{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:14:59Z","timestamp":1790640899276,"version":"4.1.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-NEUR-0002-04"],"award-info":[{"award-number":["ANR-15-NEUR-0002-04"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-LABX-0028-01"],"award-info":[{"award-number":["ANR-11-LABX-0028-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"crossref","award":["BFU2016-75412-R"],"award-info":[{"award-number":["BFU2016-75412-R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"crossref","award":["BFU2017-82375-R"],"award-info":[{"award-number":["BFU2017-82375-R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"crossref","award":["PCIN-2015-176-C02-01\/ERA-Net NeuronII"],"award-info":[{"award-number":["PCIN-2015-176-C02-01\/ERA-Net NeuronII"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Institutional CBMSO Grant from the Fundaci\u00f3n Ram\u00f3n Areces"},{"name":"Junta de Andaluc\u00eda, Spain","award":["BIO-122"],"award-info":[{"award-number":["BIO-122"]}]},{"name":"Spanish Tatiana P\u00e9rez de Guzm\u00e1n el Bueno Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2019,8,1]]},"DOI":"10.15252\/emmm.201910291","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T06:00:56Z","timestamp":1563429656000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Mouse Nr2f1 haploinsufficiency unveils new pathological mechanisms of a human optic atrophy syndrome"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4402-4974","authenticated-orcid":false,"given":"Michele","family":"Bertacchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Gruart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polynikis","family":"Kaimakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Allet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Serra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3075-1441","authenticated-orcid":false,"given":"Paolo","family":"Giacobini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M","family":"Delgado\u2010Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bovolenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7105-2957","authenticated-orcid":false,"given":"Mich\u00e8le","family":"Studer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,18]]},"reference":[{"key":"BFEMMM201910291_CR1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00018-013-1320-6","volume":"71","author":"C Alfano","year":"2013","unstructured":"Alfano C, Magrinelli E, Harb K, Studer M (2013) The nuclear receptors COUP\u2010TF: a long\u2010lasting experience in forebrain assembly. Cell Mol Life Sci 71: 43\u201362","journal-title":"Cell Mol Life Sci"},{"key":"BFEMMM201910291_CR2","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.1038\/ncomms6632","volume":"5","author":"C Alfano","year":"2014","unstructured":"Alfano C, Magrinelli E, Harb K, Hevner RF, Studer M (2014) Postmitotic control of sensory area specification during neocortical development. Nat Commun 5: 5632","journal-title":"Nat Commun"},{"key":"BFEMMM201910291_CR3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/ajmg.a.35650","volume":"161A","author":"H Al\u2010Kateb","year":"2013","unstructured":"Al\u2010Kateb H, Shimony JS, Vineyard M, Manwaring L, Kulkarni S, Shinawi M (2013) NR2F1 haploinsufficiency is associated with optic atrophy, dysmorphism and global developmental delay. Am J Med Genet A 161A: 377\u2013381","journal-title":"Am J Med Genet A"},{"key":"BFEMMM201910291_CR4","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1007\/s00429-016-1343-5","volume":"222","author":"A Alzu'bi","year":"2017","unstructured":"Alzu'bi A, Lindsay S, Kerwin J, Looi SJ, Khalil F, Clowry GJ (2017a) Distinct cortical and sub\u2010cortical neurogenic domains for GABAergic interneuron precursor transcription factors NKX2.1, OLIG2 and COUP\u2010TFII in early fetal human telencephalon. Brain Struct Funct 222: 2309\u20132328","journal-title":"Brain Struct Funct"},{"key":"BFEMMM201910291_CR5","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1093\/cercor\/bhx185","volume":"27","author":"A Alzu'bi","year":"2017","unstructured":"Alzu'bi A, Lindsay SJ, Harkin LF, McIntyre J, Lisgo SN, Clowry GJ (2017b) The transcription factors COUP\u2010TFI and COUP\u2010TFII have distinct roles in arealisation and GABAergic interneuron specification in the early human fetal telencephalon. Cereb Cortex 27: 4971\u20134987","journal-title":"Cereb Cortex"},{"key":"BFEMMM201910291_CR6","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1242\/dev.02600","volume":"133","author":"M Armentano","year":"2006","unstructured":"Armentano M, Filosa A, Andolfi G, Studer M (2006) COUP\u2010TFI is required for the formation of commissural projections in the forebrain by regulating axonal growth. Development 133: 4151\u20134162","journal-title":"Development"},{"key":"BFEMMM201910291_CR7","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/nn1958","volume":"10","author":"M Armentano","year":"2007","unstructured":"Armentano M, Chou SJ, Tomassy GS, Leingartner A, O'Leary DD, Studer M (2007) COUP\u2010TFI regulates the balance of cortical patterning between frontal\/motor and sensory areas. Nat Neurosci 10: 1277\u20131286","journal-title":"Nat Neurosci"},{"key":"BFEMMM201910291_CR8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ydbio.2006.03.007","volume":"295","author":"M Bani\u2010Yaghoub","year":"2006","unstructured":"Bani\u2010Yaghoub M, Tremblay RG, Lei JX, Zhang D, Zurakowski B, Sandhu JK, Smith B, Ribecco\u2010Lutkiewicz M, Kennedy J, Walker PR et\u00a0al (2006) Role of Sox2 in the development of the mouse neocortex. Dev Biol 295: 52\u201366","journal-title":"Dev Biol"},{"key":"BFEMMM201910291_CR9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.brainres.2018.04.024","volume":"1705","author":"M Bertacchi","year":"2018","unstructured":"Bertacchi M, Parisot J, Studer M (2018) The pleiotropic transcriptional regulator coup\u2010tfi plays multiple roles in neural development and disease. Brain Res 1705: 75\u201394","journal-title":"Brain Res"},{"key":"BFEMMM201910291_CR10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.celrep.2018.06.044","volume":"24","author":"S Bonzano","year":"2018","unstructured":"Bonzano S, Crisci I, Podlesny\u2010Drabiniok A, Rolando C, Krezel W, Studer M, De Marchis S (2018) Neuron\u2010astroglia cell fate decision in the adult mouse hippocampal neurogenic niche is cell\u2010intrinsically controlled by COUP\u2010TFI in\u00a0vivo. Cell Rep 24: 329\u2013341","journal-title":"Cell Rep"},{"key":"BFEMMM201910291_CR11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ajhg.2014.01.002","volume":"94","author":"DG Bosch","year":"2014","unstructured":"Bosch DG, Boonstra FN, Gonzaga\u2010Jauregui C, Xu M, de Ligt J, Jhangiani S, Wiszniewski W, Muzny DM, Yntema HG, Pfundt R et\u00a0al (2014) NR2F1 mutations cause optic atrophy with intellectual disability. Am J Hum Genet 94: 303\u2013309","journal-title":"Am J Hum Genet"},{"key":"BFEMMM201910291_CR12","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/ejhg.2015.186","volume":"24","author":"DG Bosch","year":"2016","unstructured":"Bosch DG, Boonstra FN, de Leeuw N, Pfundt R, Nillesen WM, de Ligt J, Gilissen C, Jhangiani S, Lupski JR, Cremers FP et\u00a0al (2016) Novel genetic causes for cerebral visual impairment. Eur J Hum Genet 24: 660\u2013665","journal-title":"Eur J Hum Genet"},{"key":"BFEMMM201910291_CR13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0165-3806(87)90181-7","volume":"430","author":"P Bovolenta","year":"1987","unstructured":"Bovolenta P, Liem RK, Mason CA (1987) Glial filament protein expression in astroglia in the mouse visual pathway. Brain Res 430: 113\u2013126","journal-title":"Brain Res"},{"key":"BFEMMM201910291_CR14","doi-asserted-by":"crossref","first-page":"R139","DOI":"10.1093\/hmg\/ddx273","volume":"26","author":"V Carelli","year":"2017","unstructured":"Carelli V, La Morgia C, Ross\u2010Cisneros FN, Sadun AA (2017) Optic neuropathies: the tip of the neurodegeneration iceberg. Hum Mol Genet 26: R139\u2013R150","journal-title":"Hum Mol Genet"},{"key":"BFEMMM201910291_CR15","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/gim.2016.18","volume":"18","author":"CA Chen","year":"2016","unstructured":"Chen CA, Bosch DG, Cho MT, Rosenfeld JA, Shinawi M, Lewis RA, Mann J, Jayakar P, Payne K, Walsh L et\u00a0al (2016) The expanding clinical phenotype of Bosch\u2010Boonstra\u2010Schaaf optic atrophy syndrome: 20 new cases and possible genotype\u2010phenotype correlations. Genet Med 18: 1143\u20131150","journal-title":"Genet Med"},{"key":"BFEMMM201910291_CR16","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1126\/science.1232806","volume":"340","author":"SJ Chou","year":"2013","unstructured":"Chou SJ, Babot Z, Leingartner A, Studer M, Nakagawa Y, O'Leary DD (2013) Geniculocortical input drives genetic distinctions between primary and higher\u2010order visual areas. Science 340: 1239\u20131242","journal-title":"Science"},{"key":"BFEMMM201910291_CR17","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1096\/fj.00-0868fje","volume":"15","author":"Y Chu","year":"2001","unstructured":"Chu Y, Hughes S, Chan\u2010Ling T (2001) Differentiation and migration of astrocyte precursor cells and astrocytes in human fetal retina: relevance to optic nerve coloboma. FASEB J 15: 2013\u20132015","journal-title":"FASEB J"},{"key":"BFEMMM201910291_CR18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.spen.2017.06.001","volume":"24","author":"BY Chun","year":"2017","unstructured":"Chun BY, Rizzo JF III (2017) Dominant optic atrophy and Leber's hereditary optic neuropathy: update on clinical features and current therapeutic approaches. Semin Pediatr Neurol 24: 129\u2013134","journal-title":"Semin Pediatr Neurol"},{"key":"BFEMMM201910291_CR19","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nrn3680","volume":"15","author":"L Conforti","year":"2014","unstructured":"Conforti L, Gilley J, Coleman MP (2014) Wallerian degeneration: an emerging axon death pathway linking injury and disease. Nat Rev Neurosci 15: 394\u2013409","journal-title":"Nat Rev Neurosci"},{"key":"BFEMMM201910291_CR21","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1093\/cercor\/bhm238","volume":"18","author":"A Faedo","year":"2008","unstructured":"Faedo A, Tomassy GS, Ruan Y, Teichmann H, Krauss S, Pleasure SJ, Tsai SY, Tsai MJ, Studer M, Rubenstein JL (2008) COUP\u2010TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK\/ERK, AKT, and beta\u2010catenin signaling. Cereb Cortex 18: 2117\u20132131","journal-title":"Cereb Cortex"},{"key":"BFEMMM201910291_CR22","first-page":"1629","volume":"27","author":"G Flore","year":"2017","unstructured":"Flore G, Di Ruberto G, Parisot J, Sannino S, Russo F, Illingworth EA, Studer M, De Leonibus E (2017) Gradient COUP\u2010TFI expression is required for functional organization of the hippocampal septo\u2010temporal longitudinal axis. Cereb Cortex 27: 1629\u20131643","journal-title":"Cereb Cortex"},{"key":"BFEMMM201910291_CR23","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/nn.3790","volume":"17","author":"SM Glasgow","year":"2014","unstructured":"Glasgow SM, Zhu W, Stolt CC, Huang TW, Chen F, LoTurco JJ, Neul JL, Wegner M, Mohila C, Deneen B (2014) Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nat Neurosci 17: 1322\u20131329","journal-title":"Nat Neurosci"},{"key":"BFEMMM201910291_CR24","doi-asserted-by":"crossref","first-page":"a008391","DOI":"10.1101\/cshperspect.a008391","volume":"4","author":"W Heavner","year":"2012","unstructured":"Heavner W, Pevny L (2012) Eye development and retinogenesis. Cold Spring Harb Perspect Biol 4: a008391","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"BFEMMM201910291_CR25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0079-6123(08)01125-4","volume":"173","author":"MR Hernandez","year":"2008","unstructured":"Hernandez MR, Miao H, Lukas T (2008) Astrocytes in glaucomatous optic neuropathy. Prog Brain Res 173: 353\u2013373","journal-title":"Prog Brain Res"},{"key":"BFEMMM201910291_CR26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1101\/lm.024760.111","volume":"19","author":"MT Jurado\u2010Parras","year":"2012","unstructured":"Jurado\u2010Parras MT, Gruart A, Delgado\u2010Garcia JM (2012) Observational learning in mice can be prevented by medial prefrontal cortex stimulation and enhanced by nucleus accumbens stimulation. Learn Mem 19: 99\u2013106","journal-title":"Learn Mem"},{"key":"BFEMMM201910291_CR27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/ICU.0000000000000410","volume":"28","author":"N Jurkute","year":"2017","unstructured":"Jurkute N, Yu\u2010Wai\u2010Man P (2017) Leber hereditary optic neuropathy: bridging the translational gap. Curr Opin Ophthalmol 28: 403\u2013409","journal-title":"Curr Opin Ophthalmol"},{"key":"BFEMMM201910291_CR28","doi-asserted-by":"crossref","first-page":"a002162","DOI":"10.1101\/mcs.a002162","volume":"3","author":"C Kaiwar","year":"2017","unstructured":"Kaiwar C, Zimmermann MT, Ferber MJ, Niu Z, Urrutia RA, Klee EW, Babovic\u2010Vuksanovic D (2017) Novel NR2F1 variants likely disrupt DNA binding: molecular modeling in two cases, review of published cases, genotype\u2010phenotype correlation, and phenotypic expansion of the Bosch\u2010Boonstra\u2010Schaaf optic atrophy syndrome. Cold Spring Harb Mol Case Stud 3: a002162","journal-title":"Cold Spring Harb Mol Case Stud"},{"key":"BFEMMM201910291_CR29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1750-1172-7-46","volume":"7","author":"G Lenaers","year":"2012","unstructured":"Lenaers G, Hamel C, Delettre C, Amati\u2010Bonneau P, Procaccio V, Bonneau D, Reynier P, Milea D (2012) Dominant optic atrophy. Orphanet J Rare Dis 7: 46","journal-title":"Orphanet J Rare Dis"},{"key":"BFEMMM201910291_CR30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.brainres.2013.04.048","volume":"1536","author":"A Lintas","year":"2013","unstructured":"Lintas A, Schwaller B, Villa AE (2013) Visual thalamocortical circuits in parvalbumin\u2010deficient mice. Brain Res 1536: 107\u2013118","journal-title":"Brain Res"},{"key":"BFEMMM201910291_CR31","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.neuron.2011.01.015","volume":"69","author":"S Lodato","year":"2011","unstructured":"Lodato S, Rouaux C, Quast KB, Jantrachotechatchawan C, Studer M, Hensch TK, Arlotta P (2011a) Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex. Neuron 69: 763\u2013779","journal-title":"Neuron"},{"key":"BFEMMM201910291_CR32","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1523\/JNEUROSCI.6580-10.2011","volume":"31","author":"S Lodato","year":"2011","unstructured":"Lodato S, Tomassy GS, De Leonibus E, Uzcategui YG, Andolfi G, Armentano M, Touzot A, Gaztelu JM, Arlotta P, Menendez de la Prida L et\u00a0al (2011b) Loss of COUP\u2010TFI alters the balance between caudal ganglionic eminence\u2010 and medial ganglionic eminence\u2010derived cortical interneurons and results in resistance to epilepsy. J Neurosci 31: 4650\u20134662","journal-title":"J Neurosci"},{"key":"BFEMMM201910291_CR33","doi-asserted-by":"crossref","first-page":"e11130","DOI":"10.1371\/journal.pone.0011130","volume":"5","author":"N Madronal","year":"2010","unstructured":"Madronal N, Lopez\u2010Aracil C, Rangel A, del Rio JA, Delgado\u2010Garcia JM, Gruart A (2010) Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice. PLoS One 5: e11130","journal-title":"PLoS One"},{"key":"BFEMMM201910291_CR34","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s10038-017-0398-3","volume":"63","author":"E Martin\u2010Hernandez","year":"2018","unstructured":"Martin\u2010Hernandez E, Rodriguez\u2010Garcia ME, Chen CA, Cotrina\u2010Vinagre FJ, Carnicero\u2010Rodriguez P, Bellusci M, Schaaf CP, Martinez\u2010Azorin F (2018) Mitochondrial involvement in a Bosch\u2010Boonstra\u2010Schaaf optic atrophy syndrome patient with a novel de novo NR2F1 gene mutation. J Hum Genet 63: 525\u2013528","journal-title":"J Hum Genet"},{"key":"BFEMMM201910291_CR35","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0168-5597(97)00101-9","volume":"108","author":"HK Meeren","year":"1998","unstructured":"Meeren HK, Van Luijtelaar EL, Coenen AM (1998) Cortical and thalamic visual evoked potentials during sleep\u2010wake states and spike\u2010wave discharges in the rat. Electroencephalogr Clin Neurophysiol 108: 306\u2013319","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"BFEMMM201910291_CR36","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature14335","volume":"522","author":"FJ Najm","year":"2015","unstructured":"Najm FJ, Madhavan M, Zaremba A, Shick E, Karl RT, Factor DC, Miller TE, Nevin ZS, Kantor C, Sargent A et\u00a0al (2015) Drug\u2010based modulation of endogenous stem cells promotes functional remyelination in\u00a0vivo. Nature 522: 216\u2013220","journal-title":"Nature"},{"key":"BFEMMM201910291_CR37","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1007\/s00429-017-1394-2","volume":"222","author":"K Ono","year":"2017","unstructured":"Ono K, Yoshii K, Tominaga H, Gotoh H, Nomura T, Takebayashi H, Ikenaka K (2017) Oligodendrocyte precursor cells in the mouse optic nerve originate in the preoptic area. Brain Struct Funct 222: 2441\u20132448","journal-title":"Brain Struct Funct"},{"key":"BFEMMM201910291_CR38","first-page":"2045","volume":"144","author":"J Parisot","year":"2017","unstructured":"Parisot J, Flore G, Bertacchi M, Studer M (2017) COUP\u2010TFI mitotically regulates production and migration of dentate granule cells and modulates hippocampal Cxcr4 expression. Development 144: 2045\u20132058","journal-title":"Development"},{"key":"BFEMMM201910291_CR39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.semcdb.2017.10.010","volume":"91","author":"A Patel","year":"2017","unstructured":"Patel A, Sowden JC (2017) Genes and pathways in optic fissure closure. Semin Cell Dev Biol 91: 55\u201365","journal-title":"Semin Cell Dev Biol"},{"key":"BFEMMM201910291_CR40","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2013.12.071","volume":"565","author":"M Pekny","year":"2014","unstructured":"Pekny M, Wilhelmsson U, Pekna M (2014) The dual role of astrocyte activation and reactive gliosis. Neurosci Lett 565: 30\u201338","journal-title":"Neurosci Lett"},{"key":"BFEMMM201910291_CR41","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/geno.1995.1237","volume":"29","author":"Y Qiu","year":"1995","unstructured":"Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang\u2010Feng T, Jenkins NA, Tsai MJ, Tsai SY (1995) Isolation, characterization, and chromosomal localization of mouse and human COUP\u2010TF I and II genes. Genomics 29: 240\u2013246","journal-title":"Genomics"},{"key":"BFEMMM201910291_CR42","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.visres.2005.09.006","volume":"46","author":"WH Ridder III","year":"2006","unstructured":"Ridder WH III, Nusinowitz S (2006) The visual evoked potential in the mouse\u2013origins and response characteristics. Vision Res 46: 902\u2013913","journal-title":"Vision Res"},{"key":"BFEMMM201910291_CR43","doi-asserted-by":"crossref","first-page":"6857","DOI":"10.1093\/nar\/18.23.6857","volume":"18","author":"HH Ritchie","year":"1990","unstructured":"Ritchie HH, Wang LH, Tsai S, O'Malley BW, Tsai MJ (1990) COUP\u2010TF gene: a structure unique for the steroid\/thyroid receptor superfamily. Nucleic Acids Res 18: 6857\u20136862","journal-title":"Nucleic Acids Res"},{"key":"BFEMMM201910291_CR44","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1523\/JNEUROSCI.3364-17.2018","volume":"38","author":"M Sanz\u2010Rodriguez","year":"2018","unstructured":"Sanz\u2010Rodriguez M, Gruart A, Escudero\u2010Ramirez J, de Castro F, Delgado\u2010Garcia JM, Wandosell F, Cubelos B (2018) R\u2010Ras1 and R\u2010Ras2 are essential for oligodendrocyte differentiation and survival for correct myelination in the central nervous system. J Neurosci 38: 5096\u20135110","journal-title":"J Neurosci"},{"key":"BFEMMM201910291_CR45","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1242\/dev.127.20.4325","volume":"127","author":"M Schwarz","year":"2000","unstructured":"Schwarz M, Cecconi F, Bernier G, Andrejewski N, Kammandel B, Wagner M, Gruss P (2000) Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6. Development 127: 4325\u20134334","journal-title":"Development"},{"key":"BFEMMM201910291_CR46","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tins.2009.08.002","volume":"32","author":"MV Sofroniew","year":"2009","unstructured":"Sofroniew MV (2009) Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 32: 638\u2013647","journal-title":"Trends Neurosci"},{"key":"BFEMMM201910291_CR47","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1101\/gad.215802","volume":"16","author":"CC Stolt","year":"2002","unstructured":"Stolt CC, Rehberg S, Ader M, Lommes P, Riethmacher D, Schachner M, Bartsch U, Wegner M (2002) Terminal differentiation of myelin\u2010forming oligodendrocytes depends on the transcription factor Sox10. Genes Dev 16: 165\u2013170","journal-title":"Genes Dev"},{"key":"BFEMMM201910291_CR48","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1242\/dev.01114","volume":"131","author":"CC Stolt","year":"2004","unstructured":"Stolt CC, Lommes P, Friedrich RP, Wegner M (2004) Transcription factors Sox8 and Sox10 perform non\u2010equivalent roles during oligodendrocyte development despite functional redundancy. Development 131: 2349\u20132358","journal-title":"Development"},{"key":"BFEMMM201910291_CR49","first-page":"2443","volume":"15","author":"X Su","year":"2018","unstructured":"Su X, Tang W, Luan Z, Yang Y, Wang Z, Zhang Y, Wang Q, Suo L, Huang Z, Wang X et\u00a0al (2018) Protective effect of miconazole on rat myelin sheaths following premature infant cerebral white matter injury. Exp Ther Med 15: 2443\u20132449","journal-title":"Exp Ther Med"},{"key":"BFEMMM201910291_CR50","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1084\/jem.20160412","volume":"214","author":"D Sun","year":"2017","unstructured":"Sun D, Moore S, Jakobs TC (2017) Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries. J Exp Med 214: 1411\u20131430","journal-title":"J Exp Med"},{"key":"BFEMMM201910291_CR51","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/dvg.20225","volume":"44","author":"EC Swindell","year":"2006","unstructured":"Swindell EC, Bailey TJ, Loosli F, Liu C, Amaya\u2010Manzanares F, Mahon KA, Wittbrodt J, Jamrich M (2006) Rx\u2010Cre, a tool for inactivation of gene expression in the developing retina. Genesis 44: 361\u2013363","journal-title":"Genesis"},{"key":"BFEMMM201910291_CR52","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1242\/dev.040568","volume":"137","author":"K Tang","year":"2010","unstructured":"Tang K, Xie X, Park JI, Jamrich M, Tsai S, Tsai MJ (2010) COUP\u2010TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis. Development 137: 725\u2013734","journal-title":"Development"},{"key":"BFEMMM201910291_CR53","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1242\/dev.075564","volume":"139","author":"K Tang","year":"2012","unstructured":"Tang K, Rubenstein JL, Tsai SY, Tsai MJ (2012) COUP\u2010TFII controls amygdala patterning by regulating neuropilin expression. Development 139: 1630\u20131639","journal-title":"Development"},{"key":"BFEMMM201910291_CR54","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbagrm.2014.05.022","volume":"1849","author":"K Tang","year":"2015","unstructured":"Tang K, Tsai SY, Tsai MJ (2015) COUP\u2010TFs and eye development. Biochim Biophys Acta 1849: 201\u2013209","journal-title":"Biochim Biophys Acta"},{"key":"BFEMMM201910291_CR55","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1242\/dev.01530","volume":"131","author":"M Tripodi","year":"2004","unstructured":"Tripodi M, Filosa A, Armentano M, Studer M (2004) The COUP\u2010TF nuclear receptors regulate cell migration in the mammalian basal forebrain. Development 131: 6119\u20136129","journal-title":"Development"},{"key":"BFEMMM201910291_CR56","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0166-2236(00)02096-8","volume":"25","author":"HH Tsai","year":"2002","unstructured":"Tsai HH, Miller RH (2002) Glial cell migration directed by axon guidance cues. Trends Neurosci 25: 173\u2013175; discussion 175\u2013176","journal-title":"Trends Neurosci"},{"key":"BFEMMM201910291_CR57","first-page":"207","volume":"1","author":"LH Wang","year":"1991","unstructured":"Wang LH, Ing NH, Tsai SY, O'Malley BW, Tsai MJ (1991) The COUP\u2010TFs compose a family of functionally related transcription factors. Gene Expr 1: 207\u2013216","journal-title":"Gene Expr"},{"key":"BFEMMM201910291_CR58","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/0014-4886(82)90235-7","volume":"77","author":"RC Wiggins","year":"1982","unstructured":"Wiggins RC, Fuller GN, Dafny N (1982) Propagation of photic evoked responses recorded from the retina, optic chiasm, lateral geniculate body, and visual cortex of the nutritionally rehabilitated rat visual system. Exp Neurol 77: 644\u2013653","journal-title":"Exp Neurol"},{"key":"BFEMMM201910291_CR59","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1101\/gad.913601","volume":"15","author":"C Zhou","year":"2001","unstructured":"Zhou C, Tsai SY, Tsai MJ (2001) COUP\u2010TFI: an intrinsic factor for early regionalization of the neocortex. Genes Dev 15: 2054\u20132059","journal-title":"Genes Dev"}],"container-title":["EMBO Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.201910291.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/emmm.201910291","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/emmm.201910291\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/emmm.201910291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.201910291.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:26:55Z","timestamp":1779085615000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/emmm.201910291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,18]]},"references-count":58,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8,1]]}},"alternative-id":["BFEMMM201910291"],"URL":"https:\/\/doi.org\/10.15252\/emmm.201910291","relation":{},"ISSN":["1757-4676","1757-4684"],"issn-type":[{"value":"1757-4676","type":"print"},{"value":"1757-4684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,18]]},"assertion":[{"value":"8 January 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"EMMM201910291"}}