{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:02:30Z","timestamp":1758636150712},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1965,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>The effects of <jats:italic>in vivo<\/jats:italic> administration of corticotrophin (ACTH) and human chorionic gonadotrophin (HCG) on rat testes were studied. HCG, administered for 14 days to young rats, led to testicular interstitial cell hypertrophy and hyperplasia, accompanied by stimulation of <jats:italic>in vitro<\/jats:italic> testicular androgen production, as manifested by increased 17\u03b1-hydroxylase and 17\u03b2-desmolase enzyme activities, with no clear-cut effect on 20\u03b1-hydroxysteroid dehydrogenase activity. The findings in ACTH-treated animals were similar to those in the saline-treated controls. The lack of influence of ACTH on the testicular enzymes involved in steroid biosynthesis is consonant with the concept that ACTH-dependent bilateral testicular tumours occurring in boys with congenital adrenocortical hyperplasia arise from \u00bbadrenocortical rest cells\u00ab rather than from testicular interstitial cells.<\/jats:p>","DOI":"10.1530\/acta.0.0500365","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:29:45Z","timestamp":1229372985000},"page":"365-378","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":16,"title":["TESTICULAR ANDROGEN BIOSYNTHESIS FOLLOWING CORTICOTROPHIN AND HUMAN CHORIONIC GONADOTROPHIN ADMINISTRATION"],"prefix":"10.1093","volume":"50","author":[{"given":"Edgar J.","family":"Schoen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo T.","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/50\/3\/acta_50_3_006.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/50\/3\/acta_50_3_006.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:26:43Z","timestamp":1676392003000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/50\/3\/365\/6890628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,11]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0500365","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1965,11]]}}}