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In this study, we showed that GBS penetration into the brain occurred initially in the meningeal and cortex capillaries, and exploits a defined host cell signaling network comprised of S1P\n                    <jats:sub>2<\/jats:sub>\n                    , EGFR, and CysLT1. GBS exploitation of such network in penetration of the blood\u2013brain barrier was demonstrated by targeting S1P\n                    <jats:sub>2<\/jats:sub>\n                    , EGFR, and CysLT1 using pharmacological inhibition, gene knockout and knockdown cells, and gene knockout animals, as well as interrogation of the network (up\u2010 and downstream of each other). More importantly, counteracting such targets as a therapeutic adjunct to antibiotic therapy was beneficial in improving the outcome of animals with GBS meningitis. These findings indicate that investigating GBS penetration of the blood\u2013brain barrier provides a novel approach for therapeutic development of GBS meningitis.\n                  <\/jats:p>","DOI":"10.15252\/emmm.202012651","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T12:37:30Z","timestamp":1611232650000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Therapeutic development of group B Streptococcus meningitis by targeting a host cell signaling network involving EGFR"],"prefix":"10.1038","volume":"13","author":[{"given":"Ningyu","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atish","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3939-8568","authenticated-orcid":false,"given":"Kwang","family":"Sik Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"BFEMMM202012651_CR1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4161\/cam.5.2.15081","volume":"5","author":"M Arpin","year":"2011","unstructured":"Arpin M, Chirivino D, Naba A, Zwaenepoel I (2011) Emerging role for ERM proteins in cell adhesion and migration. 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