{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:18:25Z","timestamp":1790936305132,"version":"4.1.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T00:00:00Z","timestamp":1511740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gothenburg County Council","award":["ALFGBG\u2010426531"],"award-info":[{"award-number":["ALFGBG\u2010426531"]}]},{"name":"the Harold Hamm Diabetes Center"},{"DOI":"10.13039\/100000053","name":"HHS | NIH | National Eye Institute","doi-asserted-by":"publisher","award":["EY024864"],"award-info":[{"award-number":["EY024864"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"HHS | NIH | National Eye Institute","doi-asserted-by":"publisher","award":["EY017017"],"award-info":[{"award-number":["EY017017"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7, Project 305485 PREVENT\u2010ROP"],"award-info":[{"award-number":["FP7, Project 305485 PREVENT\u2010ROP"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["P30AG050911"],"award-info":[{"award-number":["P30AG050911"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001209","name":"Knights Templar Eye Foundation","doi-asserted-by":"publisher","award":["76293"],"award-info":[{"award-number":["76293"]}],"id":[{"id":"10.13039\/100001209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Li2650\/1\u20101"],"award-info":[{"award-number":["Li2650\/1\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Blind Children's Center","award":["89282"],"award-info":[{"award-number":["89282"]}]},{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","award":["1U54HD090255"],"award-info":[{"award-number":["1U54HD090255"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018550","name":"Lowy Medical Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100018550","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004359","name":"The Swedish Research Council","doi-asserted-by":"publisher","award":["DNR# 2011\u20102432"],"award-info":[{"award-number":["DNR# 2011\u20102432"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["2014\u20103140"],"award-info":[{"award-number":["2014\u20103140"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Governmental ALF Research Grants"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2018,1,1]]},"DOI":"10.15252\/emmm.201707966","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T20:25:30Z","timestamp":1511814330000},"page":"76-90","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Photoreceptor glucose metabolism determines normal retinal vascular growth"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-2983","authenticated-orcid":false,"given":"Zhongjie","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chatarina A","family":"L\u00f6fqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffael","family":"Liegl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Hsiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven S","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel B","family":"Burnim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Arellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"My T","family":"Chouinard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubi","family":"Duran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Poblete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve S","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D","family":"Akula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kinter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid Hansen","family":"Pupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saswata","family":"Talukdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7644-6410","authenticated-orcid":false,"given":"Lois EH","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,27]]},"reference":[{"key":"BFEMMM201707966_CR1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/ped.12371","volume":"56","author":"M Ahmadpour\u2010Kacho","year":"2014","unstructured":"Ahmadpour\u2010Kacho M, Motlagh AJ, Rasoulinejad SA, Jahangir T, Bijani A, Pasha YZ (2014) Correlation between hyperglycemia and retinopathy of prematurity. Pediatr Int 56: 726\u2013730","journal-title":"Pediatr Int"},{"key":"BFEMMM201707966_CR2","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1167\/iovs.07-0204","volume":"48","author":"JD Akula","year":"2007","unstructured":"Akula JD, Hansen RM, Martinez\u2010Perez ME, Fulton AB (2007) Rod photoreceptor function predicts blood vessel abnormality in retinopathy of prematurity. Invest Ophthalmol Vis Sci 48: 4351\u20134359","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFEMMM201707966_CR3","first-page":"2499","volume":"14","author":"JD Akula","year":"2008","unstructured":"Akula JD, Mocko JA, Benador IY, Hansen RM, Favazza TL, Vyhovsky TC, Fulton AB (2008) The neurovascular relation in oxygen\u2010induced retinopathy. Mol Vis 14: 2499\u20132508","journal-title":"Mol Vis"},{"key":"BFEMMM201707966_CR4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.exer.2010.04.008","volume":"91","author":"JD Akula","year":"2010","unstructured":"Akula JD, Hansen RM, Tzekov R, Favazza TL, Vyhovsky TC, Benador IY, Mocko JA, McGee D, Kubota R, Fulton AB (2010) Visual cycle modulation in neurovascular retinopathy. Exp Eye Res 91: 153\u2013161","journal-title":"Exp Eye Res"},{"key":"BFEMMM201707966_CR5","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1210\/en.2016-1148","volume":"157","author":"GH Almudena","year":"2016","unstructured":"Almudena GH, Nuria B, Oscar E, Sabela DC, Gema GG, Silvia F, Manuel B (2016) Severe brown fat lipoatrophy aggravates atherosclerotic process in male mice. Endocrinology 157: 3517\u20133528","journal-title":"Endocrinology"},{"key":"BFEMMM201707966_CR6","doi-asserted-by":"crossref","first-page":"9091","DOI":"10.1038\/srep09091","volume":"5","author":"SC Au","year":"2015","unstructured":"Au SC, Tang SM, Rong SS, Chen LJ, Yam JC (2015) Association between hyperglycemia and retinopathy of prematurity: a systemic review and meta\u2010analysis. Sci Rep 5: 9091","journal-title":"Sci Rep"},{"key":"BFEMMM201707966_CR7","doi-asserted-by":"crossref","first-page":"583","DOI":"10.2337\/db06-1432","volume":"56","author":"M Bjursell","year":"2007","unstructured":"Bjursell M, Ahnmark A, Bohlooly YM, William\u2010Olsson L, Rhedin M, Peng XR, Ploj K, Gerdin AK, Arnerup G, Elmgren A et\u00a0al (2007) Opposing effects of adiponectin receptors 1 and 2 on energy metabolism. Diabetes 56: 583\u2013593","journal-title":"Diabetes"},{"key":"BFEMMM201707966_CR8","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.jpeds.2010.12.040","volume":"158","author":"SK Chacko","year":"2011","unstructured":"Chacko SK, Ordonez J, Sauer PJ, Sunehag AL (2011) Gluconeogenesis is not\u00a0regulated by either glucose or insulin in extremely low birth weight infants receiving total parenteral nutrition. J Pediatr 158: 891\u2013896","journal-title":"J Pediatr"},{"key":"BFEMMM201707966_CR9","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/jp.2011.19","volume":"31","author":"R Chavez\u2010Valdez","year":"2011","unstructured":"Chavez\u2010Valdez R, McGowan J, Cannon E, Lehmann CU (2011) Contribution of early glycemic status in the development of severe retinopathy of prematurity in a cohort of ELBW infants. J Perinatol 31: 749\u2013756","journal-title":"J Perinatol"},{"key":"BFEMMM201707966_CR10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1203\/PDR.0b013e3181e17c90","volume":"68","author":"AR Cox","year":"2010","unstructured":"Cox AR, Gottheil SK, Arany EJ, Hill DJ (2010) The effects of low protein during gestation on mouse pancreatic development and beta cell regeneration. Pediatr Res 68: 16\u201322","journal-title":"Pediatr Res"},{"key":"BFEMMM201707966_CR11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cell.2013.06.037","volume":"154","author":"K De Bock","year":"2013","unstructured":"De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquiere B, Cauwenberghs S, Eelen G et\u00a0al (2013) Role of PFKFB3\u2010driven glycolysis in vessel sprouting. Cell 154: 651\u2013663","journal-title":"Cell"},{"key":"BFEMMM201707966_CR12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.preteyeres.2006.01.001","volume":"25","author":"MI Dorrell","year":"2006","unstructured":"Dorrell MI, Friedlander M (2006) Mechanisms of endothelial cell guidance and vascular patterning in the developing mouse retina. Prog Retin Eye Res 25: 277\u2013295","journal-title":"Prog Retin Eye Res"},{"key":"BFEMMM201707966_CR13","doi-asserted-by":"crossref","first-page":"16586","DOI":"10.1073\/pnas.1314575110","volume":"110","author":"Y Du","year":"2013","unstructured":"Du Y, Veenstra A, Palczewski K, Kern TS (2013) Photoreceptor cells are major contributors to diabetes\u2010induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci USA 110: 16586\u201316591","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM201707966_CR14","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/S0140-6736(09)60553-5","volume":"373","author":"KM Dungan","year":"2009","unstructured":"Dungan KM, Braithwaite SS, Preiser JC (2009) Stress hyperglycaemia. Lancet 373: 1798\u20131807","journal-title":"Lancet"},{"key":"BFEMMM201707966_CR15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000088199","volume":"89","author":"T Ertl","year":"2006","unstructured":"Ertl T, Gyarmati J, Gaal V, Szabo I (2006) Relationship between hyperglycemia and retinopathy of prematurity in very low birth weight infants. Biol Neonate 89: 56\u201359","journal-title":"Biol Neonate"},{"key":"BFEMMM201707966_CR16","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1242\/jcs.03253","volume":"119","author":"Y Eura","year":"2006","unstructured":"Eura Y, Ishihara N, Oka T, Mihara K (2006) Identification of a novel protein that regulates mitochondrial fusion by modulating mitofusin (Mfn) protein function. J Cell Sci 119: 4913\u20134925","journal-title":"J Cell Sci"},{"key":"BFEMMM201707966_CR17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul F, Erdfelder E, Lang AG, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39: 175\u2013191","journal-title":"Behav Res Methods"},{"key":"BFEMMM201707966_CR18","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3945\/ajcn.114.099291","volume":"101","author":"Z Fu","year":"2015","unstructured":"Fu Z, Lofqvist CA, Shao Z, Sun Y, Joyal JS, Hurst CG, Cui RZ, Evans LP, Tian K, SanGiovanni JP et\u00a0al (2015) Dietary omega\u20103 polyunsaturated fatty acids decrease retinal neovascularization by adipose\u2010endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr 101: 879\u2013888","journal-title":"Am J Clin Nutr"},{"key":"BFEMMM201707966_CR19","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0042-6989(78)90119-0","volume":"18","author":"AB Fulton","year":"1978","unstructured":"Fulton AB, Rushton WA (1978) The human rod ERG: correlation with psychophysical responses in light and dark adaptation. Vision Res 18: 793\u2013800","journal-title":"Vision Res"},{"key":"BFEMMM201707966_CR20","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10633-008-9127-8","volume":"118","author":"AB Fulton","year":"2009","unstructured":"Fulton AB, Akula JD, Mocko JA, Hansen RM, Benador IY, Beck SC, Fahl E, Seeliger MW, Moskowitz A, Harris ME (2009) Retinal degenerative and hypoxic ischemic disease. Doc Ophthalmol 118: 55\u201361","journal-title":"Doc Ophthalmol"},{"key":"BFEMMM201707966_CR21","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/sj.jp.7210879","volume":"23","author":"R Garg","year":"2003","unstructured":"Garg R, Agthe AG, Donohue PK, Lehmann CU (2003) Hyperglycemia and retinopathy of prematurity in very low birth weight infants. J Perinatol 23: 186\u2013194","journal-title":"J Perinatol"},{"key":"BFEMMM201707966_CR22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.preteyeres.2016.09.004","volume":"56","author":"RM Hansen","year":"2016","unstructured":"Hansen RM, Moskowitz A, Akula JD, Fulton AB (2016) The neural retina in retinopathy of prematurity. Prog Retin Eye Res 56: 32\u201357","journal-title":"Prog Retin Eye Res"},{"key":"BFEMMM201707966_CR23","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1210\/jc.2010-2440","volume":"96","author":"I Hansen\u2010Pupp","year":"2011","unstructured":"Hansen\u2010Pupp I, Hovel H, Hellstrom A, Hellstrom\u2010Westas L, Lofqvist C, Larsson EM, Lazeyras F, Fellman V, Huppi PS, Ley D (2011) Postnatal decrease in circulating insulin\u2010like growth factor\u2010I and low brain volumes in very preterm infants. J Clin Endocrinol Metab 96: 1129\u20131135","journal-title":"J Clin Endocrinol Metab"},{"key":"BFEMMM201707966_CR24","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/pr.2013.135","volume":"74","author":"I Hansen\u2010Pupp","year":"2013","unstructured":"Hansen\u2010Pupp I, Hovel H, Lofqvist C, Hellstrom\u2010Westas L, Fellman V, Huppi PS, Hellstrom A, Ley D (2013) Circulatory insulin\u2010like growth factor\u2010I and brain volumes in relation to neurodevelopmental outcome in very preterm infants. Pediatr Res 74: 564\u2013569","journal-title":"Pediatr Res"},{"key":"BFEMMM201707966_CR25","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1542\/peds.112.5.1016","volume":"112","author":"A Hellstrom","year":"2003","unstructured":"Hellstrom A, Engstrom E, Hard AL, Albertsson\u2010Wikland K, Carlsson B, Niklasson A, Lofqvist C, Svensson E, Holm S, Ewald U et\u00a0al (2003) Postnatal serum insulin\u2010like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth. Pediatrics 112: 1016\u20131020","journal-title":"Pediatrics"},{"key":"BFEMMM201707966_CR26","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0140-6736(13)60178-6","volume":"382","author":"A Hellstrom","year":"2013","unstructured":"Hellstrom A, Smith LE, Dammann O (2013) Retinopathy of prematurity. Lancet 382: 1445\u20131457","journal-title":"Lancet"},{"key":"BFEMMM201707966_CR27","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1017\/S0952523802194028","volume":"19","author":"QV Hoang","year":"2002","unstructured":"Hoang QV, Linsenmeier RA, Chung CK, Curcio CA (2002) Photoreceptor inner segments in monkey and human retina: mitochondrial density, optics, and regional variation. Vis Neurosci 19: 395\u2013407","journal-title":"Vis Neurosci"},{"key":"BFEMMM201707966_CR28","first-page":"2948","volume":"35","author":"DC Hood","year":"1994","unstructured":"Hood DC, Birch DG (1994) Rod phototransduction in retinitis pigmentosa: estimation and interpretation of parameters derived from the rod a\u2010wave. Invest Ophthalmol Vis Sci 35: 2948\u20132961","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFEMMM201707966_CR29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s004290050289","volume":"200","author":"M Ito","year":"1999","unstructured":"Ito M, Yoshioka M (1999) Regression of the hyaloid vessels and pupillary membrane of the mouse. Anat Embryol 200: 403\u2013411","journal-title":"Anat Embryol"},{"key":"BFEMMM201707966_CR30","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/nature08991","volume":"464","author":"M Iwabu","year":"2010","unstructured":"Iwabu M, Yamauchi T, Okada\u2010Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M et\u00a0al (2010) Adiponectin and AdipoR1 regulate PGC\u20101alpha and mitochondria by Ca(2+) and AMPK\/SIRT1. Nature 464: 1313\u20131319","journal-title":"Nature"},{"key":"BFEMMM201707966_CR31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1136\/bjo.47.1.39","volume":"47","author":"HE Jones","year":"1963","unstructured":"Jones HE (1963) Hyaloid remnants in the eyes of premature babies. Br J Ophthalmol 47: 39\u201344","journal-title":"Br J Ophthalmol"},{"key":"BFEMMM201707966_CR32","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nm.4059","volume":"22","author":"JS Joyal","year":"2016","unstructured":"Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G et\u00a0al (2016) Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med 22: 439\u2013445","journal-title":"Nat Med"},{"key":"BFEMMM201707966_CR33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/jp.2010.152","volume":"31","author":"JW Kaempf","year":"2011","unstructured":"Kaempf JW, Kaempf AJ, Wu Y, Stawarz M, Niemeyer J, Grunkemeier G (2011) Hyperglycemia, insulin and slower growth velocity may increase the risk of retinopathy of prematurity. J Perinatol 31: 251\u2013257","journal-title":"J Perinatol"},{"key":"BFEMMM201707966_CR34","doi-asserted-by":"crossref","first-page":"e79545","DOI":"10.1371\/journal.pone.0079545","volume":"8","author":"E Kermorvant\u2010Duchemin","year":"2013","unstructured":"Kermorvant\u2010Duchemin E, Pinel AC, Lavalette S, Lenne D, Raoul W, Calippe B, Behar\u2010Cohen F, Sahel JA, Guillonneau X, Sennlaub F (2013) Neonatal hyperglycemia inhibits angiogenesis and induces inflammation and neuronal degeneration in the retina. PLoS One 8: e79545","journal-title":"PLoS One"},{"key":"BFEMMM201707966_CR35","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4614-8666-4","volume-title":"Application of selected reaction monitoring to highly multiplexed targeted quantitative proteomics: a replacement for western blot","author":"M Kinter","year":"2013","unstructured":"Kinter M, Kinter CS (2013) Application of selected reaction monitoring to highly multiplexed targeted quantitative proteomics: a replacement for western blot. Berlin: Springer"},{"key":"BFEMMM201707966_CR36","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrn2417","volume":"9","author":"AB Knott","year":"2008","unstructured":"Knott AB, Perkins G, Schwarzenbacher R, Bossy\u2010Wetzel E (2008) Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci 9: 505\u2013518","journal-title":"Nat Rev Neurosci"},{"key":"BFEMMM201707966_CR37","doi-asserted-by":"crossref","first-page":"8428","DOI":"10.1167\/iovs.15-17901","volume":"56","author":"K Kooragayala","year":"2015","unstructured":"Kooragayala K, Gotoh N, Cogliati T, Nellissery J, Kaden TR, French S, Balaban R, Li W, Covian R, Swaroop A (2015) Quantification of oxygen\u00a0consumption in retina ex\u00a0vivo demonstrates limited reserve capacity of photoreceptor mitochondria. Invest Ophthalmol Vis Sci 56: 8428\u20138436","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFEMMM201707966_CR38","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1113\/jphysiol.1992.sp019111","volume":"449","author":"TD Lamb","year":"1992","unstructured":"Lamb TD, Pugh EN Jr (1992) A quantitative account of the activation steps involved in phototransduction in amphibian photoreceptors. J Physiol 449: 719\u2013758","journal-title":"J Physiol"},{"key":"BFEMMM201707966_CR39","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1101\/gad.266803","volume":"17","author":"P Lindblom","year":"2003","unstructured":"Lindblom P, Gerhardt H, Liebner S, Abramsson A, Enge M, Hellstrom M, Backstrom G, Fredriksson S, Landegren U, Nystrom HC et\u00a0al (2003) Endothelial PDGF\u2010B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev 17: 1835\u20131840","journal-title":"Genes Dev"},{"key":"BFEMMM201707966_CR40","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1158\/1535-7163.MCT-13-0579","volume":"13","author":"X Liu","year":"2014","unstructured":"Liu X, Chhipa RR, Nakano I, Dasgupta B (2014) The AMPK inhibitor compound C is a potent AMPK\u2010independent antiglioma agent. Mol Cancer Ther 13: 596\u2013605","journal-title":"Mol Cancer Ther"},{"key":"BFEMMM201707966_CR41","doi-asserted-by":"crossref","first-page":"861","DOI":"10.7150\/ijbs.14213","volume":"12","author":"ZG Ma","year":"2016","unstructured":"Ma ZG, Dai J, Wei WY, Zhang WB, Xu SC, Liao HH, Yang Z, Tang QZ (2016) Asiatic acid protects against cardiac hypertrophy through activating AMPKalpha signalling pathway. Int J Biol Sci 12: 861\u2013871","journal-title":"Int J Biol Sci"},{"key":"BFEMMM201707966_CR42","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","volume":"26","author":"B MacLean","year":"2010","unstructured":"MacLean B, Tomazela DM, Shulman N, Chambers M, Finney GL, Frewen B, Kern R, Tabb DL, Liebler DC, MacCoss MJ (2010) Skyline: an open source document editor for creating and analyzing targeted proteomics experiments. Bioinformatics 26: 966\u2013968","journal-title":"Bioinformatics"},{"key":"BFEMMM201707966_CR43","doi-asserted-by":"crossref","first-page":"20493","DOI":"10.1074\/jbc.M409985200","volume":"280","author":"LD McCullough","year":"2005","unstructured":"McCullough LD, Zeng Z, Li H, Landree LE, McFadden J, Ronnett GV (2005) Pharmacological inhibition of AMP\u2010activated protein kinase provides neuroprotection in stroke. J Biol Chem 280: 20493\u201320502","journal-title":"J Biol Chem"},{"key":"BFEMMM201707966_CR44","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1542\/peds.113.3.537","volume":"113","author":"D Mitanchez\u2010Mokhtari","year":"2004","unstructured":"Mitanchez\u2010Mokhtari D, Lahlou N, Kieffer F, Magny JF, Roger M, Voyer M (2004) Both relative insulin resistance and defective islet beta\u2010cell processing of proinsulin are responsible for transient hyperglycemia in extremely preterm infants. Pediatrics 113: 537\u2013541","journal-title":"Pediatrics"},{"key":"BFEMMM201707966_CR45","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1471-2431-13-78","volume":"13","author":"S Mohamed","year":"2013","unstructured":"Mohamed S, Murray JC, Dagle JM, Colaizy T (2013) Hyperglycemia as a risk factor for the development of retinopathy of prematurity. BMC Pediatr 13: 78","journal-title":"BMC Pediatr"},{"key":"BFEMMM201707966_CR46","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/jp.2014.49","volume":"34","author":"L Mohsen","year":"2014","unstructured":"Mohsen L, Abou\u2010Alam M, El\u2010Dib M, Labib M, Elsada M, Aly H (2014) A prospective study on hyperglycemia and retinopathy of prematurity. J Perinatol 34: 453\u2013457","journal-title":"J Perinatol"},{"key":"BFEMMM201707966_CR47","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.ophtha.2003.07.019","volume":"111","author":"A Mullner\u2010Eidenbock","year":"2004","unstructured":"Mullner\u2010Eidenbock A, Amon M, Moser E, Klebermass N (2004) Persistent fetal vasculature and minimal fetal vascular remnants: a frequent cause of unilateral congenital cataracts. Ophthalmology 111: 906\u2013913","journal-title":"Ophthalmology"},{"key":"BFEMMM201707966_CR48","doi-asserted-by":"crossref","first-page":"e38481","DOI":"10.1371\/journal.pone.0038481","volume":"7","author":"A Oberthuer","year":"2012","unstructured":"Oberthuer A, Donmez F, Oberhauser F, Hahn M, Hoppenz M, Hoehn T, Roth B, Laudes M (2012) Hypoadiponectinemia in extremely low gestational age newborns with severe hyperglycemia\u2013a matched\u2010paired analysis. PLoS One 7: e38481","journal-title":"PLoS One"},{"key":"BFEMMM201707966_CR49","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature12656","volume":"503","author":"M Okada\u2010Iwabu","year":"2013","unstructured":"Okada\u2010Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura\u2010Someya T, Shirouzu M et\u00a0al (2013) A small\u2010molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503: 493\u2013499","journal-title":"Nature"},{"key":"BFEMMM201707966_CR50","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nmeth1104-163","volume":"1","author":"PJ Paddison","year":"2004","unstructured":"Paddison PJ, Cleary M, Silva JM, Chang K, Sheth N, Sachidanandam R, Hannon GJ (2004) Cloning of short hairpin RNAs for gene knockdown in mammalian cells. Nat Methods 1: 163\u2013167","journal-title":"Nat Methods"},{"key":"BFEMMM201707966_CR51","doi-asserted-by":"crossref","first-page":"E642","DOI":"10.1210\/jc.2011-2542","volume":"97","author":"RI Pereira","year":"2012","unstructured":"Pereira RI, Snell\u2010Bergeon JK, Erickson C, Schauer IE, Bergman BC, Rewers M, Maahs DM (2012) Adiponectin dysregulation and insulin resistance in type 1 diabetes. J Clin Endocrinol Metab 97: E642\u2013E647","journal-title":"J Clin Endocrinol Metab"},{"key":"BFEMMM201707966_CR52","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.metabol.2009.12.008","volume":"60","author":"SL Prior","year":"2011","unstructured":"Prior SL, Tang TS, Gill GV, Bain SC, Stephens JW (2011) Adiponectin, total antioxidant status, and urine albumin excretion in the low\u2010risk \u201cGolden Years\u201d type 1 diabetes mellitus cohort. Metabolism 60: 173\u2013179","journal-title":"Metabolism"},{"key":"BFEMMM201707966_CR53","first-page":"111","volume":"1141","author":"EN Pugh Jr","year":"1993","unstructured":"Pugh EN Jr, Lamb TD (1993) Amplification and kinetics of the activation steps in phototransduction. Biochem Biophys Acta 1141: 111\u2013149","journal-title":"Biochem Biophys Acta"},{"key":"BFEMMM201707966_CR54","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature11823","volume":"494","author":"S Rao","year":"2013","unstructured":"Rao S, Chun C, Fan J, Kofron JM, Yang MB, Hegde RS, Ferrara N, Copenhagen DR, Lang RA (2013) A direct and melanopsin\u2010dependent fetal light response regulates mouse eye development. Nature 494: 243\u2013246","journal-title":"Nature"},{"key":"BFEMMM201707966_CR55","doi-asserted-by":"crossref","first-page":"6228","DOI":"10.1038\/ncomms7228","volume":"6","author":"DS Rice","year":"2015","unstructured":"Rice DS, Calandria JM, Gordon WC, Jun B, Zhou Y, Gelfman CM, Li S, Jin M, Knott EJ, Chang B et\u00a0al (2015) Adiponectin receptor 1 conserves docosahexaenoic acid and promotes photoreceptor cell survival. Nat Commun 6: 6228","journal-title":"Nat Commun"},{"key":"BFEMMM201707966_CR56","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1387\/ijdb.041895ms","volume":"48","author":"M Saint\u2010Geniez","year":"2004","unstructured":"Saint\u2010Geniez M, D'Amore PA (2004) Development and pathology of the hyaloid, choroidal and retinal vasculature. Int J Dev Biol 48: 1045\u20131058","journal-title":"Int J Dev Biol"},{"key":"BFEMMM201707966_CR57","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1038\/nutd.2012.10","volume":"2","author":"P Sapieha","year":"2012","unstructured":"Sapieha P, Chen J, Stahl A, Seaward MR, Favazza TL, Juan AM, Hatton CJ, Joyal JS, Krah NM, Dennison RJ et\u00a0al (2012) Omega\u20103 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice. Nutr Diabetes 2: e36","journal-title":"Nutr Diabetes"},{"key":"BFEMMM201707966_CR58","doi-asserted-by":"crossref","first-page":"26746","DOI":"10.1074\/jbc.270.45.26746","volume":"270","author":"PE Scherer","year":"1995","unstructured":"Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270: 26746\u201326749","journal-title":"J Biol Chem"},{"key":"BFEMMM201707966_CR59","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nature14362","volume":"520","author":"S Schoors","year":"2015","unstructured":"Schoors S, Bruning U, Missiaen R, Queiroz KC, Borgers G, Elia I, Zecchin A, Cantelmo AR, Christen S, Goveia J et\u00a0al (2015) Fatty acid carbon is essential for dNTP synthesis in endothelial cells. Nature 520: 192\u2013197","journal-title":"Nature"},{"key":"BFEMMM201707966_CR60","first-page":"e12","volume":"49 Online","author":"V Sharma","year":"2012","unstructured":"Sharma V, Biswas S (2012) Vitreous hemorrhage in a premature infant with patent hyaloid artery and increased intracranial pressure. J Pediatr Ophthalmol Strabismus 49 Online: e12\u2013e14","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"BFEMMM201707966_CR61","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/j.1442-9071.2009.02150.x","volume":"37","author":"BS Shastry","year":"2009","unstructured":"Shastry BS (2009) Persistent hyperplastic primary vitreous: congenital malformation of the eye. Clin Exp Ophthalmol 37: 884\u2013890","journal-title":"Clin Exp Ophthalmol"},{"key":"BFEMMM201707966_CR62","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1167\/iovs.10-5176","volume":"51","author":"A Stahl","year":"2010","unstructured":"Stahl A, Connor KM, Sapieha P, Chen J, Dennison RJ, Krah NM, Seaward MR, Willett KL, Aderman CM, Guerin KI et\u00a0al (2010) The mouse retina\u00a0as an angiogenesis model. Invest Ophthalmol Vis Sci 51: 2813\u20132826","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFEMMM201707966_CR63","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1167\/iovs.03-1114","volume":"45","author":"E Tan","year":"2004","unstructured":"Tan E, Ding XQ, Saadi A, Agarwal N, Naash MI, Al\u2010Ubaidi MR (2004) Expression of cone\u2010photoreceptor\u2010specific antigens in a cell line derived from retinal tumors in transgenic mice. Invest Ophthalmol Vis Sci 45: 764\u2013768","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFEMMM201707966_CR64","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1167\/iovs.16-19859","volume":"57","author":"D Tonade","year":"2016","unstructured":"Tonade D, Liu H, Kern TS (2016) Photoreceptor cells produce inflammatory mediators that contribute to endothelial cell death in diabetes. Invest Ophthalmol Vis Sci 57: 4264\u20134271","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"BFEMMM201707966_CR65","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2147\/EB.S9078","volume":"2","author":"MT Wong\u2010Riley","year":"2010","unstructured":"Wong\u2010Riley MT (2010) Energy metabolism of the visual system. Eye Brain 2: 99\u2013116","journal-title":"Eye Brain"},{"key":"BFEMMM201707966_CR66","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/humu.22940","volume":"37","author":"M Xu","year":"2016","unstructured":"Xu M, Eblimit A, Wang J, Li J, Wang F, Zhao L, Wang X, Xiao N, Li Y, Wong LJ et\u00a0al (2016) ADIPOR1 is mutated in syndromic retinitis pigmentosa. Hum Mutat 37: 246\u2013249","journal-title":"Hum Mutat"},{"key":"BFEMMM201707966_CR67","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1242\/jcs.038513","volume":"122","author":"J Zhao","year":"2009","unstructured":"Zhao J, Liu T, Jin SB, Tomilin N, Castro J, Shupliakov O, Lendahl U, Nister M (2009) The novel conserved mitochondrial inner\u2010membrane protein MTGM regulates mitochondrial morphology and cell proliferation. J Cell Sci 122: 2252\u20132262","journal-title":"J Cell Sci"}],"container-title":["EMBO Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.201707966.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/emmm.201707966","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/emmm.201707966\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/emmm.201707966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.201707966.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:22:07Z","timestamp":1779085327000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/emmm.201707966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,27]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1,1]]}},"alternative-id":["BFEMMM201707966"],"URL":"https:\/\/doi.org\/10.15252\/emmm.201707966","relation":{},"ISSN":["1757-4676","1757-4684"],"issn-type":[{"value":"1757-4676","type":"print"},{"value":"1757-4684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,27]]},"assertion":[{"value":"1 May 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}