR18","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1006\/jmcc.1997.0381","volume":"29","author":"F Li","year":"1997","unstructured":"Li F, Wang X, Bunger PC, Gerdes AM (1997a) Formation of binucleated cardiac myocytes in rat heart: I. Role of actin\u2010myosin contractile ring. J Mol Cell Cardiol 29: 1541\u20131551","journal-title":"J Mol Cell Cardiol"},{"key":"BFEMMM201606558_CR19","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1006\/jmcc.1997.0403","volume":"29","author":"F Li","year":"1997","unstructured":"Li F, Wang X, Gerdes AM (1997b) Formation of binucleated cardiac myocytes in rat heart: II. Cytoskeletal organisation. J Mol Cell Cardiol 29: 1553\u20131565","journal-title":"J Mol Cell Cardiol"},{"key":"BFEMMM201606558_CR20","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/nprot.2007.135","volume":"2","author":"J Luo","year":"2007","unstructured":"Luo J, Deng ZL, Luo X, Tang N, Song WX, Chen J, Sharff KA, Luu HH, Haydon RC, Kinzler KW et\u00a0al (2007) A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nat Protoc 2: 1236\u20131247","journal-title":"Nat Protoc"},{"key":"BFEMMM201606558_CR21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nature12054","volume":"497","author":"AI Mahmoud","year":"2013","unstructured":"Mahmoud AI, Kocabas F, Muralidhar SA, Kimura W, Koura AS, Thet S, Porrello ER, Sadek HA (2013) Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature 497: 249\u2013253","journal-title":"Nature"},{"key":"BFEMMM201606558_CR22","doi-asserted-by":"crossref","first-page":"6716","DOI":"10.1038\/srep06716","volume":"4","author":"H Masumoto","year":"2014","unstructured":"Masumoto H, Ikuno T, Takeda M, Fukushima H, Marui A, Katayama S, Shimizu T, Ikeda T, Okano T, Sakata R et\u00a0al (2014) Human iPS cell\u2010engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration. Sci Rep 4: 6716","journal-title":"Sci Rep"},{"key":"BFEMMM201606558_CR23","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.mcn.2007.12.007","volume":"38","author":"K Mielke","year":"2008","unstructured":"Mielke K (2008) Growth\u2010arrest\u2010dependent expression and phosphorylation of p27kip at serine10 is mediated by the JNK pathway in C6 glioma cells. Mol Cell Neurosci 38: 301\u2013311","journal-title":"Mol Cell Neurosci"},{"key":"BFEMMM201606558_CR24","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cell.2014.03.035","volume":"157","author":"N Naqvi","year":"2014","unstructured":"Naqvi N, Li M, Calvert JW, Tejada T, Lambert JP, Wu JX, Kesteven SH, Holman SR, Matsuda T, Lovelock JD et\u00a0al (2014) A proliferative burst during preadolescence establishes the final cardiomyocyte number. Cell 157: 795\u2013807","journal-title":"Cell"},{"key":"BFEMMM201606558_CR25","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1126\/science.1132292","volume":"313","author":"EN Olson","year":"2006","unstructured":"Olson EN (2006) Gene regulatory networks in the evolution and development of the heart. Science 313: 1922\u20131927","journal-title":"Science"},{"key":"BFEMMM201606558_CR26","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1161\/01.RES.0000152326.91223.4F","volume":"96","author":"KB Pasumarthi","year":"2005","unstructured":"Pasumarthi KB, Nakajima H, Nakajima HO, Soonpaa MH, Field LJ (2005) Targeted expression of cyclin D2 results in cardiomyocyte DNA synthesis and infarct regression in transgenic mice. Circ Res 96: 110\u2013118","journal-title":"Circ Res"},{"key":"BFEMMM201606558_CR27","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.cell.2012.11.039","volume":"151","author":"JM Polo","year":"2012","unstructured":"Polo JM, Anderssen E, Walsh RM, Schwarz BA, Nefzger CM, Lim SM, Borkent M, Apostolou E, Alaei S, Cloutier J et\u00a0al (2012) A molecular roadmap of reprogramming somatic cells into iPS cells. Cell 151: 1617\u20131632","journal-title":"Cell"},{"key":"BFEMMM201606558_CR28","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1126\/science.1077857","volume":"298","author":"KD Poss","year":"2002","unstructured":"Poss KD, Wilson LG, Keating MT (2002) Heart regeneration in zebrafish. Science 298: 2188\u20132190","journal-title":"Science"},{"key":"BFEMMM201606558_CR29","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2741\/e502","volume":"4","author":"P Rajanahalli","year":"2012","unstructured":"Rajanahalli P, Meyer K, Zhu L, Wagner BD, Robinson ML, King DA, Hong Y (2012) Conversion of mouse fibroblasts to sphere cells induced by AlbuMAXI\u2010containing medium. Front Biosci 4: 1813\u20131822","journal-title":"Front Biosci"},{"key":"BFEMMM201606558_CR30","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/cdd.2011.205","volume":"19","author":"R Rizzi","year":"2012","unstructured":"Rizzi R, Di Pasquale E, Portararo P, Papait R, Cattaneo P, Latronico MV, Altomare C, Sala L, Zaza A, Hirsch E et\u00a0al (2012) Post\u2010natal cardiomyocytes can generate iPS cells with an enhanced capacity\u00a0toward cardiomyogenic re\u2010differentation. Cell Death Diff 19: 1162\u20131174","journal-title":"Cell Death Diff"},{"key":"BFEMMM201606558_CR31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cub.2010.11.049","volume":"21","author":"S Ruiz","year":"2011","unstructured":"Ruiz S, Panopoulos AD, Herrerias A, Bissig KD, Lutz M, Berggren WT, Verma IM, Izpisua Belmonte JC (2011) A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol 21: 45\u201352","journal-title":"Curr Biol"},{"key":"BFEMMM201606558_CR32","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/CIRCRESAHA.112.277442","volume":"112","author":"A Sengupta","year":"2013","unstructured":"Sengupta A, Kalinichenko VV, Yutzey KE (2013) FoxO1 and FoxM1 transcription factors have antagonistic functions in neonatal cardiomyocyte cell\u2010cycle withdrawal and IGF1 gene regulation. Circ Res 112: 267\u2013277","journal-title":"Circ Res"},{"key":"BFEMMM201606558_CR33","first-page":"224ra27","volume":"6","author":"SD Shapiro","year":"2014","unstructured":"Shapiro SD, Ranjan AK, Kawase Y, Cheng RK, Kara RJ, Bhattacharya R, Guzman\u2010Martinez G, Sanz J, Garcia MJ, Chaudhry HW (2014) Cyclin A2 induces cardiac regeneration after myocardial infarction through cytokinesis of adult cardiomyocytes. Sci Transl Med 6: 224ra27","journal-title":"Sci Transl Med"},{"key":"BFEMMM201606558_CR34","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1172\/JCI119453","volume":"99","author":"MH Soonpaa","year":"1997","unstructured":"Soonpaa MH, Koh GY, Pajak L, Jing SL, Wang H, Franklin MT, Kim KK, Field LJ (1997) Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice. J Clin Invest 99: 2644\u20132654","journal-title":"J Clin Invest"},{"key":"BFEMMM201606558_CR35","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","volume":"126","author":"K Takahashi","year":"2006","unstructured":"Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663\u2013676","journal-title":"Cell"},{"key":"BFEMMM201606558_CR36","doi-asserted-by":"crossref","first-page":"E12","DOI":"10.1161\/01.RES.0000049105.15329.1C","volume":"92","author":"M Tamamori\u2010Adachi","year":"2003","unstructured":"Tamamori\u2010Adachi M, Ito H, Sumrejkanchanakij P, Adachi S, Hiroe M, Shimizu M, Kawauchi J, Sunamori M, Marumo F, Kitajima S et\u00a0al (2003) Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation. Circ Res 92: E12\u2013E19","journal-title":"Circ Res"},{"key":"BFEMMM201606558_CR37","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1093\/hmg\/ddt358","volume":"22","author":"V Velecela","year":"2013","unstructured":"Velecela V, Lettice LA, Chau YY, Slight J, Berry RL, Thornburn A, Gunst QD, van den Hoff M, Reina M, Martinez FO et\u00a0al (2013) WT1 regulates the expression of inhibitory chemokines during heart development. Hum Mol Genet 22: 5083\u20135095","journal-title":"Hum Mol Genet"},{"key":"BFEMMM201606558_CR38","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cell.2012.07.035","volume":"151","author":"JA Wamstad","year":"2012","unstructured":"Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, Ding H, Wylie JN, Pico AR, Capra JA et\u00a0al (2012) Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell 151: 206\u2013220","journal-title":"Cell"},{"key":"BFEMMM201606558_CR39","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/cr.2011.171","volume":"22","author":"H Xu","year":"2012","unstructured":"Xu H, Yi BA, Wu H, Bock C, Gu H, Lui KO, Park JH, Shao Y, Riley AK, Domian IJ et\u00a0al (2012) Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature. Cell Res 22: 142\u2013154","journal-title":"Cell Res"},{"key":"BFEMMM201606558_CR40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1172\/JCI44927","volume":"122","author":"J Yoshioka","year":"2012","unstructured":"Yoshioka J, Chutkow WA, Lee S, Kim JB, Yan J, Tian R, Lindsey ML, Feener EP, Seidman CE, Seidman JG et\u00a0al (2012) Deletion of thioredoxin\u2010interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia\u2010reperfusion injury. J Clin Invest 122: 267\u2013279","journal-title":"J Clin Invest"},{"key":"BFEMMM201606558_CR41","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature12322","volume":"498","author":"R Zhang","year":"2013","unstructured":"Zhang R, Han P, Yang H, Ouyang K, Lee D, Lin YF, Ocorr K, Kang G, Chen J, Stainier DY et\u00a0al (2013) In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature 498: 497\u2013501","journal-title":"Nature"}],"container-title":["EMBO Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.201606558.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/emmm.201606558","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/emmm.201606558\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/emmm.201606558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.201606558.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:17:20Z","timestamp":1779085040000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/emmm.201606558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,23]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2,1]]}},"alternative-id":["BFEMMM201606558"],"URL":"https:\/\/doi.org\/10.15252\/emmm.201606558","relation":{},"ISSN":["1757-4676","1757-4684"],"issn-type":[{"value":"1757-4676","type":"print"},{"value":"1757-4684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,23]]},"assertion":[{"value":"28 April 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}