{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:25:21Z","timestamp":1792095921490,"version":"4.4.0"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82121001"],"award-info":[{"award-number":["82121001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["NMUB20210007"],"award-info":[{"award-number":["NMUB20210007"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201718"],"award-info":[{"award-number":["82201718"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170592"],"award-info":[{"award-number":["82170592"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200684"],"award-info":[{"award-number":["82200684"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20221032"],"award-info":[{"award-number":["BK20221032"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2023,3,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alcoholic liver disease (ALD) accounts for a large fraction of patients with cirrhosis and hepatocellular carcinoma. In the present study we investigated the involvement of Brahma\u2010related gene 1 (Brg1) in ALD pathogenesis and implication in ALD intervention. We report that Brg1 expression was elevated in mouse models of ALD, in hepatocyte exposed to alcohol, and in human ALD specimens. Manipulation of Brg1 expression in hepatocytes influenced the development of ALD in mice. Flow cytometry showed that Brg1 deficiency specifically attenuated hepatic infiltration of Ly6G\n                    <jats:sup>+<\/jats:sup>\n                    neutrophils in the ALD mice. RNA\u2010seq identified C\u2010X\u2010C motif chemokine ligand 14 (CXCL14) as a potential target for Brg1. CXCL14 knockdown alleviated whereas CXCL14 over\u2010expression enhanced ALD pathogenesis in mice. Importantly, pharmaceutical inhibition of Brg1 with a small\u2010molecule compound PFI\u20103 or administration of an antagonist to the CXCL14 receptor ameliorated ALD pathogenesis in mice. Finally, a positive correlation between Brg1 expression, CXCL14 expression, and neutrophil infiltration was detected in ALD patients. In conclusion, our data provide proof\u2010of\u2010concept for targeting the Brg1\u2010CXCL14 axis in ALD intervention.\n                  <\/jats:p>","DOI":"10.15252\/emmm.202216592","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T08:13:14Z","timestamp":1675239194000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Targetable Brg1\u2010CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking"],"prefix":"10.1038","volume":"15","author":[{"given":"Nan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulian","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6839-0883","authenticated-orcid":false,"given":"Zilong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7368-814X","authenticated-orcid":false,"given":"Zhiwen","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1470-9371","authenticated-orcid":false,"given":"Yong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"BFEMMM202216592_CR1","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1001\/jamaoncol.2017.3055","volume":"3","author":"T Akinyemiju","year":"2017","unstructured":"Akinyemiju T, Abera S, Ahmed M, Alam N, Alemayohu MA, Allen C, Al\u2010Raddadi R, Alvis\u2010Guzman N, Amoako Y, Artaman A et\u00a0al (2017) The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and National Level: results from the global burden of disease study 2015. JAMA Oncol 3: 1683\u20131691","journal-title":"JAMA Oncol"},{"key":"BFEMMM202216592_CR2","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41598-020-78854-6","volume":"11","author":"KA Babatunde","year":"2021","unstructured":"Babatunde KA, Wang X, Hopke A, Lannes N, Mantel PY, Irimia D (2021) Chemotaxis and swarming in differentiated HL\u201060 neutrophil\u2010like cells. Sci Rep 11: 778","journal-title":"Sci Rep"},{"key":"BFEMMM202216592_CR3","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","volume":"8","author":"A Bertola","year":"2013","unstructured":"Bertola A, Mathews S, Ki SH, Wang H, Gao B (2013a) Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat Protoc 8: 627\u2013637","journal-title":"Nat Protoc"},{"key":"BFEMMM202216592_CR4","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/hep.26419","volume":"58","author":"A Bertola","year":"2013","unstructured":"Bertola A, Park O, Gao B (2013b) Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E\u2010selectin. Hepatology 58: 1814\u20131823","journal-title":"Hepatology"},{"key":"BFEMMM202216592_CR5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/ni.3170","volume":"16","author":"C Bossen","year":"2015","unstructured":"Bossen C, Murre CS, Chang AN, Mansson R, Rodewald HR, Murre C (2015) The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth. Nat Immunol 16: 775\u2013784","journal-title":"Nat Immunol"},{"key":"BFEMMM202216592_CR6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064556","volume":"8","author":"I Brunskole Hummel","year":"2013","unstructured":"Brunskole Hummel I, Reinartz MT, Kalble S, Burhenne H, Schwede F, Buschauer A, Seifert R (2013) Dissociations in the effects of beta2\u2010adrenergic receptor agonists on cAMP formation and superoxide production in human neutrophils: support for the concept of functional selectivity. PLoS One 8: e64556","journal-title":"PLoS One"},{"key":"BFEMMM202216592_CR7","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jhep.2018.07.005","volume":"69","author":"TN Bukong","year":"2018","unstructured":"Bukong TN, Cho Y, Iracheta\u2010Vellve A, Saha B, Lowe P, Adejumo A, Furi I, Ambade A, Gyongyosi B, Catalano D et\u00a0al (2018) Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use. J Hepatol 69: 1145\u20131154","journal-title":"J Hepatol"},{"key":"BFEMMM202216592_CR8","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S1097-2765(00)00127-1","volume":"6","author":"S Bultman","year":"2000","unstructured":"Bultman S, Gebuhr T, Yee D, La Mantia C, Nicholson J, Gilliam A, Randazzo F, Metzger D, Chambon P, Crabtree G et\u00a0al (2000) A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI\/SNF complexes. Mol Cell 6: 1287\u20131295","journal-title":"Mol Cell"},{"key":"BFEMMM202216592_CR9","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1101\/gad.1364105","volume":"19","author":"SJ Bultman","year":"2005","unstructured":"Bultman SJ, Gebuhr TC, Magnuson T (2005) A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI\/SNF\u2010related complexes in beta\u2010globin expression and erythroid development. Genes Dev 19: 2849\u20132861","journal-title":"Genes Dev"},{"key":"BFEMMM202216592_CR10","first-page":"103","volume":"2","author":"R Celli","year":"2014","unstructured":"Celli R, Zhang X (2014) Pathology of alcoholic liver disease. J Clin Transl Hepatol 2: 103\u2013109","journal-title":"J Clin Transl Hepatol"},{"key":"BFEMMM202216592_CR11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/emboj.2012.350","volume":"32","author":"BH Chaiyachati","year":"2013","unstructured":"Chaiyachati BH, Jani A, Wan Y, Huang H, Flavell R, Chi T (2013) BRG1\u2010mediated immune tolerance: facilitation of Treg activation and partial independence of chromatin remodelling. EMBO J 32: 395\u2013408","journal-title":"EMBO J"},{"key":"BFEMMM202216592_CR12","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/aps.2009.109","volume":"30","author":"YH Chen","year":"2009","unstructured":"Chen YH, Yang CM, Chang SP, Hu ML (2009) C\/EBP beta and C\/EBP delta expression is elevated in the early phase of ethanol\u2010induced hepatosteatosis in mice. Acta Pharmacol Sin 30: 1138\u20131143","journal-title":"Acta Pharmacol Sin"},{"key":"BFEMMM202216592_CR13","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3389\/fcell.2020.00774","volume":"8","author":"B Chen","year":"2020","unstructured":"Chen B, Zhao Q, Xu T, Yu L, Zhuo L, Yang Y, Xu Y (2020) BRG1 activates PR65A transcription to regulate NO bioavailability in vascular endothelial cell. Front Cell Dev Biol 8: 774","journal-title":"Front Cell Dev Biol"},{"key":"BFEMMM202216592_CR14","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.3168\/jds.2013-7514","volume":"97","author":"YH Chiu","year":"2014","unstructured":"Chiu YH, Tsai JJ, Lin SL, Lin MY (2014) Lactobacillus casei MYL01 modulates the proinflammatory state induced by ethanol in an in\u00a0vitro model. J Dairy Sci 97: 2009\u20132016","journal-title":"J Dairy Sci"},{"key":"BFEMMM202216592_CR15","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/hep.31680","volume":"74","author":"Y Cho","year":"2021","unstructured":"Cho Y, Szabo G (2021) Two faces of neutrophils in liver disease development and progression. Hepatology 74: 503\u2013512","journal-title":"Hepatology"},{"key":"BFEMMM202216592_CR16","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/hep.22404","volume":"48","author":"S Clement","year":"2008","unstructured":"Clement S, Juge\u2010Aubry C, Sgroi A, Conzelmann S, Pazienza V, Pittet\u2010Cuenod B, Meier CA, Negro F (2008) Monocyte chemoattractant protein\u20101 secreted by adipose tissue induces direct lipid accumulation in hepatocytes. Hepatology 48: 799\u2013807","journal-title":"Hepatology"},{"key":"BFEMMM202216592_CR17","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1096\/fj.201700013R","volume":"31","author":"PJ Collins","year":"2017","unstructured":"Collins PJ, McCully ML, Martinez\u2010Munoz L, Santiago C, Wheeldon J, Caucheteux S, Thelen S, Cecchinato V, Laufer JM, Purvanov V et\u00a0al (2017) Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4. FASEB J 31: 3084\u20133097","journal-title":"FASEB J"},{"key":"BFEMMM202216592_CR18","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/sj.bjp.0705972","volume":"143","author":"C de Coupade","year":"2004","unstructured":"de Coupade C, Gear RW, Dazin PF, Sroussi HY, Green PG, Levine JD (2004) Beta 2\u2010adrenergic receptor regulation of human neutrophil function is sexually dimorphic. Br J Pharmacol 143: 1033\u20131041","journal-title":"Br J Pharmacol"},{"key":"BFEMMM202216592_CR19","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2021.100511","volume":"2","author":"S Daemen","year":"2021","unstructured":"Daemen S, Chan MM, Schilling JD (2021) Comprehensive analysis of liver macrophage composition by flow cytometry and immunofluorescence in murine NASH. STAR Protoc 2: 100511","journal-title":"STAR Protoc"},{"key":"BFEMMM202216592_CR20","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/hep.28897","volume":"65","author":"S Das","year":"2017","unstructured":"Das S, Maras JS, Hussain MS, Sharma S, David P, Sukriti S, Shasthry SM, Maiwall R, Trehanpati N, Singh TP et\u00a0al (2017) Hyperoxidized albumin modulates neutrophils to induce oxidative stress and inflammation in severe alcoholic hepatitis. Hepatology 65: 631\u2013646","journal-title":"Hepatology"},{"key":"BFEMMM202216592_CR21","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3389\/fcell.2020.00340","volume":"8","author":"W Dong","year":"2020","unstructured":"Dong W, Kong M, Zhu Y, Shao Y, Wu D, Lu J, Guo J, Xu Y (2020) Activation of TWIST transcription by chromatin remodeling protein BRG1 contributes to liver fibrosis in mice. Front Cell Dev Biol 8: 340","journal-title":"Front Cell Dev Biol"},{"key":"BFEMMM202216592_CR22","volume":"9","author":"W Dong","year":"2021","unstructured":"Dong W, Zhu Y, Zhang Y, Fan Z, Zhang Z, Fan X, Xu Y (2021) BRG1 links TLR4 trans\u2010activation to LPS\u2010induced SREBP1a expression and liver injury. Front Cell Dev Biol 9: 617073","journal-title":"Front Cell Dev Biol"},{"key":"BFEMMM202216592_CR23","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.688","volume":"12","author":"W Dong","year":"2022","unstructured":"Dong W, Kong M, Liu H, Xue Y, Li Z, Wang Y, Xu Y (2022) Myocardin\u2010related transcription factor a drives ROS\u2010fueled expansion of hepatic stellate cells by regulating p38\u2010MAPK signalling. Clin Transl Med 12: e688","journal-title":"Clin Transl Med"},{"key":"BFEMMM202216592_CR24","volume":"1862","author":"Z Fan","year":"2019","unstructured":"Fan Z, Li N, Xu Z, Wu J, Fan X, Xu Y (2019) An interaction between MKL1, BRG1, and C\/EBPbeta mediates palmitate induced CRP transcription in hepatocytes. Biochim Biophys Acta 1862: 194412","journal-title":"Biochim Biophys Acta"},{"key":"BFEMMM202216592_CR25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3389\/fcell.2020.00259","volume":"8","author":"Z Fan","year":"2020","unstructured":"Fan Z, Kong M, Li M, Hong W, Fan X, Xu Y (2020) Brahma related gene 1 (Brg1) regulates cellular cholesterol synthesis by acting as a Co\u2010factor for SREBP2. Front Cell Dev Biol 8: 259","journal-title":"Front Cell Dev Biol"},{"key":"BFEMMM202216592_CR26","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/CIRCRESAHA.113.301296","volume":"113","author":"F Fang","year":"2013","unstructured":"Fang F, Chen D, Yu L, Dai X, Yang Y, Tian W, Cheng X, Xu H, Weng X, Fang M et\u00a0al (2013) Proinflammatory stimuli engage brahma related gene 1 and brahma in endothelial injury. Circ Res 113: 986\u2013996","journal-title":"Circ Res"},{"key":"BFEMMM202216592_CR27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJMcp1204714","volume":"368","author":"PD Friedmann","year":"2013","unstructured":"Friedmann PD (2013) Clinical practice. Alcohol use in adults. N Engl J Med 368: 365\u2013373","journal-title":"N Engl J Med"},{"key":"BFEMMM202216592_CR28","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1152\/ajpgi.00537.2010","volume":"300","author":"B Gao","year":"2011","unstructured":"Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S (2011) Innate immunity in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 300: G516\u2013G525","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"BFEMMM202216592_CR29","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1053\/j.gastro.2017.01.003","volume":"152","author":"D Goldberg","year":"2017","unstructured":"Goldberg D, Ditah IC, Saeian K, Lalehzari M, Aronsohn A, Gorospe EC, Charlton M (2017) Changes in the prevalence of hepatitis C virus infection, nonalcoholic steatohepatitis, and alcoholic liver disease among patients with cirrhosis or liver failure on the waitlist for liver transplantation. Gastroenterology 152: 1090\u20131099.e1","journal-title":"Gastroenterology"},{"key":"BFEMMM202216592_CR30","doi-asserted-by":"crossref","first-page":"536","DOI":"10.15252\/embj.201591857","volume":"35","author":"B Gonzalez\u2010Teran","year":"2016","unstructured":"Gonzalez\u2010Teran B, Matesanz N, Nikolic I, Verdugo MA, Sreeramkumar V, Hernandez\u2010Cosido L, Mora A, Crainiciuc G, Saiz ML, Bernardo E et\u00a0al (2016) p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration. EMBO J 35: 536\u2013552","journal-title":"EMBO J"},{"key":"BFEMMM202216592_CR31","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev-immunol-032713-120145","volume":"32","author":"JW Griffith","year":"2014","unstructured":"Griffith JW, Sokol CL, Luster AD (2014) Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol 32: 659\u2013702","journal-title":"Annu Rev Immunol"},{"key":"BFEMMM202216592_CR32","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/hep.1840180316","volume":"18","author":"DB Hill","year":"1993","unstructured":"Hill DB, Marsano LS, McClain CJ (1993) Increased plasma interleukin\u20108 concentrations in alcoholic hepatitis. Hepatology 18: 576\u2013580","journal-title":"Hepatology"},{"key":"BFEMMM202216592_CR33","volume":"8","author":"W Hong","year":"2020","unstructured":"Hong W, Kong M, Qi M, Bai H, Fan Z, Zhang Z, Sun A, Fan X, Xu Y (2020) BRG1 mediates Nephronectin activation in hepatocytes to promote T lymphocyte infiltration in ConA\u2010induced hepatitis. Front Cell Dev Biol 8: 587502","journal-title":"Front Cell Dev Biol"},{"key":"BFEMMM202216592_CR34","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1053\/jhep.2003.50470","volume":"38","author":"S Joshi\u2010Barve","year":"2003","unstructured":"Joshi\u2010Barve S, Barve SS, Butt W, Klein J, McClain CJ (2003) Inhibition of proteasome function leads to NF\u2010kappaB\u2010independent IL\u20108 expression in human hepatocytes. Hepatology 38: 1178\u20131187","journal-title":"Hepatology"},{"key":"BFEMMM202216592_CR35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/366170a0","volume":"366","author":"PA Khavari","year":"1993","unstructured":"Khavari PA, Peterson CL, Tamkun JW, Mendel DB, Crabtree GR (1993) BRG1 contains a conserved domain of the SWI2\/SNF2 family necessary for normal mitotic growth and transcription. Nature 366: 170\u2013174","journal-title":"Nature"},{"key":"BFEMMM202216592_CR36","first-page":"13","volume":"109","author":"HJ Kim","year":"2012","unstructured":"Kim HJ, Lee JS, Kim JD, Cha HJ, Kim A, Lee SK, Lee SC, Kwon BS, Mittler RS, Cho HR et\u00a0al (2012) Reverse signaling through the costimulatory ligand CD137L in epithelial cells is essential for natural killer cell\u2010mediated acute tissue inflammation. Proc Natl Acad Sci U S A 109: E13\u2013E22","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFEMMM202216592_CR37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2220\/biomedres.31.123","volume":"31","author":"R Komori","year":"2010","unstructured":"Komori R, Ozawa S, Kato Y, Shinji H, Kimoto S, Hata R (2010) Functional characterization of proximal promoter of gene for human BRAK\/CXCL14, a tumor\u2010suppressing chemokine. Biomed Res 31: 123\u2013131","journal-title":"Biomed Res"},{"key":"BFEMMM202216592_CR38","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102079","volume":"46","author":"M Kong","year":"2021","unstructured":"Kong M, Dong W, Zhu Y, Fan Z, Miao X, Guo Y, Li C, Duan Y, Lu Y, Li Z et\u00a0al (2021a) Redox\u2010sensitive activation of CCL7 by BRG1 in hepatocytes during liver injury. Redox Biol 46: 102079","journal-title":"Redox Biol"},{"key":"BFEMMM202216592_CR39","volume":"9","author":"M Kong","year":"2021","unstructured":"Kong M, Zhu Y, Shao J, Fan Z, Xu Y (2021b) The chromatin remodeling protein BRG1 regulates SREBP maturation by activating SCAP transcription in hepatocytes. Front Cell Dev Biol 9: 622866","journal-title":"Front Cell Dev Biol"},{"key":"BFEMMM202216592_CR40","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hep.22680","volume":"49","author":"A Lemmers","year":"2009","unstructured":"Lemmers A, Moreno C, Gustot T, Marechal R, Degre D, Demetter P, de Nadai P, Geerts A, Quertinmont E, Vercruysse V et\u00a0al (2009) The interleukin\u201017 pathway is involved in human alcoholic liver disease. Hepatology 49: 646\u2013657","journal-title":"Hepatology"},{"key":"BFEMMM202216592_CR41","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1016\/j.bbadis.2018.05.022","volume":"1864","author":"N Li","year":"2018","unstructured":"Li N, Li M, Hong W, Shao J, Xu H, Shimano H, Lu J, Xu Y (2018a) Brg1 regulates pro\u2010lipogenic transcription by modulating SREBP activity in hepatocytes. Biochim Biophys Acta Mol Basis Dis 1864: 2881\u20132889","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"BFEMMM202216592_CR42","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1016\/j.bbadis.2018.08.003","volume":"1864","author":"N Li","year":"2018","unstructured":"Li N, Li M, Hong W, Shao J, Xu H, Shimano H, Lu J, Xu Y (2018b) Brg1 regulates pro\u2010lipogenic transcription by modulating SREBP activity in hepatocytes. Biochim Biophys Acta 1864: 3487\u20133495","journal-title":"Biochim Biophys Acta"},{"key":"BFEMMM202216592_CR43","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1096\/fj.201800197R","volume":"33","author":"N Li","year":"2019","unstructured":"Li N, Kong M, Zeng S, Hao C, Li M, Li L, Xu Z, Zhu M, Xu Y (2019a) Brahma related gene 1 (Brg1) contributes to liver regeneration by epigenetically activating the Wnt\/beta\u2010catenin pathway in mice. FASEB J 33: 327\u2013338","journal-title":"FASEB J"},{"key":"BFEMMM202216592_CR44","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fcell.2019.00245","volume":"7","author":"Z Li","year":"2019","unstructured":"Li Z, Chen B, Dong W, Kong M, Shao Y, Fan Z, Yu L, Wu D, Lu J, Guo J et\u00a0al (2019b) The chromatin remodeler Brg1 integrates ROS production and endothelial\u2010mesenchymal transition to promote liver fibrosis in mice. Front Dev Cell Biol 7: 245","journal-title":"Front Dev Cell Biol"},{"key":"BFEMMM202216592_CR45","doi-asserted-by":"crossref","first-page":"2101957","DOI":"10.1002\/advs.202101957","volume":"8","author":"Z Li","year":"2021","unstructured":"Li Z, Zhao Q, Lu Y, Zhang Y, Li L, Li M, Chen X, Sun D, Duan Y, Xu Y (2021) DDIT4 S\u2010Nitrosylation aids p38\u2010MAPK signaling complex assembly to promote hepatic reactive oxygen species production. Adv Sci 8: 2101957","journal-title":"Adv Sci"},{"key":"BFEMMM202216592_CR46","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1038\/s41467-019-12573-z","volume":"10","author":"M Liu","year":"2019","unstructured":"Liu M, Sun T, Li N, Peng J, Fu D, Li W, Li L, Gao WQ (2019) BRG1 attenuates colonic inflammation and tumorigenesis through autophagy\u2010dependent oxidative stress sequestration. Nat Commun 10: 4614","journal-title":"Nat Commun"},{"key":"BFEMMM202216592_CR47","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1056\/NEJMra0805786","volume":"360","author":"MR Lucey","year":"2009","unstructured":"Lucey MR, Mathurin P, Morgan TR (2009) Alcoholic hepatitis. N Engl J Med 360: 2758\u20132769","journal-title":"N Engl J Med"},{"key":"BFEMMM202216592_CR48","doi-asserted-by":"crossref","first-page":"7","DOI":"10.35946\/arcr.v41.1.07","volume":"41","author":"BJ Mason","year":"2021","unstructured":"Mason BJ, Heyser CJ (2021) Alcohol use disorder: the role of medication in recovery. Alcohol Res 41: 7","journal-title":"Alcohol Res"},{"key":"BFEMMM202216592_CR49","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1053\/j.gastro.2005.02.065","volume":"128","author":"MR McMullen","year":"2005","unstructured":"McMullen MR, Pritchard MT, Wang Q, Millward CA, Croniger CM, Nagy LE (2005) Early growth response\u20101 transcription factor is essential for ethanol\u2010induced fatty liver injury in mice. Gastroenterology 128: 2066\u20132076","journal-title":"Gastroenterology"},{"key":"BFEMMM202216592_CR50","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/hep.21737","volume":"46","author":"RP Mookerjee","year":"2007","unstructured":"Mookerjee RP, Stadlbauer V, Lidder S, Wright GA, Hodges SJ, Davies NA, Jalan R (2007) Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome. Hepatology 46: 831\u2013840","journal-title":"Hepatology"},{"key":"BFEMMM202216592_CR51","doi-asserted-by":"crossref","first-page":"30794","DOI":"10.1074\/jbc.M700412200","volume":"282","author":"N Nara","year":"2007","unstructured":"Nara N, Nakayama Y, Okamoto S, Tamura H, Kiyono M, Muraoka M, Tanaka K, Taya C, Shitara H, Ishii R et\u00a0al (2007) Disruption of CXC motif chemokine ligand\u201014 in mice ameliorates obesity\u2010induced insulin resistance. J Biol Chem 282: 30794\u201330803","journal-title":"J Biol Chem"},{"key":"BFEMMM202216592_CR52","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41577-019-0141-8","volume":"19","author":"LG Ng","year":"2019","unstructured":"Ng LG, Ostuni R, Hidalgo A (2019) Heterogeneity of neutrophils. Nat Rev Immunol 19: 255\u2013265","journal-title":"Nat Rev Immunol"},{"key":"BFEMMM202216592_CR53","doi-asserted-by":"crossref","first-page":"11257","DOI":"10.1096\/fj.202000477R","volume":"34","author":"L Niu","year":"2020","unstructured":"Niu L, Zheng Z, Xue Q, Cheng H, Liu Y, Wang H, Hu X, Zhang A, Liu B, Xu X (2020) Two coupled mutations abolished the binding of CEBPB to the promoter of CXCL14 that displayed an antiviral effect on PRRSV by activating IFN signaling. FASEB J 34: 11257\u201311271","journal-title":"FASEB J"},{"key":"BFEMMM202216592_CR54","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nri.2016.49","volume":"16","author":"S de Oliveira","year":"2016","unstructured":"de Oliveira S, Rosowski EE, Huttenlocher A (2016) Neutrophil migration in infection and wound repair: going forward in reverse. Nat Rev Immunol 16: 378\u2013391","journal-title":"Nat Rev Immunol"},{"key":"BFEMMM202216592_CR55","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1111\/add.14234","volume":"113","author":"A Peacock","year":"2018","unstructured":"Peacock A, Leung J, Larney S, Colledge S, Hickman M, Rehm J, Giovino GA, West R, Hall W, Griffiths P et\u00a0al (2018) Global statistics on alcohol, tobacco and illicit drug use: 2017 status report. Addiction 113: 1905\u20131926","journal-title":"Addiction"},{"key":"BFEMMM202216592_CR56","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/alcalc\/35.2.190","volume":"35","author":"K Poikolainen","year":"2000","unstructured":"Poikolainen K (2000) Risk factors for alcohol dependence: a case\u2010control study. Alcohol Alcohol 35: 190\u2013196","journal-title":"Alcohol Alcohol"},{"key":"BFEMMM202216592_CR57","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41385-020-0317-3","volume":"14","author":"X Qi","year":"2021","unstructured":"Qi X, Qiu J, Chang J, Ji Y, Yang Q, Cui G, Sun L, Chai Q, Qin J (2021) Brg1 restrains the pro\u2010inflammatory properties of ILC3s and modulates intestinal immunity. Mucosal Immunol 14: 38\u201352","journal-title":"Mucosal Immunol"},{"key":"BFEMMM202216592_CR58","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/01926230701584163","volume":"35","author":"SK Ramaiah","year":"2007","unstructured":"Ramaiah SK, Jaeschke H (2007) Role of neutrophils in the pathogenesis of acute inflammatory liver injury. Toxicol Pathol 35: 757\u2013766","journal-title":"Toxicol Pathol"},{"key":"BFEMMM202216592_CR59","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/hep.1840070513","volume":"7","author":"RA Robbins","year":"1987","unstructured":"Robbins RA, Zetterman RK, Kendall TJ, Gossman GL, Monsour HP, Rennard SI (1987) Elevation of chemotactic factor inactivator in alcoholic liver disease. Hepatology 7: 872\u2013877","journal-title":"Hepatology"},{"key":"BFEMMM202216592_CR60","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/cmi.2016.3","volume":"13","author":"MW Robinson","year":"2016","unstructured":"Robinson MW, Harmon C, O'Farrelly C (2016) Liver immunology and its role in inflammation and homeostasis. Cell Mol Immunol 13: 267\u2013276","journal-title":"Cell Mol Immunol"},{"key":"BFEMMM202216592_CR61","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1182\/blood-2008-12-194597","volume":"113","author":"L Salogni","year":"2009","unstructured":"Salogni L, Musso T, Bosisio D, Mirolo M, Jala VR, Haribabu B, Locati M, Sozzani S (2009) Activin a induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14. Blood 113: 5848\u20135856","journal-title":"Blood"},{"key":"BFEMMM202216592_CR62","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41572-018-0014-7","volume":"4","author":"HK Seitz","year":"2018","unstructured":"Seitz HK, Bataller R, Cortez\u2010Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H (2018) Alcoholic liver disease. Nat Rev Dis Primers 4: 16","journal-title":"Nat Rev Dis Primers"},{"key":"BFEMMM202216592_CR63","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.tiv.2012.03.012","volume":"26","author":"KJ Senthil Kumar","year":"2012","unstructured":"Senthil Kumar KJ, Liao JW, Xiao JH, Gokila Vani M, Wang SY (2012) Hepatoprotective effect of lucidone against alcohol\u2010induced oxidative stress in human hepatic HepG2 cells through the up\u2010regulation of HO\u20101\/Nrf\u20102 antioxidant genes. Toxicol In Vitro 26: 700\u2013708","journal-title":"Toxicol In Vitro"},{"key":"BFEMMM202216592_CR64","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bbrc.2019.10.109","volume":"521","author":"J Shao","year":"2020","unstructured":"Shao J, Xu Y, Fang M (2020) BRG1 deficiency in endothelial cells alleviates thioacetamide induced liver fibrosis in mice. Biochem Biophys Res Commun 521: 212\u2013219","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMMM202216592_CR65","doi-asserted-by":"crossref","first-page":"8060","DOI":"10.1093\/nar\/gkab617","volume":"49","author":"T Sharma","year":"2021","unstructured":"Sharma T, Robinson DCL, Witwicka H, Dilworth FJ, Imbalzano AN (2021) The Bromodomains of the mammalian SWI\/SNF (mSWI\/SNF) ATPases Brahma (BRM) and Brahma related gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation. Nucleic Acids Res 49: 8060\u20138077","journal-title":"Nucleic Acids Res"},{"key":"BFEMMM202216592_CR66","first-page":"1188","volume":"25","author":"G Szabo","year":"2001","unstructured":"Szabo G, Catalano D, Bellerose G, Mandrekar P (2001) Interferon alpha and alcohol augment nuclear regulatory factor\u2010kappaB activation in HepG2 cells, and interferon alpha increases pro\u2010inflammatory cytokine production. Alcohol Clin Exp Res 25: 1188\u20131197","journal-title":"Alcohol Clin Exp Res"},{"key":"BFEMMM202216592_CR67","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/hep.26207","volume":"58","author":"W Tian","year":"2013","unstructured":"Tian W, Xu H, Fang F, Chen Q, Xu Y, Shen A (2013) Brahma\u2010related gene 1 bridges epigenetic regulation of proinflammatory cytokine production to steatohepatitis in mice. Hepatology 58: 576\u2013588","journal-title":"Hepatology"},{"key":"BFEMMM202216592_CR68","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1158\/0008-5472.CAN-14-3798","volume":"75","author":"B Vangamudi","year":"2015","unstructured":"Vangamudi B, Paul TA, Shah PK, Kost\u2010Alimova M, Nottebaum L, Shi X, Zhan Y, Leo E, Mahadeshwar HS, Protopopov A et\u00a0al (2015) The SMARCA2\/4 ATPase domain surpasses the Bromodomain as a drug target in SWI\/SNF\u2010mutant cancers: insights from cDNA rescue and PFI\u20103 inhibitor studies. Cancer Res 75: 3865\u20133878","journal-title":"Cancer Res"},{"key":"BFEMMM202216592_CR69","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.molmed.2007.12.005","volume":"14","author":"M Vidali","year":"2008","unstructured":"Vidali M, Stewart SF, Albano E (2008) Interplay between oxidative stress and immunity in the progression of alcohol\u2010mediated liver injury. Trends Mol Med 14: 63\u201371","journal-title":"Trends Mol Med"},{"key":"BFEMMM202216592_CR70","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1038\/s41598-019-38568-w","volume":"9","author":"B Wang","year":"2019","unstructured":"Wang B, Kaufmann B, Engleitner T, Lu M, Mogler C, Olsavszky V, Ollinger R, Zhong S, Geraud C, Cheng Z et\u00a0al (2019) Brg1 promotes liver regeneration after partial hepatectomy via regulation of cell cycle. Sci Rep 9: 2320","journal-title":"Sci Rep"},{"key":"BFEMMM202216592_CR71","doi-asserted-by":"crossref","first-page":"27158","DOI":"10.18632\/oncotarget.8384","volume":"7","author":"Q Wu","year":"2016","unstructured":"Wu Q, Sharma S, Cui H, LeBlanc SE, Zhang H, Muthuswami R, Nickerson JA, Imbalzano AN (2016) Targeting the chromatin remodeling enzyme BRG1 increases the efficacy of chemotherapy drugs in breast cancer cells. Oncotarget 7: 27158\u201327175","journal-title":"Oncotarget"},{"key":"BFEMMM202216592_CR72","volume":"9","author":"X Wu","year":"2021","unstructured":"Wu X, Dong W, Kong M, Ren H, Wang J, Shang L, Zhu Z, Zhu W, Shi X (2021) Down\u2010regulation of CXXC5 de\u2010represses MYCL1 to promote hepatic stellate cell activation. Front Cell Dev Biol 9: 680344","journal-title":"Front Cell Dev Biol"},{"key":"BFEMMM202216592_CR73","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/cmi.2014.2","volume":"11","author":"R Xu","year":"2014","unstructured":"Xu R, Huang H, Zhang Z, Wang FS (2014) The role of neutrophils in the development of liver diseases. Cell Mol Immunol 11: 224\u2013231","journal-title":"Cell Mol Immunol"},{"key":"BFEMMM202216592_CR74","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.taap.2007.06.018","volume":"223","author":"HQ Yin","year":"2007","unstructured":"Yin HQ, Kim M, Kim JH, Kong G, Kang KS, Kim HL, Yoon BI, Lee MO, Lee BH (2007) Differential gene expression and lipid metabolism in fatty liver induced by acute ethanol treatment in mice. Toxicol Appl Pharmacol 223: 225\u2013233","journal-title":"Toxicol Appl Pharmacol"},{"key":"BFEMMM202216592_CR75","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/0016-5085(81)90617-X","volume":"81","author":"RK Zetterman","year":"1981","unstructured":"Zetterman RK, Sorrell MF (1981) Immunologic aspects of alcoholic liver disease. Gastroenterology 81: 616\u2013624","journal-title":"Gastroenterology"},{"key":"BFEMMM202216592_CR76","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ijcard.2018.07.105","volume":"269","author":"X Zhang","year":"2018","unstructured":"Zhang X, Liu S, Weng X, Zeng S, Yu L, Guo J, Xu Y (2018) Brg1 deficiency in vascular endothelial cells blocks neutrophil recruitment and ameliorates cardiac ischemia\u2010reperfusion injury in mice. Int J Cardiol 269: 250\u2013258","journal-title":"Int J Cardiol"},{"key":"BFEMMM202216592_CR77","doi-asserted-by":"crossref","first-page":"13216","DOI":"10.1002\/jcb.28595","volume":"120","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Yuan Y, Li Z, Chen H, Fang M, Xiao P, Xu Y (2019) An interaction between BRG1 and histone modifying enzymes mediates lipopolysaccharide\u2010induced proinflammatory cytokines in vascular endothelial cells. J Cell Biochem 120: 13216\u201313225","journal-title":"J Cell Biochem"},{"key":"BFEMMM202216592_CR78","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41421-020-0157-z","volume":"6","author":"J Zhao","year":"2020","unstructured":"Zhao J, Zhang S, Liu Y, He X, Qu M, Xu G, Wang H, Huang M, Pan J, Liu Z et\u00a0al (2020) Single\u2010cell RNA sequencing reveals the heterogeneity of liver\u2010resident immune cells in human. Cell Discov 6: 22","journal-title":"Cell Discov"},{"key":"BFEMMM202216592_CR79","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/hep.31780","volume":"74","author":"Y Zhou","year":"2021","unstructured":"Zhou Y, Chen Y, Zhang X, Xu Q, Wu Z, Cao X, Shao M, Shu Y, Lv T, Lu C et\u00a0al (2021) Brahma\u2010related gene 1 inhibition prevents liver fibrosis and cholangiocarcinoma by attenuating progenitor expansion. Hepatology 74: 797\u2013815","journal-title":"Hepatology"}],"container-title":["EMBO Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202216592.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/emmm.202216592","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/emmm.202216592\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/emmm.202216592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202216592.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:49:03Z","timestamp":1779086943000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/emmm.202216592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":79,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3,8]]}},"alternative-id":["BFEMMM202216592"],"URL":"https:\/\/doi.org\/10.15252\/emmm.202216592","relation":{},"ISSN":["1757-4676","1757-4684"],"issn-type":[{"value":"1757-4676","type":"print"},{"value":"1757-4684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,1]]},"assertion":[{"value":"16 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"EMMM202216592"}}