{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:12:58Z","timestamp":1792123978207,"version":"4.4.0"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"crossref","award":["IG2018\u201021594"],"award-info":[{"award-number":["IG2018\u201021594"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100022720","name":"Fondazione Regionale per la Ricerca Biomedica","doi-asserted-by":"crossref","award":["ERA PerMed 2020\u2010090"],"award-info":[{"award-number":["ERA PerMed 2020\u2010090"]}],"id":[{"id":"10.13039\/501100022720","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004710","name":"Fondazione Umberto Veronesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2023,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    MYC is a key oncogenic driver in multiple tumor types, but concomitantly endows cancer cells with a series of vulnerabilities that provide opportunities for targeted pharmacological intervention. For example, drugs that suppress mitochondrial respiration selectively kill MYC\u2010overexpressing cells. Here, we unravel the mechanistic basis for this synthetic lethal interaction and exploit it to improve the anticancer effects of the respiratory complex I inhibitor IACS\u2010010759. In a B\u2010lymphoid cell line, ectopic MYC activity and treatment with IACS\u2010010759 added up to induce oxidative stress, with consequent depletion of reduced glutathione and lethal disruption of redox homeostasis. This effect could be enhanced either with inhibitors of NADPH production through the pentose phosphate pathway, or with ascorbate (vitamin C), known to act as a pro\u2010oxidant at high doses. In these conditions, ascorbate synergized with IACS\u2010010759 to kill MYC\u2010overexpressing cells\n                    <jats:italic>in vitro<\/jats:italic>\n                    and reinforced its therapeutic action against human B\u2010cell lymphoma xenografts. Hence, complex I inhibition and high\u2010dose ascorbate might improve the outcome of patients affected by high\u2010grade lymphomas and potentially other MYC\u2010driven cancers.\n                  <\/jats:p>","DOI":"10.15252\/emmm.202216910","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T17:08:34Z","timestamp":1683652114000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC\u2010driven lymphoma"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0875-9233","authenticated-orcid":false,"given":"Giulio","family":"Donati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Nicoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8596-6650","authenticated-orcid":false,"given":"Alessandro","family":"Verrecchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2285-2711","authenticated-orcid":false,"given":"Veronica","family":"Vallelonga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavio","family":"Croci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Rodighiero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2791-4526","authenticated-orcid":false,"given":"Matteo","family":"Audano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7350-3069","authenticated-orcid":false,"given":"Laura","family":"Cassina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Ghsein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0223-7805","authenticated-orcid":false,"given":"Giorgio","family":"Binelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Boletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Mitro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2958-1799","authenticated-orcid":false,"given":"Bruno","family":"Amati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"BFEMMM202216910_CR1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s43018-022-00355-4","volume":"3","author":"H Alborzinia","year":"2022","unstructured":"Alborzinia H, Florez AF, Kreth S, Bruckner LM, Yildiz U, Gartlgruber M, Odoni DI, Poschet G, Garbowicz K, Shao C et\u00a0al (2022) MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis. Nat Cancer 3: 471\u2013485","journal-title":"Nat Cancer"},{"key":"BFEMMM202216910_CR2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","volume":"403","author":"AA Alizadeh","year":"2000","unstructured":"Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X et\u00a0al (2000) Distinct types of diffuse large B\u2010cell lymphoma identified by gene expression profiling. Nature 403: 503\u2013511","journal-title":"Nature"},{"key":"BFEMMM202216910_CR3","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.bbamcr.2012.05.010","volume":"1823","author":"CP Anderson","year":"2012","unstructured":"Anderson CP, Shen M, Eisenstein RS, Leibold EA (2012) Mammalian iron metabolism and its control by iron regulatory proteins. Biochim Biophys Acta 1823: 1468\u20131483","journal-title":"Biochim Biophys Acta"},{"key":"BFEMMM202216910_CR4","volume":"40","author":"L Baird","year":"2020","unstructured":"Baird L, Yamamoto M (2020) The molecular mechanisms regulating the KEAP1\u2010NRF2 pathway. Mol Cell Biol 40: e00099\u201020","journal-title":"Mol Cell Biol"},{"key":"BFEMMM202216910_CR5","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/s41467-020-15051-z","volume":"11","author":"R Bajpai","year":"2020","unstructured":"Bajpai R, Sharma A, Achreja A, Edgar CL, Wei C, Siddiqa AA, Gupta VA, Matulis SM, McBrayer SK, Mittal A et\u00a0al (2020) Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma. Nat Commun 11: 1228","journal-title":"Nat Commun"},{"key":"BFEMMM202216910_CR6","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aar5012","volume":"11","author":"ME Beaulieu","year":"2019","unstructured":"Beaulieu ME, Jauset T, Masso\u2010Valles D, Martinez\u2010Martin S, Rahl P, Maltais L, Zacarias\u2010Fluck MF, Casacuberta\u2010Serra S, Serrano Del Pozo E, Fiore C et\u00a0al (2019) Intrinsic cell\u2010penetrating activity propels Omomyc from proof of concept to viable anti\u2010MYC therapy. Sci Transl Med 11: eaar5012","journal-title":"Sci Transl Med"},{"key":"BFEMMM202216910_CR7","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/imr.12734","volume":"288","author":"A Bisso","year":"2019","unstructured":"Bisso A, Sab\u00f2 A, Amati B (2019) MYC in germinal center\u2010derived lymphomas:\u00a0mechanisms and therapeutic opportunities. Immunol Rev 288: 178\u2013197","journal-title":"Immunol Rev"},{"key":"BFEMMM202216910_CR8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1186\/s13046-021-02134-y","volume":"40","author":"F Bottger","year":"2021","unstructured":"Bottger F, Valles\u2010Marti A, Cahn L, Jimenez CR (2021) High\u2010dose intravenous vitamin C, a promising multi\u2010targeting agent in the treatment of cancer. J Exp Clin Cancer Res 40: 343","journal-title":"J Exp Clin Cancer Res"},{"key":"BFEMMM202216910_CR9","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.freeradbiomed.2004.05.034","volume":"37","author":"MD Brand","year":"2004","unstructured":"Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, Pakay JL, Parker N (2004) Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med 37: 755\u2013767","journal-title":"Free Radic Biol Med"},{"key":"BFEMMM202216910_CR10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.yexcr.2013.11.012","volume":"320","author":"A Bruning","year":"2014","unstructured":"Bruning A, Brem GJ, Vogel M, Mylonas I (2014) Tetracyclines cause cell stress\u2010dependent ATF4 activation and mTOR inhibition. Exp Cell Res 320: 281\u2013289","journal-title":"Exp Cell Res"},{"key":"BFEMMM202216910_CR11","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ccr.2012.08.014","volume":"22","author":"P Caro","year":"2012","unstructured":"Caro P, Kishan AU, Norberg E, Stanley IA, Chapuy B, Ficarro SB, Polak K, Tondera D, Gounarides J, Yin H et\u00a0al (2012) Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma. Cancer Cell 22: 547\u2013560","journal-title":"Cancer Cell"},{"key":"BFEMMM202216910_CR12","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.4049\/jimmunol.1302062","volume":"192","author":"A Caro\u2010Maldonado","year":"2014","unstructured":"Caro\u2010Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR et\u00a0al (2014) Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF\u2010exposed B cells. J Immunol 192: 3626\u20133636","journal-title":"J Immunol"},{"key":"BFEMMM202216910_CR13","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41591-018-0016-8","volume":"24","author":"B Chapuy","year":"2018","unstructured":"Chapuy B, Stewart C, Dunford AJ, Kim J, Kamburov A, Redd RA, Lawrence MS, Roemer MGM, Li AJ, Ziepert M et\u00a0al (2018) Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med 24: 679\u2013690","journal-title":"Nat Med"},{"key":"BFEMMM202216910_CR14","doi-asserted-by":"crossref","first-page":"13604","DOI":"10.1073\/pnas.0506390102","volume":"102","author":"Q Chen","year":"2005","unstructured":"Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M (2005) Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro\u2010drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci USA 102: 13604\u201313609","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM202216910_CR15","doi-asserted-by":"crossref","first-page":"8749","DOI":"10.1073\/pnas.0702854104","volume":"104","author":"Q Chen","year":"2007","unstructured":"Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR et\u00a0al (2007) Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo. Proc Natl Acad Sci USA 104: 8749\u20138754","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM202216910_CR16","doi-asserted-by":"crossref","first-page":"11105","DOI":"10.1073\/pnas.0804226105","volume":"105","author":"Q Chen","year":"2008","unstructured":"Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M (2008) Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci USA 105: 11105\u201311109","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM202216910_CR17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20102407","volume":"20","author":"F Collin","year":"2019","unstructured":"Collin F (2019) Chemical basis of reactive oxygen species reactivity and involvement in neurodegenerative diseases. Int J Mol Sci 20: 2407","journal-title":"Int J Mol Sci"},{"key":"BFEMMM202216910_CR18","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat5314","volume":"368","author":"M Costa\u2010Mattioli","year":"2020","unstructured":"Costa\u2010Mattioli M, Walter P (2020) The integrated stress response: from mechanism to disease. Science 368: eaat5314","journal-title":"Science"},{"key":"BFEMMM202216910_CR19","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1158\/2159-8290.CD-14-0943","volume":"5","author":"F Cottini","year":"2015","unstructured":"Cottini F, Hideshima T, Suzuki R, Tai YT, Bianchini G, Richardson PG, Anderson KC, Tonon G (2015) Synthetic lethal approaches exploiting\u00a0DNA damage in aggressive myeloma. Cancer Discov 5: 972\u2013987","journal-title":"Cancer Discov"},{"key":"BFEMMM202216910_CR20","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1182\/blood-2017-03-769620","volume":"130","author":"M Crump","year":"2017","unstructured":"Crump M, Neelapu SS, Farooq U, Van Den Neste E, Kuruvilla J, Westin J, Link BK, Hay A, Cerhan JR, Zhu L et\u00a0al (2017) Outcomes in refractory diffuse large B\u2010cell lymphoma: results from the international SCHOLAR\u20101 study. Blood 130: 1800\u20131808","journal-title":"Blood"},{"key":"BFEMMM202216910_CR21","doi-asserted-by":"crossref","first-page":"72415","DOI":"10.18632\/oncotarget.11719","volume":"7","author":"A D'Andrea","year":"2016","unstructured":"D'Andrea A, Gritti I, Nicoli P, Giorgio M, Doni M, Conti A, Bianchi V, Casoli L, Sabo A, Mironov A et\u00a0al (2016) The mitochondrial translation machinery as a therapeutic target in Myc\u2010driven lymphomas. Oncotarget 7: 72415\u201372430","journal-title":"Oncotarget"},{"key":"BFEMMM202216910_CR22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/hon.2581","volume":"37","author":"A Davies","year":"2019","unstructured":"Davies A (2019) Double\u2010hit lymphoma: so what? Hematol Oncol 37: 19\u201323","journal-title":"Hematol Oncol"},{"key":"BFEMMM202216910_CR23","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature10189","volume":"475","author":"GM DeNicola","year":"2011","unstructured":"DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES et\u00a0al (2011) Oncogene\u2010induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475: 106\u2013109","journal-title":"Nature"},{"key":"BFEMMM202216910_CR24","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41571-021-00549-2","volume":"19","author":"R Dhanasekaran","year":"2022","unstructured":"Dhanasekaran R, Deutzmann A, Mahauad\u2010Fernandez WD, Hansen AS, Gouw AM, Felsher DW (2022) The MYC oncogene \u2013 the grand orchestrator of cancer growth and immune evasion. Nat Rev Clin Oncol 19: 23\u201336","journal-title":"Nat Rev Clin Oncol"},{"key":"BFEMMM202216910_CR25","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1038\/s41467-020-16243-3","volume":"11","author":"M Di Tano","year":"2020","unstructured":"Di Tano M, Raucci F, Vernieri C, Caffa I, Buono R, Fanti M, Brandhorst S, Curigliano G, Nencioni A, de Braud F et\u00a0al (2020) Synergistic effect of fasting\u2010mimicking diet and vitamin C against KRAS mutated cancers. Nat Commun 11: 2332","journal-title":"Nat Commun"},{"key":"BFEMMM202216910_CR26","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1002\/1878-0261.13319","volume":"16","author":"G Donati","year":"2022","unstructured":"Donati G, Amati B (2022) MYC and therapy resistance in cancer: risks and opportunities. Mol Oncol 16: 3828\u20133854","journal-title":"Mol Oncol"},{"key":"BFEMMM202216910_CR27","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/1878-0261.13115","volume":"16","author":"G Donati","year":"2022","unstructured":"Donati G, Rav\u00e0 M, Filipuzzi M, Nicoli P, Cassina L, Verrecchia A, Doni M, Rodighiero S, Parodi F, Boletta A et\u00a0al (2022) Targeting mitochondrial respiration and the BCL2 family in high\u2010grade MYC\u2010associated B\u2010cell lymphoma. Mol Oncol 16: 1132\u20131152","journal-title":"Mol Oncol"},{"key":"BFEMMM202216910_CR28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1182\/hematology.2021000247","volume":"2021","author":"K Dunleavy","year":"2021","unstructured":"Dunleavy K (2021) Double\u2010hit lymphoma: optimizing therapy. Hematology Am Soc Hematol Educ Program 2021: 157\u2013163","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"BFEMMM202216910_CR29","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41586-019-1186-3","volume":"569","author":"M Ghandi","year":"2019","unstructured":"Ghandi M, Huang FW, Jane\u2010Valbuena J, Kryukov GV, Lo CC, McDonald ER III, Barretina J, Gelfand ET, Bielski CM, Li H et\u00a0al (2019) Next\u2010generation characterization of the cancer cell line encyclopedia. Nature 569: 503\u2013508","journal-title":"Nature"},{"key":"BFEMMM202216910_CR30","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27123818","volume":"27","author":"J Gonzalez\u2010Montero","year":"2022","unstructured":"Gonzalez\u2010Montero J, Chichiarelli S, Eufemi M, Altieri F, Saso L, Rodrigo R (2022) Ascorbate as a bioactive compound in cancer therapy: the old classic strikes Back. Molecules 27: 3818","journal-title":"Molecules"},{"key":"BFEMMM202216910_CR31","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nmeth.1212","volume":"5","author":"M Gutscher","year":"2008","unstructured":"Gutscher M, Pauleau AL, Marty L, Brach T, Wabnitz GH, Samstag Y, Meyer AJ, Dick TP (2008) Real\u2010time imaging of the intracellular glutathione redox potential. Nat Methods 5: 553\u2013559","journal-title":"Nat Methods"},{"key":"BFEMMM202216910_CR32","doi-asserted-by":"crossref","first-page":"31532","DOI":"10.1074\/jbc.M109.059246","volume":"284","author":"M Gutscher","year":"2009","unstructured":"Gutscher M, Sobotta MC, Wabnitz GH, Ballikaya S, Meyer AJ, Samstag Y, Dick TP (2009) Proximity\u2010based protein thiol oxidation by H2O2\u2010scavenging peroxidases. J Biol Chem 284: 31532\u201331540","journal-title":"J Biol Chem"},{"key":"BFEMMM202216910_CR33","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1093\/annonc\/mdn377","volume":"19","author":"LJ Hoffer","year":"2008","unstructured":"Hoffer LJ, Levine M, Assouline S, Melnychuk D, Padayatty SJ, Rosadiuk K, Rousseau C, Robitaille L, Miller WH Jr (2008) Phase I clinical trial of i.v. ascorbic acid in advanced malignancy. Ann Oncol 19: 1969\u20131974","journal-title":"Ann Oncol"},{"key":"BFEMMM202216910_CR34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.semcdb.2015.08.003","volume":"43","author":"AL Hsieh","year":"2015","unstructured":"Hsieh AL, Walton ZE, Altman BJ, Stine ZE, Dang CV (2015) MYC and metabolism on the path to cancer. Semin Cell Dev Biol 43: 11\u201321","journal-title":"Semin Cell Dev Biol"},{"key":"BFEMMM202216910_CR35","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1093\/bioinformatics\/btx162","volume":"33","author":"A Ianevski","year":"2017","unstructured":"Ianevski A, He L, Aittokallio T, Tang J (2017) SynergyFinder: a web application for analyzing drug combination dose\u2010response matrix data. Bioinformatics 33: 2413\u20132415","journal-title":"Bioinformatics"},{"key":"BFEMMM202216910_CR36","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1007\/s10637-021-01112-7","volume":"39","author":"F Janku","year":"2021","unstructured":"Janku F, LoRusso P, Mansfield AS, Nanda R, Spira A, Wang T, Melhem\u2010Bertrandt A, Sugg J, Ball HA (2021) First\u2010in\u2010human evaluation of the novel mitochondrial complex I inhibitor ASP4132 for treatment of cancer. Invest New Drugs 39: 1348\u20131356","journal-title":"Invest New Drugs"},{"key":"BFEMMM202216910_CR37","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22: 266\u2013282","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFEMMM202216910_CR38","doi-asserted-by":"crossref","DOI":"10.3390\/genes8060151","volume":"8","author":"M Kalkat","year":"2017","unstructured":"Kalkat M, De Melo J, Hickman KA, Lourenco C, Redel C, Resetca D, Tamachi A, Tu WB, Penn LZ (2017) MYC deregulation in primary human cancers. Genes (Basel) 8: 151","journal-title":"Genes (Basel)"},{"key":"BFEMMM202216910_CR39","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.devcel.2022.06.008","volume":"57","author":"DG Kirova","year":"2022","unstructured":"Kirova DG, Judasova K, Vorhauser J, Zerjatke T, Leung JK, Glauche I, Mansfeld J (2022) A ROS\u2010dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase. Dev Cell 57: 1712\u20131727","journal-title":"Dev Cell"},{"key":"BFEMMM202216910_CR40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0014-5793(70)80063-1","volume":"6","author":"E Kohler","year":"1970","unstructured":"Kohler E, Barrach H, Neubert D (1970) Inhibition of NADP dependent oxidoreductases by the 6\u2010aminonicotinamide analogue of NADP. FEBS Lett 6: 225\u2013228","journal-title":"FEBS Lett"},{"key":"BFEMMM202216910_CR41","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1158\/2159-8290.CD-20-0839","volume":"11","author":"N Kotlov","year":"2021","unstructured":"Kotlov N, Bagaev A, Revuelta MV, Phillip JM, Cacciapuoti MT, Antysheva Z, Svekolkin V, Tikhonova E, Miheecheva N, Kuzkina N et\u00a0al (2021) Clinical and biological subtypes of B\u2010cell lymphoma revealed by microenvironmental signatures. Cancer Discov 11: 1468\u20131489","journal-title":"Cancer Discov"},{"key":"BFEMMM202216910_CR42","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nrc3984","volume":"15","author":"TR Kress","year":"2015","unstructured":"Kress TR, Sabo A, Amati B (2015) MYC: connecting selective transcriptional control to global RNA production. Nat Rev Cancer 15: 593\u2013607","journal-title":"Nat Rev Cancer"},{"key":"BFEMMM202216910_CR43","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cmet.2017.09.009","volume":"26","author":"KM Lee","year":"2017","unstructured":"Lee KM, Giltnane JM, Balko JM, Schwarz LJ, Guerrero\u2010Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sanchez V, Sanders ME et\u00a0al (2017) MYC and MCL1 cooperatively promote chemotherapy\u2010resistant breast cancer stem cells via regulation of mitochondrial oxidative phosphorylation. Cell Metab 26: 633\u2013647","journal-title":"Cell Metab"},{"key":"BFEMMM202216910_CR44","doi-asserted-by":"crossref","first-page":"6225","DOI":"10.1128\/MCB.25.14.6225-6234.2005","volume":"25","author":"F Li","year":"2005","unstructured":"Li F, Wang Y, Zeller KI, Potter JJ, Wonsey DR, O'Donnell KA, Kim JW, Yustein JT, Lee LA, Dang CV (2005) Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis. Mol Cell Biol 25: 6225\u20136234","journal-title":"Mol Cell Biol"},{"key":"BFEMMM202216910_CR45","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1038\/s41598-018-24631-5","volume":"8","author":"L Li","year":"2018","unstructured":"Li L, Li Y, Que X, Gao X, Gao Q, Yu M, Ma K, Xi Y, Wang T (2018) Prognostic significances of overexpression MYC and\/or BCL2 in R\u2010CHOP\u2010treated diffuse large B\u2010cell lymphoma: a systematic review and meta\u2010analysis. Sci Rep 8: 6267","journal-title":"Sci Rep"},{"key":"BFEMMM202216910_CR46","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1158\/0008-5472.CAN-18-1968","volume":"79","author":"C Liang","year":"2019","unstructured":"Liang C, Shi S, Liu M, Qin Y, Meng Q, Hua J, Ji S, Zhang Y, Yang J, Xu J et\u00a0al (2019) PIN1 maintains redox balance via the c\u2010Myc\/NRF2 Axis to counteract Kras\u2010induced mitochondrial respiratory injury in pancreatic cancer cells. Cancer Res 79: 133\u2013145","journal-title":"Cancer Res"},{"key":"BFEMMM202216910_CR47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103756","volume":"75","author":"V Llombart","year":"2022","unstructured":"Llombart V, Mansour MR (2022) Therapeutic targeting of \u201cundruggable\u201d MYC. EBioMedicine 75: 103756","journal-title":"EBioMedicine"},{"key":"BFEMMM202216910_CR48","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay8707","volume":"12","author":"A Magri","year":"2020","unstructured":"Magri A, Germano G, Lorenzato A, Lamba S, Chila R, Montone M, Amodio V, Ceruti T, Sassi F, Arena S et\u00a0al (2020) High\u2010dose vitamin C enhances cancer immunotherapy. Sci Transl Med 12: eaay8707","journal-title":"Sci Transl Med"},{"key":"BFEMMM202216910_CR49","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bbrc.2011.04.137","volume":"409","author":"NP Mena","year":"2011","unstructured":"Mena NP, Bulteau AL, Salazar J, Hirsch EC, Nunez MT (2011) Effect of mitochondrial complex I inhibition on Fe\u2010S cluster protein activity. Biochem Biophys Res Commun 409: 241\u2013246","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMMM202216910_CR50","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s41591-018-0052-4","volume":"24","author":"JR Molina","year":"2018","unstructured":"Molina JR, Sun YT, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip ANA et\u00a0al (2018) An inhibitor of oxidative\u00a0phosphorylation exploits cancer vulnerability. Nat Med 24: 1036\u20131046","journal-title":"Nat Med"},{"key":"BFEMMM202216910_CR51","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1182\/blood-2004-07-2947","volume":"105","author":"S Monti","year":"2005","unstructured":"Monti S, Savage KJ, Kutok JL, Feuerhake F, Kurtin P, Mihm M, Wu B, Pasqualucci L, Neuberg D, Aguiar RC et\u00a0al (2005) Molecular profiling of diffuse large B\u2010cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood 105: 1851\u20131861","journal-title":"Blood"},{"key":"BFEMMM202216910_CR52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029794","volume":"7","author":"DA Monti","year":"2012","unstructured":"Monti DA, Mitchell E, Bazzan AJ, Littman S, Zabrecky G, Yeo CJ, Pillai MV, Newberg AB, Deshmukh S, Levine M (2012) Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. PLoS ONE 7: e29794","journal-title":"PLoS ONE"},{"key":"BFEMMM202216910_CR53","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a014225","volume":"4","author":"F Morrish","year":"2014","unstructured":"Morrish F, Hockenbery D (2014) MYC and mitochondrial biogenesis. Cold Spring Harb Perspect Med 4: a014225","journal-title":"Cold Spring Harb Perspect Med"},{"key":"BFEMMM202216910_CR54","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.celrep.2018.03.032","volume":"23","author":"A Naguib","year":"2018","unstructured":"Naguib A, Mathew G, Reczek CR, Watrud K, Ambrico A, Herzka T, Salas IC, Lee MF, El\u2010Amine N, Zheng W et\u00a0al (2018) Mitochondrial complex I inhibitors expose a vulnerability for selective killing of Pten\u2010null cells. Cell Rep 23: 58\u201367","journal-title":"Cell Rep"},{"key":"BFEMMM202216910_CR55","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0006-291X(75)90710-X","volume":"63","author":"M Nishikimi","year":"1975","unstructured":"Nishikimi M (1975) Oxidation of ascorbic acid with superoxide anion generated by the xanthine\u2010xanthine oxidase system. Biochem Biophys Res Commun 63: 463\u2013468","journal-title":"Biochem Biophys Res Commun"},{"key":"BFEMMM202216910_CR56","doi-asserted-by":"crossref","first-page":"72395","DOI":"10.18632\/oncotarget.11718","volume":"7","author":"AR Oran","year":"2016","unstructured":"Oran AR, Adams CM, Zhang XY, Gennaro VJ, Pfeiffer HK, Mellert HS, Seidel HE, Mascioli K, Kaplan J, Gaballa MR et\u00a0al (2016) Multi\u2010focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer. Oncotarget 7: 72395\u201372414","journal-title":"Oncotarget"},{"key":"BFEMMM202216910_CR57","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tibs.2014.06.005","volume":"39","author":"KC Patra","year":"2014","unstructured":"Patra KC, Hay N (2014) The pentose phosphate pathway and cancer. Trends Biochem Sci 39: 347\u2013354","journal-title":"Trends Biochem Sci"},{"key":"BFEMMM202216910_CR58","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0021-9258(18)65950-2","volume":"217","author":"E Racker","year":"1955","unstructured":"Racker E (1955) Glutathione reductase from bakers' yeast and beef liver. J Biol Chem 217: 855\u2013865","journal-title":"J Biol Chem"},{"key":"BFEMMM202216910_CR59","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1021\/bi00813a003","volume":"9","author":"R Raineri","year":"1970","unstructured":"Raineri R, Levy HR (1970) On the specificity of steroid interaction with mammary glucose 6\u2010phosphate dehydrogenase. Biochemistry 9: 2233\u20132243","journal-title":"Biochemistry"},{"key":"BFEMMM202216910_CR60","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan8723","volume":"10","author":"M Rav\u00e0","year":"2018","unstructured":"Rav\u00e0 M, D'Andrea A, Nicoli P, Gritti I, Donati G, Doni M, Giorgio M, Olivero D, Amati B (2018) Therapeutic synergy between tigecycline and venetoclax in a preclinical model of MYC\/BCL2 double\u2010hit B cell lymphoma. Sci Transl Med 10: eaan8723","journal-title":"Sci Transl Med"},{"key":"BFEMMM202216910_CR61","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cell.2017.09.027","volume":"171","author":"A Reddy","year":"2017","unstructured":"Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen\u2010Lindsberg ML et\u00a0al (2017) Genetic and functional drivers of diffuse large B cell lymphoma. Cell 171: 481\u2013494","journal-title":"Cell"},{"key":"BFEMMM202216910_CR62","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1200\/JCO.19.00743","volume":"37","author":"A Rosenwald","year":"2019","unstructured":"Rosenwald A, Bens S, Advani R, Barrans S, Copie\u2010Bergman C, Elsensohn MH, Natkunam Y, Calaminici M, Sander B, Baia M et\u00a0al (2019) Prognostic significance of MYC rearrangement and translocation partner in diffuse large B\u2010cell lymphoma: a study by the Lunenburg lymphoma biomarker consortium. J Clin Oncol 37: 3359\u20133368","journal-title":"J Clin Oncol"},{"key":"BFEMMM202216910_CR63","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jlb.47.5.440","volume":"47","author":"G Rothe","year":"1990","unstructured":"Rothe G, Valet G (1990) Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2\u2032,7\u2032\u2010dichlorofluorescin. J Leukoc Biol 47: 440\u2013448","journal-title":"J Leukoc Biol"},{"key":"BFEMMM202216910_CR64","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay2118","volume":"5","author":"DL Rudler","year":"2019","unstructured":"Rudler DL, Hughes LA, Perks KL, Richman TR, Kuznetsova I, Ermer JA, Abudulai LN, Shearwood AJ, Viola HM, Hool LC et\u00a0al (2019) Fidelity of translation initiation is required for coordinated respiratory complex assembly. Sci Adv 5: eaay2118","journal-title":"Sci Adv"},{"key":"BFEMMM202216910_CR65","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202215855","volume":"14","author":"L Sanchez-Burgos","year":"2022","unstructured":"Sanchez-Burgos L, Navarro-Gonz\u00e1lez B, Garc\u00eda-Mart\u00edn S, Sirozh O, Mota-Pino J, Fueyo-Marcos E, Tejero H, Ant\u00f3n ME, Murga M, Al-Shahrour F et\u00a0al (2022) Activation of the integrated stress response is a vulnerability for multidrug-resistant FBXW7-deficient cells. EMBO Mol Med 14: e15855","journal-title":"EMBO Mol Med"},{"key":"BFEMMM202216910_CR67","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201289","volume":"40","author":"K Sasaki","year":"2020","unstructured":"Sasaki K, Uchiumi T, Toshima T, Yagi M, Do Y, Hirai H, Igami K, Gotoh K, Kang D (2020) Mitochondrial translation inhibition triggers ATF4 activation, leading to integrated stress response but not to mitochondrial unfolded protein response. Biosci Rep 40: BSR20201289","journal-title":"Biosci Rep"},{"key":"BFEMMM202216910_CR68","doi-asserted-by":"crossref","first-page":"6695","DOI":"10.1016\/S0021-9258(18)32271-3","volume":"258","author":"M Scarpa","year":"1983","unstructured":"Scarpa M, Stevanato R, Viglino P, Rigo A (1983) Superoxide ion as active intermediate in the autoxidation of ascorbate by molecular oxygen. Effect of superoxide dismutase. J Biol Chem 258: 6695\u20136697","journal-title":"J Biol Chem"},{"key":"BFEMMM202216910_CR69","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1056\/NEJMoa1801445","volume":"378","author":"R Schmitz","year":"2018","unstructured":"Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL et\u00a0al (2018) Genetics and pathogenesis of diffuse large B\u2010cell lymphoma. N Engl J Med 378: 1396\u20131407","journal-title":"N Engl J Med"},{"key":"BFEMMM202216910_CR70","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ccell.2017.07.008","volume":"32","author":"JD Schoenfeld","year":"2017","unstructured":"Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer\u2010Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T et\u00a0al (2017) O2(\u2212) and H2O2\u2010mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate. Cancer Cell 32: 268","journal-title":"Cancer Cell"},{"key":"BFEMMM202216910_CR71","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax2863","volume":"11","author":"D Sharon","year":"2019","unstructured":"Sharon D, Cathelin S, Mirali S, Di Trani JM, Yanofsky DJ, Keon KA, Rubinstein JL, Schimmer AD, Ketela T, Chan SM (2019) Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response. Sci Transl Med 11: eaax2863","journal-title":"Sci Transl Med"},{"key":"BFEMMM202216910_CR72","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2741\/3689","volume":"16","author":"J Skommer","year":"2011","unstructured":"Skommer J, Raychaudhuri S, Wlodkowic D (2011) Timing is everything: stochastic origins of cell\u2010to\u2010cell variability in cancer cell death. Front Biosci (Landmark Ed) 16: 307\u2013314","journal-title":"Front Biosci (Landmark Ed)"},{"key":"BFEMMM202216910_CR73","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00280-013-2179-9","volume":"72","author":"CM Stephenson","year":"2013","unstructured":"Stephenson CM, Levin RD, Spector T, Lis CG (2013) Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high\u2010dose intravenous ascorbic acid in patients with advanced cancer. Cancer Chemother Pharmacol 72: 139\u2013146","journal-title":"Cancer Chemother Pharmacol"},{"key":"BFEMMM202216910_CR74","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.celrep.2018.12.043","volume":"26","author":"Y Sun","year":"2019","unstructured":"Sun Y, Bandi M, Lofton T, Smith M, Bristow CA, Carugo A, Rogers N, Leonard P, Chang Q, Mullinax R et\u00a0al (2019) Functional genomics reveals synthetic lethality between Phosphogluconate dehydrogenase and oxidative phosphorylation. Cell Rep 26: 469\u2013482","journal-title":"Cell Rep"},{"key":"BFEMMM202216910_CR75","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","volume":"127","author":"SH Swerdlow","year":"2016","unstructured":"Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD et\u00a0al (2016) The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 127: 2375\u20132390","journal-title":"Blood"},{"key":"BFEMMM202216910_CR76","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S1097-2765(02)00522-1","volume":"9","author":"H Tanaka","year":"2002","unstructured":"Tanaka H, Matsumura I, Ezoe S, Satoh Y, Sakamaki T, Albanese C, Machii T, Pestell RG, Kanakura Y (2002) E2F1 and c\u2010Myc potentiate apoptosis through inhibition of NF\u2010kappaB activity that facilitates MnSOD\u2010mediated ROS elimination. Mol Cell 9: 1017\u20131029","journal-title":"Mol Cell"},{"key":"BFEMMM202216910_CR77","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1158\/1078-0432.CCR-15-2274","volume":"22","author":"K Tateishi","year":"2016","unstructured":"Tateishi K, Iafrate AJ, Ho Q, Curry WT, Batchelor TT, Flaherty KT, Onozato ML, Lelic N, Sundaram S, Cahill DP et\u00a0al (2016) Myc\u2010driven glycolysis is a therapeutic target in glioblastoma. Clin Cancer Res 22: 4452\u20134465","journal-title":"Clin Cancer Res"},{"key":"BFEMMM202216910_CR78","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tips.2020.11.014","volume":"42","author":"DKH Thng","year":"2021","unstructured":"Thng DKH, Toh TB, Chow EK (2021) Capitalizing on synthetic lethality of MYC to treat cancer in the digital age. Trends Pharmacol Sci 42: 166\u2013182","journal-title":"Trends Pharmacol Sci"},{"key":"BFEMMM202216910_CR79","volume":"12","author":"X Tian","year":"2021","unstructured":"Tian X, Zhang S, Zhou L, Seyhan AA, Hernandez Borrero L, Zhang Y, El\u2010Deiry WS (2021) Targeting the integrated stress response in cancer therapy. Front Pharmacol 12: 747837","journal-title":"Front Pharmacol"},{"key":"BFEMMM202216910_CR80","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.ccell.2016.03.008","volume":"29","author":"EC Townsend","year":"2016","unstructured":"Townsend EC, Murakami MA, Christodoulou A, Christie AL, Koster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC et\u00a0al (2016) The public repository of xenografts enables discovery and randomized phase II\u2010like trials in mice. Cancer Cell 29: 574\u2013586","journal-title":"Cancer Cell"},{"key":"BFEMMM202216910_CR81","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S1097-2765(02)00520-8","volume":"9","author":"O Vafa","year":"2002","unstructured":"Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, Wahl GM (2002) c\u2010Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene\u2010induced genetic instability. Mol Cell 9: 1031\u20131044","journal-title":"Mol Cell"},{"key":"BFEMMM202216910_CR82","doi-asserted-by":"crossref","first-page":"24980","DOI":"10.18632\/oncotarget.25166","volume":"9","author":"HV Vangapandu","year":"2018","unstructured":"Vangapandu HV, Alston B, Morse J, Ayres ML, Wierda WG, Keating MJ, Marszalek JR, Gandhi V (2018) Biological and metabolic effects of IACS\u2010010759, an OxPhos inhibitor, on chronic lymphocytic leukemia cells. Oncotarget 9: 24980\u201324991","journal-title":"Oncotarget"},{"key":"BFEMMM202216910_CR83","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210571","volume":"218","author":"R Vendramin","year":"2021","unstructured":"Vendramin R, Katopodi V, Cinque S, Konnova A, Knezevic Z, Adnane S, Verheyden Y, Karras P, Demesmaeker E, Bosisio FM et\u00a0al (2021) Activation of the integrated stress response confers vulnerability to mitoribosome\u2010targeting antibiotics in melanoma. J Exp Med 218: e20210571","journal-title":"J Exp Med"},{"key":"BFEMMM202216910_CR84","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00280-013-2070-8","volume":"71","author":"JL Welsh","year":"2013","unstructured":"Welsh JL, Wagner BA, van't Erve TJ, Zehr PS, Berg DJ, Halfdanarson TR, Yee NS, Bodeker KL, Du J, Roberts LJ II et\u00a0al (2013) Pharmacological ascorbate with gemcitabine for the control of metastatic and node\u2010positive pancreatic cancer (PACMAN): results from a phase I clinical trial. Cancer Chemother Pharmacol 71: 765\u2013775","journal-title":"Cancer Chemother Pharmacol"},{"key":"BFEMMM202216910_CR85","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.4049\/jimmunol.1201433","volume":"189","author":"ML Wheeler","year":"2012","unstructured":"Wheeler ML, Defranco AL (2012) Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation. J Immunol 189: 4405\u20134416","journal-title":"J Immunol"},{"key":"BFEMMM202216910_CR86","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202103090","volume":"220","author":"JR Whitfield","year":"2021","unstructured":"Whitfield JR, Soucek L (2021) The long journey to bring a Myc inhibitor to the clinic. J Cell Biol 220: e202103090","journal-title":"J Cell Biol"},{"key":"BFEMMM202216910_CR87","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0021-9258(18)64988-9","volume":"224","author":"AN Wick","year":"1957","unstructured":"Wick AN, Drury DR, Nakada HI, Wolfe JB (1957) Localization of the primary metabolic block produced by 2\u2010deoxyglucose. J Biol Chem 224: 963\u2013969","journal-title":"J Biol Chem"},{"key":"BFEMMM202216910_CR88","first-page":"43","volume":"1870","author":"AJ Wolpaw","year":"2018","unstructured":"Wolpaw AJ, Dang CV (2018) MYC\u2010induced metabolic stress and tumorigenesis. Biochim Biophys Acta 1870: 43\u201350","journal-title":"Biochim Biophys Acta"},{"key":"BFEMMM202216910_CR89","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ccell.2020.03.015","volume":"37","author":"GW Wright","year":"2020","unstructured":"Wright GW, Huang DW, Phelan JD, Coulibaly ZA, Roulland S, Young RM, Wang JQ, Schmitz R, Morin RD, Tang J et\u00a0al (2020) A probabilistic classification tool for genetic subtypes of diffuse large B cell lymphoma with therapeutic implications. Cancer Cell 37: 551\u2013568","journal-title":"Cancer Cell"},{"key":"BFEMMM202216910_CR90","doi-asserted-by":"crossref","first-page":"14276","DOI":"10.1021\/acs.jmedchem.0c01013","volume":"63","author":"Y Xu","year":"2020","unstructured":"Xu Y, Xue D, Bankhead A III, Neamati N (2020) Why all the fuss about oxidative phosphorylation (OXPHOS)? J Med Chem 63: 14276\u201314307","journal-title":"J Med Chem"},{"key":"BFEMMM202216910_CR91","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41591-022-02103-8","volume":"29","author":"TA Yap","year":"2023","unstructured":"Yap TA, Daver N, Mahendra M, Zhang J, Kamiya\u2010Matsuoka C, Meric\u2010Bernstam F, Kantarjian HM, Ravandi F, Collins ME, Francesco MED et\u00a0al (2023) Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials. Nat Med 29: 115\u2013126","journal-title":"Nat Med"},{"key":"BFEMMM202216910_CR92","volume":"11","author":"L Zhang","year":"2019","unstructured":"Zhang L, Yao Y, Zhang S, Liu Y, Guo H, Ahmed M, Bell T, Zhang H, Han G, Lorence E et\u00a0al (2019) Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma. Sci Transl Med 11: eaau1167","journal-title":"Sci Transl Med"},{"key":"BFEMMM202216910_CR93","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0891-5849(03)00142-4","volume":"34","author":"H Zhao","year":"2003","unstructured":"Zhao H, Kalivendi S, Zhang H, Joseph J, Nithipatikom K, Vasquez\u2010Vivar J, Kalyanaraman B (2003) Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide. Free Radic Biol Med 34: 1359\u20131368","journal-title":"Free Radic Biol Med"},{"key":"BFEMMM202216910_CR94","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13045-022-01249-9","volume":"15","author":"Y Zhuang","year":"2022","unstructured":"Zhuang Y, Che J, Wu M, Guo Y, Xu Y, Dong X, Yang H (2022) Altered pathways and targeted therapy in double hit lymphoma. J Hematol Oncol 15: 26","journal-title":"J Hematol Oncol"}],"container-title":["EMBO Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202216910.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/emmm.202216910\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/emmm.202216910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202216910.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:44:19Z","timestamp":1779086659000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/emmm.202216910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,9]]},"references-count":93,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6,7]]}},"alternative-id":["BFEMMM202216910"],"URL":"https:\/\/doi.org\/10.15252\/emmm.202216910","relation":{},"ISSN":["1757-4676","1757-4684"],"issn-type":[{"value":"1757-4676","type":"print"},{"value":"1757-4684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,9]]},"assertion":[{"value":"19 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"EMMM202216910"}}