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We have now investigated the role of \u03b2\u2010catenin\/CTNNB1 in the evolution of T\u2010cell Acute Lymphoblastic Leukemia (T\u2010ALL) patients and its involvement in therapy resistance. We have identified a specific gene signature that is directly regulated by \u03b2\u2010catenin, TCF\/LEF factors and ZBTB33\/Kaiso in T\u2010ALL cell lines, which is highly and significantly represented in five out of six refractory patients from a cohort of 40 children with T\u2010ALL. By subsequent refinement of this gene signature, we found that a subset of \u03b2\u2010catenin target genes involved with RNA\u2010processing function are sufficient to segregate T\u2010ALL refractory patients in three independent cohorts. We demonstrate the implication of \u03b2\u2010catenin in RNA and protein synthesis in T\u2010ALL and provide\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    and\n                    <jats:italic>in\u00a0vivo<\/jats:italic>\n                    experimental evidence that \u03b2\u2010catenin is crucial for the cellular response to chemotherapy, mainly in the cellular recovery phase after treatment. We propose that combination treatments involving chemotherapy plus \u03b2\u2010catenin inhibitors will enhance chemotherapy response and prevent disease relapse in T\u2010ALL patients.\n                  <\/jats:p>","DOI":"10.15252\/emmm.202216554","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T04:07:46Z","timestamp":1672805266000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["\u03b2\u2010Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T\u2010cell acute lymphoblastic leukemia"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-4360","authenticated-orcid":false,"given":"Violeta","family":"Garc\u00eda\u2010Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Arambilet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Guill\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Lobo\u2010Jarne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9304-1714","authenticated-orcid":false,"given":"Mar\u00eda","family":"Maqueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3429-4145","authenticated-orcid":false,"given":"Christos","family":"Gekas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7732-1564","authenticated-orcid":false,"given":"Jessica","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7195-7868","authenticated-orcid":false,"given":"Arnau","family":"Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Vega\u2010Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Sent\u00eds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan L","family":"Trincado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"M\u00e1rquez\u2010L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Heyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Cam\u00f3s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2897-4099","authenticated-orcid":false,"given":"Lluis","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4801-6899","authenticated-orcid":false,"given":"Anna","family":"Bigas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"BFEMMM202216554_CR1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders S, Pyl PT, Huber W (2015) HTSeq\u2014a python framework to work with high\u2010throughput sequencing data. 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