{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:46:42Z","timestamp":1780537602278,"version":"3.54.1"},"reference-count":24,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Interv Neuroradiol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>\n                    Intradiscal oxygen-ozone (O\n                    <jats:sub>2<\/jats:sub>\n                    -O\n                    <jats:sub>3<\/jats:sub>\n                    ) chemonucleolysis is a well-known effective treatment for pain caused by protruding disc disease and nerve root compression due to bulging or herniated disc.\n                  <\/jats:p>\n                  <jats:p>\n                    The most widely used therapeutic combination is intradiscal injection of an O\n                    <jats:sub>2<\/jats:sub>\n                    -O\n                    <jats:sub>3<\/jats:sub>\n                    mixture (chemonucleolysis), followed by periradicular injection of O\n                    <jats:sub>2<\/jats:sub>\n                    -O\n                    <jats:sub>3<\/jats:sub>\n                    , steroid and local anaesthetic to enhance the anti-inflammatory and analgesic effect. The treatment is designed to resolve pain and is administered to patients without motor weakness, whereas patients with acute paralysis caused by nerve root compression undergo surgery 24\u201348h after the onset of neurological deficit.\n                  <\/jats:p>\n                  <jats:p>\n                    This paper reports on the efficacy of O\n                    <jats:sub>2<\/jats:sub>\n                    -O\n                    <jats:sub>3<\/jats:sub>\n                    chemonucleolysis associated with anti-inflammatory foraminal injection in 13 patients with low back pain and cruralgia, low back pain and sciatica and subacute partial motor weakness caused by nerve root compression unresponsive to medical treatment. All patients were managed in conjunction with our colleagues in the Neurosurgery Unit of Bellaria Hospital and the IRCCS Institute of Neurological Sciences, Bologna.\n                  <\/jats:p>\n                  <jats:p>\n                    The outcomes obtained are promising: 100% patients had a resolution of motor weakness, while 84.6% had complete pain relief. Our results demonstrate that O\n                    <jats:sub>2<\/jats:sub>\n                    -O\n                    <jats:sub>3<\/jats:sub>\n                    therapy can be considered a valid treatment option for this category of patients.\n                  <\/jats:p>","DOI":"10.15274\/inr-2014-10078","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T11:02:30Z","timestamp":1410260550000},"page":"547-554","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":27,"title":["Oxygen-Ozone Therapy for Herniated Lumbar Disc in Patients with Subacute Partial Motor Weakness Due to Nerve Root Compression"],"prefix":"10.1177","volume":"20","author":[{"given":"Massimo","family":"Dall'Olio","sequence":"first","affiliation":[{"name":"Neuroradiology Unit, IRCCS Institute of Neurological Sciences; Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Princiotta","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, IRCCS Institute of Neurological Sciences; Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, IRCCS Institute of Neurological Sciences; Bologna, Italy"},{"name":"DIMES, Department of Specialty, Diagnostic and Experimental Medicine, University of Bologna; Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Budai","sequence":"additional","affiliation":[{"name":"Radiodiagnostics Specialization School, University of Bologna; Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"de Santis","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, IRCCS Institute of Neurological Sciences; Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bartolini","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, IRCCS Institute of Neurological Sciences; Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Serchi","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, IRCCS Institute of Neurological Sciences; Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, IRCCS Institute of Neurological Sciences; Bologna, Italy"},{"name":"DIMES, Department of Specialty, Diagnostic and Experimental Medicine, University of Bologna; Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"bibr1-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.1177\/19714009090220S124"},{"key":"bibr2-INR-2014-10078","first-page":"996","volume":"24","author":"Andreula C","year":"2003","journal-title":"Am J Neuroradiol"},{"key":"bibr3-INR-2014-10078","first-page":"996","volume":"26","author":"Bonetti M","year":"2005","journal-title":"Am J Neuroradiol"},{"key":"bibr4-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.1177\/159101990901500311"},{"key":"bibr5-INR-2014-10078","first-page":"E115","volume":"15","author":"De Oliveira Magalhaes F","year":"2012","journal-title":"Pain Physician"},{"key":"bibr6-INR-2014-10078","first-page":"138","volume":"8","author":"De Santis F","year":"2009","journal-title":"International Journal of Ozone Therapy"},{"key":"bibr7-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.1177\/197140090902200116"},{"key":"bibr8-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2010.10.002"},{"key":"bibr9-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.1177\/19714009010140S105"},{"key":"bibr10-INR-2014-10078","first-page":"73","volume":"1","author":"Leonardi M","year":"2002","journal-title":"Rivista Italiana di Ossigeno-Ozonoterapia"},{"key":"bibr11-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.1177\/19714009010140S111"},{"key":"bibr12-INR-2014-10078","first-page":"33","volume":"5","author":"Leonardi M","year":"2006","journal-title":"Rivista Italiana di Ossigeno-Ozonoterapia"},{"key":"bibr13-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.1177\/19714009010140S113"},{"issue":"2","key":"bibr14-INR-2014-10078","first-page":"E115","volume":"15","author":"Magalhaes FN","year":"2012","journal-title":"Pain Physician"},{"key":"bibr15-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-008-0302-5"},{"key":"bibr16-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.1016\/S0150-9861(04)96989-1"},{"key":"bibr17-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.1177\/159101999800400403"},{"key":"bibr18-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2009.12.393"},{"issue":"1","key":"bibr19-INR-2014-10078","first-page":"224","volume":"23","author":"Pellican\u00f2 G","year":"2010","journal-title":"Neuroradiol J."},{"key":"bibr20-INR-2014-10078","first-page":"7","volume":"6","author":"Pellican\u00f2 F","year":"2007","journal-title":"International Journal of Ozone Therapy"},{"key":"bibr21-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.1177\/159101991201800113"},{"key":"bibr22-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.1177\/159101990901500204"},{"key":"bibr23-INR-2014-10078","first-page":"349","volume":"19","author":"Zennaro H","year":"1997","journal-title":"Am J Neuroradiol"},{"key":"bibr24-INR-2014-10078","doi-asserted-by":"publisher","DOI":"10.3233\/BMR-130386"}],"container-title":["Interventional Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.15274\/INR-2014-10078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.15274\/INR-2014-10078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:56:10Z","timestamp":1777460170000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.15274\/INR-2014-10078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.15274\/INR-2014-10078"],"URL":"https:\/\/doi.org\/10.15274\/inr-2014-10078","relation":{},"ISSN":["1591-0199","2385-2011"],"issn-type":[{"value":"1591-0199","type":"print"},{"value":"2385-2011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,1]]}}}