{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:57Z","timestamp":1676438637483},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1963,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>The results of 123 fractionation analyses of 17-ketosteroids are presented. The control series consisted of 16 healthy women in the fertile age and 14 women with amenorrhoea without hirsutism. The results of analysis in these two control series were compared with the results in a series of 60 patients with amenorrhoea and hirsutism. Corticotrophin and choriongonadotrophin tolerance tests were performed on some of the patients.<\/jats:p>\n        <jats:p>A statistically significant increase of the dehydro<jats:italic>epi<\/jats:italic>androsterone excretion was evident only in cases of adrenal dysfunction. Increased DHA excretion is due to a deficiency of 3\u03b2-hydroxy-dehydrogenase or to a disturbed enzyme function. Hirsutism is due to DHA.<\/jats:p>\n        <jats:p>Some patients with hypertrichosis and the Stein-Leventhal syndrome had an elevated <jats:italic>epi<\/jats:italic>androsterone excretion. The change was statistically significant. The increased <jats:italic>epi<\/jats:italic>androsterone excretion was a sign of the typical male phenomenon, which promotes the synthesis or activation of some enzyme or cofactor necessary for the 3\u03b2-oriented reduction of the 3-ketone. Hirsutism is due to a typical male reductase system.<\/jats:p>","DOI":"10.1530\/acta.0.0430220","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:29:45Z","timestamp":1229372985000},"page":"220-226","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["OBSERVATIONS ON THE CATABOLISM OF ANDROGENS IN NORMAL AND HIRSUTE WOMEN"],"prefix":"10.1093","volume":"43","author":[{"given":"S.","family":"Pesonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/43\/2\/acta_43_2_007.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/43\/2\/acta_43_2_007.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:22:22Z","timestamp":1676391742000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/43\/2\/220\/6955371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1963,6]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0430220","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1963,6]]}}}