{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:53:44Z","timestamp":1758815624042},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1967,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>The influence of metyrapone (SU4885; 2-methyl-1,2, bis-[3-pyridyl]-1-propanone), an adrenocortical blocking agent, upon aldosterone secretion was evaluated in nine normal subjects and in seven patients including four with Cushing's syndrome, two with primary aldosteronism and one with hypopituitarism. Following equilibration on a constant diet restricted in sodium, metyrapone was given orally in a dose of 750 mg at four hourly intervals for two consecutive days. Aldosterone secretion rates were measured on the day prior to and on the second day of metyrapone administration. Despite the stimulus of salt deprivation, metyrapone was uniformly effective in reducing aldosterone secretion rates in all subjects. Concomitant ACTH stimulation in one normal subject failed to overcome the metyrapone induced block. In the majority of subjects, metyrapone administration was associated with a mild natriuresis.<\/jats:p>","DOI":"10.1530\/acta.0.0560376","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:59:13Z","timestamp":1229374753000},"page":"376-384","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":4,"title":["THE EFFECT OF METYRAPONE ON ALDOSTERONE SECRETION IN MAN"],"prefix":"10.1093","volume":"56","author":[{"given":"Joseph R.","family":"Tucci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A.","family":"Espiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul I.","family":"Jagger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David P.","family":"Lauler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/56\/3\/acta_56_3_002.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/56\/3\/acta_56_3_002.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:28:47Z","timestamp":1676392127000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/56\/3\/376\/6959286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,11]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0560376","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,11]]}}}