{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T11:03:46Z","timestamp":1777806226564,"version":"3.51.4"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_00025\/11"],"award-info":[{"award-number":["MC_UU_00025\/11"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000654","name":"Marie Curie","doi-asserted-by":"publisher","award":["PCIG\u2010GA\u2010\u20102011\u2010294121"],"award-info":[{"award-number":["PCIG\u2010GA\u2010\u20102011\u2010294121"]}],"id":[{"id":"10.13039\/501100000654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013060","name":"European Molecular Biology Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["112927078 \u2010 TRR83"],"award-info":[{"award-number":["112927078 \u2010 TRR83"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["331351713 \u2010 SFB1324"],"award-info":[{"award-number":["331351713 \u2010 SFB1324"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.embopress.org"],"crossmark-restriction":false},"short-container-title":["Molecular Systems Biology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.15252\/msb.202010141","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T06:02:10Z","timestamp":1635141730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Metabolic memory underlying minimal residual disease in breast cancer"],"prefix":"10.1038","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3139-9184","authenticated-orcid":false,"given":"Ksenija","family":"Radic Shechter","sequence":"first","affiliation":[{"name":"European Molecular Biology Laboratory (EMBL) Heidelberg Germany"}]},{"given":"Eleni","family":"Kafkia","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory (EMBL) Heidelberg Germany"},{"name":"The Medical Research Council Toxicology Unit University of Cambridge Cambridge UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7518-0339","authenticated-orcid":false,"given":"Katharina","family":"Zirngibl","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory (EMBL) Heidelberg Germany"},{"name":"The Medical Research Council Toxicology Unit University of Cambridge Cambridge UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7047-3319","authenticated-orcid":false,"given":"Sylwia","family":"Gawrzak","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory (EMBL) Heidelberg Germany"}]},{"given":"Ashna","family":"Alladin","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory (EMBL) Heidelberg Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2063-5383","authenticated-orcid":false,"given":"Daniel","family":"Machado","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory (EMBL) Heidelberg Germany"}]},{"given":"Christian","family":"L\u00fcchtenborg","sequence":"additional","affiliation":[{"name":"Biochemie\u2010Zentrum der Universit\u00e4t Heidelberg (BZH) Heidelberg Germany"}]},{"given":"Daniel C","family":"Se\u0301vin","sequence":"additional","affiliation":[{"name":"Cellzome GmbH Functional Genomics GlaxoSmithKline Heidelberg Germany"}]},{"given":"Britta","family":"Br\u00fcgger","sequence":"additional","affiliation":[{"name":"Biochemie\u2010Zentrum der Universit\u00e4t Heidelberg (BZH) Heidelberg Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6166-8640","authenticated-orcid":false,"given":"Kiran R","family":"Patil","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory (EMBL) Heidelberg Germany"},{"name":"The Medical Research Council Toxicology Unit University of Cambridge Cambridge UK"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3710-4466","authenticated-orcid":false,"given":"Martin","family":"Jechlinger","sequence":"additional","affiliation":[{"name":"European Molecular Biology Laboratory (EMBL) Heidelberg Germany"},{"name":"MOLIT Institute gGmbH Heilbronn Germany"}]}],"member":"297","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2256"},{"key":"e_1_2_9_3_1","first-page":"290568","article-title":"Pathways to breast cancer recurrence","volume":"2013","author":"Ahmad A","year":"2013","journal-title":"ISRN Oncol"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3593"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-10-r106"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_2_9_7_1","unstructured":"AndrewsS(2010)FastQC: a quality control tool for high throughput sequence data.http:\/\/wwwbioinformaticsbabrahamacuk\/projects\/fastqc"},{"key":"e_1_2_9_8_1","unstructured":"BC Team(2019)TxDb.Mmusculus.UCSC.mm10.knownGene: Annotation package for TxDb object(s).https:\/\/bioconductororg\/packages\/release\/data\/annotation\/html\/TxDbMmusculusUCSCmm10knownGenehtml"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00195.2006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2015.08.003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn051"},{"key":"e_1_2_9_12_1","unstructured":"Cancer Research UK(2017)Identify and target tumour cells that remain dormant for many years after seemingly effective treatment.http:\/\/wwwcancerresearchukorg\/funding\u2010for\u2010researchers\/how\u2010we\u2010deliver\u2010research\/grand\u2010challenge\u2010award\/dormancy"},{"key":"e_1_2_9_13_1","unstructured":"CarlsonM(2018)org.Mm.eg.db: Genome wide annotation for Mouse. R package version 3.7.0.https:\/\/bioconductor.org\/packages\/release\/data\/annotation\/html\/org.Mm.eg.db.html"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq431"},{"key":"e_1_2_9_15_1","first-page":"2435","article-title":"3Bromopyruvate sensitizes human breast cancer cells to TRAIL induced apoptosis via the phosphorylated AMPK mediated upregulation of DR5","volume":"40","author":"Chen Y","year":"2018","journal-title":"Oncol Rep"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1231143"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/84691"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.10.002"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.97"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2015_10"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq149"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11030317"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-0191-z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac201267k"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu781"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-152"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2762"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0551com"},{"key":"e_1_2_9_29_1","unstructured":"HahneF LerchA StadlerMBRbowtie: An R wrapper for bowtie and SpliceMap short read aligners. R package version 1220.https:\/\/bioconductor.org\/packages\/release\/bioc\/html\/Rbowtie.html"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-4018-2"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI89914"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2019.194431"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2120"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1218595"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1801809"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot078295"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv514"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2006.08.001"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.04.049"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2124-0"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn647"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209594"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2010.10.011"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2009-10-3-r25"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp328"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.011"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.019"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-014-0366-2"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2017.08.028"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-161"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003580"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005140"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2633"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4083"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.2174\/138955709788922610"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122333"},{"key":"e_1_2_9_59_1","first-page":"e4389","article-title":"Performing vaginal lavage, crystal violet staining, and vaginal cytological evaluation for mouse estrous cycle staging identification","author":"McLean AC","year":"2012","journal-title":"J Vis Exp"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00427"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00212-X"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53939-z"},{"key":"e_1_2_9_63_1","unstructured":"NCBI(2015)National Center for Biotechnology Information; Genome Reference Consortium Mouse Build 38 Patch Release 4(GRCm38.p4).https:\/\/wwwncbinlmnihgov\/assembly\/GCF_00000163524"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0430-y"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-487-6_1"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0364-9"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406811102"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801197105"},{"key":"e_1_2_9_69_1","volume-title":"R: a language and environment for statistical computing","author":"R\u2010Core\u2010Team","year":"2016"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.11.022"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.2202\/1544-6115.1027"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1530509100"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-016-1051-4"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11986"},{"key":"e_1_2_9_77_1","unstructured":"The\u2010Bioconductor\u2010Dev\u2010Team(2014)BSgenome.Mmusculus.UCSC.mm10: Full genome sequences forMus musculus(UCSC version mm10). R package version 140.https:\/\/bioconductor.org\/packages\/release\/data\/annotation\/html\/BSgenome.Mmusculus.UCSC.mm10.html"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt111"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2005.70.039"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1582"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13611"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.02.014"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-3293"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1089"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.191056.112"}],"container-title":["Molecular Systems Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.15252\/msb.202010141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.15252\/msb.202010141","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.embopress.org\/doi\/pdf\/10.15252\/msb.202010141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:35:05Z","timestamp":1765042505000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.15252\/msb.202010141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":84,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.15252\/msb.202010141"],"URL":"https:\/\/doi.org\/10.15252\/msb.202010141","archive":["Portico"],"relation":{},"ISSN":["1744-4292","1744-4292"],"issn-type":[{"value":"1744-4292","type":"print"},{"value":"1744-4292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"2020-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e10141"}}