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We have uncovered a new link between chromosome replication\/segregation and splitting of the division septum. We show that the DNA translocase domain\u2010containing divisome protein FtsK regulates cellular levels of a peptidoglycan hydrolase Sle1, which is involved in cell separation in the bacterial pathogen\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . FtsK interacts with a chaperone (trigger factor, TF) and establishes a FtsK\u2010dependent TF concentration gradient that is higher in the septal region. Trigger factor binds Sle1 and promotes its preferential export at the septal region, while also preventing Sle1 degradation by the ClpXP proteolytic machinery. Upon conditions that lead to paused septum synthesis, such as DNA damage or impaired DNA replication\/segregation, TF gradient is dissipated and Sle1 levels are reduced, thus halting premature septum splitting.\n                  <\/jats:p>","DOI":"10.15252\/embj.2022112140","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T04:49:30Z","timestamp":1681188570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Cell division protein FtsK coordinates bacterial chromosome segregation and daughter cell separation in\n                    <i>Staphylococcus aureus<\/i>"],"prefix":"10.1038","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5345-475X","authenticated-orcid":false,"given":"Helena","family":"Veiga","sequence":"first","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier Universidade Nova de Lisboa  Oeiras Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7003-5426","authenticated-orcid":false,"given":"Ambre","family":"Jousselin","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier Universidade Nova de Lisboa  Oeiras Portugal"}]},{"given":"Simon","family":"Sch\u00e4per","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier Universidade Nova de Lisboa  Oeiras Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-5477","authenticated-orcid":false,"given":"Bruno M","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier Universidade Nova de Lisboa  Oeiras Portugal"}]},{"given":"Leonor B","family":"Marques","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier Universidade Nova de Lisboa  Oeiras Portugal"}]},{"given":"Patricia","family":"Reed","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier Universidade Nova de Lisboa  Oeiras Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3728-1833","authenticated-orcid":false,"given":"Joana","family":"Wilton","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier Universidade Nova de Lisboa  Oeiras Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1426-9540","authenticated-orcid":false,"given":"Pedro M","family":"Pereira","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier Universidade Nova de Lisboa  Oeiras Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4485-832X","authenticated-orcid":false,"given":"S\u00e9rgio R","family":"Filipe","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier Universidade Nova de Lisboa  Oeiras Portugal"},{"name":"UCIBIO\u2010REQUIMTE, Departamento de Ci\u00eancias da Vida, Faculdade de Ci\u00eancias e Tecnologia Universidade Nova de Lisboa  Caparica Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7132-8842","authenticated-orcid":false,"given":"Mariana G","family":"Pinho","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier Universidade Nova de Lisboa  Oeiras Portugal"}]}],"member":"297","published-online":{"date-parts":[[2023,4,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_2_9_3_1","unstructured":"AndrewsS(2010)FastQC: a quality control tool for high throughput sequence data. 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