{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:54:10Z","timestamp":1759964050357},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2_Suppl","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1967,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Clinical and cytogenetic studies were made of twenty four patients with Klinefelter's syndrome in order to determine the somatic consequences of X chromosomal overdosage and its effect on the incidence of metabolic and degenerative diseases. Salient features of the group were tall stature, obesity, a high incidence of diabetes mellitus, hyperlipemia, hypercholesterolemia, gall bladder disease, chronic pulmonary infection, peptic ulcer, varicose veins, laboratory indices of hypothyroidism and a disordered personality. There was a striking absence of hypertension, myocardial infarction and rheumatoid arthritis and no case of hyperthyroidism, thyroiditis or gout. Family histories revealed a high incidence of diabetes mellitus in close relatives.<\/jats:p>\n        <jats:p>Thus the second X chromosome, although it is sequestered in adult life appears to have profound metabolic as well as morphological effects.<\/jats:p>","DOI":"10.1530\/acta.0.054s005","type":"journal-article","created":{"date-parts":[[2009,10,21]],"date-time":"2009-10-21T22:07:49Z","timestamp":1256162869000},"page":"S5-S48","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":18,"title":["KLINEFELTER'S SYNDROME, A CLINICAL AND CYTOGENIC STUDY IN TWENTY-FOUR CASES"],"prefix":"10.1093","volume":"54","author":[{"given":"Klaus","family":"Zuppinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Engel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne P.","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Mantooth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Claffey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/54\/2_Suppl\/acta_54_Suppl_113_001.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/54\/2_Suppl\/acta_54_Suppl_113_001.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:28:17Z","timestamp":1676392097000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/54\/2_Supplement\/S5\/6894041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,4]]},"references-count":0,"journal-issue":{"issue":"2_Suppl"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.054s005","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,4]]}}}