{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:09:57Z","timestamp":1779088197993,"version":"3.51.4"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["FC001057"],"award-info":[{"award-number":["FC001057"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["FC001057"],"award-info":[{"award-number":["FC001057"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000265","name":"UKRI|Medical Research Council","doi-asserted-by":"publisher","award":["FC001057 and"],"award-info":[{"award-number":["FC001057 and"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UKRI|Medical Research Council","doi-asserted-by":"publisher","award":["MR\/J008060\/1"],"award-info":[{"award-number":["MR\/J008060\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AstraZeneca Postdoctoral Programme"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2022,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Peripheral T\u2010cell lymphoma (PTCL) represents a rare group of heterogeneous diseases in urgent need of effective treatments. A scarcity of disease\u2010relevant preclinical models hinders research advances. Here, we isolated a novel mouse (m)PTCL by serially transplanting a lymphoma from a germinal center B\u2010cell hyperplasia model (\n                    <jats:italic>C\u03b31<\/jats:italic>\n                    \u2010Cre\n                    <jats:italic>Blimp1<\/jats:italic>\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    ) through immune\u2010competent mice. Lymphoma cells were identified as clonal TCR\u03b2+ T\u2010helper cells expressing T\u2010follicular helper markers. We also observed coincident B\u2010cell activation and development of a\n                    <jats:italic>de novo<\/jats:italic>\n                    B\u2010cell lymphoma in the model, reminiscent of B\u2010cell activation\/lymphomagenesis found in human PTCL. Molecular profiling linked the mPTCL to the high\u2010risk \u201cGATA3\u201d subtype of PTCL, showing GATA3 and Th2 gene expression, PI3K\/mTOR pathway enrichment, hyperactivated MYC, and genome instability. Exome sequencing identified a human\u2010relevant oncogenic \u03b2\u2010catenin mutation possibly involved in T\u2010cell lymphomagenesis. Prolonged treatment responses were achieved\n                    <jats:italic>in vivo<\/jats:italic>\n                    by targeting ATR in the DNA damage response (DDR), a result corroborated in PTCL cell lines. This work provides mechanistic insight into the molecular and immunological drivers of T\u2010cell lymphomagenesis and proposes DDR inhibition as an effective and readily translatable therapy in PTCL.\n                  <\/jats:p>","DOI":"10.15252\/emmm.202215816","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T10:43:28Z","timestamp":1651747408000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A preclinical model of peripheral T\u2010cell lymphoma GATA3 reveals DNA damage response pathway vulnerability"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6924-6848","authenticated-orcid":false,"given":"Elizabeth A","family":"Kuczynski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Morlino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Peter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M L","family":"Coenen\u2010Stass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0923-229X","authenticated-orcid":false,"given":"Jennifer I","family":"Moss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Wali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oona","family":"Delpuech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinash","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anisha","family":"Solanki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-9993","authenticated-orcid":false,"given":"Charles","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8239-7184","authenticated-orcid":false,"given":"Dinis P","family":"Calado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7432-0195","authenticated-orcid":false,"given":"Larissa S","family":"Carnevalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"BFEMMM202215816_CR1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature13444","volume":"510","author":"K Ali","year":"2014","unstructured":"Ali K, Soond DR, Pi\u00f1eiro R, Hagemann T, Pearce W, Lim EL, Bouabe H, Scudamore CL, Hancox T, Maecker H et\u2009al (2014) Inactivation of PI(3)K p110\u03b4 breaks regulatory T\u2010cell\u2010mediated immune tolerance to cancer. Nature 510: 407\u2013411","journal-title":"Nature"},{"key":"BFEMMM202215816_CR2","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1182\/blood.2019000779","volume":"134","author":"C Amador","year":"2019","unstructured":"Amador C, Greiner TC, Heavican TB, Smith LM, Galvis KT, Lone W, Bouska A, D\u2019Amore F, Pedersen MB, Pileri S et\u2009al (2019) Reproducing the molecular subclassification of peripheral T\u2010cell lymphoma\u2010NOS by immunohistochemistry. Blood 134: 2159\u20132170","journal-title":"Blood"},{"key":"BFEMMM202215816_CR3","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/PAS.0b013e31802d68e9","volume":"31","author":"AD Attygalle","year":"2007","unstructured":"Attygalle AD, Kyriakou C, Dupuis J, Grogg KL, Diss TC, Wotherspoon AC, Chuang SS, Cabe\u00e7adas J, Isaacson PG, Du M\u2010Q et\u2009al (2007) Histologic evolution of angioimmunoblastic T\u2010cell lymphoma in consecutive biopsies: clinical correlation and insights into natural history and disease progression. Am J Surg Pathol 31: 1077\u20131088","journal-title":"Am J Surg Pathol"},{"key":"BFEMMM202215816_CR4","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/s41590-019-0479-x","volume":"20","author":"JT Barata","year":"2019","unstructured":"Barata JT, Durum SK, Seddon B (2019) Flip the coin: IL\u20107 and IL\u20107R in health and disease. Nat Immunol 20: 1584\u20131593","journal-title":"Nat Immunol"},{"key":"BFEMMM202215816_CR5","first-page":"1","volume":"77","author":"N Barker","year":"2000","unstructured":"Barker N, Morin PJ, Clevers H (2000) The Yin\u2010Yang of TCF\/beta\u2010catenin signaling. Adv Cancer Res 77: 1\u201324","journal-title":"Adv Cancer Res"},{"key":"BFEMMM202215816_CR6","doi-asserted-by":"crossref","first-page":"102026","DOI":"10.1016\/j.ctrv.2020.102026","volume":"88","author":"M Boudny","year":"2020","unstructured":"Boudny M, Trbusek M (2020) ATR\u2010CHK1 pathway as a therapeutic target for acute and chronic leukemias. Cancer Treat Rev 88: 102026","journal-title":"Cancer Treat Rev"},{"key":"BFEMMM202215816_CR7","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ccr.2010.11.024","volume":"18","author":"DP Calado","year":"2010","unstructured":"Calado DP, Zhang B, Srinivasan L, Sasaki Y, Seagal J, Unitt C, Rodig S, Kutok J, Tarakhovsky A, Schmidt\u2010Supprian M et\u2009al (2010) Constitutive canonical NF\u2010kappaB activation cooperates with disruption of BLIMP1 in the pathogenesis of activated B cell\u2010like diffuse large cell lymphoma. Cancer Cell 18: 580\u2013589","journal-title":"Cancer Cell"},{"key":"BFEMMM202215816_CR8","doi-asserted-by":"crossref","first-page":"102090","DOI":"10.1016\/j.ctrv.2020.102090","volume":"90","author":"L Carrassa","year":"2020","unstructured":"Carrassa L, Colombo I, Damia G, Bertoni F (2020) Targeting the DNA damage response for patients with lymphoma: preclinical and clinical evidences. Cancer Treat Rev 90: 102090","journal-title":"Cancer Treat Rev"},{"key":"BFEMMM202215816_CR9","doi-asserted-by":"crossref","first-page":"7396","DOI":"10.1073\/pnas.0602353103","volume":"103","author":"S Casola","year":"2006","unstructured":"Casola S, Cattoretti G, Uyttersprot N, Koralov SB, Seagal J, Hao Z, Waisman A, Egert A, Ghitza D, Rajewsky K (2006) Tracking germinal center B cells expressing germ\u2010line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci USA 103: 7396\u20137401","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM202215816_CR10","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.3390\/ijms21031098","volume":"21","author":"F Chiarini","year":"2020","unstructured":"Chiarini F, Paganelli F, Martelli AM, Evangelisti C (2020) The role played by Wnt\/\u03b2\u2010catenin signaling pathway in acute lymphoblastic leukemia. Int J Mol Sci 21: 1098","journal-title":"Int J Mol Sci"},{"key":"BFEMMM202215816_CR11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ccell.2018.01.001","volume":"33","author":"JR Cortes","year":"2018","unstructured":"Cortes JR, Ambesi\u2010Impiombato A, Couronn\u00e9 L, Quinn SA, Kim CS, da Silva Almeida AC, West Z, Belver L, Martin MS, Scourzic L et\u2009al (2018) RHOA G17V induces T follicular helper cell specification and promotes lymphomagenesis. Cancer Cell 33: 259\u2013273.e257","journal-title":"Cancer Cell"},{"key":"BFEMMM202215816_CR12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","volume":"29","author":"S Crotty","year":"2011","unstructured":"Crotty S (2011) Follicular helper CD4 T cells (TFH). Annu Rev Immunol 29: 621\u2013663","journal-title":"Annu Rev Immunol"},{"key":"BFEMMM202215816_CR13","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1158\/1535-7163.MCT-11-0824-T","volume":"11","author":"BR Davies","year":"2012","unstructured":"Davies BR, Greenwood H, Dudley P, Crafter C, Yu D\u2010H, Zhang J, Li J, Gao B, Ji Q, Maynard J et\u2009al (2012) Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol Cancer Ther 11: 873\u2013887","journal-title":"Mol Cancer Ther"},{"key":"BFEMMM202215816_CR14","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1182\/blood-2006-10-055145","volume":"109","author":"L de Leval","year":"2007","unstructured":"de Leval L, Rickman DS, Thielen C, Reynies AD, Huang Y\u2010L, Delsol G, Lamant L, Leroy K, Bri\u00e8re J, Molina T et\u2009al (2007) The gene expression profile of nodal peripheral T\u2010cell lymphoma demonstrates a molecular link between angioimmunoblastic T\u2010cell lymphoma (AITL) and follicular helper T (TFH) cells. Blood 109: 4952\u20134963","journal-title":"Blood"},{"key":"BFEMMM202215816_CR15","doi-asserted-by":"crossref","first-page":"v165","DOI":"10.1093\/annonc\/mdz244.012","volume":"30","author":"M Dillon","year":"2019","unstructured":"Dillon M, Guevara J, Mohammed K, Smith SA, Dean E, McLellan L, Boylan Z, Spicer J, Forster MD, Harrington KJ (2019) A phase I study of ATR inhibitor, AZD6738, as monotherapy in advanced solid tumours (PATRIOT part A, B). Ann Oncol 30: v165\u2013v166","journal-title":"Ann Oncol"},{"key":"BFEMMM202215816_CR16","doi-asserted-by":"crossref","first-page":"a014423","DOI":"10.1101\/cshperspect.a014423","volume":"4","author":"D Dominguez\u2010Sola","year":"2014","unstructured":"Dominguez\u2010Sola D, Gautier J (2014) MYC and the control of DNA replication. Cold Spring Harbor Perspect Med 4: a014423","journal-title":"Cold Spring Harbor Perspect Med"},{"key":"BFEMMM202215816_CR17","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature05953","volume":"448","author":"D Dominguez\u2010Sola","year":"2007","unstructured":"Dominguez\u2010Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J, Dalla\u2010Favera R (2007) Non\u2010transcriptional control of DNA replication by c\u2010Myc. Nature 448: 445\u2013451","journal-title":"Nature"},{"key":"BFEMMM202215816_CR18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1073\/pnas.1315752111","volume":"111","author":"M Dose","year":"2014","unstructured":"Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K, Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL et\u2009al (2014) \u03b2\u2010Catenin induces T\u2010cell transformation by promoting genomic instability. Proc Natl Acad Sci USA 111: 391\u2013396","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM202215816_CR19","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3324\/haematol.2019.226647","volume":"105","author":"F Drieux","year":"2020","unstructured":"Drieux F, Ruminy P, Abdel\u2010Sater A, Lemonnier F, Viailly P\u2010J, Fataccioli V, Marchand V, Bisig B, Letourneau A, Parrens M et\u2009al (2020) Defining signatures of peripheral T\u2010cell lymphoma with a targeted 20\u2010marker gene expression profiling assay. Haematologica 105: 1582\u20131592","journal-title":"Haematologica"},{"key":"BFEMMM202215816_CR20","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1182\/blood-2011-07-365130","volume":"120","author":"JI Ellyard","year":"2012","unstructured":"Ellyard JI, Chia T, Rodriguez\u2010Pinilla S\u2010M, Martin JL, Hu X, Navarro\u2010Gonzalez M, Garcia JF, Delfau\u2010Larue M\u2010H, Montes\u2010Moreno S, Gaulard P et\u2009al (2012) Heterozygosity for Roquinsan leads to angioimmunoblastic T\u2010cell lymphoma\u2010like tumors in mice. Blood 120: 812\u2013821","journal-title":"Blood"},{"key":"BFEMMM202215816_CR21","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1038\/onc.2011.358","volume":"31","author":"PT Ferrao","year":"2012","unstructured":"Ferrao PT, Bukczynska EP, Johnstone RW, McArthur GA (2012) Efficacy of CHK inhibitors as single agents in MYC\u2010driven lymphoma cells. Oncogene 31: 1661\u20131672","journal-title":"Oncogene"},{"key":"BFEMMM202215816_CR22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41568-020-0247-0","volume":"20","author":"D Fiore","year":"2020","unstructured":"Fiore D, Cappelli LV, Broccoli A, Zinzani PL, Chan WC, Inghirami G (2020) Peripheral T cell lymphomas: from the bench to the clinic. Nat Rev Cancer 20: 323\u2013342","journal-title":"Nat Rev Cancer"},{"key":"BFEMMM202215816_CR23","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pharmthera.2018.03.005","volume":"188","author":"JV Forment","year":"2018","unstructured":"Forment JV, O'Connor MJ (2018) Targeting the replication stress response in cancer. Pharmacol Ther 188: 155\u2013167","journal-title":"Pharmacol Ther"},{"key":"BFEMMM202215816_CR24","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1182\/blood.2020006513","volume":"136","author":"K Fukumoto","year":"2020","unstructured":"Fukumoto K, Sakata\u2010Yanagimoto M, Fujisawa M, Sakamoto T, Miyoshi H, Suehara Y, Nguyen TB, Suma S, Yanagimoto S, Shiraishi Y et\u2009al (2020) VAV1 mutations contribute to development of T\u2010cell neoplasms in mice. Blood 136: 3018\u20133032","journal-title":"Blood"},{"key":"BFEMMM202215816_CR25","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1158\/0008-5472.CAN-17-2802","volume":"78","author":"MA Gadhikar","year":"2018","unstructured":"Gadhikar MA, Zhang J, Shen L, Rao X, Wang J, Zhao M, Kalu NN, Johnson FM, Byers LA, Heymach J et\u2009al (2018) CDKN2A\/p16 deletion in head and neck cancer cells is associated with CDK2 activation, replication stress, and vulnerability to CHK1 inhibition. Cancer Res 78: 781\u2013797","journal-title":"Cancer Res"},{"key":"BFEMMM202215816_CR26","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1038\/leu.2016.106","volume":"30","author":"C Gekas","year":"2016","unstructured":"Gekas C, D'Altri T, Aligu\u00e9 R, Gonz\u00e1lez J, Espinosa L, Bigas A (2016) \u03b2\u2010Catenin is required for T\u2010cell leukemia initiation and MYC transcription downstream of Notch1. Leukemia 30: 2002\u20132010","journal-title":"Leukemia"},{"key":"BFEMMM202215816_CR27","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41586-019-1186-3","volume":"569","author":"M Ghandi","year":"2019","unstructured":"Ghandi M, Huang FW, Jan\u00e9\u2010Valbuena J, Kryukov GV, Lo CC, McDonald ER, Barretina J, Gelfand ET, Bielski CM, Li H et\u2009al (2019) Next\u2010generation characterization of the cancer cell line encyclopedia. Nature 569: 503\u2013508","journal-title":"Nature"},{"key":"BFEMMM202215816_CR28","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.3390\/cancers11111654","volume":"11","author":"A Ghelli Luserna Di Ror\u00e0","year":"2019","unstructured":"Ghelli Luserna Di Ror\u00e0 A, Bocconcelli M, Ferrari A, Terragna C, Bruno S, Imbrogno E, Beeharry N, Robustelli V, Ghetti M, Napolitano R et\u2009al (2019) Synergism through WEE1 and CHK1 inhibition in acute lymphoblastic leukemia. Cancers 11: 1654","journal-title":"Cancers"},{"key":"BFEMMM202215816_CR29","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1158\/0008-5472.CAN-08-1322","volume":"68","author":"RW Groen","year":"2008","unstructured":"Groen RW, Oud ME, Schilder\u2010Tol EJ, Overdijk MB, ten Berge D, Nusse R, Spaargaren M, Pals ST (2008) Illegitimate WNT pathway activation by beta\u2010catenin mutation or autocrine stimulation in T\u2010cell malignancies. Cancer Res 68: 6969\u20136977","journal-title":"Cancer Res"},{"key":"BFEMMM202215816_CR30","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s11899-015-0292-z","volume":"10","author":"AA Gru","year":"2015","unstructured":"Gru AA, Haverkos BH, Freud AG, Hastings J, Nowacki NB, Barrionuevo C, Vigil CE, Rochford R, Natkunam Y, Baiocchi RA et\u2009al (2015) The Epstein\u2010Barr virus (EBV) in T cell and NK cell lymphomas: time for a reassessment. Curr Hematol Malig Rep 10: 456\u2013467","journal-title":"Curr Hematol Malig Rep"},{"key":"BFEMMM202215816_CR31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","volume":"14","author":"S H\u00e4nzelmann","year":"2013","unstructured":"H\u00e4nzelmann S, Castelo R, Guinney J (2013) GSVA: gene set variation analysis for microarray and RNA\u2010Seq data. BMC Bioinformatics 14: 7","journal-title":"BMC Bioinformatics"},{"key":"BFEMMM202215816_CR32","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1126\/science.281.5382.1509","volume":"281","author":"TC He","year":"1998","unstructured":"He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B, Kinzler KW (1998) Identification of c\u2010MYC as a target of the APC pathway. Science 281: 1509\u20131512","journal-title":"Science"},{"key":"BFEMMM202215816_CR33","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1182\/blood-2018-09-872549","volume":"133","author":"TB Heavican","year":"2019","unstructured":"Heavican TB, Bouska A, Yu J, Lone W, Amador C, Gong Q, Zhang W, Li Y, Dave BJ, Nairism\u00e4gi M\u2010L et\u2009al (2019) Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T\u2010cell lymphoma. Blood 133: 1664\u20131676","journal-title":"Blood"},{"key":"BFEMMM202215816_CR34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.humpath.2015.09.033","volume":"48","author":"JC Hoffmann","year":"2016","unstructured":"Hoffmann JC, Chisholm KM, Cherry A, Chen J, Arber DA, Natkunam Y, Warnke RA, Ohgami RS (2016) An analysis of MYC and EBV in diffuse large B\u2010cell lymphomas associated with angioimmunoblastic T\u2010cell lymphoma and peripheral T\u2010cell lymphoma not otherwise specified. Hum Pathol 48: 9\u201317","journal-title":"Hum Pathol"},{"key":"BFEMMM202215816_CR35","doi-asserted-by":"crossref","first-page":"7067","DOI":"10.1158\/1078-0432.CCR-11-1198","volume":"17","author":"A Hoglund","year":"2011","unstructured":"Hoglund A, Nilsson LM, Muralidharan SV, Hasvold LA, Merta P, Rudelius M, Nikolova V, Keller U, Nilsson JA (2011) Therapeutic implications for the induced levels of Chk1 in Myc\u2010expressing cancer cells. Clin Cancer Res 17: 7067\u20137079","journal-title":"Clin Cancer Res"},{"key":"BFEMMM202215816_CR36","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1182\/blood-2017-08-802470","volume":"131","author":"SM Horwitz","year":"2018","unstructured":"Horwitz SM, Koch R, Porcu P, Oki Y, Moskowitz A, Perez M, Myskowski P, Officer A, Jaffe JD, Morrow SN et\u2009al (2018) Activity of the PI3K\u2010\u03b4, \u03b3 inhibitor duvelisib in a phase 1 trial and preclinical models of T\u2010cell lymphoma. Blood 131: 888\u2013898","journal-title":"Blood"},{"key":"BFEMMM202215816_CR37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13045-015-0206-5","volume":"8","author":"I Iacobucci","year":"2015","unstructured":"Iacobucci I, Di Ror\u00e0 AGL, Falzacappa MVV, Agostinelli C, Derenzini E, Ferrari A, Papayannidis C, Lonetti A, Righi S, Imbrogno E et\u2009al (2015) In vitro and in vivo single\u2010agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemia. J Hematol Oncol 8: 125","journal-title":"J Hematol Oncol"},{"key":"BFEMMM202215816_CR38","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1182\/blood-2009-06-227579","volume":"115","author":"J Iqbal","year":"2010","unstructured":"Iqbal J, Weisenburger DD, Greiner TC, Vose JM, McKeithan T, Kucuk C, Geng H, Deffenbacher K, Smith L, Dybkaer K et\u2009al (2010) Molecular signatures to improve diagnosis in peripheral T\u2010cell lymphoma and prognostication in angioimmunoblastic T\u2010cell lymphoma. Blood 115: 1026\u20131036","journal-title":"Blood"},{"key":"BFEMMM202215816_CR39","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1182\/blood-2013-11-536359","volume":"123","author":"J Iqbal","year":"2014","unstructured":"Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA et\u2009al (2014) Gene expression signatures delineate biological and prognostic subgroups in peripheral T\u2010cell lymphoma. Blood 123: 2915\u20132923","journal-title":"Blood"},{"key":"BFEMMM202215816_CR40","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1126\/science.1175870","volume":"325","author":"RJ Johnston","year":"2009","unstructured":"Johnston RJ, Poholek AC, DiToro D, Yusuf I, Eto D, Barnett B, Dent AL, Craft J, Crotty S (2009) Bcl6 and Blimp\u20101 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325: 1006\u20131010","journal-title":"Science"},{"key":"BFEMMM202215816_CR41","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1182\/blood-2012-12-471904","volume":"122","author":"D Kaveri","year":"2013","unstructured":"Kaveri D, Kastner P, Demb\u00e9l\u00e9 D, Nerlov C, Chan S, Kirstetter P (2013) \u03b2\u2010Catenin activation synergizes with Pten loss and Myc overexpression in Notch\u2010independent T\u2010ALL. Blood 122: 694\u2013704","journal-title":"Blood"},{"key":"BFEMMM202215816_CR42","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1158\/2159-8290.CD-17-1461","volume":"8","author":"P Kotsantis","year":"2018","unstructured":"Kotsantis P, Petermann E, Boulton SJ (2018) Mechanisms of oncogene\u2010induced replication stress: jigsaw falling into place. Cancer Discov 8: 537\u2013555","journal-title":"Cancer Discov"},{"key":"BFEMMM202215816_CR43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.canlet.2018.05.011","volume":"430","author":"K Kr\u00fcger","year":"2018","unstructured":"Kr\u00fcger K, Geist K, Stuhldreier F, Schumacher L, Bl\u00fcmel L, Remke M, Wesselborg S, Stork B, Kl\u00f6cker N, Bormann S et\u2009al (2018) Multiple DNA damage\u2010dependent and DNA damage\u2010independent stress responses define the outcome of ATR\/Chk1 targeting in medulloblastoma cells. Cancer Lett 430: 34\u201346","journal-title":"Cancer Lett"},{"key":"BFEMMM202215816_CR44","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1182\/blood-2015-05-644872","volume":"127","author":"M Kwok","year":"2016","unstructured":"Kwok M, Davies N, Agathanggelou A, Smith E, Oldreive C, Petermann E, Stewart G, Brown J, Lau A, Pratt G et\u2009al (2016) ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53\u2010 or ATM\u2010defective chronic lymphocytic leukemia cells. Blood 127: 582\u2013595","journal-title":"Blood"},{"key":"BFEMMM202215816_CR45","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41379-019-0279-8","volume":"33","author":"MA Laginestra","year":"2020","unstructured":"Laginestra MA, Cascione L, Motta G, Fuligni F, Agostinelli C, Rossi M, Sapienza MR, Righi S, Broccoli A, Indio V et\u2009al (2020) Whole exome sequencing reveals mutations in FAT1 tumor suppressor gene clinically impacting on peripheral T\u2010cell lymphoma not otherwise specified. Mod Pathol 33: 179\u2013187","journal-title":"Mod Pathol"},{"key":"BFEMMM202215816_CR46","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1053\/j.gastro.2019.11.302","volume":"158","author":"P Liu","year":"2020","unstructured":"Liu P, Liang B, Liu M, Lebbink JHG, Li S, Qian M, Lavrijsen M, Peppelenbosch MP, Chen X, Smits R (2020) Oncogenic mutations in armadillo repeats 5 and 6 of \u03b2\u2010catenin reduce binding to APC, increasing signaling and transcription of target genes. Gastroenterology 158: 1029\u20131043.e1010","journal-title":"Gastroenterology"},{"key":"BFEMMM202215816_CR47","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.4049\/jimmunol.1800633","volume":"201","author":"J van Loosdregt","year":"2018","unstructured":"van Loosdregt J, Coffer PJ (2018) The role of WNT signaling in mature T cells: T cell factor is coming home. J Immunol 201: 2193\u20132200","journal-title":"J Immunol"},{"key":"BFEMMM202215816_CR48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012794","volume":"5","author":"M Lovatt","year":"2010","unstructured":"Lovatt M, Bijlmakers MJ (2010) Stabilisation of beta\u2010catenin downstream of T cell receptor signalling. PLoS One 5: e12794","journal-title":"PLoS One"},{"key":"BFEMMM202215816_CR49","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1182\/blood-2016-09-692541","volume":"129","author":"MA Lunning","year":"2017","unstructured":"Lunning MA, Vose JM (2017) Angioimmunoblastic T\u2010cell lymphoma: the many\u2010faced lymphoma. Blood 129: 1095\u20131102","journal-title":"Blood"},{"key":"BFEMMM202215816_CR50","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ccr.2010.10.030","volume":"18","author":"J Mandelbaum","year":"2010","unstructured":"Mandelbaum J, Bhagat G, Tang H, Mo T, Brahmachary M, Shen Q, Chadburn A, Rajewsky K, Tarakhovsky A, Pasqualucci L et\u2009al (2010) BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell\u2010like diffuse large B cell lymphoma. Cancer Cell 18: 568\u2013579","journal-title":"Cancer Cell"},{"key":"BFEMMM202215816_CR51","doi-asserted-by":"crossref","first-page":"e336","DOI":"10.3324\/haematol.2016.143768","volume":"101","author":"R Manso","year":"2016","unstructured":"Manso R, Bellas C, Mart\u00edn\u2010Acosta P, Mollejo M, Men\u00e1rguez J, Rojo F, Llamas P, Piris MA, Rodr\u00edguez\u2010Pinilla SM (2016) C\u2010MYC is related to GATA3 expression and associated with poor prognosis in nodal peripheral T\u2010cell lymphomas. Haematologica 101: e336\u2013338","journal-title":"Haematologica"},{"key":"BFEMMM202215816_CR52","doi-asserted-by":"crossref","first-page":"E4782","DOI":"10.1073\/pnas.1703683114","volume":"114","author":"JP McNally","year":"2017","unstructured":"McNally JP, Millen SH, Chaturvedi V, Lakes N, Terrell CE, Elfers EE, Carroll KR, Hogan SP, Andreassen PR, Kanter J et\u2009al (2017) Manipulating DNA damage\u2010response signaling for the treatment of immune\u2010mediated diseases. Proc Natl Acad Sci USA 114: E4782\u2013e4791","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM202215816_CR53","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1158\/1535-7163.MCT-16-0378","volume":"16","author":"A Min","year":"2017","unstructured":"Min A, Im S\u2010A, Jang H, Kim S, Lee M, Kim DK, Yang Y, Kim H\u2010J, Lee K\u2010H, Kim JW et\u2009al (2017) AZD6738, A novel oral inhibitor of ATR, induces synthetic lethality with ATM deficiency in gastric cancer cells. Mol Cancer Ther 16: 566\u2013577","journal-title":"Mol Cancer Ther"},{"key":"BFEMMM202215816_CR54","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/nsmb.2189","volume":"18","author":"M Murga","year":"2011","unstructured":"Murga M, Campaner S, Lopez\u2010Contreras AJ, Toledo LI, Soria R, Monta\u00f1a MF, D'Artista L, Schleker T, Guerra C, Garcia E et\u2009al (2011) Exploiting oncogene\u2010induced replicative stress for the selective killing of Myc\u2010driven tumors. Nat Struct Mol Biol 18: 1331\u20131335","journal-title":"Nat Struct Mol Biol"},{"key":"BFEMMM202215816_CR55","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1158\/1078-0432.CCR-08-1808","volume":"15","author":"M Nakagawa","year":"2009","unstructured":"Nakagawa M, Nakagawa\u2010Oshiro A, Karnan S, Tagawa H, Utsunomiya A, Nakamura S, Takeuchi I, Ohshima K, Seto M (2009) Array comparative genomic hybridization analysis of PTCL\u2010U reveals a distinct subgroup with genetic alterations similar to lymphoma\u2010type adult T\u2010cell leukemia\/lymphoma. Clin Cancer Res 15: 30\u201338","journal-title":"Clin Cancer Res"},{"key":"BFEMMM202215816_CR56","first-page":"935","volume":"132","author":"SY Ng","year":"2018","unstructured":"Ng SY, Brown L, Stevenson K, deSouza T, Aster JC, Louissaint Jr A, Weinstock DM (2018) RhoA G17V is sufficient to induce autoimmunity and promotes T\u2010cell lymphomagenesis in mice. Blood 132: 935\u2013947","journal-title":"Blood"},{"key":"BFEMMM202215816_CR57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000296","volume":"8","author":"D Notani","year":"2010","unstructured":"Notani D, Gottimukkala KP, Jayani RS, Limaye AS, Damle MV, Mehta S, Purbey PK, Joseph J, Galande S (2010) Global regulator SATB1 recruits beta\u2010catenin and regulates T(H)2 differentiation in Wnt\u2010dependent manner. PLoS Biol 8: e1000296","journal-title":"PLoS Biol"},{"key":"BFEMMM202215816_CR58","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.1176676","volume":"325","author":"RI Nurieva","year":"2009","unstructured":"Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, Matskevitch TD, Wang YH, Dong C (2009) Bcl6 mediates the development of T follicular helper cells. Science 325: 1001\u20131005","journal-title":"Science"},{"key":"BFEMMM202215816_CR59","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1084\/jem.20052204","volume":"203","author":"L Pasqualucci","year":"2006","unstructured":"Pasqualucci L, Compagno M, Houldsworth J, Monti S, Grunn A, Nandula SV, Aster JC, Murty VV, Shipp MA, Dalla\u2010Favera R (2006) Inactivation of the PRDM1\/BLIMP1 gene in diffuse large B cell lymphoma. J Exp Med 203: 311\u2013317","journal-title":"J Exp Med"},{"key":"BFEMMM202215816_CR60","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1084\/jem.20092042","volume":"207","author":"K Pechloff","year":"2010","unstructured":"Pechloff K, Holch J, Ferch U, Schweneker M, Brunner K, Kremer M, Sparwasser T, Quintanilla\u2010Martinez L, Zimber\u2010Strobl U, Streubel B et\u2009al (2010) The fusion kinase ITK\u2010SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med 207: 1031\u20131044","journal-title":"J Exp Med"},{"key":"BFEMMM202215816_CR61","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ccr.2014.03.005","volume":"25","author":"C Pilati","year":"2014","unstructured":"Pilati C, Letouz\u00e9 E, Nault J\u2010C, Imbeaud S, Boulai A, Calderaro J, Poussin K, Franconi A, Couchy G, Morcrette G et\u2009al (2014) Genomic profiling of hepatocellular adenomas reveals recurrent FRK\u2010activating mutations and the mechanisms of malignant transformation. Cancer Cell 25: 428\u2013441","journal-title":"Cancer Cell"},{"key":"BFEMMM202215816_CR62","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1002\/hep.28638","volume":"64","author":"S Rebouissou","year":"2016","unstructured":"Rebouissou S, Franconi A, Calderaro J, Letouze E, Imbeaud S, Pilati C, Nault JC, Couchy G, Laurent A, Balabaud C et\u2009al (2016) Genotype\u2010phenotype correlation of CTNNB1 mutations reveals different ss\u2010catenin activity associated with liver tumor progression. Hepatology 64: 2047\u20132061","journal-title":"Hepatology"},{"key":"BFEMMM202215816_CR63","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/hon.786","volume":"24","author":"T R\u00fcdiger","year":"2006","unstructured":"R\u00fcdiger T, Geissinger E, M\u00fcller\u2010Hermelink HK (2006) 'Normal counterparts' of nodal peripheral T\u2010cell lymphoma. Hematol Oncol 24: 175\u2013180","journal-title":"Hematol Oncol"},{"key":"BFEMMM202215816_CR64","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/leu.2014.261","volume":"29","author":"JH Schatz","year":"2015","unstructured":"Schatz JH, Horwitz SM, Teruya\u2010Feldstein J, Lunning MA, Viale A, Huberman K, Socci ND, Lailler N, Heguy A, Dolgalev I et\u2009al (2015) Targeted mutational profiling of peripheral T\u2010cell lymphoma not otherwise specified highlights new mechanisms in a heterogeneous pathogenesis. Leukemia 29: 237\u2013241","journal-title":"Leukemia"},{"key":"BFEMMM202215816_CR65","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/bjh.14473","volume":"176","author":"N Schmitz","year":"2017","unstructured":"Schmitz N, de Leval L (2017) How I manage peripheral T\u2010cell lymphoma, not otherwise specified and angioimmunoblastic T\u2010cell lymphoma: current practice and a glimpse into the future. Br J Haematol 176: 851\u2013866","journal-title":"Br J Haematol"},{"key":"BFEMMM202215816_CR66","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","volume":"127","author":"SH Swerdlow","year":"2016","unstructured":"Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD et\u2009al (2016) The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 127: 2375\u20132390","journal-title":"Blood"},{"key":"BFEMMM202215816_CR67","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","volume":"100","author":"SJ Szabo","year":"2000","unstructured":"Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH (2000) A novel transcription factor, T\u2010bet, directs Th1 lineage commitment. Cell 100: 655\u2013669","journal-title":"Cell"},{"key":"BFEMMM202215816_CR68","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1182\/blood-2016-02-698977","volume":"128","author":"D Vallois","year":"2016","unstructured":"Vallois D, Dobay MPD, Morin RD, Lemonnier F, Missiaglia E, Juilland M, Iwaszkiewicz J, Fataccioli V, Bisig B, Roberti A et\u2009al (2016) Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T\u2010cell\u2010derived lymphomas. Blood 128: 1490\u20131502","journal-title":"Blood"},{"key":"BFEMMM202215816_CR69","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","volume":"17","author":"JJM van Dongen","year":"2003","unstructured":"van Dongen JJM, Langerak AW, Br\u00fcggemann M, Evans PAS, Hummel M, Lavender FL, Delabesse E, Davi F, Schuuring E, Garc\u00eda\u2010Sanz R et\u2009al (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T\u2010cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED\u20102 concerted action BMH4\u2010CT98\u20103936. Leukemia 17: 2257\u20132317","journal-title":"Leukemia"},{"key":"BFEMMM202215816_CR70","doi-asserted-by":"crossref","first-page":"44289","DOI":"10.18632\/oncotarget.6247","volume":"6","author":"FP Vendetti","year":"2015","unstructured":"Vendetti FP, Lau A, Schamus S, Conrads TP, O'Connor MJ, Bakkenist CJ (2015) The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti\u2010tumor effects of cisplatin to resolve ATM\u2010deficient non\u2010small cell lung cancer in vivo. Oncotarget 6: 44289\u201344305","journal-title":"Oncotarget"},{"key":"BFEMMM202215816_CR71","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood-2013-12-544809","volume":"123","author":"T Wang","year":"2014","unstructured":"Wang T, Feldman AL, Wada DA, Lu YE, Polk A, Briski R, Ristow K, Habermann TM, Thomas D, Ziesmer SC et\u2009al (2014a) GATA\u20103 expression identifies a high\u2010risk subset of PTCL, NOS with distinct molecular and clinical features. Blood 123: 3007\u20133015","journal-title":"Blood"},{"key":"BFEMMM202215816_CR72","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1172\/JCI37210","volume":"121","author":"XI Wang","year":"2011","unstructured":"Wang XI, Werneck MBF, Wilson BG, Kim H\u2010J, Kluk MJ, Thom CS, Wischhusen JW, Evans JA, Jesneck JL, Nguyen P et\u2009al (2011) TCR\u2010dependent transformation of mature memory phenotype T cells in mice. J Clin Invest 121: 3834\u20133845","journal-title":"J Clin Invest"},{"key":"BFEMMM202215816_CR73","first-page":"3432","volume":"7","author":"Y Wang","year":"2014","unstructured":"Wang Y, Xie B, Chen Y, Huang Z, Tan H (2014b) Development of angioimmunoblastic T\u2010cell lymphoma after treatment of diffuse large B\u2010cell lymphoma: a case report and review of literature. Int J Clin Exp Pathol 7: 3432\u20133438","journal-title":"Int J Clin Exp Pathol"},{"key":"BFEMMM202215816_CR74","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nature24649","volume":"552","author":"T Wartewig","year":"2017","unstructured":"Wartewig T, Kurgyis Z, Keppler S, Pechloff K, Hameister E, \u00d6llinger R, Maresch R, Buch T, Steiger K, Winter C et\u2009al (2017) PD\u20101 is a haploinsufficient suppressor of T cell lymphomagenesis. Nature 552: 121\u2013125","journal-title":"Nature"},{"key":"BFEMMM202215816_CR75","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1038\/s41375-019-0473-1","volume":"33","author":"Y Watatani","year":"2019","unstructured":"Watatani Y, Sato Y, Miyoshi H, Sakamoto K, Nishida K, Gion Y, Nagata Y, Shiraishi Y, Chiba K, Tanaka H et\u2009al (2019) Molecular heterogeneity in peripheral T\u2010cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling. Leukemia 33: 2867\u20132883","journal-title":"Leukemia"},{"key":"BFEMMM202215816_CR76","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1309\/VD2D-98ME-MB3F-WH34","volume":"118","author":"Y Xu","year":"2002","unstructured":"Xu Y, McKenna RW, Hoang MP, Collins RH, Kroft SH (2002) Composite angioimmunoblastic T\u2010cell lymphoma and diffuse large B\u2010cell lymphoma: a case report and review of the literature. Am J Clin Pathol 118: 848\u2013854","journal-title":"Am J Clin Pathol"},{"key":"BFEMMM202215816_CR77","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1200\/JCO.19.02404","volume":"38","author":"TA Yap","year":"2020","unstructured":"Yap TA, O\u2019Carrigan B, Penney MS, Lim JS, Brown JS, de Miguel Luken MJ, Tunariu N, Perez\u2010Lopez R, Rodrigues DN, Riisnaes R et\u2009al (2020) Phase I trial of first\u2010in\u2010class ATR inhibitor M6620 (VX\u2010970) as monotherapy or in combination with carboplatin in patients with advanced solid tumors. J Clin Oncol 38: 3195\u20133204","journal-title":"J Clin Oncol"},{"key":"BFEMMM202215816_CR78","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1158\/2159-8290.CD-20-0868","volume":"11","author":"TA Yap","year":"2021","unstructured":"Yap TA, Tan DSP, Terbuch A, Caldwell R, Guo C, Goh BC, Heong V, Haris NRM, Bashir S, Drew Y et\u2009al (2021) First\u2010in\u2010human trial of the oral ataxia telangiectasia and RAD3\u2010related (ATR) inhibitor BAY 1895344 in patients with advanced solid tumors. Cancer Discov 11: 80\u201391","journal-title":"Cancer Discov"},{"key":"BFEMMM202215816_CR79","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1158\/0008-5472.CAN-18-2480","volume":"79","author":"LA Young","year":"2019","unstructured":"Young LA, O'Connor LO, de Renty C, Veldman\u2010Jones MH, Dorval T, Wilson Z, Jones DR, Lawson D, Odedra R, Maya\u2010Mendoza A et\u2009al (2019) Differential activity of ATR and WEE1 inhibitors in a highly sensitive subpopulation of DLBCL linked to replication stress. Cancer Res 79: 3762\u20133775","journal-title":"Cancer Res"},{"key":"BFEMMM202215816_CR80","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/ni.1762","volume":"10","author":"Q Yu","year":"2009","unstructured":"Yu Q, Sharma A, Oh SY, Moon HG, Hossain MZ, Salay TM, Leeds KE, Du H, Wu B, Waterman ML et\u2009al (2009) T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA\u20103 and repressing interferon\u2010gamma. Nat Immunol 10: 992\u2013999","journal-title":"Nat Immunol"},{"key":"BFEMMM202215816_CR81","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1309\/6UTX-GVC0-12ND-JJEU","volume":"117","author":"A Zettl","year":"2002","unstructured":"Zettl A, Lee S\u2010S, R\u00fcdiger T, Starostik P, Marino M, Kirchner T, Ott M, M\u00fcller\u2010Hermelink HK, Ott G (2002) Epstein\u2010Barr virus\u2013associated B\u2010cell lymphoproliferative disorders in angioimmunoblastic T\u2010cell lymphoma and peripheral T\u2010cell lymphoma, unspecified. Am J Clin Pathol 117: 368\u2013379","journal-title":"Am J Clin Pathol"},{"key":"BFEMMM202215816_CR82","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)80240-8","volume":"89","author":"W Zheng","year":"1997","unstructured":"Zheng W, Flavell RA (1997) The transcription factor GATA\u20103 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89: 587\u2013596","journal-title":"Cell"}],"container-title":["EMBO Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202215816.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/emmm.202215816","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/emmm.202215816\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/emmm.202215816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202215816.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:45:08Z","timestamp":1779086708000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/emmm.202215816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":82,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,8]]}},"alternative-id":["BFEMMM202215816"],"URL":"https:\/\/doi.org\/10.15252\/emmm.202215816","relation":{},"ISSN":["1757-4676","1757-4684"],"issn-type":[{"value":"1757-4676","type":"print"},{"value":"1757-4684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,5]]},"assertion":[{"value":"2 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"EMMM202215816"}}