{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:43:18Z","timestamp":1759542198587},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1967,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Defective binding of iodine accumulated in the thyroid gland to tyrosyl radicals of thyroglobulin (organic binding) has been found in goitrous, mainly hypothyroid patients by a number of investigators since its first description by Stanbury &amp; Hedge in 1950. A hypothyroid goitrous cretin with this defect is briefly described in this paper.<\/jats:p>\n        <jats:p>Defective organic binding of iodine has also been found in goitrous, mainly euthyroid patients in association with deafness. This disorder has become known as Pendred's syndrome. A systematic search in two schools for the deaf yielded nine patients with the syndrome and nine cases (including the mother of one of the first-mentioned patients) where the diagnosis was probable.<\/jats:p>\n        <jats:p>Evidence is further presented in this paper that Stanbury &amp; Hedge's defect and Pendred's syndrome are expressions of essentially the same disease, presenting quantitative rather than qualitative differences.<\/jats:p>","DOI":"10.1530\/acta.0.0560567","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:59:13Z","timestamp":1229374753000},"page":"567-576","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":0,"title":["DISTURBED ORGANIC BINDING IN THE THYROID: ONE OR TWO DEFECTS?"],"prefix":"10.1093","volume":"56","author":[{"given":"G. M.","family":"Bax","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Wiener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/56\/4\/acta_56_4_002.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/56\/4\/acta_56_4_002.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:28:52Z","timestamp":1676392132000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/56\/4\/567\/6894191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,12]]},"references-count":0,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0560567","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,12]]}}}