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Here, we describe a large\u2010scale community effort to build an open access, interoperable and computable repository of COVID\u201019 molecular mechanisms. The COVID\u201019 Disease Map (C19DMap) is a graphical, interactive representation of disease\u2010relevant molecular mechanisms linking many knowledge sources. Notably, it is a computational resource for graph\u2010based analyses and disease modelling. To this end, we established a framework of tools, platforms and guidelines necessary for a multifaceted community of biocurators, domain experts, bioinformaticians and computational biologists. The diagrams of the C19DMap, curated from the literature, are integrated with relevant interaction and text mining databases. We demonstrate the application of network analysis and modelling approaches by concrete examples to highlight new testable hypotheses. 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