{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:26:26Z","timestamp":1676438786417},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3_Suppl","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1968,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Six women with atypical forms of adrenal cortical hyperfunction were studied by means of urinary excretion of 17-ketosteroids and 17-hydroxycorticoids and their response to ACTH stimulation and corticosteroid suppression. Unusual responses were observed, particularly with respect to the independence of 17-KS and 17-OHCS excretion. The adrenals of 3 patients were anatomically normal whereas the others showed hyperplasia. Minced adrenal tissue was incubated with 4-<jats:sup>14<\/jats:sup>C progesterone and the metabolites isolated and definitively identified. The pattern of biosynthesized corticosteroids showed great variation, and in some instances clarified certain clinical features. The pattern of certain C<jats:sub>19<\/jats:sub>-metabolites could not be studied adequately because of the use of a \u0394<jats:sup>4<\/jats:sup> rather than a \u0394<jats:sup>5<\/jats:sup> substrate.<\/jats:p>","DOI":"10.1530\/acta.0.058s005","type":"journal-article","created":{"date-parts":[[2009,10,21]],"date-time":"2009-10-21T22:07:49Z","timestamp":1256162869000},"page":"S5-S34","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":0,"title":["ATYPICAL ADRENAL HYPERFUNCTION: IN VIVO STUDIES AND INCUBATIONS OF ADRENAL TISSUE WITH 4-14C PROGESTERONE"],"prefix":"10.1093","volume":"58","author":[{"given":"Joseph W.","family":"Goldzieher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard R.","family":"Axelrod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur S.","family":"Weissbein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/58\/3_Suppl\/acta_58_Suppl_129_001.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/58\/3_Suppl\/acta_58_Suppl_129_001.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:31:02Z","timestamp":1676392262000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/58\/3_Supplement\/S5\/6894289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,8]]},"references-count":0,"journal-issue":{"issue":"3_Suppl"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.058s005","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,8]]}}}