{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:12:29Z","timestamp":1790770349066,"version":"4.1.0"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007188","name":"DOD | Uniformed Services University of the Health Sciences","doi-asserted-by":"publisher","award":["MIC\u2010732515"],"award-info":[{"award-number":["MIC\u2010732515"]}],"id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007188","name":"DOD | Uniformed Services University of the Health Sciences","doi-asserted-by":"publisher","award":["HU00011920118"],"award-info":[{"award-number":["HU00011920118"]}],"id":[{"id":"10.13039\/100007188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["U01GM109887"],"award-info":[{"award-number":["U01GM109887"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI125552"],"award-info":[{"award-number":["R01AI125552"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI057168"],"award-info":[{"award-number":["AI057168"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2023,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infections with rabies virus (RABV) and related lyssaviruses are uniformly fatal once virus accesses the central nervous system (CNS) and causes disease signs. Current immunotherapies are thus focused on the early, pre\u2010symptomatic stage of disease, with the goal of peripheral neutralization of virus to prevent CNS infection. Here, we evaluated the therapeutic efficacy of F11, an anti\u2010lyssavirus human monoclonal antibody (mAb), on established lyssavirus infections. We show that a single dose of F11 limits viral load in the brain and reverses disease signs following infection with a lethal dose of lyssavirus, even when administered after initiation of robust virus replication in the CNS. Importantly, we found that F11\u2010dependent neutralization is not sufficient to protect animals from mortality, and a CD4 T cell\u2010dependent adaptive immune response is required for successful control of infection. F11 significantly changes the spectrum of leukocyte populations in the brain, and the FcR\u03b3\u2010binding function of F11 contributes to therapeutic efficacy. Thus, mAb therapy can drive potent neutralization\u2010independent T cell\u2010mediated effects, even against an established CNS infection by a lethal neurotropic virus.<\/jats:p>","DOI":"10.15252\/emmm.202216394","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T06:00:48Z","timestamp":1695880848000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["mAb therapy controls CNS\u2010resident lyssavirus infection via a CD4 T cell\u2010dependent mechanism"],"prefix":"10.1038","volume":"15","author":[{"given":"Kate E","family":"Mastraccio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Huaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si'Ana A","family":"Coggins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlyn","family":"Clouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1760-2070","authenticated-orcid":false,"given":"Madeline","family":"Rader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianying","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1477-1004","authenticated-orcid":false,"given":"Pratyusha","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3177-4706","authenticated-orcid":false,"given":"Imran","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar E","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trung","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Feasley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bang K","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5807-3737","authenticated-orcid":false,"given":"Ina L","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Markotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn L","family":"Weir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5574-2584","authenticated-orcid":false,"given":"Eric D","family":"Laing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5382-0510","authenticated-orcid":false,"given":"Christopher C","family":"Broder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8877-3507","authenticated-orcid":false,"given":"Brian C","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"BFEMMM202216394_CR1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/cei.13295","volume":"196","author":"B Afrough","year":"2019","unstructured":"Afrough B, Dowall S, Hewson R (2019) Emerging viruses and current strategies for vaccine intervention. Clin Exp Immunol 196: 157\u2013166","journal-title":"Clin Exp Immunol"},{"key":"BFEMMM202216394_CR2","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.4049\/jimmunol.179.7.4580","volume":"179","author":"S Akilesh","year":"2007","unstructured":"Akilesh S, Christianson GJ, Roopenian DC, Shaw AS (2007) Neonatal FcR expression in bone marrow\u2010derived cells functions to protect serum IgG from catabolism. J Immunol 179: 4580\u20134588","journal-title":"J Immunol"},{"key":"BFEMMM202216394_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-387040-7.00001-9","volume":"79","author":"AA Albertini","year":"2011","unstructured":"Albertini AA, Ruigrok RW, Blondel D (2011) Rabies virus transcription and replication. Adv Virus Res 79: 1\u201322","journal-title":"Adv Virus Res"},{"key":"BFEMMM202216394_CR4","doi-asserted-by":"crossref","first-page":"504","DOI":"10.33321\/cdi.1996.20.83","volume":"20","author":"A Allworth","year":"1996","unstructured":"Allworth A, Murray K, Morgan J (1996) A human case of encephalitis due to a lyssavirus recently identified in fruit bats. Commun Dis Intell 20: 504","journal-title":"Commun Dis Intell"},{"key":"BFEMMM202216394_CR5","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1128\/JVI.02698-07","volume":"82","author":"NP Andrews","year":"2008","unstructured":"Andrews NP, Pack CD, Lukacher AE (2008) Generation of antiviral major histocompatibility complex class I\u2010restricted T cells in the absence of CD8 coreceptors. J Virol 82: 4697\u20134705","journal-title":"J Virol"},{"key":"BFEMMM202216394_CR6","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/898165","volume":"2013","author":"Y Arima","year":"2013","unstructured":"Arima Y, Kamimura D, Sabharwal L, Yamada M, Bando H, Ogura H, Atsumi T, Murakami M (2013) Regulation of immune cell infiltration into the CNS by regional neural inputs explained by the gate theory. Mediators Inflamm 2013: 898165","journal-title":"Mediators Inflamm"},{"key":"BFEMMM202216394_CR7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature12744","volume":"503","author":"DH Barouch","year":"2013","unstructured":"Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, Stephenson KE, Chang HW, Shekhar K, Gupta S et\u00a0al (2013) Therapeutic efficacy of potent neutralizing HIV\u20101\u2010specific monoclonal antibodies in SHIV\u2010infected rhesus monkeys. Nature 503: 224\u2013228","journal-title":"Nature"},{"key":"BFEMMM202216394_CR8","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1001\/jamaneurol.2017.1460","volume":"74","author":"BJ Billioux","year":"2017","unstructured":"Billioux BJ, Nath A, Stavale EJ, Dorbor J, Fallah MP, Sneller MC, Smith BR, Partnership for Research on Ebola Virus in Liberia IIISG (2017) Cerebrospinal fluid examination in survivors of Ebola virus disease. JAMA Neurol 74: 1141\u20131143","journal-title":"JAMA Neurol"},{"key":"BFEMMM202216394_CR9","doi-asserted-by":"crossref","first-page":"4513","DOI":"10.4049\/jimmunol.1601444","volume":"198","author":"EK Bongiorno","year":"2017","unstructured":"Bongiorno EK, Garcia SA, Sauma S, Hooper DC (2017) Type 1 immune mechanisms driven by the response to infection with attenuated rabies virus result in changes in the immune bias of the tumor microenvironment and necrosis of mouse GL261 brain tumors. J Immunol 198: 4513\u20134523","journal-title":"J Immunol"},{"key":"BFEMMM202216394_CR10","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S1473-3099(11)70340-1","volume":"12","author":"L Both","year":"2012","unstructured":"Both L, Banyard AC, van Dolleweerd C, Horton DL, Ma JK, Fooks AR (2012) Passive immunity in the prevention of rabies. Lancet Infect Dis 12: 397\u2013407","journal-title":"Lancet Infect Dis"},{"key":"BFEMMM202216394_CR11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.coviro.2017.02.006","volume":"23","author":"K Caviness","year":"2017","unstructured":"Caviness K, Kuhn JH, Palacios G (2017) Ebola virus persistence as a new focus in clinical research. Curr Opin Virol 23: 43\u201348","journal-title":"Curr Opin Virol"},{"key":"BFEMMM202216394_CR12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s004010050674","volume":"94","author":"KM Charlton","year":"1997","unstructured":"Charlton KM, Nadin\u2010Davis S, Casey GA, Wandeler AI (1997) The long incubation period in rabies: delayed progression of infection in muscle at the site of exposure. Acta Neuropathol 94: 73\u201377","journal-title":"Acta Neuropathol"},{"key":"BFEMMM202216394_CR13","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1017\/S0950268816000054","volume":"144","author":"AA Chughtai","year":"2016","unstructured":"Chughtai AA, Barnes M, Macintyre CR (2016) Persistence of Ebola virus\u00a0in\u00a0various body fluids during convalescence: evidence and implications for disease transmission and control. Epidemiol Infect 144: 1652\u20131660","journal-title":"Epidemiol Infect"},{"key":"BFEMMM202216394_CR14","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/eji.1830260133","volume":"26","author":"AH Dalloul","year":"1996","unstructured":"Dalloul AH, Ngo K, Fung\u2010Leung WP (1996) CD4\u2010negative cytotoxic T cells with a T cell receptor alpha\/beta intermediate expression in CD8\u2010deficient mice. Eur J Immunol 26: 213\u2013218","journal-title":"Eur J Immunol"},{"key":"BFEMMM202216394_CR15","volume-title":"Virus taxonomy: classification and nomenclature of viruses","author":"AJ Davison","year":"2017","unstructured":"Davison AJ, Siddell S, Simmonds P (2017\u20132020) Online report of the International Committee on Taxonomy of Viruses. In Virus taxonomy: classification and nomenclature of viruses, Lefkowitz EJ (ed). Amsterdam: Elsevier"},{"key":"BFEMMM202216394_CR16","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftz023","volume":"77","author":"BE Dawes","year":"2019","unstructured":"Dawes BE, Freiberg AN (2019) Henipavirus infection of the central nervous system. Pathog Dis 77: ftz023","journal-title":"Pathog Dis"},{"key":"BFEMMM202216394_CR17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.15252\/emmm.201505986","volume":"8","author":"P De Benedictis","year":"2016","unstructured":"De Benedictis P, Minola A, Rota Nodari E, Aiello R, Zecchin B, Salomoni A, Foglierini M, Agatic G, Vanzetta F, Lavenir R et\u00a0al (2016) Development of broad\u2010spectrum human monoclonal antibodies for rabies post\u2010exposure prophylaxis. EMBO Mol Med 8: 407\u2013421","journal-title":"EMBO Mol Med"},{"key":"BFEMMM202216394_CR18","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1128\/jvi.64.6.3087-3090.1990","volume":"64","author":"B Dietzschold","year":"1990","unstructured":"Dietzschold B, Gore M, Casali P, Ueki Y, Rupprecht CE, Notkins AL, Koprowski H (1990) Biological characterization of human monoclonal antibodies to rabies virus. J Virol 64: 3087\u20133090","journal-title":"J Virol"},{"key":"BFEMMM202216394_CR19","doi-asserted-by":"crossref","first-page":"7252","DOI":"10.1073\/pnas.89.15.7252","volume":"89","author":"B Dietzschold","year":"1992","unstructured":"Dietzschold B, Kao M, Zheng YM, Chen ZY, Maul G, Fu ZF, Rupprecht CE, Koprowski H (1992) Delineation of putative mechanisms involved in antibody\u2010mediated clearance of rabies virus from the central nervous system. Proc Natl Acad Sci U S A 89: 7252\u20137256","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFEMMM202216394_CR20","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2217\/17460794.3.5.481","volume":"3","author":"B Dietzschold","year":"2008","unstructured":"Dietzschold B, Li J, Faber M, Schnell M (2008) Concepts in the pathogenesis of rabies. Future Virol 3: 481\u2013490","journal-title":"Future Virol"},{"key":"BFEMMM202216394_CR21","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1158\/2326-6066.CIR-15-0120","volume":"3","author":"DJ DiLillo","year":"2015","unstructured":"DiLillo DJ, Ravetch JV (2015) Fc\u2010receptor interactions regulate both cytotoxic and immunomodulatory therapeutic antibody effector functions. Cancer Immunol Res 3: 704\u2013713","journal-title":"Cancer Immunol Res"},{"key":"BFEMMM202216394_CR22","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1084\/jem.20190736","volume":"216","author":"JT Earnest","year":"2019","unstructured":"Earnest JT, Basore K, Roy V, Bailey AL, Wang D, Alter G, Fremont DH, Diamond MS (2019) Neutralizing antibodies against Mayaro virus require Fc effector functions for protective activity. J Exp Med 216: 2282\u20132301","journal-title":"J Exp Med"},{"key":"BFEMMM202216394_CR23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/400_020","volume":"43","author":"B Engelhardt","year":"2006","unstructured":"Engelhardt B (2006) Regulation of immune cell entry into the central nervous system. Results Probl Cell Differ 43: 259\u2013280","journal-title":"Results Probl Cell Differ"},{"key":"BFEMMM202216394_CR24","doi-asserted-by":"crossref","first-page":"15511","DOI":"10.1073\/pnas.0807656105","volume":"105","author":"MJ Fabis","year":"2008","unstructured":"Fabis MJ, Phares TW, Kean RB, Koprowski H, Hooper DC (2008) Blood\u2010brain barrier changes and cell invasion differ between therapeutic immune clearance of neurotrophic virus and CNS autoimmunity. Proc Natl Acad Sci U S A 105: 15511\u201315516","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFEMMM202216394_CR25","doi-asserted-by":"crossref","DOI":"10.3390\/v15010088","volume":"15","author":"L Feige","year":"2022","unstructured":"Feige L, Kozaki T, Dias de Melo G, Guillemot V, Larrous F, Ginhoux F, Bourhy H (2022) Susceptibilities of CNS cells towards rabies virus infection is linked to cellular innate immune responses. Viruses 15: 88","journal-title":"Viruses"},{"key":"BFEMMM202216394_CR26","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1128\/jvi.71.10.7281-7288.1997","volume":"71","author":"S Finke","year":"1997","unstructured":"Finke S, Conzelmann KK (1997) Ambisense gene expression from recombinant rabies virus: random packaging of positive\u2010 and negative\u2010strand ribonucleoprotein complexes into rabies virions. J Virol 71: 7281\u20137288","journal-title":"J Virol"},{"key":"BFEMMM202216394_CR27","volume":"4","author":"JM Fox","year":"2019","unstructured":"Fox JM, Roy V, Gunn BM, Huang L, Edeling MA, Mack M, Fremont DH, Doranz BJ, Johnson S, Alter G et\u00a0al (2019) Optimal therapeutic activity of monoclonal antibodies against chikungunya virus requires Fc\u2010FcgammaR interaction on monocytes. Sci Immunol 4: eaav5062","journal-title":"Sci Immunol"},{"key":"BFEMMM202216394_CR28","doi-asserted-by":"crossref","first-page":"e1063","DOI":"10.1542\/peds.2013-1782","volume":"133","author":"JR Francis","year":"2014","unstructured":"Francis JR, Nourse C, Vaska VL, Calvert S, Northill JA, McCall B, Mattke AC (2014) Australian Bat Lyssavirus in a child: the first reported case. Pediatrics 133: e1063\u2013e1067","journal-title":"Pediatrics"},{"key":"BFEMMM202216394_CR29","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1016\/j.vaccine.2009.09.034","volume":"27","author":"R Franka","year":"2009","unstructured":"Franka R, Wu X, Jackson FR, Velasco\u2010Villa A, Palmer DP, Henderson H, Hayat W, Green DB, Blanton JD, Greenberg L et\u00a0al (2009) Rabies virus pathogenesis in relationship to intervention with inactivated and attenuated rabies vaccines. Vaccine 27: 7149\u20137155","journal-title":"Vaccine"},{"key":"BFEMMM202216394_CR30","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s13365-018-0655-z","volume":"24","author":"SA Garcia","year":"2018","unstructured":"Garcia SA, Lebrun A, Kean RB, Craig Hooper D (2018) Clearance of attenuated rabies virus from brain tissues is required for long\u2010term protection against CNS challenge with a pathogenic variant. J Neurovirol 24: 606\u2013615","journal-title":"J Neurovirol"},{"key":"BFEMMM202216394_CR31","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/eji.1830260327","volume":"26","author":"V Ghetie","year":"1996","unstructured":"Ghetie V, Hubbard JG, Kim JK, Tsen MF, Lee Y, Ward ES (1996) Abnormally short serum half\u2010lives of IgG in beta 2\u2010microglobulin\u2010deficient mice. Eur J Immunol 26: 690\u2013696","journal-title":"Eur J Immunol"},{"key":"BFEMMM202216394_CR32","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/00005072-198611000-00002","volume":"45","author":"JP Gillet","year":"1986","unstructured":"Gillet JP, Derer P, Tsiang H (1986) Axonal transport of rabies virus in the central nervous system of the rat. J Neuropathol Exp Neurol 45: 619\u2013634","journal-title":"J Neuropathol Exp Neurol"},{"key":"BFEMMM202216394_CR33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0168-1702(98)00025-2","volume":"54","author":"AR Gould","year":"1998","unstructured":"Gould AR, Hyatt AD, Lunt R, Kattenbelt JA, Hengstberger S, Blacksell SD (1998) Characterisation of a novel lyssavirus isolated from Pteropid bats in Australia. Virus Res 54: 165\u2013187","journal-title":"Virus Res"},{"key":"BFEMMM202216394_CR34","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3389\/fimmu.2015.00249","volume":"6","author":"M Greter","year":"2015","unstructured":"Greter M, Lelios I, Croxford AL (2015) Microglia versus myeloid cell nomenclature during brain inflammation. Front Immunol 6: 249","journal-title":"Front Immunol"},{"key":"BFEMMM202216394_CR35","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100537","volume":"2","author":"IH Guldner","year":"2021","unstructured":"Guldner IH, Golomb SM, Wang Q, Wang E, Zhang S (2021) Isolation of mouse brain\u2010infiltrating leukocytes for single cell profiling of epitopes and transcriptomes. STAR Protoc 2: 100537","journal-title":"STAR Protoc"},{"key":"BFEMMM202216394_CR36","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.2460\/javma.1999.215.10.1444","volume":"215","author":"CA Hanlon","year":"1999","unstructured":"Hanlon CA, Smith JS, Anderson GR (1999) Recommendations of a national working group on prevention and control of rabies in the United States. Article II: Laboratory diagnosis of rabies. The National Working Group on Rabies Prevention and Control. J Am Vet Med Assoc 215: 1444\u20131446","journal-title":"J Am Vet Med Assoc"},{"key":"BFEMMM202216394_CR37","doi-asserted-by":"crossref","first-page":"597","DOI":"10.5694\/j.1326-5377.2000.tb124126.x","volume":"172","author":"JN Hanna","year":"2000","unstructured":"Hanna JN, Carney IK, Smith GA, Tannenberg AE, Deverill JE, Botha JA, Serafin IL, Harrower BJ, Fitzpatrick PF, Searle JW (2000) Australian bat lyssavirus infection: a second human case, with a long incubation period. Med J Aust 172: 597\u2013599","journal-title":"Med J Aust"},{"key":"BFEMMM202216394_CR38","doi-asserted-by":"crossref","first-page":"3711","DOI":"10.1128\/JVI.72.5.3711-3719.1998","volume":"72","author":"DC Hooper","year":"1998","unstructured":"Hooper DC, Morimoto K, Bette M, Weihe E, Koprowski H, Dietzschold B (1998) Collaboration of antibody and inflammation in clearance of rabies virus from the central nervous system. J Virol 72: 3711\u20133719","journal-title":"J Virol"},{"key":"BFEMMM202216394_CR39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000535","volume":"3","author":"DC Hooper","year":"2009","unstructured":"Hooper DC, Phares TW, Fabis MJ, Roy A (2009) The production of antibody by invading B cells is required for the clearance of rabies virus from the central nervous system. PLoS Negl Trop Dis 3: e535","journal-title":"PLoS Negl Trop Dis"},{"key":"BFEMMM202216394_CR40","doi-asserted-by":"crossref","first-page":"11841","DOI":"10.1128\/JVI.01153-10","volume":"84","author":"DL Horton","year":"2010","unstructured":"Horton DL, McElhinney LM, Marston DA, Wood JL, Russell CA, Lewis N, Kuzmin IV, Fouchier RA, Osterhaus AD, Fooks AR et\u00a0al (2010) Quantifying antigenic relationships among the lyssaviruses. J Virol 84: 11841\u201311848","journal-title":"J Virol"},{"key":"BFEMMM202216394_CR41","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.3201\/eid2408.171367","volume":"24","author":"PJ Howlett","year":"2018","unstructured":"Howlett PJ, Walder AR, Lisk DR, Fitzgerald F, Sevalie S, Lado M, N'Jai A, Brown CS, Sahr F, Sesay F et\u00a0al (2018) Case series of severe neurologic sequelae of Ebola virus disease during epidemic, Sierra Leone. Emerg Infect Dis 24: 1412\u20131421","journal-title":"Emerg Infect Dis"},{"key":"BFEMMM202216394_CR42","doi-asserted-by":"crossref","first-page":"e231","DOI":"10.1016\/S1473-3099(20)30282-6","volume":"20","author":"PL Iversen","year":"2020","unstructured":"Iversen PL, Kane CD, Zeng X, Panchal RG, Warren TK, Radoshitzky SR, Kuhn JH, Mudhasani RR, Cooper CL, Shurtleff AC et\u00a0al (2020) Recent successes in therapeutics for Ebola virus disease: no time for complacency. Lancet Infect Dis 20: e231\u2013e237","journal-title":"Lancet Infect Dis"},{"key":"BFEMMM202216394_CR43","volume":"13","author":"KS Jensen","year":"2018","unstructured":"Jensen KS, Adams R, Bennett RS, Bernbaum J, Jahrling PB, Holbrook MR (2018) Development of a novel real\u2010time polymerase chain reaction assay for the quantitative detection of Nipah virus replicative viral RNA. PloS One 13: e0199534","journal-title":"PloS One"},{"key":"BFEMMM202216394_CR44","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1073\/pnas.93.11.5512","volume":"93","author":"RP Junghans","year":"1996","unstructured":"Junghans RP, Anderson CL (1996) The protection receptor for IgG catabolism is the beta2\u2010microglobulin\u2010containing neonatal intestinal transport receptor. Proc Natl Acad Sci U S A 93: 5512\u20135516","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFEMMM202216394_CR45","doi-asserted-by":"crossref","DOI":"10.3390\/v13061037","volume":"13","author":"SP Keeler","year":"2021","unstructured":"Keeler SP, Fox JM (2021) Requirement of Fc\u2010Fc gamma receptor interaction for antibody\u2010based protection against emerging virus infections. Viruses 13: 1037","journal-title":"Viruses"},{"key":"BFEMMM202216394_CR46","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.med.58.061705.145053","volume":"58","author":"J de Kruif","year":"2007","unstructured":"de Kruif J, Bakker AB, Marissen WE, Kramer RA, Throsby M, Rupprecht CE, Goudsmit J (2007) A human monoclonal antibody cocktail as a novel component of rabies postexposure prophylaxis. Annu Rev Med 58: 359\u2013368","journal-title":"Annu Rev Med"},{"key":"BFEMMM202216394_CR47","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/B978-0-12-387040-7.00003-2","volume":"79","author":"M Lafon","year":"2011","unstructured":"Lafon M (2011) Evasive strategies in rabies virus infection. Adv Virus Res 79: 33\u201353","journal-title":"Adv Virus Res"},{"key":"BFEMMM202216394_CR48","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.4049\/jimmunol.1501274","volume":"195","author":"A Lebrun","year":"2015","unstructured":"Lebrun A, Portocarrero C, Kean RB, Barkhouse DA, Faber M, Hooper DC (2015) T\u2010bet is required for the rapid clearance of attenuated rabies virus from central nervous system tissue. J Immunol 195: 4358\u20134368","journal-title":"J Immunol"},{"key":"BFEMMM202216394_CR49","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real\u2010time quantitative PCR and the 2(\u2010Delta Delta C(T)) Method. Methods 25: 402\u2013408","journal-title":"Methods"},{"key":"BFEMMM202216394_CR50","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1074\/jbc.M116.767749","volume":"292","author":"M Lo","year":"2017","unstructured":"Lo M, Kim HS, Tong RK, Bainbridge TW, Vernes JM, Zhang Y, Lin YL, Chung S, Dennis MS, Zuchero YJ et\u00a0al (2017) Effector\u2010attenuating substitutions that maintain antibody stability and reduce toxicity in mice. J Biol Chem 292: 3900\u20133908","journal-title":"J Biol Chem"},{"key":"BFEMMM202216394_CR51","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00401-015-1511-3","volume":"131","author":"M Ludlow","year":"2016","unstructured":"Ludlow M, Kortekaas J, Herden C, Hoffmann B, Tappe D, Trebst C, Griffin DE, Brindle HE, Solomon T, Brown AS et\u00a0al (2016) Neurotropic virus infections as the cause of immediate and delayed neuropathology. Acta Neuropathol 131: 159\u2013184","journal-title":"Acta Neuropathol"},{"key":"BFEMMM202216394_CR52","first-page":"1","volume":"57","author":"SE Manning","year":"2008","unstructured":"Manning SE, Rupprecht CE, Fishbein D, Hanlon CA, Lumlertdacha B, Guerra M, Meltzer MI, Dhankhar P, Vaidya SA, Jenkins SR et\u00a0al (2008) Human rabies prevention\u2013United States, 2008: recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep 57: 1\u201328","journal-title":"MMWR Recomm Rep"},{"key":"BFEMMM202216394_CR53","doi-asserted-by":"crossref","first-page":"385","DOI":"10.20506\/rst.37.2.2809","volume":"37","author":"W Markotter","year":"2018","unstructured":"Markotter W, Coertse J (2018) Bat lyssaviruses. Rev Sci Tech 37: 385\u2013400","journal-title":"Rev Sci Tech"},{"key":"BFEMMM202216394_CR54","doi-asserted-by":"crossref","DOI":"10.1016\/j.jviromet.2020.113882","volume":"281","author":"KE Mastraccio","year":"2020","unstructured":"Mastraccio KE, Huaman C, Warrilow D, Smith GA, Craig SB, Weir DL, Laing ED, Smith IL, Broder CC, Schaefer BC (2020) Establishment of a longitudinal pre\u2010clinical model of lyssavirus infection. J Virol Methods 281: 113882","journal-title":"J Virol Methods"},{"key":"BFEMMM202216394_CR55","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.coviro.2017.01.003","volume":"23","author":"MK McCarthy","year":"2017","unstructured":"McCarthy MK, Morrison TE (2017) Persistent RNA virus infections: do PAMPS drive chronic disease? Curr Opin Virol 23: 8\u201315","journal-title":"Curr Opin Virol"},{"key":"BFEMMM202216394_CR56","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202012628","volume":"12","author":"GD de Melo","year":"2020","unstructured":"de Melo GD, Sonthonnax F, Lepousez G, Jouvion G, Minola A, Zatta F, Larrous F, Kergoat L, Mazo C, Moigneu C et\u00a0al (2020) A combination of two human monoclonal antibodies cures symptomatic rabies. EMBO Mol Med 12: e12628","journal-title":"EMBO Mol Med"},{"key":"BFEMMM202216394_CR57","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0065-2776(07)96005-8","volume":"96","author":"F Nimmerjahn","year":"2007","unstructured":"Nimmerjahn F, Ravetch JV (2007) Fc\u2010receptors as regulators of immunity. Adv Immunol 96: 179\u2013204","journal-title":"Adv Immunol"},{"key":"BFEMMM202216394_CR58","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/13550280591002450","volume":"11","author":"KJ Olival","year":"2005","unstructured":"Olival KJ, Daszak P (2005) The ecology of emerging neurotropic viruses. J Neurovirol 11: 441\u2013446","journal-title":"J Neurovirol"},{"key":"BFEMMM202216394_CR59","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.4049\/jimmunol.1200356","volume":"189","author":"MB Overdijk","year":"2012","unstructured":"Overdijk MB, Verploegen S, Ortiz Buijsse A, Vink T, Leusen JH, Bleeker WK, Parren PW (2012) Crosstalk between human IgG isotypes and murine effector cells. J Immunol 189: 3430\u20133438","journal-title":"J Immunol"},{"key":"BFEMMM202216394_CR60","doi-asserted-by":"crossref","first-page":"7334","DOI":"10.4049\/jimmunol.178.11.7334","volume":"178","author":"TW Phares","year":"2007","unstructured":"Phares TW, Fabis MJ, Brimer CM, Kean RB, Hooper DC (2007) A peroxynitrite\u2010dependent pathway is responsible for blood\u2010brain barrier permeability changes during a central nervous system inflammatory response: TNF\u2010alpha is neither necessary nor sufficient. J Immunol 178: 7334\u20137343","journal-title":"J Immunol"},{"key":"BFEMMM202216394_CR61","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1473-3099(19)30634-6","volume":"20","author":"EG Playford","year":"2020","unstructured":"Playford EG, Munro T, Mahler SM, Elliott S, Gerometta M, Hoger KL, Jones ML, Griffin P, Lynch KD, Carroll H et\u00a0al (2020) Safety, tolerability, pharmacokinetics, and immunogenicity of a human monoclonal antibody targeting the G glycoprotein of henipaviruses in healthy adults: a first\u2010in\u2010human, randomised, controlled, phase 1 study. Lancet Infect Dis 20: 445\u2013454","journal-title":"Lancet Infect Dis"},{"key":"BFEMMM202216394_CR62","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1086\/375247","volume":"188","author":"M Prosniak","year":"2003","unstructured":"Prosniak M, Faber M, Hanlon CA, Rupprecht CE, Hooper DC, Dietzschold B (2003) Development of a cocktail of recombinant\u2010expressed human rabies virus\u2010neutralizing monoclonal antibodies for postexposure prophylaxis of rabies. J Infect Dis 188: 53\u201356","journal-title":"J Infect Dis"},{"key":"BFEMMM202216394_CR63","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nri2155","volume":"7","author":"DC Roopenian","year":"2007","unstructured":"Roopenian DC, Akilesh S (2007) FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol 7: 715\u2013725","journal-title":"Nat Rev Immunol"},{"key":"BFEMMM202216394_CR64","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1586\/14760584.2016.1140040","volume":"15","author":"CE Rupprecht","year":"2016","unstructured":"Rupprecht CE, Nagarajan T, Ertl H (2016) Current status and development of vaccines and other biologics for human rabies prevention. Expert Rev Vaccines 15: 731\u2013749","journal-title":"Expert Rev Vaccines"},{"key":"BFEMMM202216394_CR65","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1093\/cid\/civ606","volume":"61","author":"E Sagui","year":"2015","unstructured":"Sagui E, Janvier F, Baize S, Foissaud V, Koulibaly F, Savini H, Maugey N, Aletti M, Granier H, Carmoi T (2015) Severe Ebola virus infection with encephalopathy: evidence for direct virus involvement. Clin Infect Dis 61: 1627\u20131628","journal-title":"Clin Infect Dis"},{"key":"BFEMMM202216394_CR66","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1080\/07853890802698842","volume":"41","author":"H Samaranayake","year":"2009","unstructured":"Samaranayake H, Wirth T, Schenkwein D, Raty JK, Yla\u2010Herttuala S (2009) Challenges in monoclonal antibody\u2010based therapies. Ann Med 41: 322\u2013331","journal-title":"Ann Med"},{"key":"BFEMMM202216394_CR67","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","volume":"75","author":"K Schroder","year":"2004","unstructured":"Schroder K, Hertzog PJ, Ravasi T, Hume DA (2004) Interferon\u2010gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75: 163\u2013189","journal-title":"J Leukoc Biol"},{"key":"BFEMMM202216394_CR68","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1172\/JCI114260","volume":"84","author":"CL Schumacher","year":"1989","unstructured":"Schumacher CL, Dietzschold B, Ertl HC, Niu HS, Rupprecht CE, Koprowski H (1989) Use of mouse anti\u2010rabies monoclonal antibodies in postexposure treatment of rabies. J Clin Invest 84: 971\u2013975","journal-title":"J Clin Invest"},{"key":"BFEMMM202216394_CR69","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature12746","volume":"503","author":"M Shingai","year":"2013","unstructured":"Shingai M, Nishimura Y, Klein F, Mouquet H, Donau OK, Plishka R, Buckler\u2010White A, Seaman M, Piatak M Jr, Lifson JD et\u00a0al (2013) Antibody\u2010mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature 503: 277\u2013280","journal-title":"Nature"},{"key":"BFEMMM202216394_CR70","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1099\/jgv.0.001269","volume":"100","author":"SP Smith","year":"2019","unstructured":"Smith SP, Wu G, Fooks AR, Ma J, Banyard AC (2019) Trying to treat the untreatable: experimental approaches to clear rabies virus infection from the CNS. J Gen Virol 100: 1171\u20131186","journal-title":"J Gen Virol"},{"key":"BFEMMM202216394_CR71","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1126\/science.8016643","volume":"265","author":"V Steimle","year":"1994","unstructured":"Steimle V, Siegrist CA, Mottet A, Lisowska\u2010Grospierre B, Mach B (1994) Regulation of MHC class II expression by interferon\u2010gamma mediated by the transactivator gene CIITA. Science 265: 106\u2013109","journal-title":"Science"},{"key":"BFEMMM202216394_CR72","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s40265-013-0007-5","volume":"73","author":"M Studahl","year":"2013","unstructured":"Studahl M, Lindquist L, Eriksson BM, Gunther G, Bengner M, Franzen\u2010Rohl E, Fohlman J, Bergstrom T, Aurelius E (2013) Acute viral infections of the central nervous system in immunocompetent adults: diagnosis and management. Drugs 73: 131\u2013158","journal-title":"Drugs"},{"key":"BFEMMM202216394_CR73","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/ana.10212","volume":"51","author":"CT Tan","year":"2002","unstructured":"Tan CT, Goh KJ, Wong KT, Sarji SA, Chua KB, Chew NK, Murugasu P, Loh YL, Chong HT, Tan KS et\u00a0al (2002) Relapsed and late\u2010onset Nipah encephalitis. Ann Neurol 51: 703\u2013708","journal-title":"Ann Neurol"},{"key":"BFEMMM202216394_CR74","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1016\/j.immuni.2021.08.015","volume":"54","author":"I Ullah","year":"2021","unstructured":"Ullah I, Prevost J, Ladinsky MS, Stone H, Lu M, Anand SP, Beaudoin\u2010Bussieres G, Symmes K, Benlarbi M, Ding S et\u00a0al (2021) Live imaging of SARS\u2010CoV\u20102 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy. Immunity 54: 2143\u20132158","journal-title":"Immunity"},{"key":"BFEMMM202216394_CR75","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/s41590-020-0711-8","volume":"21","author":"SL Urban","year":"2020","unstructured":"Urban SL, Jensen IJ, Shan Q, Pewe LL, Xue HH, Badovinac VP, Harty JT (2020) Peripherally induced brain tissue\u2010resident memory CD8(+) T\u00a0cells\u00a0mediate protection against CNS infection. Nat Immunol 21: 938\u2013949","journal-title":"Nat Immunol"},{"key":"BFEMMM202216394_CR76","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-013-0179-5","author":"ML Velandia\u2010Romero","year":"2013","unstructured":"Velandia\u2010Romero ML, Castellanos JE, Martinez\u2010Gutierrez M (2013) In vivo differential susceptibility of sensory neurons to rabies virus infection. J Neurovirol https:\/\/doi.org\/10.1007\/s13365\u2010013\u20100179\u20105","journal-title":"J Neurovirol"},{"key":"BFEMMM202216394_CR77","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nri.2017.148","volume":"18","author":"LM Walker","year":"2018","unstructured":"Walker LM, Burton DR (2018) Passive immunotherapy of viral infections: \u2018super\u2010antibodies\u2019 enter the fray. Nat Rev Immunol 18: 297\u2013308","journal-title":"Nat Rev Immunol"},{"key":"BFEMMM202216394_CR78","volume":"14","author":"KW Walker","year":"2019","unstructured":"Walker KW, Salimi\u2010Moosavi H, Arnold GE, Chen Q, Soto M, Jacobsen FW, Hui J (2019) Pharmacokinetic comparison of a diverse panel of non\u2010targeting human antibodies as matched IgG1 and IgG2 isotypes in rodents and non\u2010human primates. PloS One 14: e0217061","journal-title":"PloS One"},{"key":"BFEMMM202216394_CR79","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3390\/v13030391","volume":"13","author":"DL Weir","year":"2021","unstructured":"Weir DL, Coggins SA, Vu BK, Coertese J, Yan L, Smith IL, Laing ED, Markotter W, Broder CC, Schaefer BC (2021) Isolation and characterization of cross\u2010reactive human mono\u2010clonal antibodies that potently neutralize Australian bat lyssa\u2010virus variants and other phylogroup 1 lyssaviruses. Viruses 13: 391","journal-title":"Viruses"},{"key":"BFEMMM202216394_CR80","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1016\/j.vaccine.2018.06.061","volume":"36","author":"World Health Organization","year":"2018","unstructured":"World Health Organization (2018) Rabies vaccines: WHO position paper, April 2018 \u2013 Recommendations. Vaccine 36: 5500\u20135503","journal-title":"Vaccine"},{"key":"BFEMMM202216394_CR81","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1016\/j.vaccine.2011.03.104","volume":"29","author":"X Wu","year":"2011","unstructured":"Wu X, Franka R, Henderson H, Rupprecht CE (2011) Live attenuated rabies virus co\u2010infected with street rabies virus protects animals against rabies. Vaccine 29: 4195\u20134201","journal-title":"Vaccine"},{"key":"BFEMMM202216394_CR82","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1086\/528801","volume":"197","author":"Z Zhu","year":"2008","unstructured":"Zhu Z, Bossart KN, Bishop KA, Crameri G, Dimitrov AS, McEachern JA, Feng Y, Middleton D, Wang LF, Broder CC et\u00a0al (2008) Exceptionally potent cross-reactive neutralization of Nipah and Hendra viruses by a human monoclonal antibody. J Infect Dis 197: 846\u2013853","journal-title":"J Infect Dis"}],"container-title":["EMBO Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202216394.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/emmm.202216394\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/emmm.202216394","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/emmm.202216394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202216394.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:48:04Z","timestamp":1779086884000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/emmm.202216394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,28]]},"references-count":82,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10,11]]}},"alternative-id":["BFEMMM202216394"],"URL":"https:\/\/doi.org\/10.15252\/emmm.202216394","relation":{},"ISSN":["1757-4676","1757-4684"],"issn-type":[{"value":"1757-4676","type":"print"},{"value":"1757-4684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,28]]},"assertion":[{"value":"12 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"EMMM202216394"}}