{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T04:06:20Z","timestamp":1779077180558,"version":"3.51.4"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Syst Biol"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cells of the innate immune system represent the first line of defense against SARS\u2010CoV\u20102 and play an essential role in activating adaptive immunity, which mediates long\u2010term protection. In addition, the same cells are key drivers of tissue damage by causing the hyperinflammatory state and cytokine storm that makes COVID\u201019 a deadly disease. Thus, careful dissection of the host\u2013pathogen interaction on a cellular level is essential to understanding SARS\u2010CoV\u20102 pathogenesis and developing new treatment modalities against COVID\u201019. In their recent work, Goffinet and colleagues (Kazmierski\n                    <jats:italic>et\u2009al<\/jats:italic>\n                    ,\u20092022) investigate the cell\u2010intrinsic responses of human primary peripheral blood mononuclear cells (PBMCs) exposed to SARS coronaviruses.\n                  <\/jats:p>","DOI":"10.15252\/msb.202211256","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T07:05:48Z","timestamp":1662966348000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Monocyte\u2010crosstalk drives interferon\u2010mediated signaling following SARS\u2010CoV\u20102 exposure"],"prefix":"10.1038","volume":"18","author":[{"given":"Sebastian J","family":"Theobald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8351-2690","authenticated-orcid":false,"given":"Jan","family":"Rybniker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"BFMSB202211256_CR1","doi-asserted-by":"crossref","unstructured":"Kazmierski J, Friedmann K, Postmus D, Emanuel J, Fischer C, Jansen J, Richter A, Bosquillon de Jarcy L, Sch\u00fcler C, Sohn M (2022) Non\u2010productive exposure of PBMCs to SARS\u2010CoV\u20102 induces cell\u2010intrinsic innate immune responses. 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EMBO Mol Med 13: e14150","journal-title":"EMBO Mol Med"},{"key":"BFMSB202211256_CR8","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202215888","volume":"14","author":"SJ Theobald","year":"2022","unstructured":"Theobald SJ, Simonis A, Mudler JM, Gobel U, Acton R, Kohlhas V, Albert MC, Hellmann AM, Malin JJ, Winter S et\u2009al (2022) Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS\u2010CoV\u20102 mRNA vaccination. EMBO Mol Med 14: e15888","journal-title":"EMBO Mol Med"},{"key":"BFMSB202211256_CR9","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021107826","volume":"40","author":"LG Thorne","year":"2021","unstructured":"Thorne LG, Reuschl AK, Zuliani\u2010Alvarez L, Whelan MVX, Turner J, Noursadeghi M, Jolly C, Towers GJ (2021) SARS\u2010CoV\u20102 sensing by RIG\u2010I and MDA5 links epithelial infection to macrophage inflammation. 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