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Failure to modulate these processes can be detrimental to human health as evidenced by dominantly inherited, pathogenic variants in\n                    <jats:italic>OPA1<\/jats:italic>\n                    , an effector enzyme of mitochondrial fusion, that lead to network fragmentation, cristae dysmorphology and impaired oxidative respiration, manifesting typically as isolated optic atrophy. However, a significant number of patients develop more severe, systemic phenotypes, although no genetic modifiers of OPA1\u2010related disease have been identified to date. In this issue of\n                    <jats:italic>EMBO Molecular Medicine<\/jats:italic>\n                    , supervised machine learning algorithms underlie a novel tool that enables automated, high throughput and unbiased screening of changes in mitochondrial morphology measured using confocal microscopy. By coupling this approach with a bespoke siRNA library targeting the entire mitochondrial proteome, the work described by Cretin and colleagues yielded significant insight into mitochondrial biology, discovering 91 candidate genes whose endogenous depletion can remedy impaired mitochondrial dynamics caused by OPA1 deficiency.\n                  <\/jats:p>","DOI":"10.15252\/emmm.202114316","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T14:01:15Z","timestamp":1622124075000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Machine learning algorithms reveal the secrets of mitochondrial dynamics"],"prefix":"10.1038","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6282-0301","authenticated-orcid":false,"given":"Jack J","family":"Collier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7768-8873","authenticated-orcid":false,"given":"Robert W","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"BFEMMM202114316_CR1","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202013579","volume":"13","author":"E Cretin","year":"2021","unstructured":"Cretin E, Lopes P, Vimont E, Tatsuta T, Langer T, Gazi A, Sachse M, Yu\u2010Wai\u2010Man P, Reynier P, Wai T (2021) High\u2010throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts. EMBO Mol Med 13: e13579","journal-title":"EMBO Mol Med"},{"key":"BFEMMM202114316_CR2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41580-020-0210-7","volume":"21","author":"M Giacomello","year":"2020","unstructured":"Giacomello M, Pyakurel A, Glytsou C, Scorrano L (2020) The cell biology of mitochondrial membrane dynamics. Nat Rev Mol Cell Biol 21: 204\u2013224","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMMM202114316_CR3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/brain\/awm272","volume":"131","author":"G Hudson","year":"2008","unstructured":"Hudson G, Amati\u2010Bonneau P, Blakely EL, Stewart JD, He L, Schaefer AM, Griffiths PG, Ahlqvist K, Suomalainen A, Reynier P et al (2008) Mutation of OPA1 causes dominant optic atrophy with external ophthalmoplegia, ataxia, deafness and multiple mitochondrial DNA deletions: a novel disorder of mtDNA maintenance. 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J Med Genet 53: 127\u2013131","journal-title":"J Med Genet"},{"key":"BFEMMM202114316_CR8","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.tcb.2019.08.003","volume":"29","author":"HG Sprenger","year":"2019","unstructured":"Sprenger HG, Langer T (2019) The good and the bad of mitochondrial breakups. Trends Cell Biol 29: 888\u2013900","journal-title":"Trends Cell Biol"},{"key":"BFEMMM202114316_CR9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.acthis.2017.03.001","volume":"119","author":"AJ Valente","year":"2017","unstructured":"Valente AJ, Maddalena LA, Robb EL, Moradi F, Stuart JA (2017) A simple ImageJ macro tool for analyzing mitochondrial network morphology in mammalian cell culture. 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