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However, individually, these treatments produce only modest levels of recovery in animal models of SCI that could hamper their implementation into therapeutic strategies in spinal cord injured humans. Combinational strategies have demonstrated greater beneficial outcomes than their individual components alone by addressing multiple aspects of SCI pathology. Clinical trial designs in the future will eventually also need to align with this notion. The scenario will become increasingly complex as this happens and conversations between basic researchers and clinicians are required to ensure accurate study designs and functional readouts.<\/jats:p>","DOI":"10.15252\/emmm.201911505","type":"journal-article","created":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T11:08:45Z","timestamp":1582542525000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":203,"title":["Therapeutic repair for spinal cord injury: combinatory approaches to address a multifaceted problem"],"prefix":"10.1038","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3013-8057","authenticated-orcid":false,"given":"Jarred M","family":"Griffin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-3772","authenticated-orcid":false,"given":"Frank","family":"Bradke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,24]]},"reference":[{"key":"BFEMMM201911505_CR1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nature10199","volume":"475","author":"WJ Alilain","year":"2011","unstructured":"Alilain WJ, Horn KP, Hu H, Dick TE, Silver J (2011) Functional regeneration of respiratory pathways after spinal cord injury. 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Witte, A. Ert\u00fcrk, F. Hellal and F. Bradke filed a patent on the use of microtubule\u2010stabilising compounds for the treatment of lesion of CNS axons (European Patent no. 1858498; European patent application EP 11 00 9155.0; U.S. patent application 11\/908,118). The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"EMMM201911505"}}