{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:31:14Z","timestamp":1790713874101,"version":"4.1.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2023,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Malaria remains a huge burden on global public health. Annually there are more than 200 million cases with\u2009&gt;\u2009600,000 deaths worldwide, the vast majority of which occur within Sub\u2010Saharan Africa (WHO; World Malaria Report, 2021). Malaria disease is the consequence of infection by a protozoan parasite from the genus\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    with most morbidity and mortality caused by\n                    <jats:italic>P. falciparum.<\/jats:italic>\n                    With rates of infection plateauing and rebounding in some areas (in particular, as a result of the disruption caused by the COVID\u201019 pandemic), there have been increasing calls for new initiatives that can reduce malaria incidence towards local elimination or the hoped for goal of global eradication. In 2021, the World Health Organisation approved the first malaria vaccine RTS,S\/AS01 (also called Mosquirix\u2122), indicating it to be safe for use in young children and advocating its integration into routine immunisation programmes. Approval of this vaccine clearly represents a major landmark in global efforts towards malaria control and eradication aspirations. RTS,S modest efficacy, however, points at the need to better understand immune responses to the parasite if we hope to design next generation malaria vaccines with increased potency.\n                  <\/jats:p>","DOI":"10.15252\/emmm.202317556","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T03:14:33Z","timestamp":1682046873000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A sting in the tail\u2014are antibodies against the C\u2010terminus of Plasmodium falciparum circumsporozoite protein protective?"],"prefix":"10.1038","volume":"15","author":[{"given":"Jem","family":"Murdoch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0275-352X","authenticated-orcid":false,"given":"Jake","family":"Baum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"BFEMMM202317556_CR1","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abo6646","volume":"14","author":"JG Beeson","year":"2022","unstructured":"Beeson JG, Kurtovic L, Valim C, Asante KP, Boyle MJ, Mathanga D, Dobano C, Moncunill G (2022) The RTS,S malaria vaccine: current impact and foundation for the future. Sci Transl Med 14: eabo6646","journal-title":"Sci Transl Med"},{"key":"BFEMMM202317556_CR2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010409","volume":"18","author":"N Beutler","year":"2022","unstructured":"Beutler N, Pholcharee T, Oyen D, Flores\u2010Garcia Y, MacGill RS, Garcia E, Calla J, Parren M, Yang L, Volkmuth W et\u00a0al (2022) A novel CSP C\u2010terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum. PLoS Pathog 18: e1010409","journal-title":"PLoS Pathog"},{"key":"BFEMMM202317556_CR3","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108996","volume":"35","author":"D Chatterjee","year":"2021","unstructured":"Chatterjee D, Lewis FJ, Sutton HJ, Kaczmarski JA, Gao X, Cai Y, McNamara HA, Jackson CJ, Cockburn IA (2021) Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes. 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Proc Natl Acad Sci U S A 85: 1199\u20131203","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFEMMM202317556_CR7","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41541-022-00510-z","volume":"7","author":"B Mordm\u00fcller","year":"2022","unstructured":"Mordm\u00fcller B, Sulyok Z, Sulyok M, Molnar Z, Lalremruata A, Calle CL, Bayon PG, Eses M, Gmeiner M, Held J et\u00a0al (2022) A PfSPZ vaccine immunization regimen equally protective against homologous and heterologous controlled human malaria infection. NPJ Vaccines 7: 100","journal-title":"NPJ Vaccines"},{"key":"BFEMMM202317556_CR8","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202317454","volume":"15","author":"OE Oludada","year":"2023","unstructured":"Oludada OE, Costa G, Aschner CB, Obraztsova AS, Prieto K, Canetta C, Hoffman SL, Kremsner PG, Mordm\u00fcller B, Murugan R et\u00a0al (2023) Molecular and functional properties of human plasmodium falciparum CSP C\u2010terminus antibodies. EMBO Mol Med 15: e17454","journal-title":"EMBO Mol Med"},{"key":"BFEMMM202317556_CR9","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0140-6736(15)00725-4","volume":"387","author":"MA Penny","year":"2016","unstructured":"Penny MA, Verity R, Bever CA, Sauboin C, Galactionova K, Flasche S, White MT, Wenger EA, van den Velde N, Pemberton\u2010Ross P et\u00a0al (2016) Public health impact and cost\u2010effectiveness of the RTS,S\/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models. 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