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For understanding the susceptibility for SARS\u2010CoV\u20102 infection, the cell type\u2010specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across &gt;\u00a0150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS\u2010CoV\u20102 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.<\/jats:p>","DOI":"10.15252\/msb.20209610","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T02:12:44Z","timestamp":1595815964000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":906,"title":["The protein expression profile of ACE2 in human tissues"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3750-9308","authenticated-orcid":false,"given":"Feria","family":"Hikmet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren","family":"M\u00e9ar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa","family":"Edvinsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Micke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4858-8056","authenticated-orcid":false,"given":"Mathias","family":"Uhl\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5611-1015","authenticated-orcid":false,"given":"Cecilia","family":"Lindskog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,26]]},"reference":[{"key":"BFMSB209610_CR1","doi-asserted-by":"crossref","unstructured":"Aguiar JA, Tremblay BJ, Mansfield MJ, Woody O, Lobb B, Banerjee A, Chandiramohan A, Tiessen N, Dvorkin\u2010Gheva A, Revill S et\u00a0al (2020) Gene expression and in\u00a0situ protein profiling of candidate SARS\u2010CoV\u20102 receptors in human airway epithelial cells and lung tissue. bioRxiv https:\/\/doi.org\/10.1101\/2020.04.07.030742 [PREPRINT]","DOI":"10.1101\/2020.04.07.030742"},{"key":"BFMSB209610_CR2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler A, Hoffman P, Smibert P, Papalexi E, Satija R (2018) Integrating single\u2010cell transcriptomic data across different conditions, technologies, and species. 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