{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:31:04Z","timestamp":1756992664959},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1969,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Incubation of [<jats:sup>14<\/jats:sup>C] pregnenolone with sliced adrenal tissue from a newborn anencephalic infant yielded [<jats:sup>14<\/jats:sup>C] 16\u03b1-hydroxy-dehydro<jats:italic>epi<\/jats:italic>androsterone (16\u03b1-OH-D). When [<jats:sup>3<\/jats:sup>H]dehydro<jats:italic>epi<\/jats:italic>androsterone (D) was incubated with this tissue, [<jats:sup>3<\/jats:sup>H] 16\u03b1-OH-D could not be detected. Incubation of [<jats:sup>3<\/jats:sup>H] pregnenolone and [<jats:sup>14<\/jats:sup>C]D together in equimolar quantities yielded 16\u03b1-OH-D containing <jats:sup>3<\/jats:sup>H but not <jats:sup>14<\/jats:sup>C. This evidence suggests that 16\u03b1-OH-D can be formed in <jats:italic>vitro<\/jats:italic> by the adrenal of the newborn anencephalic infant from a C<jats:sub>21<\/jats:sub> steroid by a pathway which avoids D.<\/jats:p>\n        <jats:p>16\u03b1-OH-D is an efficient precursor of oestriol in late pregnancy. The pathway demonstrated <jats:italic>in vitro<\/jats:italic> could therefore provide another source of oestriol precursor from foetal tissues, similar to that which <jats:italic>Kirschner et al<\/jats:italic>. (1966) suggested may operate in maternal tissues.<\/jats:p>","DOI":"10.1530\/acta.0.0600491","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:59:13Z","timestamp":1229374753000},"page":"491-500","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":4,"title":["A NEW PATHWAY OF OESTRIOL BIOSYNTHESIS IN PREGNANCY?"],"prefix":"10.1093","volume":"60","author":[{"given":"M. M.","family":"Shahwan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Oakey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Stitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/60\/3\/acta_60_3_013.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/60\/3\/acta_60_3_013.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:31:46Z","timestamp":1676392306000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/60\/3\/491\/6894423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0600491","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,3]]}}}