{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:48:53Z","timestamp":1784825333560,"version":"3.55.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021821","name":"Oncode Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021821","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014685","name":"Universiteit Twente","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014685","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2022,9,7]]},"DOI":"10.15252\/emmm.202216333","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T04:45:35Z","timestamp":1657773935000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis"],"prefix":"10.1038","volume":"14","author":[{"given":"Richell","family":"Booijink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Salgado\u2010Polo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Jamieson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-6227","authenticated-orcid":false,"given":"Anastassis","family":"Perrakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2470-5876","authenticated-orcid":false,"given":"Ruchi","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"BFEMMM202216333_CR1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.bbadis.2017.12.001","volume":"1864","author":"BO Akcora","year":"2018","unstructured":"Akcora BO, Storm G, Bansal R (2018) Inhibition of canonical WNT signaling pathway by beta\u2010catenin\/CBP inhibitor ICG\u2010001 ameliorates liver fibrosis in\u2009vivo through suppression of stromal CXCL12. Biochim Biophys Acta Mol Basis Dis 1864: 804\u2013818","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"BFEMMM202216333_CR2","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/hep4.1230","volume":"2","author":"W Ando","year":"2018","unstructured":"Ando W, Yokomori H, Kaneko F, Kaneko M, Igarashi K, Suzuki H (2018) Serum Autotaxin concentrations reflect changes in liver stiffness and fibrosis after antiviral therapy in patients with chronic hepatitis C. Hepatol Commun 2: 1111\u20131122","journal-title":"Hepatol Commun"},{"key":"BFEMMM202216333_CR3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41575-019-0145-7","volume":"16","author":"QM Anstee","year":"2019","unstructured":"Anstee QM, Reeves HL, Kotsiliti E, Govaere O, Heikenwalder M (2019) From NASH to HCC: Current concepts and future challenges. Nat Rev Gastroenterol Hepatol 16: 411\u2013428","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"BFEMMM202216333_CR4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","volume":"70","author":"SK Asrani","year":"2019","unstructured":"Asrani SK, Devarbhavi H, Eaton J, Kamath PS (2019) Burden of liver diseases in the world. J Hepatol 70: 151\u2013171","journal-title":"J Hepatol"},{"key":"BFEMMM202216333_CR5","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/bph.14118","volume":"175","author":"M Baader","year":"2018","unstructured":"Baader M, Bretschneider T, Broermann A, Rippmann JF, Stierstorfer B, Kuttruff CA, Mark M (2018) Characterization of the properties of a selective, orally bioavailable autotaxin inhibitor in preclinical models of advanced stages of liver fibrosis. Br J Pharmacol 175: 693\u2013707","journal-title":"Br J Pharmacol"},{"key":"BFEMMM202216333_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/jpet.116.237156","volume":"360","author":"G Bain","year":"2017","unstructured":"Bain G, Shannon KE, Huang F, Darlington J, Goulet L, Prodanovich P, Ma GL, Santini AM, Stein AJ, Lonergan D et\u2009al (2017) Selective inhibition of Autotaxin is efficacious in mouse models of liver fibrosis. J Pharmacol Exp Ther 360: 1\u201313","journal-title":"J Pharmacol Exp Ther"},{"key":"BFEMMM202216333_CR7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ejmech.2018.02.049","volume":"148","author":"A Balupuri","year":"2018","unstructured":"Balupuri A, Lee MH, Chae S, Jung E, Yoon W, Kim Y, Son SJ, Ryu J, Kang D\u2010H, Yang Y\u2010J et\u2009al (2018) Discovery and optimization of ATX inhibitors via modeling, synthesis and biological evaluation. Eur J Med Chem 148: 397\u2013409","journal-title":"Eur J Med Chem"},{"key":"BFEMMM202216333_CR8","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/hep.24395","volume":"54","author":"R Bansal","year":"2011","unstructured":"Bansal R, Prakash J, Post E, Beljaars L, Schuppan D, Poelstra K (2011) Novel engineered targeted interferon\u2010gamma blocks hepatic fibrogenesis in mice. Hepatology 54: 586\u2013596","journal-title":"Hepatology"},{"key":"BFEMMM202216333_CR9","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0140-6736(10)60274-7","volume":"376","author":"W Bernal","year":"2010","unstructured":"Bernal W, Auzinger G, Dhawan A, Wendon J (2010) Acute liver failure. Lancet 376: 190\u2013201","journal-title":"Lancet"},{"key":"BFEMMM202216333_CR10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101526","volume":"298","author":"R Borza","year":"2022","unstructured":"Borza R, Salgado\u2010Polo F, Moolenaar WH, Perrakis A (2022) Structure and function of the ecto\u2010nucleotide pyrophosphatase\/phosphodiesterase (ENPP) family: tidying up diversity. J Biol Chem 298: 101526","journal-title":"J Biol Chem"},{"key":"BFEMMM202216333_CR11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208099","volume":"14","author":"JA Brandon","year":"2019","unstructured":"Brandon JA, Kraemer M, Vandra J, Halder S, Ubele M, Morris AJ, Smyth SS (2019) Adipose\u2010derived autotaxin regulates inflammation and\u2009steatosis associated with diet\u2010induced obesity. PLoS One 14: e0208099","journal-title":"PLoS One"},{"key":"BFEMMM202216333_CR12","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","volume":"62","author":"CD Byrne","year":"2015","unstructured":"Byrne CD, Targher G (2015) NAFLD: A multisystem disease. J Hepatol 62: S47\u2013S64","journal-title":"J Hepatol"},{"key":"BFEMMM202216333_CR13","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1002\/art.39797","volume":"68","author":"FV Castelino","year":"2016","unstructured":"Castelino FV, Bain G, Pace VA, Black KE, George L, Probst CK, Goulet L, Lafyatis R, Tager AM (2016) An Autotaxin\/lysophosphatidic acid\/Interleukin\u20106 amplification loop drives scleroderma fibrosis. Arthritis Rheumatol 68: 2964\u20132974","journal-title":"Arthritis Rheumatol"},{"key":"BFEMMM202216333_CR14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev.pharmtox.010909.105753","volume":"50","author":"JW Choi","year":"2010","unstructured":"Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN et\u2009al (2010) LPA receptors: subtypes and biological actions. Annu Rev Pharmacol Toxicol 50: 157\u2013186","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"BFEMMM202216333_CR15","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1016\/j.biomaterials.2010.01.149","volume":"31","author":"KA Corin","year":"2010","unstructured":"Corin KA, Gibson LJ (2010) Cell contraction forces in scaffolds with varying pore size and cell density. Biomaterials 31: 4835\u20134845","journal-title":"Biomaterials"},{"key":"BFEMMM202216333_CR16","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1021\/acs.jmedchem.7b00032","volume":"60","author":"N Desroy","year":"2017","unstructured":"Desroy N, Housseman C, Bock X, Joncour A, Bienvenu N, Cherel L, Labeguere V, Rondet E, Peixoto C, Grassot JM et\u2009al (2017) Discovery of 2\u2010[[2\u2010Ethyl\u20106\u2010[4\u2010[2\u2010(3\u2010hydroxyazetidin\u20101\u2010yl)\u20102\u2010oxoethyl]piperazin\u20101\u2010yl]\u20108\u2010methyli midazo[1,2\u2010a]pyridin\u20103\u2010yl]methylamino]\u20104\u2010(4\u2010fluorophenyl)thiazole\u20105\u2010carbonitrile (GLPG1690), a first\u2010in\u2010class Autotaxin inhibitor undergoing clinical evaluation for the treatment of idiopathic pulmonary fibrosis. J Med Chem 60: 3580\u20133590","journal-title":"J Med Chem"},{"key":"BFEMMM202216333_CR17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124544","volume":"10","author":"I Frades","year":"2015","unstructured":"Frades I, Andreasson E, Mato JM, Alexandersson E, Matthiesen R, Martinez\u2010Chantar ML (2015) Integrative genomic signatures of hepatocellular carcinoma derived from nonalcoholic fatty liver disease. PLoS One 10: e0124544","journal-title":"PLoS One"},{"key":"BFEMMM202216333_CR18","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jhep.2016.04.005","volume":"65","author":"SM Francque","year":"2016","unstructured":"Francque SM, van der Graaff D, Kwanten WJ (2016) Non\u2010alcoholic fatty liver disease and cardiovascular risk: pathophysiological mechanisms and implications. J Hepatol 65: 425\u2013443","journal-title":"J Hepatol"},{"key":"BFEMMM202216333_CR19","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3748\/wjg.v24.i11.1239","volume":"24","author":"N Fujimori","year":"2018","unstructured":"Fujimori N, Umemura T, Kimura T, Tanaka N, Sugiura A, Yamazaki T, Joshita S, Komatsu M, Usami Y, Sano K et\u2009al (2018) Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non\u2010alcoholic fatty liver disease. World J Gastroenterol 24: 1239\u20131249","journal-title":"World J Gastroenterol"},{"key":"BFEMMM202216333_CR20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41392-020-00367-5","volume":"6","author":"LHM Geraldo","year":"2021","unstructured":"Geraldo LHM, Spohr TCLS, Amaral RF, Fonseca ACC, Garcia C, Mendes FA, Freitas C, dosSantos MF, Lima FRS (2021) Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies. Signal Transduct Target Ther 6: 45","journal-title":"Signal Transduct Target Ther"},{"key":"BFEMMM202216333_CR21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70967-2","volume":"10","author":"OL Gurvich","year":"2020","unstructured":"Gurvich OL, Puttonen KA, Bailey A, Kailaanm\u00e4ki A, Skirdenko V, Sivonen M, Pietik\u00e4inen S, Parker NR, Yl\u00e4\u2010Herttuala S, Kekarainen T (2020) Transcriptomics uncovers substantial variability associated with alterations in manufacturing processes of macrophage cell therapy products. Sci Rep 10: 14049","journal-title":"Sci Rep"},{"key":"BFEMMM202216333_CR22","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nsmb.1980","volume":"18","author":"J Hausmann","year":"2011","unstructured":"Hausmann J, Kamtekar S, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HM, van Meeteren LA, Houben AJ, van Zeijl L et\u2009al (2011) Structural basis of substrate discrimination and integrin binding by autotaxin. Nat Struct Mol Biol 18: 198\u2013204","journal-title":"Nat Struct Mol Biol"},{"key":"BFEMMM202216333_CR23","volume":"15","author":"L He","year":"2020","unstructured":"He L, Yuan H, Liang J, Hong J, Qu C (2020) Expression of hepatic stellate cell activation\u2010related genes in HBV\u2010, HCV\u2010, and nonalcoholic fatty liver disease\u2010associated fibrosis. PLoS One 15: e0233702","journal-title":"PLoS One"},{"key":"BFEMMM202216333_CR24","volume":"1866","author":"LTY Ho","year":"2020","unstructured":"Ho LTY, Osterwald A, Ruf I, Hunziker D, Mattei P, Challa P, Vann R, Ullmer C, Rao PV (2020) Role of the autotaxin\u2010lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity. Biochim Biophys Acta Mol Basis Dis 1866: 165560","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"BFEMMM202216333_CR25","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/hep.21752","volume":"46","author":"S Joshi\u2010Barve","year":"2007","unstructured":"Joshi\u2010Barve S, Barve SS, Amancherla K, Gobejishvili L, Hill D, Cave M, Hote P, McClain CJ (2007) Palmitic acid induces production of proinflammatory cytokine interleukin\u20108 from hepatocytes. Hepatology 46: 823\u2013830","journal-title":"Hepatology"},{"key":"BFEMMM202216333_CR26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/hepr.12997","volume":"48","author":"S Joshita","year":"2018","unstructured":"Joshita S, Ichikawa Y, Umemura T, Usami Y, Sugiura A, Shibata S, Yamazaki T, Fujimori N, Komatsu M, Matsumoto A et\u2009al (2018) Serum autotaxin is a useful liver fibrosis marker in patients with chronic hepatitis B virus infection. Hepatol Res 48: 275\u2013285","journal-title":"Hepatol Res"},{"key":"BFEMMM202216333_CR27","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/hep.28973","volume":"65","author":"E Kaffe","year":"2017","unstructured":"Kaffe E, Katsifa A, Xylourgidis N, Ninou I, Zannikou M, Harokopos V, Foka P, Dimitriadis A, Evangelou K, Moulas AN et\u2009al (2017) Hepatocyte autotaxin expression promotes liver fibrosis and cancer. Hepatology 65: 1369\u20131383","journal-title":"Hepatology"},{"key":"BFEMMM202216333_CR28","first-page":"81","volume":"157","author":"K Kano","year":"2014","unstructured":"Kano K, Aikawa S, Hashimoto T, Aoki J (2014) Lysophosphatidic acid as a lipid mediator with multiple biological actions. J Biochem 157: 81\u201389","journal-title":"J Biochem"},{"key":"BFEMMM202216333_CR29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41575-018-0082-x","volume":"16","author":"K Kazankov","year":"2019","unstructured":"Kazankov K, J\u00f8rgensen SMD, Thomsen KL, M\u00f8ller HJ, Vilstrup H, George J, Schuppan D, Gr\u00f8nb\u00e6k H (2019) The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Nat Rev Gastroenterol Hepatol 16: 145\u2013159","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"BFEMMM202216333_CR30","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1074\/jbc.M115.695940","volume":"291","author":"KM Kedziora","year":"2016","unstructured":"Kedziora KM, Leyton\u2010Puig D, Argenzio E, Boumeester AJ, van Butselaar B, Yin T, Wu YI, van Leeuwen FN, Innocenti M, Jalink K et\u2009al (2016) Rapid remodeling of Invadosomes by Gi\u2010coupled receptors: DISSECTING THE ROLE OF rho GTPases. J Biol Chem 291: 4323\u20134333","journal-title":"J Biol Chem"},{"key":"BFEMMM202216333_CR31","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1021\/acs.jmedchem.6b01743","volume":"60","author":"W\u2010J Keune","year":"2017","unstructured":"Keune W\u2010J, Potjewyd F, Heidebrecht T, Salgado\u2010Polo F, Macdonald SJF, Chelvarajan L, Abdel Latif A, Soman S, Morris AJ, Watson AJB et\u2009al (2017) Rational design of Autotaxin inhibitors by structural evolution of endogenous modulators. J Med Chem 60: 2006\u20132017","journal-title":"J Med Chem"},{"key":"BFEMMM202216333_CR32","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.cca.2014.03.006","volume":"433","author":"M Kondo","year":"2014","unstructured":"Kondo M, Ishizawa T, Enooku K, Tokuhara Y, Ohkawa R, Uranbileg B, Nakagawa H, Tateishi R, Yoshida H, Kokudo N et\u2009al (2014) Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma. Clin Chim Acta 433: 128\u2013134","journal-title":"Clin Chim Acta"},{"key":"BFEMMM202216333_CR33","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jhep.2017.10.015","volume":"68","author":"MA Konerman","year":"2018","unstructured":"Konerman MA, Jones JC, Harrison SA (2018) Pharmacotherapy for NASH: Current and emerging. J Hepatol 68: 362\u2013375","journal-title":"J Hepatol"},{"key":"BFEMMM202216333_CR34","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1016\/j.ymthe.2018.08.016","volume":"26","author":"Y Lao","year":"2018","unstructured":"Lao Y, Li Y, Zhang P, Shao Q, Lin W, Qiu B, Lv Y, Tang L, Su S, Zhang H et\u2009al (2018) Targeting endothelial Erk1\/2\u2010Akt Axis as a regeneration strategy to bypass fibrosis during chronic liver injury in mice. Mol Ther 26: 2779\u20132797","journal-title":"Mol Ther"},{"key":"BFEMMM202216333_CR35","volume":"10","author":"MV Machado","year":"2015","unstructured":"Machado MV, Michelotti GA, Xie G, Almeida Pereira T, Boursier J, Bohnic B, Guy CD, Diehl AM (2015) Mouse models of diet\u2010induced nonalcoholic steatohepatitis reproduce the heterogeneity of the human disease. PLoS One 10: e0127991","journal-title":"PLoS One"},{"key":"BFEMMM202216333_CR36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/liv.13682","volume":"38","author":"P Marcellin","year":"2018","unstructured":"Marcellin P, Kutala BK (2018) Liver diseases: a major, neglected global public health problem requiring urgent actions and large\u2010scale screening. Liver Int 38: 2\u20136","journal-title":"Liver Int"},{"key":"BFEMMM202216333_CR37","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2119\/molmed.2008.00110","volume":"15","author":"VR Mas","year":"2009","unstructured":"Mas VR, Maluf DG, Archer KJ, Yanek K, Kong X, Kulik L, Freise CE, Olthoff KM, Ghobrial RM, McIver P et\u2009al (2009) Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus\u2010induced hepatocellular carcinoma. Mol Med 15: 85\u201394","journal-title":"Mol Med"},{"key":"BFEMMM202216333_CR38","doi-asserted-by":"crossref","unstructured":"Matas\u2010Rico E, Frijlink E, van der Haar \u00c0vila I, Menegakis A, van Zon M, Morris AJ, Koster J, Salgado\u2010Polo F, de Kivit S, Lan\u00e7a T, Mazzocca A, Johnson Z, Haanen J, Schumacher TN, Perrakis A, Verbrugge I, van den Berg J, Borst J, Moolenaar WH (2021) Autotaxin impedes anti\u2010tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells. bioRxivhttps:\/\/doi.org\/10.1101\/2020.02.26.966291 [PREPRINT]","DOI":"10.1101\/2020.02.26.966291"},{"key":"BFEMMM202216333_CR39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.plipres.2007.02.001","volume":"46","author":"LA van Meeteren","year":"2007","unstructured":"van Meeteren LA, Moolenaar WH (2007) Regulation and biological activities of the autotaxin\u2010LPA axis. Prog Lipid Res 46: 145\u2013160","journal-title":"Prog Lipid Res"},{"key":"BFEMMM202216333_CR40","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nrm3188","volume":"12","author":"WH Moolenaar","year":"2011","unstructured":"Moolenaar WH, Perrakis A (2011) Insights into autotaxin: how to produce and present a lipid mediator. Nat Rev Mol Cell Biol 12: 674\u2013679","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMMM202216333_CR41","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1476-5381.2011.01622.x","volume":"165","author":"T Mutoh","year":"2012","unstructured":"Mutoh T, Rivera R, Chun J (2012) Insights into the pharmacological relevance of lysophospholipid receptors. Br J Pharmacol 165: 829\u2013844","journal-title":"Br J Pharmacol"},{"key":"BFEMMM202216333_CR42","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cca.2011.03.014","volume":"412","author":"H Nakagawa","year":"2011","unstructured":"Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y et\u2009al (2011) Autotaxin as a novel serum marker of liver fibrosis. Clin Chim Acta 412: 1201\u20131206","journal-title":"Clin Chim Acta"},{"key":"BFEMMM202216333_CR43","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jhep.2020.04.011","volume":"73","author":"YA Nevzorova","year":"2020","unstructured":"Nevzorova YA, Boyer\u2010Diaz Z, Cubero FJ, Gracia\u2010Sancho J (2020) Animal models for liver disease \u2010 a practical approach for translational research. J Hepatol 73: 423\u2013440","journal-title":"J Hepatol"},{"key":"BFEMMM202216333_CR44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nsmb.1998","volume":"18","author":"H Nishimasu","year":"2011","unstructured":"Nishimasu H, Okudaira S, Hama K, Mihara E, Dohmae N, Inoue A, Ishitani R, Takagi J, Aoki J, Nureki O (2011) Crystal structure of autotaxin and insight into GPCR activation by lipid mediators. Nat Struct Mol Biol 18: 205\u2013212","journal-title":"Nat Struct Mol Biol"},{"key":"BFEMMM202216333_CR45","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/hep.21614","volume":"45","author":"SM Rahman","year":"2007","unstructured":"Rahman SM, Schroeder\u2010Gloeckler JM, Janssen RC, Jiang H, Qadri I, Maclean KN, Friedman JE (2007) CCAAT\/enhancing binding protein \u03b2 deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet\u2010induced nonalcoholic steatohepatitis. Hepatology 45: 1108\u20131117","journal-title":"Hepatology"},{"key":"BFEMMM202216333_CR46","doi-asserted-by":"crossref","unstructured":"Salgado\u2010Polo F, Borza R, Marsais F, Jagerschmidt C, Waeckel L, Moolenaar WH, Ford P, Heckmann B, Perrakis A (2022) Autotaxin facilitates selective LPA receptor signaling. bioRxiv 10.1101\/2022.04.09.487723 [PREPRINT]","DOI":"10.1101\/2022.04.09.487723"},{"key":"BFEMMM202216333_CR47","doi-asserted-by":"crossref","first-page":"14312","DOI":"10.1074\/jbc.RA118.004450","volume":"293","author":"F Salgado\u2010Polo","year":"2018","unstructured":"Salgado\u2010Polo F, Fish A, Matsoukas MT, Heidebrecht T, Keune WJ, Perrakis A (2018) Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency. J Biol Chem 293: 14312\u201314327","journal-title":"J Biol Chem"},{"key":"BFEMMM202216333_CR48","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.3390\/cancers11101577","volume":"11","author":"F Salgado\u2010Polo","year":"2019","unstructured":"Salgado\u2010Polo F, Perrakis A (2019) The structural binding mode of the four Autotaxin inhibitor types that differentially affect catalytic and non\u2010catalytic functions. Cancer 11: 1577","journal-title":"Cancer"},{"key":"BFEMMM202216333_CR49","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/0023677215571192","volume":"49","author":"D Scholten","year":"2015","unstructured":"Scholten D, Trebicka J, Liedtke C, Weiskirchen R (2015) The carbon tetrachloride model in mice. Lab Anim 49: 4\u201311","journal-title":"Lab Anim"},{"key":"BFEMMM202216333_CR50","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/hep.27332","volume":"61","author":"E Seki","year":"2015","unstructured":"Seki E, Schwabe RF (2015) Hepatic inflammation and fibrosis: functional links and key pathways. Hepatology 61: 1066\u20131079","journal-title":"Hepatology"},{"key":"BFEMMM202216333_CR51","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1242\/dev.121723","volume":"142","author":"X Sheng","year":"2015","unstructured":"Sheng X, Yung YC, Chen A, Chun J (2015) Lysophosphatidic acid signalling in development. Development 142: 1390\u20131395","journal-title":"Development"},{"key":"BFEMMM202216333_CR52","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1038\/srep03470","volume":"3","author":"MK Son","year":"2013","unstructured":"Son MK, Ryu YL, Jung KH, Lee H, Lee HS, Yan HH, Park HJ, Ryu JK, Suh JK, Hong S et\u2009al (2013) HS\u2010173, a novel PI3K inhibitor, attenuates the activation of hepatic stellate cells in liver fibrosis. Sci Rep 3: 3470","journal-title":"Sci Rep"},{"key":"BFEMMM202216333_CR53","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/iub.220","volume":"61","author":"ST Teo","year":"2009","unstructured":"Teo ST, Yung YC, Herr DR, Chun J (2009) Lysophosphatidic acid in vascular development and disease. IUBMB Life 61: 791\u2013799","journal-title":"IUBMB Life"},{"key":"BFEMMM202216333_CR54","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S0163-7827(03)00035-3","volume":"42","author":"G Tigyi","year":"2003","unstructured":"Tigyi G, Parrill AL (2003) Molecular mechanisms of lysophosphatidic acid action. Prog Lipid Res 42: 498\u2013526","journal-title":"Prog Lipid Res"},{"key":"BFEMMM202216333_CR55","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4049\/jimmunol.1601515","volume":"198","author":"E Vergadi","year":"2017","unstructured":"Vergadi E, Ieronymaki E, Lyroni K, Vaporidi K, Tsatsanis C (2017) Akt signaling pathway in macrophage activation and M1\/M2 polarization. J Immunol 198: 1006\u20131014","journal-title":"J Immunol"},{"key":"BFEMMM202216333_CR56","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1007\/s00109-020-01997-6","volume":"98","author":"Z Wang","year":"2020","unstructured":"Wang Z, Shi W, Tian D, Qin H, Vallance BA, Yang H, Yu HB, Yu Q (2020) Autotaxin stimulates LPA2 receptor in macrophages and exacerbates dextran sulfate sodium\u2010induced acute colitis. J Mol Med (Berl) 98: 1781\u20131794","journal-title":"J Mol Med (Berl)"},{"key":"BFEMMM202216333_CR57","doi-asserted-by":"crossref","first-page":"46705","DOI":"10.1038\/srep46705","volume":"7","author":"T Yamazaki","year":"2017","unstructured":"Yamazaki T, Joshita S, Umemura T, Usami Y, Sugiura A, Fujimori N, Shibata S, Ichikawa Y, Komatsu M, Matsumoto A et\u2009al (2017) Association of Serum Autotaxin levels with liver fibrosis in patients with chronic hepatitis C. Sci Rep 7: 46705","journal-title":"Sci Rep"},{"key":"BFEMMM202216333_CR58","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1006\/bbrc.2000.3634","volume":"277","author":"M Yanase","year":"2000","unstructured":"Yanase M, Ikeda H, Matsui A, Maekawa H, Noiri E, Tomiya T, Arai M, Yano T, Shibata M, Ikebe M et\u2009al (2000) Lysophosphatidic acid enhances collagen gel contraction by hepatic stellate cells: association with rho\u2010kinase. Biochem Biophys Res Commun 277: 72\u201378","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMMM202216333_CR59","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrgastro.2017.109","volume":"15","author":"Z Younossi","year":"2018","unstructured":"Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J, Bugianesi E (2018) Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol 15: 11\u201320","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"BFEMMM202216333_CR60","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1194\/jlr.R046458","volume":"55","author":"YC Yung","year":"2014","unstructured":"Yung YC, Stoddard NC, Chun J (2014) LPA receptor signaling: pharmacology, physiology, and pathophysiology. J Lipid Res 55: 1192\u20131214","journal-title":"J Lipid Res"},{"key":"BFEMMM202216333_CR61","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.3748\/wjg.v22.i48.10512","volume":"22","author":"CY Zhang","year":"2016","unstructured":"Zhang CY, Yuan WG, He P, Lei JH, Wang CX (2016) Liver fibrosis and hepatic stellate cells: etiology, pathological hallmarks and therapeutic targets. World J Gastroenterol 22: 10512\u201310522","journal-title":"World J Gastroenterol"},{"key":"BFEMMM202216333_CR62","first-page":"97","volume":"12","author":"S Zulfikar","year":"2020","unstructured":"Zulfikar S, Mulholland S, Adamali H, Barratt SL (2020) Inhibitors of the Autotaxin\u2010lysophosphatidic acid Axis and their potential in the treatment of interstitial lung disease: Current perspectives. Clin Pharmacol 12: 97\u2013108","journal-title":"Clin Pharmacol"}],"container-title":["EMBO Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202216333.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/emmm.202216333","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/emmm.202216333\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/emmm.202216333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202216333.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:44:05Z","timestamp":1779086645000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/emmm.202216333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,14]]},"references-count":62,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,7]]}},"alternative-id":["BFEMMM202216333"],"URL":"https:\/\/doi.org\/10.15252\/emmm.202216333","relation":{},"ISSN":["1757-4676","1757-4684"],"issn-type":[{"value":"1757-4676","type":"print"},{"value":"1757-4684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,14]]},"assertion":[{"value":"18 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"EMMM202216333"}}