{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:37:18Z","timestamp":1756993038418},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1969,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Vesicles of hydatidiform moles were incubated in the presence of [7\u03b1-<jats:sup>3<\/jats:sup>H]pregnenolone, After the incubation and extraction of tissues and media, 17\u03b1-hydroxy-pregnenolone*, 17\u03b1-hydroxy-progesterone and progesterone were identified using a number of TLC systems, followed by crystallization to a constant specific activity. [7\u03b1-<jats:sup>3<\/jats:sup>H] pregnenolone was not converted to oestrone, 17\u03b2-oestradiol and oestriol. The experimental findings indicate that hydatidiform moles, like full term placentas, are deficient in the enzymes necessary to convert C<jats:sub>21<\/jats:sub> to C<jats:sub>19<\/jats:sub> steroids. The production of 17\u03b1-hydroxy-progesterone and progesterone in the molar trophoblast <jats:italic>in situ<\/jats:italic> may contribute to the considerable urinary excretion of pregnanetriol and pregnanediol in patients with hydatidiform moles.<\/jats:p>","DOI":"10.1530\/acta.0.0610068","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:59:13Z","timestamp":1229374753000},"page":"68-75","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":1,"title":["FORMATION OF 17\u03b1-HYDROXY-PREGNENOLONE, 17\u03b1-HYDROXY-PROGESTERONE AND PROGESTERONE BY HYDATIDIFORM MOLES IN VITRO"],"prefix":"10.1093","volume":"61","author":[{"given":"Hubertus A.","family":"van Leusden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Siemerink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/61\/1\/acta_61_1_007.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/61\/1\/acta_61_1_007.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:32:01Z","timestamp":1676392321000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/61\/1\/68\/6894480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,5]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0610068","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,5]]}}}