{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:05:14Z","timestamp":1790312714524,"version":"4.1.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2019,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mitochondrial diseases are a diverse group of inborn disorders affecting cellular energy production by oxidative phosphorylation (OXPHOS) via the five (CI\u2010CV) mitochondrial respiratory chain (MRC) complexes. The sea squirt alternative oxidase (AOX) is able to bypass the distal part of the MRC and was shown to alleviate the consequences of CIII and CIV defects in several cellular and\n                    <jats:italic>Drosophila<\/jats:italic>\n                    models. In this issue of\n                    <jats:italic>EMBO Molecular Medicine<\/jats:italic>\n                    , Rajendran\n                    <jats:italic>et\u00a0al<\/jats:italic>\n                    (2019) demonstrate the first proof of concept in mammals, by showing that AOX is capable to extend lifespan and prevent heart failure in a CIII deficient mouse model, raising the possibility of future human AOX bypass treatment.\n                  <\/jats:p>","DOI":"10.15252\/emmm.201809962","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T10:45:15Z","timestamp":1544438715000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sea squirt alternative oxidase bypasses fatal mitochondrial heart disease"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2951-0656","authenticated-orcid":false,"given":"Ann","family":"Saada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,10]]},"reference":[{"key":"BFEMMM201809962_CR1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/emmm.200900001","volume":"1","author":"EP Dassa","year":"2009","unstructured":"Dassa EP, Dufour E, Gon\u00e7alves S, Paupe V, Hakkaart GA, Jacobs HT, Rustin P (2009) Expression of the alternative oxidase complements cytochrome c oxidase deficiency in human cells. 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Hum Mol Genet 23: 2078\u20132093","journal-title":"Hum Mol Genet"},{"key":"BFEMMM201809962_CR8","doi-asserted-by":"crossref","first-page":"e9456","DOI":"10.15252\/emmm.201809456","volume":"11","author":"J Rajendran","year":"2019","unstructured":"Rajendran J, Purhonen J, Tegelberg S, Smolander OP, M\u00f6rgelin M, Rozman J, Gailus\u2010Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P et\u00a0al (2019) Alternative oxidase\u2010mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med 11: e9456","journal-title":"EMBO Mol Med"},{"key":"BFEMMM201809962_CR9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrm.2017.66","volume":"19","author":"A Suomalainen","year":"2018","unstructured":"Suomalainen A, Battersby BJ (2018) Mitochondrial diseases: the contribution of organelle stress responses to pathology. 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