{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:45:43Z","timestamp":1769831143223,"version":"3.49.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":1718,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR40615"],"award-info":[{"award-number":["AR40615"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["0430076N"],"award-info":[{"award-number":["0430076N"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30330160"],"award-info":[{"award-number":["30330160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2004CB720005"],"award-info":[{"award-number":["2004CB720005"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biophysical Journal"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1529\/biophysj.108.137224","type":"journal-article","created":{"date-parts":[[2008,7,25]],"date-time":"2008-07-25T20:33:56Z","timestamp":1217018036000},"page":"4289-4299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Structural and Functional Characterization of Ryanodine Receptor-Natrin Toxin Interaction"],"prefix":"10.1016","volume":"95","author":[{"given":"Qiang","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong-Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyan","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence","family":"Wagenknecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Cheng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen-Fang","family":"Sui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1529\/biophysj.108.137224_bib1","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1073\/pnas.78.3.1675","article-title":"Isolation, culture, and immunocytochemical characterization of epididymal epithelial cells from pubertal and adult rats","volume":"78","author":"Kierszenbaum","year":"1981","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1529\/biophysj.108.137224_bib2","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1095\/biolreprod67.4.1225","article-title":"Expression and structure-function analysis of DE, a sperm cysteine-rich secretory protein that mediates gamete fusion","volume":"67","author":"Ellerman","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1529\/biophysj.108.137224_bib3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0888-7543(89)90019-0","article-title":"Cloning and mapping of a testis-specific gene with sequence similarity to a sperm-coating glycoprotein gene","volume":"5","author":"Kasahara","year":"1989","journal-title":"Genomics"},{"key":"10.1529\/biophysj.108.137224_bib4","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1046\/j.1440-169x.1999.00470.x","article-title":"Expression pattern, subcellular localization and structure-function relationship of rat Tpx-1, a spermatogenic cell adhesion molecule responsible for association with Sertoli cells","volume":"41","author":"Maeda","year":"1999","journal-title":"Dev. Growth Differ."},{"key":"10.1529\/biophysj.108.137224_bib5","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1432-1033.1996.t01-1-00827.x","article-title":"The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3","volume":"236","author":"Kratzschmar","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1529\/biophysj.108.137224_bib6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.toxicon.2004.05.023","article-title":"Structure and function of snake venom cysteine-rich secretory proteins","volume":"44","author":"Yamazaki","year":"2004","journal-title":"Toxicon"},{"key":"10.1529\/biophysj.108.137224_bib7","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1095\/biolreprod.104.035758","article-title":"Mouse cysteine-rich secretory protein 4 (CRISP4): a member of the CRISP family exclusively expressed in the epididymis in an androgen-dependent manner","volume":"72","author":"Jalkanen","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1529\/biophysj.108.137224_bib8","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1152\/physrev.1997.77.3.699","article-title":"Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions","volume":"77","author":"Franzini-Armstrong","year":"1997","journal-title":"Physiol. Rev."},{"key":"10.1529\/biophysj.108.137224_bib9","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1016\/S0006-3495(95)80410-8","article-title":"Primary structure and properties of helothermine, a peptide toxin that blocks ryanodine receptors","volume":"68","author":"Morrissette","year":"1995","journal-title":"Biophys. J."},{"key":"10.1529\/biophysj.108.137224_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF00232674","article-title":"The toxin helothermine affects potassium currents in newborn rat cerebellar granule cells","volume":"139","author":"Nobile","year":"1994","journal-title":"J. Membr. Biol."},{"key":"10.1529\/biophysj.108.137224_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF00241369","article-title":"Helothermine, a lizard venom toxin, inhibits calcium current in cerebellar granules","volume":"110","author":"Nobile","year":"1996","journal-title":"Exp. Brain Res."},{"key":"10.1529\/biophysj.108.137224_bib12","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1074\/jbc.M506849200","article-title":"The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling","volume":"281","author":"Gibbs","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1529\/biophysj.108.137224_bib13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0003-9861(03)00028-6","article-title":"Wide distribution of cysteine-rich secretory proteins in snake venoms: isolation and cloning of novel snake venom cysteine-rich secretory proteins","volume":"412","author":"Yamazaki","year":"2003","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1529\/biophysj.108.137224_bib14","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0041-0101(96)00192-4","article-title":"Cloning and expression of a cysteine-rich venom protein from Trimeresurus mucrosquamatus (Taiwan habu)","volume":"35","author":"Chang","year":"1997","journal-title":"Toxicon"},{"key":"10.1529\/biophysj.108.137224_bib15","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0041-0101(03)00234-4","article-title":"Purification and cloning of cysteine-rich proteins from Trimeresurus jerdonii and Naja atra venoms","volume":"42","author":"Jin","year":"2003","journal-title":"Toxicon"},{"key":"10.1529\/biophysj.108.137224_bib16","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1046\/j.1432-1033.2002.02940.x","article-title":"Cloning and characterization of novel snake venom proteins that block smooth muscle contraction","volume":"269","author":"Yamazaki","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1529\/biophysj.108.137224_bib17","doi-asserted-by":"crossref","first-page":"10145","DOI":"10.1021\/bi050614m","article-title":"Blocking effect and crystal structure of natrin toxin, a cysteine-rich secretory protein from Naja atra venom that targets the BKCa channel","volume":"44","author":"Wang","year":"2005","journal-title":"Biochemistry"},{"key":"10.1529\/biophysj.108.137224_bib18","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bbrc.2006.10.067","article-title":"Structural and functional analysis of natrin, a venom protein that targets various ion channels","volume":"351","author":"Wang","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1529\/biophysj.108.137224_bib19","doi-asserted-by":"crossref","first-page":"12405","DOI":"10.1074\/jbc.M413566200","article-title":"Crystal structure of the cysteine-rich secretory protein Stecrisp reveals that the CRD has a K+ channel inhibitor-like fold","volume":"280","author":"Guo","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1529\/biophysj.108.137224_bib20","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jmb.2005.05.020","article-title":"Crystal structure of a CRISP family Ca2+-channel blocker derived from snake venom","volume":"350","author":"Shikamoto","year":"2005","journal-title":"J. Mol. Biol."},{"key":"10.1529\/biophysj.108.137224_bib21","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1083\/jcb.99.3.875","article-title":"Preparation and morphology of sarcoplasmic reticulum terminal cisternae from rabbit skeletal muscle","volume":"99","author":"Saito","year":"1984","journal-title":"J. Cell Biol."},{"key":"10.1529\/biophysj.108.137224_bib22","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1016\/S0021-9258(19)75701-9","article-title":"Purification of the ryanodine receptor and identity with feet structures of junctional terminal cisternae of sarcoplasmic reticulum from fast skeletal muscle","volume":"262","author":"Inui","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1529\/biophysj.108.137224_bib23","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/35023625","article-title":"Intrinsic lattice formation by the ryanodine receptor calcium-release channel","volume":"2","author":"Yin","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1529\/biophysj.108.137224_bib24","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0006-3495(99)76881-5","article-title":"Activation and inhibition of skeletal RyR channels by a part of the skeletal DHPR II\u2013III loop: effects of DHPR Ser687 and FKBP12","volume":"77","author":"Dulhunty","year":"1999","journal-title":"Biophys. J."},{"key":"10.1529\/biophysj.108.137224_bib25","doi-asserted-by":"crossref","first-page":"6104","DOI":"10.1073\/pnas.111382798","article-title":"Three-dimensional reconstruction of the recombinant type 3 ryanodine receptor and localization of its amino terminus","volume":"98","author":"Liu","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1529\/biophysj.108.137224_bib26","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/jsbi.1996.0030","article-title":"SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields","volume":"116","author":"Frank","year":"1996","journal-title":"J. Struct. Biol."},{"key":"10.1529\/biophysj.108.137224_bib27","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1006\/jmbi.1998.1859","article-title":"Escherichia coli 70S ribosome at 15\u00c5 resolution by cryo-electron microscopy: localization of fMet-tRNAfMet and fitting of L1 protein","volume":"280","author":"Malhotra","year":"1998","journal-title":"J. Mol. Biol."},{"key":"10.1529\/biophysj.108.137224_bib28","doi-asserted-by":"crossref","first-page":"6134","DOI":"10.1073\/pnas.95.11.6134","article-title":"Visualization of elongation factor G on the Escherichia coli 70S ribosome: the mechanism of translocation","volume":"95","author":"Agrawal","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1529\/biophysj.108.137224_bib29","doi-asserted-by":"crossref","first-page":"33259","DOI":"10.1074\/jbc.273.50.33259","article-title":"Characterization of recombinant rabbit cardiac and skeletal muscle Ca2+ release channels (ryanodine receptors) with a novel [3H]ryanodine binding assay","volume":"273","author":"Du","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1529\/biophysj.108.137224_bib30","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0026-895X(25)10918-8","article-title":"Ryanodine as a probe for the functional state of the skeletal muscle sarcoplasmic reticulum calcium release channel","volume":"37","author":"Chu","year":"1990","journal-title":"Mol. Pharmacol."},{"key":"10.1529\/biophysj.108.137224_bib31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1083\/jcb.127.2.411","article-title":"Cryo-electron microscopy and three-dimensional reconstruction of the calcium release channel\/ryanodine receptor from skeletal muscle","volume":"127","author":"Radermacher","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1529\/biophysj.108.137224_bib32","series-title":"Three-Dimensional Electron Microscopy of Macromolecular Assemblies","first-page":"145","article-title":"Multivariate data analysis and classification of images","author":"Frank","year":"2006"},{"key":"10.1529\/biophysj.108.137224_bib33","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nsmb938","article-title":"Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM","volume":"12","author":"Samso","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1529\/biophysj.108.137224_bib34","doi-asserted-by":"crossref","first-page":"37941","DOI":"10.1074\/jbc.M505714200","article-title":"Localization of a disease-associated mutation site on the three-dimensional structure of cardiac ryanodine receptor","volume":"280","author":"Liu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1529\/biophysj.108.137224_bib35","doi-asserted-by":"crossref","first-page":"17785","DOI":"10.1074\/jbc.M700660200","article-title":"Localization of an NH2-terminal disease-causing mutation hotspot to the \u201cclamp\u201d region in the three-dimensional structure of the cardiac ryanodine receptor","volume":"282","author":"Wang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1529\/biophysj.108.137224_bib36","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/(SICI)1098-1004(200005)15:5<410::AID-HUMU2>3.0.CO;2-D","article-title":"Ryanodine receptor mutations in malignant hyperthermia and central core disease","volume":"15","author":"McCarty","year":"2000","journal-title":"Hum. Mutat."},{"key":"10.1529\/biophysj.108.137224_bib37","doi-asserted-by":"crossref","first-page":"d671","DOI":"10.2741\/ikemoto","article-title":"Regulation of calcium release by interdomain interaction within ryanodine receptors","volume":"7","author":"Ikemoto","year":"2002","journal-title":"Front. Biosci."},{"key":"10.1529\/biophysj.108.137224_bib38","doi-asserted-by":"crossref","first-page":"11618","DOI":"10.1074\/jbc.275.16.11618","article-title":"Postulated role of interdomain interaction within the ryanodine receptor in Ca2+ channel regulation","volume":"275","author":"Yamamoto","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1529\/biophysj.108.137224_bib39","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1074\/jbc.M102347200","article-title":"T-tubule depolarization-induced local events in the ryanodine receptor, as monitored with the fluorescent conformational probe incorporated by mediation of peptide A","volume":"277","author":"Yamamoto","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1529\/biophysj.108.137224_bib40","doi-asserted-by":"crossref","first-page":"C2070","DOI":"10.1152\/ajpcell.2001.281.1.C207","article-title":"Effects of a domain peptide of the ryanodine receptor on Ca2+ release in skinned skeletal muscle fibers","volume":"281","author":"Lamb","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1529\/biophysj.108.137224_bib41","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1085\/jgp.119.1.15","article-title":"Interdomain interactions within ryanodine receptors regulate Ca2+ spark frequency in skeletal muscle","volume":"119","author":"Shtifman","year":"2002","journal-title":"J. Gen. Physiol."},{"key":"10.1529\/biophysj.108.137224_bib42","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/S0021-9258(19)39968-5","article-title":"Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum","volume":"265","author":"Zorzato","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1529\/biophysj.108.137224_bib43","doi-asserted-by":"crossref","first-page":"13472","DOI":"10.1016\/S0021-9258(18)77371-7","article-title":"Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum","volume":"265","author":"Otsu","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1529\/biophysj.108.137224_bib44","doi-asserted-by":"crossref","first-page":"18429","DOI":"10.1074\/jbc.273.29.18429","article-title":"Cryoelectron microscopy and image analysis of the cardiac ryanodine receptor","volume":"273","author":"Sharma","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1529\/biophysj.108.137224_bib45","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2165\/00003495-198632020-00003","article-title":"Dantrolene: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neurolept malignant syndrome, and an update of its use in muscle spasticity","volume":"32","author":"Ward","year":"1986","journal-title":"Drugs"},{"key":"10.1529\/biophysj.108.137224_bib46","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1161\/CIRCULATIONAHA.104.507921","article-title":"Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure","volume":"111","author":"Oda","year":"2005","journal-title":"Circulation"},{"key":"10.1529\/biophysj.108.137224_bib47","doi-asserted-by":"crossref","first-page":"6580","DOI":"10.1074\/jbc.M408375200","article-title":"Dantrolene stabilizes domain interactions within the ryanodine receptor","volume":"280","author":"Kobayashi","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1529\/biophysj.108.137224_bib48","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1073\/pnas.0711074105","article-title":"Remodeling of ryanodine receptor complex causes \u201cleaky\u201d channels: a molecular mechanism for decreased exercise capacity","volume":"105","author":"Bellinger","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1529\/biophysj.108.137224_bib49","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nsb0496-317","article-title":"Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone","volume":"3","author":"Tudor","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"10.1529\/biophysj.108.137224_bib50","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1074\/jbc.272.7.4302","article-title":"On the convergent evolution of animal toxins. Conservation of a diad of functional residues in potassium channel-blocking toxins with unrelated structures","volume":"272","author":"Dauplais","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1529\/biophysj.108.137224_bib51","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1073\/pnas.96.2.754","article-title":"Pseudechetoxin: a peptide blocker of cyclic nucleotide-gated ion channels","volume":"96","author":"Brown","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1529\/biophysj.108.137224_bib52","doi-asserted-by":"crossref","first-page":"11331","DOI":"10.1021\/bi026132h","article-title":"Purification and cloning of toxins from elapid venoms that target cyclic nucleotide-gated ion channels","volume":"41","author":"Yamazaki","year":"2002","journal-title":"Biochemistry"}],"container-title":["Biophysical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349508785680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006349508785680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:26:01Z","timestamp":1762100761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006349508785680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0006349508785680"],"URL":"https:\/\/doi.org\/10.1529\/biophysj.108.137224","relation":{},"ISSN":["0006-3495"],"issn-type":[{"value":"0006-3495","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural and Functional Characterization of Ryanodine Receptor-Natrin Toxin Interaction","name":"articletitle","label":"Article Title"},{"value":"Biophysical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1529\/biophysj.108.137224","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 The Biophysical Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}