{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:08:51Z","timestamp":1791673731202,"version":"4.3.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jiangsu Biobank of Clinical Resources","award":["BM2015004"],"award-info":[{"award-number":["BM2015004"]}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071600"],"award-info":[{"award-number":["82071600"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171618"],"award-info":[{"award-number":["82171618"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971336"],"award-info":[{"award-number":["81971336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Key Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82030040"],"award-info":[{"award-number":["82030040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2021YFC2701603"],"award-info":[{"award-number":["2021YFC2701603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDA16040300"],"award-info":[{"award-number":["XDA16040300"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2023,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Macrophages are a key and heterogeneous cell population involved in endometrial repair and regeneration during the menstrual cycle, but their role in the development of intrauterine adhesion (IUA) and sequential endometrial fibrosis remains unclear. Here, we reported that CD301\n                    <jats:sup>+<\/jats:sup>\n                    macrophages were significantly increased and showed their most active interaction with profibrotic cells in the endometria of IUA patients compared with the normal endometria by single\u2010cell RNA sequencing, bulk RNA sequencing, and experimental verification. Increasing CD301\n                    <jats:sup>+<\/jats:sup>\n                    macrophages promoted the differentiation of endometrial stromal cells into myofibroblasts and resulted in extracellular matrix accumulation, which destroyed the physiological architecture of endometrial tissue, drove endometrial fibrosis, and ultimately led to female infertility or adverse pregnancy outcomes. Mechanistically, CD301\n                    <jats:sup>+<\/jats:sup>\n                    macrophages secreted GAS6 to activate the AXL\/NF\u2010\u03baB pathway, upregulating the profibrotic protein synthesis. Targeted deletion of CD301\n                    <jats:sup>+<\/jats:sup>\n                    macrophages or inhibition of AXL by\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.medchemexpress.cn\/R428.html\" ext-link-type=\"uri\">Bemcentinib<\/jats:ext-link>\n                    blunted the pathology and improved the outcomes of pregnancy in mice, supporting the therapeutic potential of targeting CD301\n                    <jats:sup>+<\/jats:sup>\n                    macrophages for treating endometrial fibrosis.\n                  <\/jats:p>","DOI":"10.15252\/emmm.202317601","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T03:46:14Z","timestamp":1690775174000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Targeting CD301+ macrophages inhibits endometrial fibrosis and improves pregnancy outcome"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0365-8305","authenticated-orcid":false,"given":"Haining","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2924-9232","authenticated-orcid":false,"given":"Zhongrui","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3379-9053","authenticated-orcid":false,"given":"Jianwu","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guijun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenrui","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4604-6971","authenticated-orcid":false,"given":"Guangfeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5475-7840","authenticated-orcid":false,"given":"Yali","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"BFEMMM202317601_CR1","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S0015-0282(16)59942-7","volume":"49","author":"American Fertility Society","year":"1988","unstructured":"American Fertility Society (1988) The American Fertility Society classifications of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, m\u00fcllerian anomalies and intrauterine adhesions. Fertil Steril 49: 944\u2013955","journal-title":"Fertil Steril"},{"key":"BFEMMM202317601_CR2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41586-019-1456-0","volume":"572","author":"AA Barkal","year":"2019","unstructured":"Barkal AA, Brewer RE, Markovic M, Kowarsky M, Barkal SA, Zaro BW, Krishnan V, Hatakeyama J, Dorigo O, Barkal LJ et\u00a0al (2019) CD24 signalling through macrophage Siglec\u201010 is a target for cancer immunotherapy. Nature 572: 392\u2013396","journal-title":"Nature"},{"key":"BFEMMM202317601_CR3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s10006-020-00851-w","volume":"24","author":"CV Bumm","year":"2020","unstructured":"Bumm CV, Folwaczny M, W\u00f6lfle UC (2020) Necrotizing periodontitis or medication\u2010related osteonecrosis of the jaw (MRONJ) in a patient receiving Bemcentinib\u2010a case report. Oral Maxillofac Surg 24: 353\u2013358","journal-title":"Oral Maxillofac Surg"},{"key":"BFEMMM202317601_CR4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler A, Hoffman P, Smibert P, Papalexi E, Satija R (2018) Integrating single\u2010cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol 36: 411\u2013420","journal-title":"Nat Biotechnol"},{"key":"BFEMMM202317601_CR5","doi-asserted-by":"crossref","first-page":"9110","DOI":"10.1200\/JCO.2021.39.15_suppl.9110","volume":"39","author":"LA Byers","year":"2021","unstructured":"Byers LA, Gold KA, Peguero JA, Johnson ML, Nieva JJ, Harb WA, Chiappori A, Rybkin II, Strauss JF, Gerber DE (2021) Ph I\/II study of oral selective AXL inhibitor bemcentinib (BGB324) in combination with erlotinib in patients with advanced EGFRm NSCLC: end of trial update. J Clin Oncol 39: 9110\u20139110","journal-title":"J Clin Oncol"},{"key":"BFEMMM202317601_CR6","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s13287-018-0904-3","volume":"9","author":"Y Cao","year":"2018","unstructured":"Cao Y, Sun H, Zhu H, Zhu X, Tang X, Yan G, Wang J, Bai D, Wang J, Wang L et\u00a0al (2018) Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion: a phase I clinical trial. Stem Cell Res Ther 9: 192","journal-title":"Stem Cell Res Ther"},{"key":"BFEMMM202317601_CR7","doi-asserted-by":"crossref","first-page":"6432","DOI":"10.1126\/science.aau0964","volume":"363","author":"S Chakarov","year":"2019","unstructured":"Chakarov S, Lim HY, Tan L, Lim SY, See P, Lum J, Zhang XM, Foo S, Nakamizo S, Duan K et\u00a0al (2019) Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches. Science 363: 6432","journal-title":"Science"},{"key":"BFEMMM202317601_CR8","volume":"8","author":"S Chen","year":"2017","unstructured":"Chen S, Jiang S, Zheng W, Tu B, Liu S, Ruan H, Fan C (2017) RelA\/p65 inhibition prevents tendon adhesion by modulating inflammation, cell proliferation, and apoptosis. Cell Death Dis 8: e2710","journal-title":"Cell Death Dis"},{"key":"BFEMMM202317601_CR9","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/mrd.23523","volume":"88","author":"L de Miguel\u2010G\u00f3mez","year":"2021","unstructured":"de Miguel\u2010G\u00f3mez L, Romeu M, Pellicer A, Cervell\u00f3 I (2021) Strategies for managing asherman's syndrome and endometrial atrophy: since the classical experimental models to the new bioengineering approach. Mol Reprod Dev 88: 527\u2013543","journal-title":"Mol Reprod Dev"},{"key":"BFEMMM202317601_CR10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.immuni.2019.06.010","volume":"51","author":"JF Deniset","year":"2019","unstructured":"Deniset JF, Belke D, Lee WY, Jorch SK, Deppermann C, Hassanabad AF, Turnbull JD, Teng G, Rozich I, Hudspeth K et\u00a0al (2019) Gata6+ pericardial cavity macrophages relocate to the injured heart and prevent cardiac fibrosis. Immunity 51: 131\u2013140","journal-title":"Immunity"},{"key":"BFEMMM202317601_CR11","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s00204-014-1428-y","volume":"89","author":"J Dong","year":"2015","unstructured":"Dong J, Porter DW, Batteli LA, Wolfarth MG, Richardson DL, Ma Q (2015) Pathologic and molecular profiling of rapid\u2010onset fibrosis and inflammation induced by multi\u2010walled carbon nanotubes. Arch Toxicol 89: 621\u2013633","journal-title":"Arch Toxicol"},{"key":"BFEMMM202317601_CR12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/dvdy.24100","volume":"243","author":"LE Dupuis","year":"2014","unstructured":"Dupuis LE, Kern CB (2014) Small leucine\u2010rich proteoglycans exhibit unique spatiotemporal expression profiles during cardiac valve development. Dev Dyn 243: 601\u2013611","journal-title":"Dev Dyn"},{"key":"BFEMMM202317601_CR13","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41596-020-0292-x","volume":"15","author":"M Efremova","year":"2020","unstructured":"Efremova M, Vento\u2010Tormo M, Teichmann SA, Vento\u2010Tormo R (2020) CellPhoneDB: inferring cell\u2010cell communication from combined expression of multi\u2010subunit ligand\u2010receptor complexes. Nat Protoc 15: 1484\u20131506","journal-title":"Nat Protoc"},{"key":"BFEMMM202317601_CR14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrneph.2014.246","volume":"11","author":"LL Falke","year":"2015","unstructured":"Falke LL, Gholizadeh S, Goldschmeding R, Kok RJ, Nguyen TQ (2015) Diverse origins of the myofibroblast\u2014implications for kidney fibrosis. Nat Rev Nephrol 11: 233\u2013244","journal-title":"Nat Rev Nephrol"},{"key":"BFEMMM202317601_CR15","volume":"10","author":"Z Fang","year":"2022","unstructured":"Fang Z, Tian Y, Sui C, Guo Y, Hu X, Lai Y, Liao Z, Li J, Feng G, Jin L et\u00a0al (2022) Single\u2010cell transcriptomics of proliferative phase endometrium: systems analysis of cell\u2010cell communication network using CellChat. Front Cell Dev Biol 10: 919731","journal-title":"Front Cell Dev Biol"},{"key":"BFEMMM202317601_CR16","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.fertnstert.2021.06.037","volume":"116","author":"MF Freedman","year":"2021","unstructured":"Freedman MF, Schlaff WD (2021) Avoiding Asherman's syndrome: refining our approach to uterine evacuation. Fertil Steril 116: 961\u2013962","journal-title":"Fertil Steril"},{"key":"BFEMMM202317601_CR17","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/CIRCULATIONAHA.118.034165","volume":"139","author":"VC Ganta","year":"2019","unstructured":"Ganta VC, Choi M, Farber CR, Annex BH (2019) Antiangiogenic VEGF165b regulates macrophage polarization via S100A8\/S100A9 in peripheral artery disease. Circulation 139: 226\u2013242","journal-title":"Circulation"},{"key":"BFEMMM202317601_CR18","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1471-0528.2010.02630.x","volume":"117","author":"R Garry","year":"2010","unstructured":"Garry R, Hart R, Karthigasu KA, Burke C (2010) Structural changes in endometrial basal glands during menstruation. BJOG 117: 1175\u20131185","journal-title":"BJOG"},{"key":"BFEMMM202317601_CR19","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.fertnstert.2015.08.039","volume":"104","author":"MM Hanstede","year":"2015","unstructured":"Hanstede MM, van der Meij E, Goedemans L, Emanuel MH (2015) Results of centralized Asherman surgery, 2003\u20132013. Fertil Steril 104: 1561\u20131568","journal-title":"Fertil Steril"},{"key":"BFEMMM202317601_CR20","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2013776118","volume":"118","author":"C Hogg","year":"2021","unstructured":"Hogg C, Panir K, Dhami P, Rosser M, Mack M, Soong D, Pollard JW, Jenkins SJ, Horne AW, Greaves E (2021) Macrophages inhibit and enhance endometriosis depending on their origin. Proc Natl Acad Sci USA 118: e2013776118","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM202317601_CR21","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1158\/0008-5472.CAN-09-2997","volume":"70","author":"SJ Holland","year":"2010","unstructured":"Holland SJ, Pan A, Franci C, Hu Y, Chang B, Li W, Duan M, Torneros A, Yu J, Heckrodt TJ et\u00a0al (2010) R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res 70: 1544\u20131554","journal-title":"Cancer Res"},{"key":"BFEMMM202317601_CR22","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1600-0897.2012.01181.x","volume":"68","author":"AL Jensen","year":"2012","unstructured":"Jensen AL, Collins J, Shipman EP, Wira CR, Guyre PM, Pioli PA (2012) A subset of human uterine endometrial macrophages is alternatively activated. Am J Reprod Immunol 68: 374\u2013386","journal-title":"Am J Reprod Immunol"},{"key":"BFEMMM202317601_CR23","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1007\/s11427-018-9520-2","volume":"62","author":"P Jiang","year":"2019","unstructured":"Jiang P, Tang X, Wang H, Dai C, Su J, Zhu H, Song M, Liu J, Nan Z, Ru T et\u00a0al (2019) Collagen\u2010binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study. Sci China Life Sci 62: 1617\u20131629","journal-title":"Sci China Life Sci"},{"key":"BFEMMM202317601_CR24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1172\/JCI85610","volume":"127","author":"MS Kariolis","year":"2017","unstructured":"Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS II, Kapur S, Mathews II, Koong AC et\u00a0al (2017) Inhibition of the GAS6\/AXL pathway augments the efficacy of chemotherapies. J Clin Invest 127: 183\u2013198","journal-title":"J Clin Invest"},{"key":"BFEMMM202317601_CR25","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002123R","volume":"35","author":"PM Kirkwood","year":"2021","unstructured":"Kirkwood PM, Gibson DA, Smith JR, Wilson\u2010Kanamori JR, Kelepouri O, Esnal\u2010Zufiaurre A, Dobie R, Henderson NC, Saunders P (2021) Single\u2010cell RNA sequencing redefines the mesenchymal cell landscape of mouse endometrium. FASEB J 35: e21285","journal-title":"FASEB J"},{"key":"BFEMMM202317601_CR26","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.immuni.2013.08.029","volume":"39","author":"Y Kumamoto","year":"2013","unstructured":"Kumamoto Y, Linehan M, Weinstein JS, Laidlaw BJ, Craft JE, Iwasaki A (2013) CD301b+ dermal dendritic cells drive T helper 2 cell\u2010mediated immunity. Immunity 39: 733\u2013743","journal-title":"Immunity"},{"key":"BFEMMM202317601_CR27","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.immuni.2016.08.002","volume":"45","author":"Y Kumamoto","year":"2016","unstructured":"Kumamoto Y, Camporez J, Jurczak MJ, Shanabrough M, Horvath T, Shulman GI, Iwasaki A (2016) CD301b(+) mononuclear phagocytes maintain positive energy balance through secretion of resistin\u2010like molecule alpha. Immunity 45: 583\u2013596","journal-title":"Immunity"},{"key":"BFEMMM202317601_CR28","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001651","volume":"1","author":"T Lawrence","year":"2009","unstructured":"Lawrence T (2009) The nuclear factor NF\u2010kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1: a001651","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"BFEMMM202317601_CR29","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1124\/jpet.110.178046","volume":"337","author":"HR Lijnen","year":"2011","unstructured":"Lijnen HR, Christiaens V, Scroyen L (2011) Growth arrest\u2010specific protein 6 receptor antagonism impairs adipocyte differentiation and adipose tissue development in mice. J Pharmacol Exp Ther 337: 457\u2013464","journal-title":"J Pharmacol Exp Ther"},{"key":"BFEMMM202317601_CR30","volume":"83","author":"D Liu","year":"2020","unstructured":"Liu D, Wang J, Zhao G, Jiang P, Song M, Ding H, Wang Z, Lv H, Hu Y (2020a) CSF1\u2010associated decrease in endometrial macrophages may contribute to Asherman's syndrome. Am J Reprod Immunol 83: e13191","journal-title":"Am J Reprod Immunol"},{"key":"BFEMMM202317601_CR31","volume":"125","author":"J Liu","year":"2020","unstructured":"Liu J, Ying Y, Wang S, Li J, Xu J, Lv P, Chen J, Zhou C, Liu Y, Wu Y et\u00a0al (2020b) The effects and mechanisms of GM\u2010CSF on endometrial regeneration. Cytokine 125: 154850","journal-title":"Cytokine"},{"key":"BFEMMM202317601_CR32","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1016\/j.immuni.2021.09.009","volume":"54","author":"SS Liu","year":"2021","unstructured":"Liu SS, Liu C, Lv XX, Cui B, Yan J, Li YX, Li K, Hua F, Zhang XW, Yu JJ et\u00a0al (2021) The chemokine CCL1 triggers an AMFR\u2010SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis. Immunity 54: 2433\u20132435","journal-title":"Immunity"},{"key":"BFEMMM202317601_CR33","doi-asserted-by":"crossref","first-page":"7043","DOI":"10.1200\/JCO.2019.37.15_suppl.7043","volume":"37","author":"S Loges","year":"2019","unstructured":"Loges S, Heuser M, Chromik J, Vigil CE, Paschka P, Francesca RE, Renzo ND, Lemoli R, Mattei D, Batalla IB et\u00a0al. (2019) First-in class selective AXL inhibitor bemcentinib (BGB324) in combination with LDAC or decitabine exerts anti-leukaemic activity in AML patients unfit for intensive chemotherapy: phase II open-label study. J Clin Oncol 37: 7043\u20137043","journal-title":"J Clin Oncol"},{"key":"BFEMMM202317601_CR34","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41419-019-1928-z","volume":"10","author":"H Lv","year":"2019","unstructured":"Lv H, Nan Z, Jiang P, Wang Z, Song M, Ding H, Liu D, Zhao G, Zheng Y, Hu Y (2019) Vascular endothelial growth factor 165 inhibits pro\u2010fibrotic differentiation of stromal cells via the DLL4\/Notch4\/smad7 pathway. Cell Death Dis 10: 681","journal-title":"Cell Death Dis"},{"key":"BFEMMM202317601_CR35","volume":"119","author":"H Lv","year":"2022","unstructured":"Lv H, Zhao G, Jiang P, Wang H, Wang Z, Yao S, Zhou Z, Wang L, Liu D, Deng W et\u00a0al (2022) Deciphering the endometrial niche of human thin endometrium at single\u2010cell resolution. Proc Natl Acad Sci USA 119: e2115912119","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM202317601_CR36","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1161\/CIRCULATIONAHA.117.033144","volume":"137","author":"LA Meier","year":"2018","unstructured":"Meier LA, Auger JL, Engelson BJ, Cowan HM, Breed ER, Gonzalez\u2010Torres MI, Boyer JD, Verma M, Marath A, Binstadt BA (2018) CD301b\/MGL2+ mononuclear phagocytes orchestrate autoimmune cardiac valve inflammation and fibrosis. Circulation 137: 2478\u20132493","journal-title":"Circulation"},{"key":"BFEMMM202317601_CR37","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/hep.26068","volume":"57","author":"A Moles","year":"2013","unstructured":"Moles A, Sanchez AM, Banks PS, Murphy LB, Luli S, Borthwick L, Fisher A, O'Reilly S, van Laar JM, White SA et\u00a0al (2013) Inhibition of RelA\u2010Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response. Hepatology 57: 817\u2013828","journal-title":"Hepatology"},{"key":"BFEMMM202317601_CR38","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.kint.2021.05.036","volume":"100","author":"K M\u00f6ller\u2010Hackbarth","year":"2021","unstructured":"M\u00f6ller\u2010Hackbarth K, Dabaghie D, Charrin E, Zambrano S, Genov\u00e9 G, Li X, Wernerson A, Lal M, Patrakka J (2021) Retinoic acid receptor responder1 promotes development of glomerular diseases via the Nuclear Factor\u2010\u03baB signaling pathway. Kidney Int 100: 809\u2013823","journal-title":"Kidney Int"},{"key":"BFEMMM202317601_CR39","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1158\/0008-5472.CAN-15-1260","volume":"76","author":"C Ning","year":"2016","unstructured":"Ning C, Xie B, Zhang L, Li C, Shan W, Yang B, Luo X, Gu C, He Q, Jin H et\u00a0al (2016) Infiltrating macrophages induce ER\u03b1 expression through an IL17A\u2010mediated epigenetic mechanism to sensitize endometrial cancer cells to estrogen. Cancer Res 76: 1354\u20131366","journal-title":"Cancer Res"},{"key":"BFEMMM202317601_CR40","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1053\/j.gastro.2009.02.081","volume":"136","author":"F Oakley","year":"2009","unstructured":"Oakley F, Teoh V, Ching\u2010A\u2010Sue G, Bataller R, Colmenero J, Jonsson JR, Eliopoulos AG, Watson MR, Manas D, Mann DA (2009) Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. Gastroenterology 136: 2334\u20132344","journal-title":"Gastroenterology"},{"key":"BFEMMM202317601_CR41","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1073\/pnas.1507387112","volume":"112","author":"D Pilling","year":"2015","unstructured":"Pilling D, Vakil V, Cox N, Gomer RH (2015) TNF\u2010\u03b1\u2010stimulated fibroblasts secrete lumican to promote fibrocyte differentiation. Proc Natl Acad Sci USA 112: 11929\u201311934","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFEMMM202317601_CR42","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41586-019-1631-3","volume":"575","author":"P Ramachandran","year":"2019","unstructured":"Ramachandran P, Dobie R, Wilson\u2010Kanamori JR, Dora EF, Henderson B, Luu NT, Portman JR, Matchett KP, Brice M, Marwick JA et\u00a0al (2019) Resolving the fibrotic niche of human liver cirrhosis at single\u2010cell level. Nature 575: 512\u2013518","journal-title":"Nature"},{"key":"BFEMMM202317601_CR43","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/eurheartj\/ehy188","volume":"40","author":"P Rodriguez","year":"2019","unstructured":"Rodriguez P, Sassi Y, Troncone L, Benard L, Ishikawa K, Gordon RE, Lamas S, Laborda J, Hajjar RJ, Lebeche D (2019) Deletion of delta\u2010like 1 homologue accelerates fibroblast\u2010myofibroblast differentiation and induces myocardial fibrosis. Eur Heart J 40: 967\u2013978","journal-title":"Eur Heart J"},{"key":"BFEMMM202317601_CR44","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.fertnstert.2018.10.024","volume":"110","author":"X Santamaria","year":"2018","unstructured":"Santamaria X (2018) Is hyaluronic acid really ineffective. Fertil Steril 110: 1253\u20131254","journal-title":"Fertil Steril"},{"key":"BFEMMM202317601_CR45","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.jid.2016.05.107","volume":"136","author":"B Shook","year":"2016","unstructured":"Shook B, Xiao E, Kumamoto Y, Iwasaki A, Horsley V (2016) CD301b+ macrophages are essential for effective skin wound healing. J Invest Dermatol 136: 1885\u20131891","journal-title":"J Invest Dermatol"},{"key":"BFEMMM202317601_CR46","doi-asserted-by":"crossref","DOI":"10.1126\/science.aar2971","volume":"362","author":"BA Shook","year":"2018","unstructured":"Shook BA, Wasko RR, Rivera\u2010Gonzalez GC, Salazar\u2010Gatzimas E, L\u00f3pez\u2010Gir\u00e1ldez F, Dash BC, Mu\u00f1oz\u2010Rojas AR, Aultman KD, Zwick RK, Lei V et\u00a0al (2018) Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair. Science 362: eaar2971","journal-title":"Science"},{"key":"BFEMMM202317601_CR47","volume":"10","author":"M Song","year":"2021","unstructured":"Song M, Zhao G, Sun H, Yao S, Zhou Z, Jiang P, Wu Q, Zhu H, Wang H, Dai C et\u00a0al (2021) circPTPN12\/miR\u201021\u20105 p\/\u2206Np63\u03b1 pathway contributes to human endometrial fibrosis. Elife 10: e65735","journal-title":"Elife"},{"key":"BFEMMM202317601_CR48","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41581-019-0234-4","volume":"16","author":"S Tang","year":"2020","unstructured":"Tang S, Yiu WH (2020) Innate immunity in diabetic kidney disease. Nat Rev Nephrol 16: 206\u2013222","journal-title":"Nat Rev Nephrol"},{"key":"BFEMMM202317601_CR49","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1189\/jlb.0712327","volume":"93","author":"U Thiruchelvam","year":"2013","unstructured":"Thiruchelvam U, Dransfield I, Saunders PT, Critchley HO (2013) The importance of the macrophage within the human endometrium. J Leukoc Biol 93: 217\u2013225","journal-title":"J Leukoc Biol"},{"key":"BFEMMM202317601_CR50","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1136\/annrheumdis-2018-214865","volume":"78","author":"E Valenzi","year":"2019","unstructured":"Valenzi E, Bulik M, Tabib T, Morse C, Sembrat J, Trejo Bittar H, Rojas M, Lafyatis R (2019) Single\u2010cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis\u2010associated interstitial lung disease. Ann Rheum Dis 78: 1379\u20131387","journal-title":"Ann Rheum Dis"},{"key":"BFEMMM202317601_CR51","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.1038\/s41467-021-26495-2","volume":"12","author":"V Vorstandlechner","year":"2021","unstructured":"Vorstandlechner V, Laggner M, Copic D, Klas K, Direder M, Chen Y, Golabi B, Haslik W, Radtke C, Tschachler E et\u00a0al (2021) The serine proteases dipeptidyl\u2010peptidase 4 and urokinase are key molecules in human and mouse scar formation. Nat Commun 12: 6242","journal-title":"Nat Commun"},{"key":"BFEMMM202317601_CR52","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/s41591-020-1040-z","volume":"26","author":"W Wang","year":"2020","unstructured":"Wang W, Vilella F, Alama P, Moreno I, Mignardi M, Isakova A, Pan W, Simon C, Quake SR (2020) Single\u2010cell transcriptomic atlas of the human endometrium during the menstrual cycle. Nat Med 26: 1644\u20131653","journal-title":"Nat Med"},{"key":"BFEMMM202317601_CR53","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1165\/rcmb.2020-0303OC","volume":"64","author":"DC Yang","year":"2021","unstructured":"Yang DC, Gu S, Li JM, Hsu SW, Chen SJ, Chang WH, Chen CH (2021a) Targeting the AXL receptor in combating smoking\u2010related pulmonary fibrosis. Am J Respir Cell Mol Biol 64: 734\u2013746","journal-title":"Am J Respir Cell Mol Biol"},{"key":"BFEMMM202317601_CR54","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1002\/hep.31987","volume":"74","author":"W Yang","year":"2021","unstructured":"Yang W, He H, Wang T, Su N, Zhang F, Jiang K, Zhu J, Zhang C, Niu K, Wang L et\u00a0al (2021b) Single\u2010cell transcriptomic analysis reveals a hepatic stellate cell\u2010activation roadmap and myofibroblast origin during liver fibrosis in mice. Hepatology 74: 2774\u20132790","journal-title":"Hepatology"},{"key":"BFEMMM202317601_CR55","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2018.36.5_suppl.TPS43","volume":"36","author":"M Yule","year":"2018","unstructured":"Yule M, Davidsen K, Bloe M, Hodneland L, Engelsen A, Lie M, Bougnaud S, D'Mello S, Aguilera K, Ahmed L et\u00a0al (2018) Combination of bemcentinib (BGB324): a first\u2010in\u2010class selective oral AXL inhibitor, with pembrolizumab in patients with triple negative breast cancer and adenocarcinoma of the lung. J Clin Oncol 36: TPS43","journal-title":"J Clin Oncol"},{"key":"BFEMMM202317601_CR56","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s11427-016-0328-y","volume":"60","author":"G Zhao","year":"2017","unstructured":"Zhao G, Cao Y, Zhu X, Tang X, Ding L, Sun H, Li J, Li X, Dai C, Ru T et\u00a0al (2017) Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating \u0394Np63 expression in Asherman's syndrome. Sci China Life Sci 60: 404\u2013416","journal-title":"Sci China Life Sci"},{"key":"BFEMMM202317601_CR57","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41419-020-2666-y","volume":"11","author":"G Zhao","year":"2020","unstructured":"Zhao G, Li R, Cao Y, Song M, Jiang P, Wu Q, Zhou Z, Zhu H, Wang H, Dai C et\u00a0al (2020) \u0394Np63\u03b1\u2010induced DUSP4\/GSK3\u03b2\/SNAI1 pathway in epithelial cells drives endometrial fibrosis. Cell Death Dis 11: 449","journal-title":"Cell Death Dis"},{"key":"BFEMMM202317601_CR58","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/humrep\/dez001","volume":"34","author":"H Zhu","year":"2019","unstructured":"Zhu H, Pan Y, Jiang Y, Li J, Zhang Y, Zhang S (2019) Activation of the Hippo\/TAZ pathway is required for menstrual stem cells to suppress myofibroblast and inhibit transforming growth factor \u03b2 signaling in human endometrial stromal cells. Hum Reprod 34: 635\u2013645","journal-title":"Hum Reprod"},{"key":"BFEMMM202317601_CR59","first-page":"145","volume":"36","author":"X Zhu","year":"2021","unstructured":"Zhu X, Yu F, Yan G, Hu Y, Sun H, Ding L (2021) Human endometrial perivascular stem cells exhibit a limited potential to regenerate endometrium after xenotransplantation. Hum Reprod 36: 145\u2013159","journal-title":"Hum Reprod"},{"key":"BFEMMM202317601_CR60","doi-asserted-by":"crossref","DOI":"10.1126\/science.abe0595","volume":"371","author":"J Zindel","year":"2021","unstructured":"Zindel J, Peiseler M, Hossain M, Deppermann C, Lee WY, Haenni B, Zuber B, Deniset JF, Surewaard B, Candinas D et\u00a0al (2021) Primordial GATA6 macrophages function as extravascular platelets in sterile injury. Science 371: eabe0595","journal-title":"Science"}],"container-title":["EMBO Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202317601.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.15252\/emmm.202317601\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/emmm.202317601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.15252\/emmm.202317601.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:45:27Z","timestamp":1779086727000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.15252\/emmm.202317601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":60,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9,11]]}},"alternative-id":["BFEMMM202317601"],"URL":"https:\/\/doi.org\/10.15252\/emmm.202317601","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.06.09.544336","asserted-by":"object"}]},"ISSN":["1757-4676","1757-4684"],"issn-type":[{"value":"1757-4676","type":"print"},{"value":"1757-4684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,31]]},"assertion":[{"value":"20 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"EMMM202317601"}}