{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:48Z","timestamp":1676438628213},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1963,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p><jats:list list-type=\"order\"><jats:list-item><jats:p>In the presence of human serum albumin, three preparations of parathyroid hormone release radiocalcium from boiled, dried, <jats:sup>45<\/jats:sup>Ca-labelled adult mouse bones. \u03b2- or \u03b3-globulin do not replace whole serum or albumin for this effect.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>The action is not abolished by heating serum to 55\u00b0 C, indicating that calcium release is not the result of activation of phosphatases or other thermolabile substances.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>Concentration-action relation is arithmetically linear from 0.07 to 6.7 IU\/ml. Under the conditions used, higher concentrations produce no significant further release of radiocalcium.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>ACTH, \u03b1-MSH, \u03b2-MSH, \u03b9-thyroxine and cortisol do not release radiocalcium in this system.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>Sera of patients with hyperparathyroidism have osteolytic activity equal to that of 2.9 \u00b1 0.15 IU of parathyroid peptide per ml. Following surgical cure, and during postoperative hypocalcaemia tetany, the value falls to normal, but not below.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>Sera of women with disseminated breast cancer have osteolytic activity greater than that of 6.7 IU\/ml.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>It is suggested that this physicochemical action of parathyroid peptide may explain some of its biologic functions as a result of binding of divalent cations by an albumin-parathyroid peptide complex.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p>","DOI":"10.1530\/acta.0.0440481","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:29:45Z","timestamp":1229372985000},"page":"481-489","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":5,"title":["A DIRECT ACTION OF PARATHYROID HORMONE ON DEAD BONE IN VITRO"],"prefix":"10.1093","volume":"44","author":[{"given":"Gilbert S.","family":"Gordan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/44\/4\/acta_44_4_001.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/44\/4\/acta_44_4_001.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:22:50Z","timestamp":1676391770000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/44\/4\/481\/6955448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1963,12]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0440481","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1963,12]]}}}