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However, the mechanisms of mitotic transcriptional inactivation and their interplay with chromosome assembly remain largely unknown\n                    <jats:italic>.<\/jats:italic>\n                    By monitoring ongoing transcription in\n                    <jats:italic>Drosophila<\/jats:italic>\n                    early embryos, we reveal that eviction of nascent mRNAs from mitotic chromatin occurs after substantial chromosome compaction and is not promoted by condensin I. Instead, we show that the timely removal of transcripts from mitotic chromatin is driven by the SNF2 helicase\u2010like protein Lodestar (Lds), identified here as a modulator of sister chromatid cohesion defects. In addition to the eviction of nascent transcripts, we uncover that Lds cooperates with Topoisomerase 2 to ensure efficient sister chromatid resolution and mitotic fidelity. We conclude that the removal of nascent transcripts upon mitotic entry is not a passive consequence of cell cycle progression and\/or chromosome compaction but occurs via dedicated mechanisms with functional parallelisms to sister chromatid resolution.\n                  <\/jats:p>","DOI":"10.15252\/embr.202256463","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T06:57:12Z","timestamp":1689663432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A dual\u2010function\n                    <scp>SNF2<\/scp>\n                    protein drives chromatid resolution and nascent transcript removal in mitosis"],"prefix":"10.1038","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0083-0146","authenticated-orcid":false,"given":"Catarina","family":"Carmo","sequence":"first","affiliation":[{"name":"Instituto Gulbenkian de Ci\u00eancia  Oeiras 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