{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:02:10Z","timestamp":1761955330856,"version":"build-2065373602"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1962,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>The <jats:italic>in vivo<\/jats:italic> mechanism of cortisone induced eosinopenia is disputed. Studies are presented which show <jats:italic>in vitro<\/jats:italic> eosinolysis in venous blood collected in sequestrine tubes with ethylenediamine tetra acetic acid as the anticoagulant. Free cortisol, cortisone and the synthetic anti-inflammatory analogues as well as Reichstein's Compound S were shown to be capable of inducing <jats:italic>in vitro<\/jats:italic> eosinopenia; the acetate and hemisuccinate salts of cortisol were inactive <jats:italic>in vitro<\/jats:italic> as were such compounds as deoxycorticosterone, 17\u03b1-hydroxyprogesterone, corticotrophin, heparin, epinephrine and acetylsalicylic acid.<\/jats:p>\n        <jats:p>The speed of the reaction was roughly proportional to the concentration of cortisol in a range from 25 to 200 \u03bcg\/100 ml. The ultimate degree of eosinolysis was not related to the amount of steroid. The eosinophils remaining after eosinolysis were resistant to further steroid.<\/jats:p>","DOI":"10.1530\/acta.0.0390135","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:21:29Z","timestamp":1229372489000},"page":"135-144","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":2,"title":["INDUCED EOSINOPENIA AND BASOPHILOPENIA BY \u00bbFREE\u00ab STEROIDS IN VITRO"],"prefix":"10.1093","volume":"39","author":[{"given":"J. Victoriano","family":"Navarrete","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald W.","family":"Petit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/39\/1\/acta_39_1_014.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/39\/1\/acta_39_1_014.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:19:39Z","timestamp":1676391579000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/39\/1\/135\/6954910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1962,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0390135","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"type":"print","value":"0804-4643"},{"type":"electronic","value":"1479-683X"}],"subject":[],"published":{"date-parts":[[1962,1]]}}}