{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:09:53Z","timestamp":1779088193370,"version":"3.51.4"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["EMBO Mol Med"],"published-print":{"date-parts":[[2023,11,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cytomegalovirus (CMV) infection is one of the severe opportunistic infections faced by severely immunocompromised patients. High viral loads cause tissue\u2010invasive disease and expose to death or various indirect effects. Substantial progress was made in monitoring active infection, and antiviral drugs were developed. However, dose\u2010limiting toxicities and genotypic resistance limit therapeutic efficacy and vaccine development is hampered by the complex biology of the virus. In this issue of\n                    <jats:italic>EMBO Molecular Medicine<\/jats:italic>\n                    , Kandalla\n                    <jats:italic>et\u00a0al<\/jats:italic>\n                    (2023) suggest an innovative strategy using the cytokine macrophage colony\u2010stimulating factor (M\u2010CSF) whose clinical development was left behind two decades ago. By stimulating an endogenous immune defense mechanism, M\u2010CSF promotes viral clearance in a mouse model of hematopoietic stem cell transplantation, without impairing stem cell engraftment. These results reactivate the interest in the potential therapeutic use of this cytokine.\n                  <\/jats:p>","DOI":"10.15252\/emmm.202318319","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T03:39:42Z","timestamp":1694489982000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Macrophage colony\u2010stimulating factor as a weapon against cytomegalovirus"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8629-1341","authenticated-orcid":false,"given":"Eric","family":"Solary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"BFEMMM202318319_CR1","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/s41579-021-00582-z","volume":"19","author":"P Griffiths","year":"2021","unstructured":"Griffiths P, Reeves M (2021) Pathogenesis of human cytomegalovirus in the immunocompromised host. 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Blood 119: 1810\u20131820","journal-title":"Blood"},{"key":"BFEMMM202318319_CR4","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1084\/jem.20151975","volume":"213","author":"PK Kandalla","year":"2016","unstructured":"Kandalla PK, Sarrazin S, Molawi K, Berruyer C, Redelberger D, Favel A, Bordi C, de Bentzmann S, Sieweke MH (2016) M\u2010CSF improves protection against bacterial and fungal infections after hematopoietic stem\/progenitor cell transplantation. J Exp Med 213: 2269\u20132279","journal-title":"J Exp Med"},{"key":"BFEMMM202318319_CR5","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202317694","volume":"15","author":"PK Kandalla","year":"2023","unstructured":"Kandalla PK, Subburayalu J, Cocita C, de Laval B, Tomasello E, Iacono J, Nitsche J, Canali MM, Cathou W, Bessou G et\u00a0al (2023) M\u2010CSF primes myeloid and NK cells to protect from\u00a0CMV after hematopoietic stem cell transplantation. EMBO Mol Med 15: e17694","journal-title":"EMBO Mol Med"},{"key":"BFEMMM202318319_CR6","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1182\/blood-2018-01-829663","volume":"132","author":"S Kaur","year":"2018","unstructured":"Kaur S, Raggatt LJ, Millard SM, Wu AC, Batoon L, Jacobsen RN, Winkler IG, MacDonald KP, Perkins AC, Hume DA et\u00a0al (2018) Self\u2010repopulating recipient bone marrow resident macrophages promote long\u2010term hematopoietic stem cell engraftment. Blood 132: 735\u2013749","journal-title":"Blood"},{"key":"BFEMMM202318319_CR7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nature12026","volume":"497","author":"N Mossadegh\u2010Keller","year":"2013","unstructured":"Mossadegh\u2010Keller N, Sarrazin S, Kandalla PK, Espinosa L, Stanley ER, Nutt SL, Moore J, Sieweke MH (2013) M\u2010CSF instructs myeloid lineage fate in single haematopoietic stem cells. 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