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The precise function of innate natural killer (NK) cells during the initiation and propagation of asthma has been very confusing, in part because different, not entirely specific, strategies were used to target these cells. We show that HDM inhalation rapidly led to the accumulation of NK cells in the lung\u2010draining lymph nodes and of activated CD69\n                    <jats:sup>+<\/jats:sup>\n                    NK cells in the bronchoalveolar lumen. However, genetically engineered\n                    <jats:italic>Ncr1<\/jats:italic>\n                    \u2010DTA or\n                    <jats:italic>Ncr1<\/jats:italic>\n                    \u2010DTR mice that constitutively or temporarily lack NK cells, still developed all key features of acute or chronic HDM\u2010driven asthma, such as bronchial hyperreactivity, Th2 cytokine production, eosinophilia, mucus overproduction, and Th2\u2010dependent immunoglobulin serum titers. The same results were obtained by administration of conventional NK1.1 or asialo\u2010GM1 NK cell\u2010depleting antibodies, antibody\u2010mediated blocking of the NKG2D receptor, or genetic NKG2D deficiency. Thus, although NK cells accumulate in allergen\u2010challenged lungs, our findings comprehensively demonstrate that these cells are not required for HDM\u2010driven asthma in the mouse.\n                  <\/jats:p>","DOI":"10.15252\/emmm.201708657","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T20:45:16Z","timestamp":1518641116000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Role of NKp46+ natural killer cells in house dust mite\u2010driven asthma"],"prefix":"10.1038","volume":"10","author":[{"given":"Eline","family":"Haspeslagh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J","family":"van Helden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Deswarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"De Prijck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"van Moorleghem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Boon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamida","family":"Hammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vivier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-6834","authenticated-orcid":false,"given":"Bart N","family":"Lambrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"BFEMMM201708657_CR1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jaci.2011.10.025","volume":"129","author":"TR Abrahamsson","year":"2012","unstructured":"Abrahamsson TR, Jakobsson HE, Andersson AF, Bj\u00f6rkst\u00e9n B, Engstrand L, Jenmalm MC (2012) Low diversity of the gut microbiota in infants with atopic eczema. 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