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However, despite the tremendous progress that has been made in this field, many misconceptions remain among much of the broader scientific community about the manner in which miRNAs function. In this review, we focus on miR\u201033, one of the most extensively studied miRNAs, as an example, to highlight many of the advances that have been made in the miRNA field and the hurdles that must be cleared to promote the development of miRNA\u2010based therapies. We discuss how the generation of novel animal models and newly developed experimental techniques helped to elucidate the specialized roles of miR\u201033 within different tissues and begin to define the specific mechanisms by which miR\u201033 contributes to cardiometabolic diseases including obesity and atherosclerosis. This review will summarize what is known about miR\u201033 and highlight common obstacles in the miRNA field and then describe recent advances and approaches that have allowed researchers to provide a more complete picture of the specific functions of this miRNA.<\/jats:p>","DOI":"10.15252\/emmm.202012606","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T06:36:04Z","timestamp":1620023764000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["miR\u201033 in cardiometabolic diseases: lessons learned from novel animal models and approaches"],"prefix":"10.1038","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2821-9608","authenticated-orcid":false,"given":"Nathan L","family":"Price","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh","family":"Goedeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4549-2953","authenticated-orcid":false,"given":"Yajaira","family":"Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3950-1924","authenticated-orcid":false,"given":"Carlos","family":"Fern\u00e1ndez\u2010Hernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"BFEMMM202012606_CR1","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/emmm.201201228","volume":"4","author":"RM Allen","year":"2012","unstructured":"Allen RM, Marquart TJ, Albert CJ, Suchy FJ, Wang DQ, Ananthanarayanan M, Ford DA, Baldan A (2012) miR\u201033 controls the expression of biliary transporters, and mediates statin\u2010 and diet\u2010induced hepatotoxicity. 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