{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:08:40Z","timestamp":1791331720000,"version":"4.3.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2021,12,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Early embryonic arrest and fragmentation (EEAF) is a common phenotype observed in\n                    <jats:italic>in vitro<\/jats:italic>\n                    fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles. The phenotype causes female infertility and recurrent failed IVF\/ICSI attempts. However, the molecular mechanisms behind EEAF remain largely unknown. In this issue of\n                    <jats:italic>EMBO Molecular Medicine<\/jats:italic>\n                    , Zhang\n                    <jats:italic>et al<\/jats:italic>\n                    (2021) present the novel causative gene\n                    <jats:italic>MOS<\/jats:italic>\n                    in patients with the EEAF phenotype. The relationship between\n                    <jats:italic>MOS<\/jats:italic>\n                    variants and human EEAF is comprehensively established through a series of\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    experiments, thus clarifying the role of MOS during human oocyte maturation and early embryo development. These findings suggest that\n                    <jats:italic>MOS<\/jats:italic>\n                    is a new diagnostic marker of EEAF and is a potential therapeutic target for treatment of EEAF patients.\n                  <\/jats:p>","DOI":"10.15252\/emmm.202115323","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T07:40:32Z","timestamp":1637566832000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["MOS is a novel genetic marker for human early embryonic arrest and fragmentation"],"prefix":"10.1038","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3400-0434","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9895-1394","authenticated-orcid":false,"given":"Qing","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"key":"BFEMMM202115323_CR1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s43032-020-00279-3","volume":"28","author":"R Bala","year":"2021","unstructured":"Bala R, Singh V, Rajender S, Singh K (2021) Environment, lifestyle, and female infertility. 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J Assist Reprod Genet 38: 993\u20131002","journal-title":"J Assist Reprod Genet"},{"key":"BFEMMM202115323_CR8","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1242\/dev.144410","volume":"144","author":"QQ Sha","year":"2017","unstructured":"Sha QQ, Dai XX, Dang Y, Tang F, Liu J, Zhang YL, Fan HY (2017) A MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocytes. Development (Cambridge, England) 144: 452\u2013463","journal-title":"Development (Cambridge, England)"},{"key":"BFEMMM202115323_CR9","volume":"13","author":"YL Zhang","year":"2021","unstructured":"Zhang YL, Zheng W, Ren PP, Hu HL, Tong XM, Zhang SP, Li X, Wang HC, Jiang JC, Jin JM et al (2021) Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation. 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