{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:02:34Z","timestamp":1759683754774},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1967,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>When human chorionic gonadotrophin from the urine of pregnant women is assayed both biologically and immunologically, the ratio (B\/I) between the two activities is less than unity, and changes as pregnancy progresses. This suggests that the two methods do not wholly measure the same activity. Urines from women with a hydatidiform mole have a B\/I ratio higher than urines from women with normal pregnancies, and this difference can be used to distinguish between a pregnancy and a hydatidiform mole. The B\/I ratio of the serum from pregnant women is significantly higher than that of the urine. The B\/I ratio of serum from women with a hydatidiform mole, and from those with a normal pregnancy, are of the same magnitude. Factors which might influence the immunological and biological HCG activity in the urine and serum are discussed.<\/jats:p>","DOI":"10.1530\/acta.0.0540105","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:59:13Z","timestamp":1229374753000},"page":"105-112","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":6,"title":["IMMUNOLOGICAL AND BIOLOGICAL ACTIVITY OF HUMAN CHORIONIC GONADOTROPHIN IN URINE AND SERUM OF PREGNANT WOMEN AND WOMEN WITH A HYDATIDIFORM MOLE"],"prefix":"10.1093","volume":"54","author":[{"given":"Leif","family":"Wide","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Hobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/54\/1\/acta_54_1_012.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/54\/1\/acta_54_1_012.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:27:57Z","timestamp":1676392077000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/54\/1\/105\/6894009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0540105","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,1]]}}}