{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:34:58Z","timestamp":1790634898444,"version":"4.1.0"},"reference-count":109,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AFM\u2010telethon grants","award":["17036"],"award-info":[{"award-number":["17036"]}]},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","award":["00086505"],"award-info":[{"award-number":["00086505"]}],"id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["NAD\u2010Heart # 17\u2010CE17\u20100015\u201001"],"award-info":[{"award-number":["NAD\u2010Heart # 17\u2010CE17\u20100015\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201019\u2010CE14\u20100031\u201001"],"award-info":[{"award-number":["ANR\u201019\u2010CE14\u20100031\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201013\u2010BSV1\u20100023\u201001"],"award-info":[{"award-number":["ANR\u201013\u2010BSV1\u20100023\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["AG58812"],"award-info":[{"award-number":["AG58812"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201010\u2010LABX\u201033"],"award-info":[{"award-number":["ANR\u201010\u2010LABX\u201033"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2022,5,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Duchenne muscular dystrophy (DMD) is characterized by progressive muscle degeneration. Two important deleterious features are a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    dysregulation linked to Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influxes associated with ryanodine receptor hyperactivation, and a muscular nicotinamide adenine dinucleotide (NAD\n                    <jats:sup>+<\/jats:sup>\n                    ) deficit. Here, we identified that deletion in\n                    <jats:italic>mdx<\/jats:italic>\n                    mice of CD38, a NAD\n                    <jats:sup>+<\/jats:sup>\n                    glycohydrolase\u2010producing modulators of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling, led to a fully restored heart function and structure, with skeletal muscle performance improvements, associated with a reduction in inflammation and senescence markers. Muscle NAD\n                    <jats:sup>+<\/jats:sup>\n                    levels were also fully restored, while the levels of the two main products of CD38, nicotinamide and ADP\u2010ribose, were reduced, in heart, diaphragm, and limb. In cardiomyocytes from\n                    <jats:italic>mdx\/CD38<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice, the pathological spontaneous Ca\n                    <jats:sup>2+<\/jats:sup>\n                    activity was reduced, as well as in myotubes from DMD patients treated with isatuximab (SARCLISA\n                    <jats:sup>\u00ae<\/jats:sup>\n                    ) a monoclonal anti\u2010CD38 antibody. Finally, treatment of\n                    <jats:italic>mdx<\/jats:italic>\n                    and utrophin\u2013dystrophin\u2010deficient (\n                    <jats:italic>mdx\/utr<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <jats:italic>)<\/jats:italic>\n                    mice with CD38 inhibitors resulted in improved skeletal muscle performances. Thus, we demonstrate that CD38 actively contributes to DMD physiopathology. We propose that a selective anti\u2010CD38 therapeutic intervention could be highly relevant to develop for DMD patients.\n                  <\/jats:p>","DOI":"10.15252\/emmm.202012860","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T09:25:13Z","timestamp":1647509113000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["CD38\u2010NADase is a new major contributor to Duchenne muscular dystrophic phenotype"],"prefix":"10.1038","volume":"14","author":[{"given":"Antoine","family":"de Z\u00e9licourt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3844-5438","authenticated-orcid":false,"given":"Abdallah","family":"Fayssoil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-0037","authenticated-orcid":false,"given":"Mbarka","family":"Dakouane\u2010Giudicelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isley","family":"De Jesus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Karoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faouzi","family":"Zarrouki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Lefebvre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Mansart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Marie","family":"Launay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Piquereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana G","family":"Tarrag\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1446-7456","authenticated-orcid":false,"given":"Marcel","family":"Bonay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-2372","authenticated-orcid":false,"given":"Anne","family":"Forand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4247-3039","authenticated-orcid":false,"given":"Sophie","family":"Moog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6258-7594","authenticated-orcid":false,"given":"France","family":"Pi\u00e9tri\u2010Rouxel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Brisebard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia C S","family":"Chini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonu","family":"Kashyap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-7042","authenticated-orcid":false,"given":"Matthew J","family":"Fogarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary C","family":"Sieck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6779-092X","authenticated-orcid":false,"given":"Mathias","family":"Mericskay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo N","family":"Chini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0009-2884","authenticated-orcid":false,"given":"Ana Maria","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6234-1500","authenticated-orcid":false,"given":"Jos\u00e9\u2010Manuel","family":"Cancela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7725-8646","authenticated-orcid":false,"given":"Sabine","family":"de la Porte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"BFEMMM202012860_CR1","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.bbrc.2006.05.042","volume":"345","author":"P Aksoy","year":"2006","unstructured":"Aksoy P, White TA, Thompson M, Chini EN (2006) Regulation of intracellular levels of NAD: a novel role for CD38. Biochem Biophys Res Commun 345: 1386\u20131392","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMMM202012860_CR2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1152\/physrev.00007.2015","volume":"96","author":"DG Allen","year":"2016","unstructured":"Allen DG, Whitehead NP, Froehner SC (2016) Absence of dystrophin disrupts skeletal muscle signaling: roles of Ca2+, reactive oxygen species, and nitric oxide in the development of muscular dystrophy. Physiol Rev 96: 253\u2013305","journal-title":"Physiol Rev"},{"key":"BFEMMM202012860_CR3","doi-asserted-by":"crossref","first-page":"20876","DOI":"10.1074\/jbc.M112.344929","volume":"287","author":"F Altamirano","year":"2012","unstructured":"Altamirano F, L\u00f3pez JR, Henr\u00edquez C, Molinski T, Allen PD, Jaimovich E (2012) Increased resting intracellular calcium modulates NF\u2010\u03baB\u2010dependent inducible nitric\u2010oxide synthase gene expression in dystrophic mdx skeletal myotubes. J Biol Chem 287: 20876\u201320887","journal-title":"J Biol Chem"},{"key":"BFEMMM202012860_CR4","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.hrthm.2012.12.016","volume":"10","author":"S Ather","year":"2013","unstructured":"Ather S, Wang W, Wang Q, Li N, Anderson ME, Wehrens XHT (2013) Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy. Heart Rhythm 10: 592\u2013599","journal-title":"Heart Rhythm"},{"key":"BFEMMM202012860_CR5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1365-2613.2010.00750.x","volume":"92","author":"CG Au","year":"2011","unstructured":"Au CG, Butler TL, Sherwood MC, Egan JR, North KN, Winlaw DS (2011) Increased connective tissue growth factor associated with cardiac fibrosis in the mdx mouse model of dystrophic cardiomyopathy. Int J Exp Pathol 92: 57\u201365","journal-title":"Int J Exp Pathol"},{"key":"BFEMMM202012860_CR6","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1096\/fj.07-8290com","volume":"21","author":"MTP Barbosa","year":"2007","unstructured":"Barbosa MTP, Soares SM, Novak CM, Sinclair D, Levine JA, Aksoy P, Chini EN (2007) The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet\u2010induced obesity. FASEB J 21: 3629\u20133639","journal-title":"FASEB J"},{"key":"BFEMMM202012860_CR7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1161\/CIRCULATIONAHA.118.038891","volume":"141","author":"F Bartoli","year":"2020","unstructured":"Bartoli F, Bailey MA, Rode B, Mateo P, Antigny F, Bedouet K, Gerbaud P, Gosain R, Plante J, Norman K et\u00a0al (2020) Orai1 channel inhibition preserves left ventricular systolic function and normal Ca2+ handling after pressure overload. Circulation 141: 199\u2013216","journal-title":"Circulation"},{"key":"BFEMMM202012860_CR8","doi-asserted-by":"crossref","first-page":"E76","DOI":"10.3390\/cancers13010076","volume":"13","author":"N Baum","year":"2020","unstructured":"Baum N, Fliegert R, Bauche A, Hambach J, Menzel S, Haag F, Bannas P, Koch\u2010Nolte F (2020) Daratumumab and nanobody\u2010based heavy chain antibodies inhibit the ADPR cyclase but not the NAD+ hydrolase activity of CD38\u2010expressing multiple myeloma cells. Cancers (Basel) 13: E76","journal-title":"Cancers (Basel)"},{"key":"BFEMMM202012860_CR9","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/107999099313299","volume":"19","author":"B Bauvois","year":"1999","unstructured":"Bauvois B, Durant L, Laboureau J, Barth\u00e9l\u00e9my E, Rouillard D, Boulla G, Deterre P (1999) Upregulation of CD38 gene expression in leukemic B cells by interferon types I and II. J Interferon Cytokine Res 19: 1059\u20131066","journal-title":"J Interferon Cytokine Res"},{"key":"BFEMMM202012860_CR10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nm.1916","volume":"15","author":"AM Bellinger","year":"2009","unstructured":"Bellinger AM, Reiken S, Carlson C, Mongillo M, Liu X, Rothman L, Matecki S, Lacampagne A, Marks AR (2009) Hypernitrosylated ryanodine receptor\/calcium release channels are leaky in dystrophic muscle. Nat Med 15: 325\u2013330","journal-title":"Nat Med"},{"key":"BFEMMM202012860_CR11","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1469-7793.2001.0151k.x","volume":"537","author":"JP B\u00e9nitah","year":"2001","unstructured":"B\u00e9nitah JP, Perrier E, G\u00f3mez AM, Vassort G (2001) Effects of aldosterone on transient outward K+ current density in rat ventricular myocytes. J Physiol (Lond) 537: 151\u2013160","journal-title":"J Physiol (Lond)"},{"issue":"Pt 3","key":"BFEMMM202012860_CR12","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1042\/bj3301383","volume":"330","author":"V Berthelier","year":"1998","unstructured":"Berthelier V, Tixier JM, Muller\u2010Steffner H, Schuber F, Deterre P (1998) Human CD38 is an authentic NAD(P)+ glycohydrolase. Biochem J 330(Pt 3): 1383\u20131390","journal-title":"Biochem J"},{"key":"BFEMMM202012860_CR13","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1474-4422(18)30025-5","volume":"17","author":"DJ Birnkrant","year":"2018","unstructured":"Birnkrant DJ, Bushby K, Bann CM, Alman BA, Apkon SD, Blackwell A, Case LE, Cripe L, Hadjiyannakis S, Olson AK et\u00a0al (2018a) Diagnosis and management of Duchenne muscular dystrophy, part 2: respiratory, cardiac, bone health, and orthopaedic management. Lancet Neurol 17: 347\u2013361","journal-title":"Lancet Neurol"},{"key":"BFEMMM202012860_CR14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1474-4422(18)30024-3","volume":"17","author":"DJ Birnkrant","year":"2018","unstructured":"Birnkrant DJ, Bushby K, Bann CM, Apkon SD, Blackwell A, Brumbaugh D, Case LE, Clemens PR, Hadjiyannakis S, Pandya S et\u00a0al (2018b) Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and neuromuscular, rehabilitation, endocrine, and gastrointestinal and nutritional management. Lancet Neurol 17: 251\u2013267","journal-title":"Lancet Neurol"},{"key":"BFEMMM202012860_CR15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1474-4422(18)30026-7","volume":"17","author":"DJ Birnkrant","year":"2018","unstructured":"Birnkrant DJ, Bushby K, Bann CM, Apkon SD, Blackwell A, Colvin MK, Cripe L, Herron AR, Kennedy A, Kinnett K et\u00a0al (2018c) Diagnosis and management of Duchenne muscular dystrophy, part 3: primary care, emergency management, psychosocial care, and transitions of care across the lifespan. Lancet Neurol 17: 445\u2013455","journal-title":"Lancet Neurol"},{"key":"BFEMMM202012860_CR16","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1002\/ijc.29095","volume":"136","author":"E Blacher","year":"2015","unstructured":"Blacher E, Ben Baruch B, Levy A, Geva N, Green KD, Garneau\u2010Tsodikova S, Fridman M, Stein R (2015) Inhibition of glioma progression by a newly discovered CD38 inhibitor. Int J Cancer 136: 1422\u20131433","journal-title":"Int J Cancer"},{"key":"BFEMMM202012860_CR17","doi-asserted-by":"crossref","first-page":"C297","DOI":"10.1152\/ajpcell.00139.2017","volume":"314","author":"J Boslett","year":"2018","unstructured":"Boslett J, Hemann C, Christofi FL, Zweier JL (2018) Characterization of CD38 in the major cell types of the heart: endothelial cells highly express CD38 with activation by hypoxia\u2010reoxygenation triggering NAD(P)H depletion. Am J Physiol, Cell Physiol 314: C297\u2013C309","journal-title":"Am J Physiol, Cell Physiol"},{"key":"BFEMMM202012860_CR18","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.nmd.2004.06.008","volume":"14","author":"A Briguet","year":"2004","unstructured":"Briguet A, Courdier\u2010Fruh I, Foster M, Meier T, Magyar JP (2004) Histological parameters for the quantitative assessment of muscular dystrophy in the mdx\u2010mouse. Neuromuscul Disord 14: 675\u2013682","journal-title":"Neuromuscul Disord"},{"key":"BFEMMM202012860_CR19","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.cmet.2016.05.006","volume":"23","author":"J Camacho\u2010Pereira","year":"2016","unstructured":"Camacho\u2010Pereira J, Tarrag\u00f3 MG, Chini CCS, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A et\u00a0al (2016) CD38 dictates age\u2010related NAD decline and mitochondrial dysfunction through an SIRT3\u2010dependent mechanism. Cell Metab 23: 1127\u20131139","journal-title":"Cell Metab"},{"key":"BFEMMM202012860_CR20","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s00424-003-1035-x","volume":"446","author":"JM Cancela","year":"2003","unstructured":"Cancela JM, Charpentier G, Petersen OH (2003) Co\u2010ordination of Ca(2+) signalling in mammalian cells by the new Ca(2+)\u2010releasing messenger NAADP. Pflugers Arch 446: 322\u2013327","journal-title":"Pflugers Arch"},{"key":"BFEMMM202012860_CR21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.phrs.2016.02.016","volume":"106","author":"RF Capogrosso","year":"2016","unstructured":"Capogrosso RF, Cozzoli A, Mantuano P, Camerino GM, Massari AM, Sblendorio VT, De Bellis M, Tamma R, Giustino A, Nico B et\u00a0al (2016) Assessment of resveratrol, apocynin and taurine on mechanical\u2010metabolic uncoupling and oxidative stress in a mouse model of Duchenne muscular dystrophy: a comparison with the gold standard, \u03b1\u2010methyl prednisolone. Pharmacol Res 106: 101\u2013113","journal-title":"Pharmacol Res"},{"key":"BFEMMM202012860_CR22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004490","volume":"10","author":"A Chalkiadaki","year":"2014","unstructured":"Chalkiadaki A, Igarashi M, Nasamu AS, Knezevic J, Guarente L (2014) Muscle\u2010specific SIRT1 gain\u2010of\u2010function increases slow\u2010twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy. PLoS Genet 10: e1004490","journal-title":"PLoS Genet"},{"key":"BFEMMM202012860_CR23","first-page":"1","volume":"11","author":"S\u2010J Chen","year":"2020","unstructured":"Chen S\u2010J, Bao L, Keefer K, Shanmughapriya S, Chen L, Lee J, Wang JF, Zhang X\u2010Q, Hirschler\u2010Laszkiewicz I, Merali S et\u00a0al (2020) Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy. Cell Death Dis 11: 1\u201317","journal-title":"Cell Death Dis"},{"key":"BFEMMM202012860_CR24","doi-asserted-by":"crossref","first-page":"C148","DOI":"10.1152\/ajpcell.1996.270.1.C148","volume":"270","author":"H Cheng","year":"1996","unstructured":"Cheng H, Lederer MR, Lederer WJ, Cannell MB (1996) Calcium sparks and [Ca2+]i waves in cardiac myocytes. Am J Physiol 270: C148\u2013C159","journal-title":"Am J Physiol"},{"key":"BFEMMM202012860_CR25","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1126\/science.8235594","volume":"262","author":"H Cheng","year":"1993","unstructured":"Cheng H, Lederer WJ, Cannell MB (1993) Calcium sparks: elementary events underlying excitation\u2010contraction coupling in heart muscle. Science 262: 740\u2013744","journal-title":"Science"},{"key":"BFEMMM202012860_CR26","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.bbrc.2019.03.199","volume":"513","author":"C Chini","year":"2019","unstructured":"Chini C, Hogan KA, Warner GM, Tarrag\u00f3 MG, Peclat TR, Tchkonia T, Kirkland JL, Chini E (2019) The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age\u2010related cellular NAD+ decline. Biochem Biophys Res Commun 513: 486\u2013493","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMMM202012860_CR27","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/s42255-020-00298-z","volume":"2","author":"CCS Chini","year":"2020","unstructured":"Chini CCS, Peclat TR, Warner GM, Kashyap S, Espindola\u2010Netto JM, de Oliveira GC, Gomez LS, Hogan KA, Tarrag\u00f3 MG, Puranik AS et\u00a0al (2020) CD38 ecto\u2010enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. Nat Metab 2: 1284\u20131304","journal-title":"Nat Metab"},{"key":"BFEMMM202012860_CR28","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.tips.2018.02.001","volume":"39","author":"EN Chini","year":"2018","unstructured":"Chini EN, Chini CCS, Espindola Netto JM, de Oliveira GC, van Schooten W (2018) The pharmacology of CD38\/NADase: an emerging target in cancer and diseases of aging. Trends Pharmacol Sci 39: 424\u2013436","journal-title":"Trends Pharmacol Sci"},{"key":"BFEMMM202012860_CR29","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1152\/japplphysiol.00587.2003","volume":"96","author":"CM Consolino","year":"2004","unstructured":"Consolino CM, Brooks SV (2004) Susceptibility to sarcomere injury induced by single stretches of maximally activated muscles of mdx mice. J Appl Physiol (1985) 96: 633\u2013638","journal-title":"J Appl Physiol (1985)"},{"key":"BFEMMM202012860_CR30","doi-asserted-by":"crossref","first-page":"38251","DOI":"10.1074\/jbc.M110.125864","volume":"285","author":"F Cosker","year":"2010","unstructured":"Cosker F, Cheviron N, Yamasaki M, Menteyne A, Lund FE, Moutin M\u2010J, Galione A, Cancela J\u2010M (2010) The ecto\u2010enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells. J Biol Chem 285: 38251\u201338259","journal-title":"J Biol Chem"},{"key":"BFEMMM202012860_CR31","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0092-8674(00)80532-2","volume":"90","author":"AE Deconinck","year":"1997","unstructured":"Deconinck AE, Rafael JA, Skinner JA, Brown SC, Potter AC, Metzinger L, Watt DJ, Dickson JG, Tinsley JM, Davies KE (1997) Utrophin\u2010dystrophin\u2010deficient mice as a model for Duchenne muscular dystrophy. Cell 90: 717\u2013727","journal-title":"Cell"},{"key":"BFEMMM202012860_CR32","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1096\/fj.02-0450fje","volume":"17","author":"DA Deshpande","year":"2003","unstructured":"Deshpande DA, Walseth TF, Panettieri RA, Kannan MS (2003) CD38\/cyclic ADP\u2010ribose\u2010mediated Ca2+ signaling contributes to airway smooth muscle hyper\u2010responsiveness. FASEB J 17: 452\u2013454","journal-title":"FASEB J"},{"key":"BFEMMM202012860_CR33","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/mt.2009.322","volume":"18","author":"J Dumonceaux","year":"2010","unstructured":"Dumonceaux J, Marie S, Beley C, Trollet C, Vignaud A, Ferry A, Butler\u2010Browne G, Garcia L (2010) Combination of myostatin pathway interference and dystrophin rescue enhances tetanic and specific force in dystrophic mdx mice. Mol Ther 18: 881\u2013887","journal-title":"Mol Ther"},{"key":"BFEMMM202012860_CR34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ceca.2016.02.010","volume":"60","author":"A Espinosa","year":"2016","unstructured":"Espinosa A, Henr\u00edquez\u2010Olgu\u00edn C, Jaimovich E (2016) Reactive oxygen species and calcium signals in skeletal muscle: a crosstalk involved in both normal signaling and disease. Cell Calcium 60: 172\u2013179","journal-title":"Cell Calcium"},{"key":"BFEMMM202012860_CR35","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.neuron.2017.02.022","volume":"93","author":"K Essuman","year":"2017","unstructured":"Essuman K, Summers DW, Sasaki Y, Mao X, DiAntonio A, Milbrandt J (2017) The SARM1 toll\/interleukin\u20101 receptor domain possesses intrinsic NAD+ cleavage activity that promotes pathological axonal degeneration. Neuron 93: 1334\u20131343","journal-title":"Neuron"},{"key":"BFEMMM202012860_CR36","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1073\/pnas.0908540107","volume":"107","author":"J Fauconnier","year":"2010","unstructured":"Fauconnier J, Thireau J, Reiken S, Cassan C, Richard S, Matecki S, Marks AR, Lacampagne A (2010) Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy. Proc Natl Acad Sci USA 107: 1559\u20131564","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM202012860_CR37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3233\/JND-160194","volume":"4","author":"A Fayssoil","year":"2017","unstructured":"Fayssoil A, Abasse S, Silverston K (2017) Cardiac involvement classification and therapeutic management in patients with Duchenne muscular dystrophy. J Neuromuscul Dis 4: 17\u201323","journal-title":"J Neuromuscul Dis"},{"key":"BFEMMM202012860_CR38","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/nchembio.2415","volume":"13","author":"R Fliegert","year":"2017","unstructured":"Fliegert R, Bauche A, Wolf P\u00e9rez A\u2010M, Watt JM, Rozewitz MD, Winzer R, Janus M, Gu F, Rosche A, Harneit A et\u00a0al (2017a) 2\u2019\u2010Deoxyadenosine 5\u2019\u2010diphosphoribose is an endogenous TRPM2 superagonist. Nat Chem Biol 13: 1036\u20131044","journal-title":"Nat Chem Biol"},{"key":"BFEMMM202012860_CR39","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ceca.2018.11.001","volume":"76","author":"R Fliegert","year":"2018","unstructured":"Fliegert R, H\u00f6lzer HT, Guse AH (2018) TRPM2 activation: paradigm shifted? Cell Calcium 76: 132\u2013134","journal-title":"Cell Calcium"},{"key":"BFEMMM202012860_CR40","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.3389\/fimmu.2020.02018","volume":"11","author":"R Fliegert","year":"2020","unstructured":"Fliegert R, Riekehr WM, Guse AH (2020) Does cyclic ADP\u2010ribose (cADPR) activate the non\u2010selective cation channel TRPM2? Front Immunol 11: 2018","journal-title":"Front Immunol"},{"key":"BFEMMM202012860_CR41","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1042\/BCJ20170091","volume":"474","author":"R Fliegert","year":"2017","unstructured":"Fliegert R, Watt JM, Sch\u00f6bel A, Rozewitz MD, Moreau C, Kirchberger T, Thomas MP, Sick W, Araujo AC, Harneit A et\u00a0al (2017b) Ligand\u2010induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349. Biochem J 474: 2159\u20132175","journal-title":"Biochem J"},{"key":"BFEMMM202012860_CR42","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.omtm.2020.03.011","volume":"17","author":"A Forand","year":"2020","unstructured":"Forand A, Muchir A, Mougenot N, Sevoz\u2010Couche C, Peccate C, Lemaitre M, Izabelle C, Wood M, Lorain S, Pi\u00e9tri\u2010Rouxel F (2020) Combined treatment with peptide\u2010conjugated phosphorodiamidate morpholino oligomer\u2010PPMO and AAV\u2010U7 rescues the severe DMD phenotype in mice. Mol Ther Methods Clin Dev 17: 695\u2013708","journal-title":"Mol Ther Methods Clin Dev"},{"key":"BFEMMM202012860_CR43","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nm.3765","volume":"21","author":"A Goyenvalle","year":"2015","unstructured":"Goyenvalle A, Griffith G, Babbs A, Andaloussi SE, Ezzat K, Avril A, Dugovic B, Chaussenot R, Ferry A, Voit T et\u00a0al (2015) Functional correction in mouse models of muscular dystrophy using exon\u2010skipping tricyclo\u2010DNA oligomers. Nat Med 21: 270\u2013275","journal-title":"Nat Med"},{"key":"BFEMMM202012860_CR44","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0092-8674(00)80533-4","volume":"90","author":"RM Grady","year":"1997","unstructured":"Grady RM, Teng H, Nichol MC, Cunningham JC, Wilkinson RS, Sanes JR (1997) Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy. Cell 90: 729\u2013738","journal-title":"Cell"},{"key":"BFEMMM202012860_CR45","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1111\/jcmm.13076","volume":"21","author":"X\u2010H Guan","year":"2017","unstructured":"Guan X\u2010H, Hong X, Zhao N, Liu X\u2010H, Xiao Y\u2010F, Chen T\u2010T, Deng L\u2010B, Wang X\u2010L, Wang J\u2010B, Ji G\u2010J et\u00a0al (2017) CD38 promotes angiotensin II\u2010induced cardiac hypertrophy. J Cell Mol Med 21: 1492\u20131502","journal-title":"J Cell Mol Med"},{"key":"BFEMMM202012860_CR46","volume":"2016","author":"X\u2010H Guan","year":"2016","unstructured":"Guan X\u2010H, Liu X\u2010H, Hong X, Zhao N, Xiao Y\u2010F, Wang L\u2010F, Tang L, Jiang K, Qian Y\u2010S, Deng K\u2010Y et\u00a0al (2016) CD38 deficiency protects the heart from ischemia\/reperfusion injury through activating SIRT1\/FOXOs\u2010mediated antioxidative stress pathway. Oxid Med Cell Longev 2016: 7410257","journal-title":"Oxid Med Cell Longev"},{"key":"BFEMMM202012860_CR47","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1139\/cjpp-2014-0410","volume":"93","author":"AGP Guedes","year":"2015","unstructured":"Guedes AGP, Deshpande DA, Dileepan M, Walseth TF, Panettieri RA, Subramanian S, Kannan MS (2015) CD38 and airway hyper\u2010responsiveness: studies on human airway smooth muscle cells and mouse models. Can J Physiol Pharmacol 93: 145\u2013153","journal-title":"Can J Physiol Pharmacol"},{"key":"BFEMMM202012860_CR48","volume":"11","author":"R Gul","year":"2016","unstructured":"Gul R, Park D\u2010R, Shawl AI, Im S\u2010Y, Nam T\u2010S, Lee S\u2010H, Ko J\u2010K, Jang KY, Kim D, Kim U\u2010H (2016) Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and cyclic ADP\u2010ribose (cADPR) mediate Ca2+ signaling in cardiac hypertrophy induced by \u03b2\u2010adrenergic stimulation. PLoS One 11: e0149125","journal-title":"PLoS One"},{"key":"BFEMMM202012860_CR49","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1101\/gad.1525107","volume":"21","author":"C Handschin","year":"2007","unstructured":"Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP, Spiegelman BM (2007) PGC\u20101alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes Dev 21: 770\u2013783","journal-title":"Genes Dev"},{"issue":"Pt 1","key":"BFEMMM202012860_CR50","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1042\/bj3520197","volume":"352","author":"H Higashida","year":"2000","unstructured":"Higashida H, Zhang J, Hashii M, Shintaku M, Higashida C, Takeda Y (2000) Angiotensin II stimulates cyclic ADP\u2010ribose formation in neonatal rat cardiac myocytes. Biochem J 352(Pt 1): 197\u2013202","journal-title":"Biochem J"},{"key":"BFEMMM202012860_CR51","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/0092-8674(87)90579-4","volume":"51","author":"EP Hoffman","year":"1987","unstructured":"Hoffman EP, Brown RH, Kunkel LM (1987) Dystrophin: the protein product of the Duchenne muscular dystrophy locus. Cell 51: 919\u2013928","journal-title":"Cell"},{"key":"BFEMMM202012860_CR52","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.3389\/fimmu.2019.01187","volume":"10","author":"KA Hogan","year":"2019","unstructured":"Hogan KA, Chini CCS, Chini EN (2019) The multi\u2010faceted Ecto\u2010enzyme CD38: roles in immunomodulation, cancer, aging, and metabolic diseases. Front Immunol 10: 1187","journal-title":"Front Immunol"},{"key":"BFEMMM202012860_CR53","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1042\/bj20020584","volume":"367","author":"M Hohenegger","year":"2002","unstructured":"Hohenegger M, Suko J, Gscheidlinger R, Drobny H, Zidar A (2002) Nicotinic acid\u2010adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptor. Biochem J 367: 423\u2013431","journal-title":"Biochem J"},{"key":"BFEMMM202012860_CR54","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3233\/JND-150106","volume":"2","author":"J Hyzewicz","year":"2015","unstructured":"Hyzewicz J, Ruegg UT, Takeda S (2015) Comparison of experimental protocols of physical exercise for mdx mice and Duchenne muscular dystrophy patients. J Neuromuscul Dis 2: 325\u2013342","journal-title":"J Neuromuscul Dis"},{"key":"BFEMMM202012860_CR55","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1096\/fj.05-4585fje","volume":"20","author":"B\u2010N Kang","year":"2006","unstructured":"Kang B\u2010N, Tirumurugaan KG, Deshpande DA, Amrani Y, Panettieri RA, Walseth TF, Kannan MS (2006) Transcriptional regulation of CD38 expression by tumor necrosis factor\u2010alpha in human airway smooth muscle cells: role of NF\u2010kappaB and sensitivity to glucocorticoids. FASEB J 20: 1000\u20131002","journal-title":"FASEB J"},{"key":"BFEMMM202012860_CR56","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1158\/0008-5472.CAN-14-3639","volume":"75","author":"TA Karakasheva","year":"2015","unstructured":"Karakasheva TA, Waldron TJ, Eruslanov E, Kim S\u2010B, Lee J\u2010S, O'Brien S, Hicks PD, Basu D, Singhal S, Malavasi F et\u00a0al (2015) CD38\u2010expressing myeloid\u2010derived suppressor cells promote tumor growth in a murine model of esophageal cancer. Cancer Res 75: 4074\u20134085","journal-title":"Cancer Res"},{"key":"BFEMMM202012860_CR57","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.rehab.2013.06.002","volume":"56","author":"P Kieny","year":"2013","unstructured":"Kieny P, Chollet S, Delalande P, Le Fort M, Magot A, Pereon Y, Perrouin Verbe B (2013) Evolution of life expectancy of patients with Duchenne muscular dystrophy at AFM Yolaine de Kepper centre between 1981 and 2011. Ann Phys Rehabil Med 56: 443\u2013454","journal-title":"Ann Phys Rehabil Med"},{"key":"BFEMMM202012860_CR58","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1074\/jbc.M109.076216","volume":"285","author":"S\u2010Y Kim","year":"2010","unstructured":"Kim S\u2010Y, Cho BH, Kim U\u2010H (2010) CD38\u2010mediated Ca2+ signaling contributes to angiotensin II\u2010induced activation of hepatic stellate cells: attenuation of hepatic fibrosis by CD38 ablation. J Biol Chem 285: 576\u2013582","journal-title":"J Biol Chem"},{"key":"BFEMMM202012860_CR59","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1089\/ars.1999.1.1-55","volume":"1","author":"S Kumasaka","year":"1999","unstructured":"Kumasaka S, Shoji H, Okabe E (1999) Novel mechanisms involved in superoxide anion radical\u2010triggered Ca2+ release from cardiac sarcoplasmic reticulum linked to cyclic ADP\u2010ribose stimulation. Antioxid Redox Signal 1: 55\u201369","journal-title":"Antioxid Redox Signal"},{"key":"BFEMMM202012860_CR60","doi-asserted-by":"crossref","first-page":"15555","DOI":"10.1038\/s41598-018-33930-w","volume":"8","author":"A Kuno","year":"2018","unstructured":"Kuno A, Hosoda R, Sebori R, Hayashi T, Sakuragi H, Tanabe M, Horio Y (2018) Resveratrol ameliorates mitophagy disturbance and improves cardiac pathophysiology of dystrophin\u2010deficient mdx mice. Sci Rep 8: 15555","journal-title":"Sci Rep"},{"key":"BFEMMM202012860_CR61","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10654-020-00613-8","volume":"35","author":"E Landfeldt","year":"2020","unstructured":"Landfeldt E, Thompson R, Sejersen T, McMillan HJ, Kirschner J, Lochm\u00fcller H (2020) Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta\u2010analysis. Eur J Epidemiol 35: 643\u2013653","journal-title":"Eur J Epidemiol"},{"key":"BFEMMM202012860_CR62","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1113\/jphysiol.2011.207456","volume":"589","author":"JM Lawler","year":"2011","unstructured":"Lawler JM (2011) Exacerbation of pathology by oxidative stress in respiratory and locomotor muscles with Duchenne muscular dystrophy. J Physiol (Lond) 589: 2161\u20132170","journal-title":"J Physiol (Lond)"},{"key":"BFEMMM202012860_CR63","first-page":"317","volume":"12","author":"HC Lee","year":"2006","unstructured":"Lee HC (2006) Structure and enzymatic functions of human CD38. Mol Med 12: 317\u2013323","journal-title":"Mol Med"},{"key":"BFEMMM202012860_CR64","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1152\/japplphysiol.00687.2017","volume":"124","author":"S\u2010H Lee","year":"2018","unstructured":"Lee S\u2010H, Kim B\u2010J, Park D\u2010R, Kim U\u2010H (2018) Exercise induces muscle fiber type switching via transient receptor potential melastatin 2\u2010dependent Ca2+ signaling. J Appl Physiol (1985) 124: 364\u2013373","journal-title":"J Appl Physiol (1985)"},{"key":"BFEMMM202012860_CR65","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1165\/rcmb.2014-0141OC","volume":"52","author":"S Lee","year":"2015","unstructured":"Lee S, Paudel O, Jiang Y, Yang X\u2010R, Sham JSK (2015) CD38 mediates angiotensin II\u2010induced intracellular Ca(2+) release in rat pulmonary arterial smooth muscle cells. Am J Respir Cell Mol Biol 52: 332\u2013341","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFEMMM202012860_CR67","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nature00904","volume":"418","author":"J Lin","year":"2002","unstructured":"Lin J, Wu H, Tarr PT, Zhang C\u2010Y, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN et\u00a0al (2002) Transcriptional co\u2010activator PGC\u20101 alpha drives the formation of slow\u2010twitch muscle fibres. Nature 418: 797\u2013801","journal-title":"Nature"},{"key":"BFEMMM202012860_CR68","doi-asserted-by":"crossref","first-page":"13243","DOI":"10.1074\/jbc.M117.789347","volume":"292","author":"WK Lin","year":"2017","unstructured":"Lin WK, Bolton EL, Cortopassi WA, Wang Y, O'Brien F, Maciejewska M, Jacobson MP, Garnham C, Ruas M, Parrington J et\u00a0al (2017) Synthesis of the Ca2+\u2010mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in \u03b2\u2010adrenoceptor signaling. J Biol Chem 292: 13243\u201313257","journal-title":"J Biol Chem"},{"key":"BFEMMM202012860_CR70","doi-asserted-by":"crossref","first-page":"8283","DOI":"10.1073\/pnas.1703718114","volume":"114","author":"J Liu","year":"2017","unstructured":"Liu J, Zhao YJ, Li WH, Hou YN, Li T, Zhao ZY, Fang C, Li SL, Lee HC (2017) Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP\u2010ribose levels. Proc Natl Acad Sci USA 114: 8283\u20138288","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM202012860_CR71","doi-asserted-by":"crossref","first-page":"C66","DOI":"10.1152\/ajpcell.00357.2013","volume":"307","author":"V Ljubicic","year":"2014","unstructured":"Ljubicic V, Burt M, Lunde JA, Jasmin BJ (2014) Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1\u2010PGC\u20101\u03b1 axis. Am J Physiol Cell Physiol 307: C66\u2013C82","journal-title":"Am J Physiol Cell Physiol"},{"key":"BFEMMM202012860_CR72","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s12013-013-9517-8","volume":"66","author":"C Lorin","year":"2013","unstructured":"Lorin C, Gueffier M, Bois P, Faivre J\u2010F, Cognard C, Sebille S (2013) Ultrastructural and functional alterations of EC coupling elements in mdx cardiomyocytes: an analysis from membrane surface to depth. Cell Biochem Biophys 66: 723\u2013736","journal-title":"Cell Biochem Biophys"},{"key":"BFEMMM202012860_CR73","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/mus.23810","volume":"48","author":"JR Mendell","year":"2013","unstructured":"Mendell JR, Lloyd\u2010Puryear M (2013) Report of MDA muscle disease symposium on newborn screening for Duchenne muscular dystrophy. Muscle Nerve 48: 21\u201326","journal-title":"Muscle Nerve"},{"key":"BFEMMM202012860_CR74","doi-asserted-by":"crossref","first-page":"H1010","DOI":"10.1152\/ajpheart.00906.2012","volume":"304","author":"BA Miller","year":"2013","unstructured":"Miller BA, Wang JF, Hirschler\u2010Laszkiewicz I, Gao E, Song J, Zhang X\u2010Q, Koch WJ, Madesh M, Mallilankaraman K, Gu T et\u00a0al (2013) The second member of transient receptor potential\u2010melastatin channel family protects hearts from ischemia\u2010reperfusion injury. Am J Physiol Heart Circ Physiol 304: H1010\u2013H1022","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFEMMM202012860_CR75","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s004240000465","volume":"441","author":"A Mojzisov\u00e1","year":"2001","unstructured":"Mojzisov\u00e1 A, Krizanov\u00e1 O, Z\u00e1cikov\u00e1 L, Kom\u00ednkov\u00e1 V, Ondrias K (2001) Effect of nicotinic acid adenine dinucleotide phosphate on ryanodine calcium release channel in heart. Pflugers Arch 441: 674\u2013677","journal-title":"Pflugers Arch"},{"key":"BFEMMM202012860_CR76","doi-asserted-by":"crossref","first-page":"16017","DOI":"10.1074\/jbc.M112.441246","volume":"288","author":"M Nebel","year":"2013","unstructured":"Nebel M, Schwoerer AP, Warszta D, Siebrands CC, Limbrock A\u2010C, Swarbrick JM, Fliegert R, Weber K, Bruhn S, Hohenegger M et\u00a0al (2013) Nicotinic acid adenine dinucleotide phosphate (NAADP)\u2010mediated calcium signaling and arrhythmias in the heart evoked by \u03b2\u2010adrenergic stimulation. J Biol Chem 288: 16017\u201316030","journal-title":"J Biol Chem"},{"key":"BFEMMM202012860_CR77","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0167-5273(90)90082-G","volume":"26","author":"G Nigro","year":"1990","unstructured":"Nigro G, Comi LI, Politano L, Bain RJ (1990) The incidence and evolution of cardiomyopathy in Duchenne muscular dystrophy. Int J Cardiol 26: 271\u2013277","journal-title":"Int J Cardiol"},{"key":"BFEMMM202012860_CR78","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1089\/ars.2000.2.1-47","volume":"2","author":"E Okabe","year":"2000","unstructured":"Okabe E, Tsujimoto Y, Kobayashi Y (2000) Calmodulin and cyclic ADP\u2010ribose interaction in Ca2+ signaling related to cardiac sarcoplasmic reticulum: superoxide anion radical\u2010triggered Ca2+ release. Antioxid Redox Signal 2: 47\u201354","journal-title":"Antioxid Redox Signal"},{"key":"BFEMMM202012860_CR79","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1159\/000489441","volume":"46","author":"D\u2010R Park","year":"2018","unstructured":"Park D\u2010R, Nam T\u2010S, Kim Y\u2010W, Lee S\u2010H, Kim U\u2010H (2018) CD38\u2010cADPR\u2010SERCA signaling axis determines skeletal muscle contractile force in response to \u03b2\u2010adrenergic stimulation. Cell Physiol Biochem 46: 2017\u20132030","journal-title":"Cell Physiol Biochem"},{"key":"BFEMMM202012860_CR80","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/nm1101-1209","volume":"7","author":"S Partida\u2010S\u00e1nchez","year":"2001","unstructured":"Partida\u2010S\u00e1nchez S, Cockayne DA, Monard S, Jacobson EL, Oppenheimer N, Garvy B, Kusser K, Goodrich S, Howard M, Harmsen A et\u00a0al (2001) Cyclic ADP\u2010ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in\u00a0vivo. Nat Med 7: 1209\u20131216","journal-title":"Nat Med"},{"key":"BFEMMM202012860_CR81","doi-asserted-by":"crossref","first-page":"7827","DOI":"10.4049\/jimmunol.179.11.7827","volume":"179","author":"S Partida\u2010Sanchez","year":"2007","unstructured":"Partida\u2010Sanchez S, Gasser A, Fliegert R, Siebrands CC, Dammermann W, Shi G, Mousseau BJ, Sumoza\u2010Toledo A, Bhagat H, Walseth TF et\u00a0al (2007) Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp\u2010ribose, the major product generated by the CD38 enzyme reaction. J Immunol 179: 7827\u20137839","journal-title":"J Immunol"},{"key":"BFEMMM202012860_CR82","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0968-0004(01)01896-5","volume":"26","author":"S Patel","year":"2001","unstructured":"Patel S, Churchill GC, Galione A (2001) Coordination of Ca2+ signalling by NAADP. Trends Biochem Sci 26: 482\u2013489","journal-title":"Trends Biochem Sci"},{"key":"BFEMMM202012860_CR83","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1471-2474-14-26","volume":"14","author":"C Pertl","year":"2013","unstructured":"Pertl C, Eblenkamp M, Pertl A, Pfeifer S, Wintermantel E, Lochm\u00fcller H, Walter MC, Krause S, Thirion C (2013) A new web\u2010based method for automated analysis of muscle histology. BMC Musculoskelet Disord 14: 26","journal-title":"BMC Musculoskelet Disord"},{"key":"BFEMMM202012860_CR84","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1136\/thx.2003.009894","volume":"59","author":"B Polla","year":"2004","unstructured":"Polla B, D\u2019Antona G, Bottinelli R, Reggiani C (2004) Respiratory muscle fibres: specialisation and plasticity. Thorax 59: 808\u2013817","journal-title":"Thorax"},{"key":"BFEMMM202012860_CR85","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1126\/science.1202768","volume":"333","author":"BL Prosser","year":"2011","unstructured":"Prosser BL, Ward CW, Lederer WJ (2011) X\u2010ROS signaling: rapid mechano\u2010chemo transduction in heart. Science 333: 1440\u20131445","journal-title":"Science"},{"key":"BFEMMM202012860_CR86","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.nmd.2004.04.007","volume":"14","author":"JG Quinlan","year":"2004","unstructured":"Quinlan JG, Hahn HS, Wong BL, Lorenz JN, Wenisch AS, Levin LS (2004) Evolution of the mdx mouse cardiomyopathy: physiological and morphological findings. Neuromuscul Disord 14: 491\u2013496","journal-title":"Neuromuscul Disord"},{"key":"BFEMMM202012860_CR87","doi-asserted-by":"crossref","first-page":"17820","DOI":"10.1074\/jbc.274.25.17820","volume":"274","author":"S Rakovic","year":"1999","unstructured":"Rakovic S, Cui Y, Iino S, Galione A, Ashamu GA, Potter BV, Terrar DA (1999) An antagonist of cADP\u2010ribose inhibits arrhythmogenic oscillations of intracellular Ca2+ in heart cells. J Biol Chem 274: 17820\u201317827","journal-title":"J Biol Chem"},{"key":"BFEMMM202012860_CR88","first-page":"299rv4","volume":"7","author":"AS Rosenberg","year":"2015","unstructured":"Rosenberg AS, Puig M, Nagaraju K, Hoffman EP, Villalta SA, Rao VA, Wakefield LM, Woodcock J (2015) Immune\u2010mediated pathology in Duchenne muscular dystrophy. Sci Transl Med 7: 299rv4","journal-title":"Sci Transl Med"},{"key":"BFEMMM202012860_CR89","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13023-017-0631-3","volume":"12","author":"S Ryder","year":"2017","unstructured":"Ryder S, Leadley RM, Armstrong N, Westwood M, de Kock S, Butt T, Jain M, Kleijnen J (2017) The burden, epidemiology, costs and treatment for Duchenne muscular dystrophy: an evidence review. Orphanet J Rare Dis 12: 79","journal-title":"Orphanet J Rare Dis"},{"key":"BFEMMM202012860_CR90","first-page":"361ra139","volume":"8","author":"D Ryu","year":"2016","unstructured":"Ryu D, Zhang H, Ropelle ER, Sorrentino V, M\u00e1zala DAG, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM et\u00a0al (2016) NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med 8: 361ra139","journal-title":"Sci Transl Med"},{"key":"BFEMMM202012860_CR91","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.yjmcc.2018.04.003","volume":"118","author":"J Sabourin","year":"2018","unstructured":"Sabourin J, Boet A, Rucker\u2010Martin C, Lambert M, Gomez A\u2010M, Benitah J\u2010P, Perros F, Humbert M, Antigny F (2018) Ca2+ handling remodeling and STIM1L\/Orai1\/TRPC1\/TRPC4 upregulation in monocrotaline\u2010induced right ventricular hypertrophy. J Mol Cell Cardiol 118: 208\u2013224","journal-title":"J Mol Cell Cardiol"},{"key":"BFEMMM202012860_CR92","doi-asserted-by":"crossref","first-page":"13165","DOI":"10.1073\/pnas.1004509107","volume":"107","author":"S Sarma","year":"2010","unstructured":"Sarma S, Li N, van Oort RJ, Reynolds C, Skapura DG, Wehrens XHT (2010) Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy. Proc Natl Acad Sci USA 107: 13165\u201313170","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM202012860_CR93","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9179270","volume":"2018","author":"R Sebori","year":"2018","unstructured":"Sebori R, Kuno A, Hosoda R, Hayashi T, Horio Y (2018) Resveratrol decreases oxidative stress by restoring mitophagy and improves the pathophysiology of Dystrophin\u2010deficient mdx mice. Oxid Med Cell Longev 2018: 9179270","journal-title":"Oxid Med Cell Longev"},{"key":"BFEMMM202012860_CR94","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030063","volume":"7","author":"JT Selsby","year":"2012","unstructured":"Selsby JT, Morine KJ, Pendrak K, Barton ER, Sweeney HL (2012) Rescue of dystrophic skeletal muscle by PGC\u20101\u03b1 involves a fast to slow fiber type shift in the mdx mouse. PLoS One 7: e30063","journal-title":"PLoS One"},{"key":"BFEMMM202012860_CR95","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/mus.21873","volume":"43","author":"J\u2010H Shin","year":"2011","unstructured":"Shin J\u2010H, Hakim CH, Zhang K, Duan D (2011) Genotyping mdx, mdx3cv, and mdx4cv mice by primer competition polymerase chain reaction. Muscle Nerve 43: 283\u2013286","journal-title":"Muscle Nerve"},{"key":"BFEMMM202012860_CR96","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.nmd.2008.03.008","volume":"18","author":"CF Spurney","year":"2008","unstructured":"Spurney CF, Knoblach S, Pistilli EE, Nagaraju K, Martin GR, Hoffman EP (2008) Dystrophin\u2010deficient cardiomyopathy in mouse: expression of Nox4 and Lox are associated with fibrosis and altered functional parameters in the heart. Neuromuscul Disord 18: 371\u2013381","journal-title":"Neuromuscul Disord"},{"key":"BFEMMM202012860_CR97","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/352536a0","volume":"352","author":"HH Stedman","year":"1991","unstructured":"Stedman HH, Sweeney HL, Shrager JB, Maguire HC, Panettieri RA, Petrof B, Narusawa M, Leferovich JM, Sladky JT, Kelly AM (1991) The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy. Nature 352: 536\u2013539","journal-title":"Nature"},{"key":"BFEMMM202012860_CR98","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.cmet.2018.03.016","volume":"27","author":"MG Tarrag\u00f3","year":"2018","unstructured":"Tarrag\u00f3 MG, Chini CCS, Kanamori KS, Warner GM, Caride A, de Oliveira GC, Rud M, Samani A, Hein KZ, Huang R et\u00a0al (2018) A potent and specific CD38 inhibitor ameliorates age\u2010related metabolic dysfunction by reversing tissue NAD+ decline. Cell Metab 27: 1081\u20131095","journal-title":"Cell Metab"},{"key":"BFEMMM202012860_CR99","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1111\/febs.12142","volume":"280","author":"JR Terrill","year":"2013","unstructured":"Terrill JR, Radley\u2010Crabb HG, Iwasaki T, Lemckert FA, Arthur PG, Grounds MD (2013) Oxidative stress and pathology in muscular dystrophies: focus on protein thiol oxidation and dysferlinopathies. FEBS J 280: 4149\u20134164","journal-title":"FEBS J"},{"key":"BFEMMM202012860_CR100","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nm0309-243","volume":"15","author":"JG Tidball","year":"2009","unstructured":"Tidball JG, Villalta SA (2009) NO may prompt calcium leakage in dystrophic muscle. Nat Med 15: 243\u2013244","journal-title":"Nat Med"},{"key":"BFEMMM202012860_CR101","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1096\/fj.13-244798","volume":"28","author":"S Vianello","year":"2014","unstructured":"Vianello S, Consolaro F, Bich C, Cancela J\u2010M, Roulot M, Lanchec E, Touboul D, Brunelle A, Isra\u00ebl M, Benoit E et\u00a0al (2014) Low doses of arginine butyrate derivatives improve dystrophic phenotype and restore membrane integrity in DMD models. FASEB J 28: 2603\u20132619","journal-title":"FASEB J"},{"key":"BFEMMM202012860_CR102","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1159\/000492651","volume":"48","author":"L\u2010F Wang","year":"2018","unstructured":"Wang L\u2010F, Huang C\u2010C, Xiao Y\u2010F, Guan X\u2010H, Wang X\u2010N, Cao Q, Liu YU, Huang X, Deng L\u2010B, Deng K\u2010Y et\u00a0al (2018) CD38 deficiency protects heart from high fat diet\u2010induced oxidative stress via activating Sirt3\/FOXO3 pathway. Cell Physiol Biochem 48: 2350\u20132363","journal-title":"Cell Physiol Biochem"},{"key":"BFEMMM202012860_CR103","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ncb1254","volume":"7","author":"XU Wang","year":"2005","unstructured":"Wang XU, Weisleder N, Collet C, Zhou J, Chu YI, Hirata Y, Zhao X, Pan Z, Brotto M, Cheng H et\u00a0al (2005) Uncontrolled calcium sparks act as a dystrophic signal for mammalian skeletal muscle. Nat Cell Biol 7: 525\u2013530","journal-title":"Nat Cell Biol"},{"key":"BFEMMM202012860_CR104","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0092-8674(88)90463-1","volume":"52","author":"C Webster","year":"1988","unstructured":"Webster C, Silberstein L, Hays AP, Blau HM (1988) Fast muscle fibers are preferentially affected in Duchenne muscular dystrophy. Cell 52: 503\u2013513","journal-title":"Cell"},{"key":"BFEMMM202012860_CR105","doi-asserted-by":"crossref","first-page":"H846","DOI":"10.1152\/ajpheart.00688.2006","volume":"292","author":"IA Williams","year":"2007","unstructured":"Williams IA, Allen DG (2007) Intracellular calcium handling in ventricular myocytes from mdx mice. Am J Physiol Heart Circ Physiol 292: H846\u2013855","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFEMMM202012860_CR106","doi-asserted-by":"crossref","first-page":"11180","DOI":"10.1074\/jbc.M004849200","volume":"276","author":"HL Wilson","year":"2001","unstructured":"Wilson HL, Dipp M, Thomas JM, Lad C, Galione A, Evans AM (2001) Adp\u2010ribosyl cyclase and cyclic ADP\u2010ribose hydrolase act as a redox sensor. a primary role for cyclic ADP\u2010ribose in hypoxic pulmonary vasoconstriction. J Biol Chem 276: 11180\u201311188","journal-title":"J Biol Chem"},{"key":"BFEMMM202012860_CR107","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.mvr.2003.11.001","volume":"67","author":"AY Zhang","year":"2004","unstructured":"Zhang AY, Yi F, Teggatz EG, Zou A\u2010P, Li P\u2010L (2004) Enhanced production and action of cyclic ADP\u2010ribose during oxidative stress in small bovine coronary arterial smooth muscle. Microvasc Res 67: 159\u2013167","journal-title":"Microvasc Res"},{"key":"BFEMMM202012860_CR108","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1126\/science.aaf2693","volume":"352","author":"H Zhang","year":"2016","unstructured":"Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D\u2019Amico D, Ropelle ER, Lutolf MP, Aebersold R et\u00a0al (2016) NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science 352: 1436\u20131443","journal-title":"Science"},{"key":"BFEMMM202012860_CR109","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/cvr\/cvp212","volume":"84","author":"X Zhang","year":"2009","unstructured":"Zhang X, Tallini YN, Chen Z, Gan L, Wei B, Doran R, Miao L, Xin H\u2010B, Kotlikoff MI, Ji G (2009) Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP\u2010ribose but not \u03b2eta\u2010adrenergic stimulation in mouse cardiomyocytes. Cardiovasc Res 84: 253\u2013262","journal-title":"Cardiovasc Res"},{"key":"BFEMMM202012860_CR110","first-page":"ra67","volume":"5","author":"YJ Zhao","year":"2012","unstructured":"Zhao YJ, Lam CMC, Lee HC (2012) The membrane\u2010bound enzyme CD38 exists in two opposing orientations. Sci Signal 5: ra67","journal-title":"Sci Signal"},{"key":"BFEMMM202012860_CR111","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.isci.2019.05.001","volume":"15","author":"ZY Zhao","year":"2019","unstructured":"Zhao ZY, Xie XJ, Li WH, Liu J, Chen Z, Zhang B, Li T, Li SL, Lu JG, Zhang L et\u00a0al (2019) A cell\u2010permeant mimetic of NMN activates SARM1 to produce cyclic ADP\u2010ribose and induce non\u2010apoptotic cell death. iScience 15: 452\u2013466","journal-title":"iScience"}],"container-title":["EMBO Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202012860.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/emmm.202012860","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/emmm.202012860\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/emmm.202012860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202012860.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:40:18Z","timestamp":1779086418000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/emmm.202012860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,17]]},"references-count":109,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,9]]}},"alternative-id":["BFEMMM202012860"],"URL":"https:\/\/doi.org\/10.15252\/emmm.202012860","relation":{},"ISSN":["1757-4676","1757-4684"],"issn-type":[{"value":"1757-4676","type":"print"},{"value":"1757-4684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,17]]},"assertion":[{"value":"1 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"EMMM202012860"}}