{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T05:23:44Z","timestamp":1676438624820},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":["eje.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1970,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n        <jats:p>Thyroxine-binding globulin (TBG) levels were found to be significantly lower in 40 thyrotoxic patients than in 70 healthy subjects. A similar mean fall in TBG of 18% was produced by administration of 'physiological' doses of triiodothyronine to healthy volunteers. However, intramuscular injection of thyroid-stimulating hormone (TSH) had no consistent effect on the level of TBG as measured up to 4 days after injection. These findings are believed to explain the anomalous results described by earlier workers. It is suggested that TBG concentration is regulated by unknown mechanisms subject to the influence of many hormones, including triiodothyronine.<\/jats:p>","DOI":"10.1530\/acta.0.0630527","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T20:59:13Z","timestamp":1229374753000},"page":"527-532","update-policy":"http:\/\/dx.doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":3,"title":["CHANGES IN THYROXINE-BINDING GLOBULIN LEVELS IN THYROTOXICOSIS AND IN HEALTHY SUBJECTS AFTER TRIIODOTHYRONINE ADMINISTRATION"],"prefix":"10.1093","volume":"63","author":[{"given":"R. F.","family":"Harvey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. S.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P.","family":"Ekins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","container-title":["Acta Endocrinologica"],"original-title":[],"link":[{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/63\/3\/acta_63_3_016.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eje.bioscientifica.com\/view\/journals\/eje\/63\/3\/acta_63_3_016.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T16:10:47Z","timestamp":1676391047000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ejendo\/article\/63\/3\/527\/6893381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/acta.0.0630527","relation":{},"ISSN":["0804-4643","1479-683X"],"issn-type":[{"value":"0804-4643","type":"print"},{"value":"1479-683X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,3]]}}}