{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T11:25:25Z","timestamp":1693481125504},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1968,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>The effect of clomiphene administration on steroid and gonadotrophin output has been studied in three male patients with adrenocortical insufficiency and in three castrate men.<\/jats:p>\n        <jats:p>In the patients with adrenocortical insufficiency the main effect of clomiphene was to produce a marked increase in the output of urinary testosterone and of its metabolites, androsterone and aetiocholanolone. It is concluded that this effect results from testicular stimulation.<\/jats:p>\n        <jats:p>In the castrate males clomiphene caused a less marked rise in the excretion of dehydro<jats:italic>epi<\/jats:italic>androsterone (DHA), androsterone and aetiocholanolone, presumably indicating adrenocortical stimulation. Testosterone levels may have fallen slightly during the administration of the compound.<\/jats:p>\n        <jats:p>Little or no effect on the output of \u00bbtotal gonadotrophic activity\u00ab or of follicle-stimulating hormone (FSH) was produced by clomiphene.<\/jats:p>","DOI":"10.1530\/acta.0.0580038","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:59:13Z","timestamp":1229374753000},"page":"38-48","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":2,"title":["THE EFFECTS OF CLOMIPHENE ON ENDOCRINE FUNCTION IN MALE PATIENTS WITH ADRENOCORTICAL INSUFFICIENCY AND FOLLOWING CASTRATION"],"prefix":"10.1093","volume":"58","author":[{"given":"R. A.","family":"Harkness","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. T.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Loraine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. A. A.","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. I.","family":"Morse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/58\/1\/acta_58_1_005.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/58\/1\/acta_58_1_005.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:30:42Z","timestamp":1676392242000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/58\/1\/38\/6894267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0580038","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,5]]}}}