{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:40Z","timestamp":1676438620850},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1962,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p><jats:list list-type=\"order\"><jats:list-item><jats:p>1. An oestradiol tolerance test was performed in ten cases of secondary amenorrhoea. Oestrogen was administered as a single injection of 10 mg of oestradiol phenyl propionate + 2.5 mg of oestradiol benzoate (Dimenformon prolongatum \u00bbOrganon\u00ab).<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>2. The oestrogenic effect was estimated by the vaginal smear method, by the cervical fern phenomenon and by registering the interval before the occurrence of withdrawal bleeding.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>3. The urinary excretion of oestrogens was measured by Ahlmark's biological method and in three cases by the chemical method of Brown.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>4. The maximal urinary output as determined by both methods occurred on the third day after the injection. The maximal oestrogen effect was noted in the vaginal cells on the sixth and in the fern phenomenon, on the third day.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>5. The initial output values of the \u00bbclassical oestrogens\u00ab were obtained again after ten days. There was a return to the initial values of the vaginal cell effect and of the fern phenomenon after twenty days.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>6. Withdrawal bleeding occurred in nine out of the ten cases, the interval being fifteen to forty-five days (mean twenty-two days).<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>7. In a case of secondary amenorrhoea combined with hypothyroidism, a slow oestrogen metabolism resulted in a relatively increased excretion of oestradiol and oestrone.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>8. Individual variations in an oestrogen tolerance test are most conveniently registered by an oestrone + oestradiol\/total oestrogens percentage curve.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p>","DOI":"10.1530\/acta.0.0390491","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:21:29Z","timestamp":1229372489000},"page":"491-505","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":0,"title":["OESTRADIOL TOLERANCE TEST IN SECONDARY AMENORRHOEA"],"prefix":"10.1093","volume":"39","author":[{"given":"S.","family":"Timonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.-J.","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Hirvonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/39\/4\/acta_39_4_002.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/39\/4\/acta_39_4_002.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:19:52Z","timestamp":1676391592000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/39\/4\/491\/6954872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1962,4]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0390491","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1962,4]]}}}