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To identify novel regulators of this process, we used next\u2010generation sequencing to profile changes in micro\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    expression occurring in purified human naive\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4 T cells in response to\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    stimulation and\/or\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    infection. Our results demonstrate, for the first time, the transcriptional up\u2010regulation of miR\u201034c\u20105p in response to\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    stimulation in naive\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4 T cells. The induction of this miR was further consistently found to be reduced by both\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    \u20101 and\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    \u20102 infections. Overexpression of miR\u201034c\u20105p led to changes in the expression of several genes involved in\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    signaling and cell activation, confirming its role as a novel regulator of naive\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4 T\u2010cell activation. We additionally show that miR\u201034c\u20105p promotes\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    \u20101 replication, suggesting that its down\u2010regulation during\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    infection may be part of an anti\u2010viral host response.\n                  <\/jats:p>","DOI":"10.15252\/embj.201694335","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T20:35:40Z","timestamp":1482179740000},"page":"346-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["mi\n                    <scp>RNA<\/scp>\n                    profiling of human naive\n                    <scp>CD<\/scp>\n                    4 T cells links miR\u201034c\u20105p to cell activation and\n                    <scp>HIV<\/scp>\n                    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