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Innate immune cells have been implicated in the response to GBS infection, but the impact of \u03b2\u2010h\/c on their response is poorly defined. We show that GBS modulates innate immune cell states by subversion of host inflammation through \u03b2\u2010h\/c, allowing worse outcomes. We used an ascending mouse model of GBS infection to measure placental cell state changes over time following infection with a \u03b2\u2010h\/c\u2010deficient and isogenic wild type GBS strain. Transcriptomic analysis suggests that \u03b2\u2010h\/c\u2010producing GBS elicit a worse phenotype through suppression of host inflammatory signaling in placental macrophages and neutrophils, and comparison of human placental macrophages infected with the same strains recapitulates these results. Our findings have implications for identification of new targets in GBS disease to support host defense against pathogenic challenge.\n                  <\/jats:p>","DOI":"10.15252\/msb.202211021","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T03:55:45Z","timestamp":1675655745000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Host inflammatory dynamics reveal placental immune modulation by Group B Streptococcus during pregnancy"],"prefix":"10.1038","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4276-8889","authenticated-orcid":false,"given":"Felicia","family":"Kuperwaser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-7152","authenticated-orcid":false,"given":"Gal","family":"Avital","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4885-4745","authenticated-orcid":false,"given":"Michelle J","family":"Vaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3396-3172","authenticated-orcid":false,"given":"Kristen N","family":"Noble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7921-4196","authenticated-orcid":false,"given":"Allison N","family":"Dammann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0348-6766","authenticated-orcid":false,"given":"Tara M","family":"Randis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-6121","authenticated-orcid":false,"given":"David M","family":"Aronoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1761-794X","authenticated-orcid":false,"given":"Adam J","family":"Ratner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-2741","authenticated-orcid":false,"given":"Itai","family":"Yanai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"BFMSB202211021_CR1","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat6114","volume":"4","author":"SE Ander","year":"2019","unstructured":"Ander SE, Diamond MS, Coyne CB (2019) Immune responses at the maternal\u2010fetal interface. 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