{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:16:14Z","timestamp":1756995374865},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1966,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>The effects of HCG and\/or ACTH administration have been investigated in 2 normal subjects and in 12 male patients suffering from various endocrinopathies. It was found that:<\/jats:p>\n        <jats:p><jats:list list-type=\"order\"><jats:list-item><jats:p>In normal adult males 3000 IU HCG given daily over three days appear to be sufficient to obtain a significant increase in urinary testosterone excretion. The degree of the increase appears to be dependent on the age of the patient.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>Prolonged HCG administration in secondary hypogonadism can lead to significant sustained increases of testosterone and epitestosterone excretions.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>Endogenous HCG of the type produced by chorionepitheliomas does not necessarily have an effect on testosterone and epitestosterone production in male patients.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>HCG stimulates the testosterone and epitestosterone secretion of the testes only; it thus has no effect on orchiectomized patients.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>Exogenous ACTH increases the testosterone and epitestosterone production of the adrenal cortex, the latter apparently more than the former; the testosterone\/epitestosterone quotient in the urine falls.<\/jats:p><\/jats:list-item> <jats:list-item><jats:p>In orchiectomized patients ACTH administration leads to an increase of oestrogen production from the adrenal cortex and of oestriol excretion in the urine.<\/jats:p><\/jats:list-item><\/jats:list><\/jats:p>","DOI":"10.1530\/acta.0.0530061","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:29:45Z","timestamp":1229372985000},"page":"61-72","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":24,"title":["THE EFFECTS OF ACTH AND HCG ON THE URINARY EXCRETION OF TESTOSTERONE IN MALE PATIENTS WITH VARIOUS ENDOCRINE DISORDERS"],"prefix":"10.1093","volume":"53","author":[{"given":"J.","family":"Tamm","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Apostolakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. D.","family":"Voigt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/53\/1\/acta_53_1_006.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/53\/1\/acta_53_1_006.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:27:32Z","timestamp":1676392052000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/53\/1\/61\/6893964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,9]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0530061","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,9]]}}}