{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:24:09Z","timestamp":1676438649576},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1967,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>We have previously reported that, in the rat, pituitary transplantation performed on the 1st day of gestation, occasionally leads to nidations that are usually delayed and sometimes asynchronous; however, pregnancy is not usually maintained beyond implantation, and few foetuses survive to term. Under these conditions we were unable to ascertain whether the hormonal imbalance of gestation due to the pituitary transplantation, could have a teratogenic effect.<\/jats:p>\n        <jats:p>To improve the endocrine conditions prevailing after pituitary transplantation, and in the hope of increasing the foetal material available for the search of embryopathies, we have given various substitution treatments during the pre-implantation period to pregnant rats, hypophysectomized and grafted with a pituitary gland under the kidney capsule, between the 1st and the 4th day of gestation.<\/jats:p>\n        <jats:p>Progesterone does not modify the effect exerted by the pituitary transplantation on the mechanism of ovo-implantation: as in hypophysectomized, grafted, untreated animals, nidations are not numerous and generally delayed. Implantation is only favoured by treatments including oestrogens: nidations occur frequently at the normal time. Nevertheless, this beneficial effect of oestrogens is not constant and is closely dependent on the nature of the injected oestrogen, the time of the treatment and the strain of rats used.<\/jats:p>\n        <jats:p>Maintenance of pregnancy is rare, regardless of the treatments administered. In the surviving foetuses, the rate of visceral malformations is markedly and significantly increased. The cause of these embryopathies remains debatable: they may be due to a toxic effect of oestrogens, acting directly on the conceptus, or they may result from the hormonal imbalance of pregnancy, induced by the pituitary transplantation and ineffective substitution treatments.<\/jats:p>","DOI":"10.1530\/acta.0.0550010","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:59:13Z","timestamp":1229374753000},"page":"10-30","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["PROGRESS OF PREGNANCY AND FOETAL MORPHOLOGY AFTER EARLY PITUITARY TRANSPLANTATION AND HORMONAL THERAPY IN THE RAT"],"prefix":"10.1093","volume":"55","author":[{"given":"G.","family":"Carpent","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Desclin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/55\/1\/acta_55_1_002.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/55\/1\/acta_55_1_002.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:28:17Z","timestamp":1676392097000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/55\/1\/10\/6894088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0550010","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,5]]}}}