{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:45:54Z","timestamp":1785426354892,"version":"3.56.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Alexander Jansons Myocarditis UK"},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/CRTF\/23\/24448"],"award-info":[{"award-number":["FS\/CRTF\/23\/24448"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/CRTF\/23\/24444"],"award-info":[{"award-number":["FS\/CRTF\/23\/24444"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"British Society of Heart Failure"},{"name":"British Heart Foundation and Deutsches Zentrum f\u00fcr Herz\u2010Kreislauf\u2010Forschung","award":["SP\/19\/1\/34461"],"award-info":[{"award-number":["SP\/19\/1\/34461"]}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"crossref","award":["2019\u2010202666"],"award-info":[{"award-number":["2019\u2010202666"]}],"id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"crossref","award":["2021\u2010237882"],"award-info":[{"award-number":["2021\u2010237882"]}],"id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2023,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Idiopathic inflammatory myopathies (IIM), also referred to as \u201cmyositis,\u201d are a group of heterogeneous autoimmune disorders characterised by muscle weakness, atrophy and progressive reduced mobility (Lundberg\n                    <jats:italic>et\u00a0al<\/jats:italic>\n                    , 2021). IIM represent a significant health burden in adult populations, affecting individuals at a mean age\u00a0of 50 with an estimated prevalence of 2.9\u201334 per 100,000 (Dobloug\n                    <jats:italic>et\u00a0al<\/jats:italic>\n                    , 2015; Svensson\n                    <jats:italic>et\u00a0al<\/jats:italic>\n                    , 2017). IIM encompass several subtypes including dermatomyositis, immune\u2010mediated necrotising myopathy, inclusion\u2010body myositis, antisynthetase syndrome and polymyositis, which are characterised by specific clinical features, histopathological findings and autoantibody status (Pinal\u2010Fernandez\n                    <jats:italic>et\u00a0al<\/jats:italic>\n                    , 2020).\n                  <\/jats:p>","DOI":"10.15252\/emmm.202318190","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T08:44:38Z","timestamp":1695890678000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Single cell RNA sequencing sheds light on infiltrating T cells in idiopathic inflammatory myopathies"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1776-8070","authenticated-orcid":false,"given":"Momina","family":"Yazdani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7824-4468","authenticated-orcid":false,"given":"Lukas","family":"Mach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9553-5029","authenticated-orcid":false,"given":"Michela","family":"Noseda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"BFEMMM202318190_CR1","doi-asserted-by":"publisher","unstructured":"Argyriou A, Horuluoglu B, Galindo\u2010Feria AS, Diaz\u2010Boada JS, Sijbranda M, Notarnicola A, Dani L, van Vollenhoven A, Ramsk\u00f6ld D, Nennesmo I et\u00a0al (2023) Single\u2010cell profiling of muscle\u2010infiltrating T cells in idiopathic inflammatory myopathies. EMBO Mol Med e17240 https:\/\/doi.org\/10.15252\/emmm.202217240","DOI":"10.15252\/emmm.202217240"},{"key":"BFEMMM202318190_CR2","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/s41586-022-05432-3","volume":"611","author":"ML Axelrod","year":"2022","unstructured":"Axelrod ML, Meijers WC, Screever EM, Qin J, Carroll MG, Sun X, Tannous E, Zhang Y, Sugiura A, Taylor BC et\u00a0al (2022) T cells specific for \u03b1\u2010myosin drive immunotherapy\u2010related myocarditis. Nature 611: 818\u2013826","journal-title":"Nature"},{"key":"BFEMMM202318190_CR3","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1136\/ard.2005.045690","volume":"65","author":"IM Bronner","year":"2006","unstructured":"Bronner IM, van der Meulen MFG, de Visser M, Kalmijn S, van Venrooij WJ, Voskuyl AE, Dinant HJ, Linssen WHJP, Wokke JHJ, Hoogendijk JE (2006) Long\u2010term outcome in polymyositis and dermatomyositis. Ann Rheum Dis 65: 1456\u20131461","journal-title":"Ann Rheum Dis"},{"key":"BFEMMM202318190_CR4","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1136\/annrheumdis-2013-205127","volume":"74","author":"C Dobloug","year":"2015","unstructured":"Dobloug C, Garen T, Bitter H, Stj\u00e4rne J, Stenseth G, Gr\u00f8vle L, Sem M, Gran JT, Molberg \u00d8 (2015) Prevalence and clinical characteristics of adult polymyositis and dermatomyositis; data from a large and unselected Norwegian cohort. Ann Rheum Dis 74: 1551\u20131556","journal-title":"Ann Rheum Dis"},{"key":"BFEMMM202318190_CR5","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1038\/s41596-022-00795-3","volume":"18","author":"CA Lareau","year":"2023","unstructured":"Lareau CA, Liu V, Muus C, Praktiknjo SD, Nitsch L, Kautz P, Sandor K, Yin Y, Gutierrez JC, Pelka K et\u00a0al (2023) Mitochondrial single\u2010cell ATAC\u2010seq for high\u2010throughput multi\u2010omic detection of mitochondrial genotypes and chromatin accessibility. Nat Protoc 18: 1416\u20131440","journal-title":"Nat Protoc"},{"key":"BFEMMM202318190_CR6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41572-021-00321-x","volume":"7","author":"IE Lundberg","year":"2021","unstructured":"Lundberg IE, Fujimoto M, Vencovsky J, Aggarwal R, Holmqvist M, Christopher\u2010Stine L, Mammen AL, Miller FW (2021) Idiopathic inflammatory myopathies. 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