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The aim of this study is to evaluate circulating level of sphingosine\u20101\u2010phosphate (S1P) along with severity markers, in COVID\u201019 patients. One hundred eleven COVID\u201019 patients and forty\u2010seven healthy subjects were included. The severity of COVID\u201019 was found significantly associated with anemia, lymphocytopenia, and significant increase of neutrophil\u2010to\u2010lymphocyte ratio, ferritin, fibrinogen, aminotransferases, lactate dehydrogenase (LDH), C\u2010reactive protein (CRP), and D\u2010dimer. Serum S1P level was inversely associated with COVID\u201019 severity, being significantly correlated with CRP, LDH, ferritin, and D\u2010dimer. The decrease in S1P was strongly associated with the number of erythrocytes, the major source of plasma S1P, and both apolipoprotein M and albumin, the major transporters of blood S1P. Not last, S1P was found to be a relevant predictor of admission to an intensive care unit, and patient\u2019s outcome. Circulating S1P emerged as negative biomarker of severity\/mortality of COVID\u201019 patients. Restoring abnormal S1P levels to a normal range may have the potential to be a therapeutic target in patients with COVID\u201019.<\/jats:p>","DOI":"10.15252\/emmm.202013424","type":"journal-article","created":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T01:29:16Z","timestamp":1605403756000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Decreased serum level of sphingosine\u20101\u2010phosphate: a novel predictor of clinical severity in COVID\u201019"],"prefix":"10.1038","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5849-7000","authenticated-orcid":false,"given":"Giovanni","family":"Marfia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Navone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Guarnaccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Campanella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Mondoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Barassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Fontana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Garzia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Ciniglio Appiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Chiumello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Miozzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Centanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Riboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"BFEMMM202013424_CR1","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.bbalip.2018.07.009","volume":"1863","author":"L Abdel Hadi","year":"2018","unstructured":"Abdel Hadi L, Anelli V, Guarnaccia L, Navone S, Beretta M, Moccia F, Tringali C, Urechie V, Campanella R, Marfia G et al (2018) A bidirectional crosstalk between glioblastoma and brain endothelial cells potentiates the angiogenic and proliferative signaling of sphingosine\u20101\u2010phosphate in the glioblastoma microenvironment. 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