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Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx in immune cells is regulated by stromal interaction molecule 1 (STIM1) and its activation of the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel ORAI1. We here identify patients with a novel mutation in STIM1 (p.L374P) that abolished Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx and resulted in increased susceptibility to fungal and other infections. In mice, deletion of STIM1 in all immune cells enhanced susceptibility to mucosal\n                    <jats:italic>C.\u00a0albicans<\/jats:italic>\n                    infection, whereas T cell\u2010specific deletion of STIM1 impaired immunity to systemic\n                    <jats:italic>C.\u00a0albicans<\/jats:italic>\n                    infection. STIM1 deletion impaired the production of Th17 cytokines essential for antifungal immunity and compromised the expression of genes in several metabolic pathways including Foxo and HIF1\u03b1 signaling that regulate glycolysis and oxidative phosphorylation (OXPHOS). Our study further revealed distinct roles of STIM1 in regulating transcription and metabolic programs in non\u2010pathogenic Th17 cells compared to pathogenic, proinflammatory Th17 cells, a finding that may potentially be exploited for the treatment of Th17 cell\u2010mediated inflammatory diseases.\n                  <\/jats:p>","DOI":"10.15252\/emmm.201911592","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T12:30:20Z","timestamp":1593606620000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["STIM1\u2010mediated calcium influx controls antifungal immunity and the metabolic function of non\u2010pathogenic Th17 cells"],"prefix":"10.1038","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8813-1061","authenticated-orcid":false,"given":"Sascha","family":"Kahlfuss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel R","family":"Concepcion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Noyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrius","family":"Raphael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Vaeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Pancholi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mate","family":"Maus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Kozhaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Khodadadi\u2010Jamayran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Unutmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0536-6656","authenticated-orcid":false,"given":"Peter B","family":"Stathopulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cori","family":"Feist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott B","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart E","family":"Turvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5431-8178","authenticated-orcid":false,"given":"Stefan","family":"Feske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"BFEMMM201911592_CR77","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.clim.2016.03.012","volume":"166","author":"YR Badran","year":"2016","unstructured":"Badran YR, Massaad MJ, Bainter W, Cangemi B, Naseem SUR, Javad H, Al\u2010Tamemi S, Geha RS, Chou J (2016)  Combined immunodeficiency due to a homozygous mutation in ORAI1 that deletes the C\u2010terminus that interacts with STIM 1.  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